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PubMed1983

Changes of plasminogen activator in human uterine tissue induced by intrauterine contraceptive devices.

Potassium thiocyanate-extractable uterine plasminogen activator activity was determined to be highest in the endometrium surrounding intrauterine devices (IUDs). Such activity was significantly higher than that encountered in control endometrium or in the endometrium remote to IUDs. As in control cases, extracted endometrial activity fluctuated during the intermenstrual ovarian cycle. It was highest in the pre- or periovulation part of the cycle, and it rose again prior to menstruation. These peaks of activity seem to correspond to times in the cycle when metrorrhagia and abnormal menstruation are usually encountered. Possible implications of the myometrial and endometrial patterns of plasminogen activator in control and IUD-exposed uterine tissue are discussed.

Endometrium↗
PubMed1988

A comparative study of the ease of removal of intrauterine contraceptive devices.

This study compares the rates of easy and difficult removals of various types of IUDs. Eight-hundred-sixteen IUDs were removed in Auckland Family Planning Clinics in an 8-month period. Nearly 80% were the standard Multiload Copper 250. Eight-eight percent of all IUDs were easy to remove with another 7% requiring a hard pull. Of the remaining 5%, 3.5% required simple intracervical exploration, 1% required intrauterine exploration and 0.5% were referred to hospital. When compared with the standard Multiload, no IUD was statistically easier and only the Mini-Copper 7 was harder to remove at the 5% level of significance.

Family Planning Services↗
PubMed1989

Asymptomatic salpingitis in intrauterine contraceptive device users.

Serial histological sections of the fallopian tubes of 50 asymptomatic subjects undergoing voluntary tubal ligation were evaluated for morphological evidence of inflammation. Twenty-five subjects had history of IUD use (the study group) and the rest 25 had never used a device (the control group). Evidence of inflammation was found in 11 out of 25 subjects in the IUD users compared to only 2 out of 25 subjects in the non-users (p less than 0.001). The relative risk was 5.5 times. Both acute and chronic inflammation of the oviducts were observed more often in the IUD users, though clinically and at surgery there was no apparent evidence of pelvic inflammatory disease.

Adult↗