Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “CHARACTER”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 541 records · Page 30Linked to original sources

Character development in adolescents.

This study explored the effects of a program consisting of communication and counseling skills, assertiveness training and moral dilemmas on the character development, i.e., moral reasoning, ego development, and assertiveness of high school students. It was hypothesized that exposure to the experimental treatment would enhance the character development of high school students. Fifty-four high school seniors enrolled in three psychology classes were assigned randomly to two treatment groups and one control group. Assessment instruments were the Defining Issues Test, to measure moral reasoning, the Washington University Sentence Completion Test, to measure ego development, and the Rathus Assertiveness Schedule, to measure assertiveness. A repeated measures analysis of variance was used to determine significant differences between control and treatment posttest means with respect to the dependent variables--moral reasoning, ego development, and assertiveness. The results demonstrated that the character development of the students in the experimental treatment group was affected significantly over time by the program.

Achievement↗

[Spontaneous rate of occurrence of 2 characters of the transformation phenotype in a mouse fibroblast culture].

The spontaneous rate of occurrence of two characters of malignant transformation was studied in mouse embryo fibroblasts C3H10T1/2, clone 8. This cell line, though "immortal" in vitro, is characterized by a normal phenotype in respect to many other properties. The spontaneous rate of occurrence of anchorage-independence (aga+) and dense foci on cell monolayer varied in different experiments from 0.65 X 10(-6) to 1.2 X 10(-6) and from 1.2 X 10(-6) to 3.6 X 10(-6) per cell per generation, respectively. The fluctuation test has shown that both characters occur as random spontaneous events. The altered colony morphology proved to be stable in all 28 foci of independent origin tested. In most cases, the morphological transformants were anchorage-independent. It is suggested that the occurrence of the characters studied is due to mutation in a gene with pleiotropic effect.

Animals↗

Directional selection and developmental stability: evidence from fluctuating asymmetry of morphometric characters in rats.

Developmental stability was assessed among lines of rats selected for increased (up lines), decreased (down lines), and no body weight gain (controls) by the measurement of fluctuating asymmetry (FA) in 11 bilateral osteometric characters. This was done primarily to test the hypothesis that developmental stability should be lower (and thus FA higher) in both selection lines compared to the control line. FA values were obtained for all characters in each sex, line, and replicate (two each) within lines. Expressed as a proportion of the total variance, the FA values ranged from about 2% to over 50%, the average being 23%. FA for 3 of the 11 characters showed statistically significant differences among the lines, and in a multivariate analysis of variance, lines (but not sex or replicates) also showed overall significance (P less than 0.05). For the pooled sexes and replicates, seven of 11 FA values in the high line were greater than the comparable values in the control line (especially that for femur length), this conforming with theoretical expectations. Only one FA value in the down line was greater than that of the controls, however, and it was hypothesized that this was a consequence of the action of natural selection opposing artificial selection for decreased body weight gain.

Animals↗

The existence of atypical blood group galactosyltransferase which causes an expression of A2 character in A1B red blood cells.

It is generally accepted that the blood group subtypes A1 and A2 expressions are controlled by two different blood group N-acetylgalactosaminyl-transferases, that is, A1-enzyme and A2-enzyme, respectively, and that the two types of enzymes are governed by the allelic A1 and A2 genes. The observed frequencies of blood types in Caucasians are compatible to this model. However, the subtype A2 character is far more frequently observed in AB red cells than in A red cells in some black and Oriental populations. Two black blood samples with phenotype A2B contained A1-enzyme, but not A2-enzyme, and exhibited several times higher B-enzyme activity than control AB and B blood. The kinetic properties, that is, pH-activity profile and Km for UDP-Gal, of the B-enzyme from these two A2B subjects differed from that of control B-enzyme. In these two cases, therefore, the A2 character was not caused by the subactive A2-enzyme, but because of an insufficient formation of the A-substances in red cell membranes presumably caused by the competition between the A1-enzyme and the super active atypical B-enzyme at the common H-sites. The results suggest that the B gene can be subdivided into usual B1 and atypical B2, and that not only A2B subjects but also A1B2 subjects could express A2 character in their red cells. The B2 gene may be common in certain black and Oriental populations.

ABO Blood-Group System↗

[Analysis of the relation between character expressions on the right and left sides of the body for genes with bilateral phenotype action. Experimental studies on Drosophila].

The interdependence between manifestations of character on different sides of the body in case of mutations with incomplete penetrance affecting phenotypically symmetrical parts of the body was analysed in several stocks of Drosophila melanogaster. According to Astaurov's conception, if manifestations of character on different sides of the body of an individual are independent events, the heterogeneity of genetic background and environment causes a positive dependency in the mutant stock. About 130 anomalous characters of 15 alleles of 6 genes were examined. It was found that the dependence in the stocks is practically always positive. In view of the heterogeneity of environment and genotypes in the natural populations, the dependence among predisposed genotypes of a population is obviously positive. Except for one case, we could not obtain negative dependency between the sides by selection for 14-16 generations in several mutant stocks. The possibility to use mutations with incomplete penetrance affecting antimeres for evaluation of heterogeneity of the environment and the genetic background in the cultivated stocks is shown. A quantitative criterion of the heterogeneity is given.

Animals↗

[Variation of a complex of wing characters in natural populations of Drosophila melanogaster].

Genetic variation of a set of morphometric wing characters in natural populations of Drosophila melanogaster from different regions of the former USSR was examined. It was shown that the proximal-distal ratio of characters of the posterior compartment significantly differs in southern and northern populations. These results suggest the operation of natural selection for wing shape in natural populations of Drosophila. Contributions of different characters into the geographic differentiation is considered.

Animals↗

[Taxonomic characters of "Clostridium tyrobutyricum" (author's transl)].

The taxonomic characters of 77 strains of Clostridium tyrobutyricum have been studied and compared to those of known strains. This work shows the insufficiency of the Bergey's Manual (8th edition) nine characters distinguishing Clostridium groupe I to identify C. tyrobutyricum. To be more representative of the species, addition of one or two characters to this key of determination and some modifications to the complementary description of C. tyrobutyricum in this manual are proposed.

Carbohydrate Metabolism↗

Relationship between interpersonal psychotherapy problem areas with temperament and character: a pilot study.

OBJECTIVE: To examine the relationships between dimensions of personality assessed by using the Temperament and Character Inventory and presenting problem areas in Interpersonal Psychotherapy. METHOD: One hundred two depressed patients completed the Temperament and Character Inventory (TCI), and Interpersonal Psychotherapy (IPT) problem areas were assessed using a clinician-rated questionnaire. RESULTS: Following multiple regression analysis, patients rated as having problems with grief scored low on self transcendence, those with disputes had low cooperativeness, those with role transitions had low novelty seeking, and those with deficits had low reward dependence. CONCLUSIONS: Both temperament and character may be relevant to the nature of presenting problems related to Interpersonal Psychotherapy. An understanding of how personality is relevant to presenting interpersonal problems may provide both a framework and a focus with which to work in this form of psychotherapy.

Adult↗

Temperament and character in eating disorders: ten years of studies.

In recent years a number of studies of personality have been performed in subjects with Eating Disorders (EDs) to investigate the clinical differences between controls and ED patients and among EDs subtypes, and its role in the development and course of symptoms. The Tridimensional Personality Questionnaire (TPQ) and the Temperament and Character Inventory (TCI) have been widely used at this purpose, allowing the description of specific temperament and character profiles for EDs. High Harm Avoidance (HA) and low Self-Directedness (SD) are shared by all EDs. Slight differences on some facets have been found among ED subgroups. Nevertheless, HA is influenced by mood and both high HA and low SD are personality traits shared by many mental disorders, whose specificity is rather low. Restrictor anorectics are characterized by high Persistence (P) and a relatively higher SD, and bulimics by higher Novelty Seeking (NS) and the lowest SD, while binge/purging and purging anorectics share some traits with anorexia and some with bulimia. Though current data justify the discrimination among anorexia subtypes, they are not in contrast with the thesis of a continuum in ED personality traits. Since some personality traits display a prognostic value with regard to therapy and clinical outcome, further studies are needed on treatments and prognostic factors in EDs. Moreover, studies attempting to define the neurobiological and genetic correlates of temperament should be supported by clinical pharmacological trials.

Character↗

[Temperament and character in persons with borderline personality disorder].

High comorbidity, suicidal ideation, difficult temperament, and character are key symptoms of persons with borderline personality disorder (BPD). We investigated 478 persons, 40 of whom had a BPD according SCID-II, self-rating. Participants were examined with a semistructured interview and several self-rating questionnaires in their households. Taking the high comorbidity of persons with BPD into account, we compared the BPD group with four control groups with different axis 1 or personality disorders and one nonclinical group. Persons with BPD showed high comorbidity with affective, anxiety, and alcohol use disorders. With respect to suicidality, 75% reported that they wish to be dead at least sometimes, and about one-third said that they had already attempted suicide. Regarding temperament and character dimensions, our analyses revealed higher novelty seeking for persons with BPD compared to participants without BPD, although this difference was primarily attributable to males with BPD. Additionally, participants with BPD reported higher harm avoidance compared to control groups, while this was more distinctive for females. Finally, we found that persons with BPD had very low levels of self-directedness. This effect was independent from gender and was found in all group comparisons. Therapy of BPD should take into account high comorbidity and suicidality of patients. Moreover, our results show that low self-directedness seems to be specific for persons with BPD. Therefore, therapy must address those deficits by focusing on skills training as well as on aspects of maturation.

Adult↗

Temperament and character: prognostic factors in whiplash patients?

We studied the relationship between whiplash injury and personality in 40 whiplash patients who admitted the hospital within 8 h from the car accident and 80 age- and gender-matched controls. For this purpose we used the Temperament and Character Inventory (TCI). We found that personality dimensions in whiplash patients both in the acute phase and at follow-up 2 years later showed the same results, i.e., significantly less Harm Avoidant (less anxious; low HA) than controls, but when dividing patients into groups depending on severity of outcome from whiplash injury 2 years after, no differences were found. According to our results personality symptoms related to whiplash injury is probably not a secondary phenomenon. Whiplash patients were normally developed in character, i.e., self-directedness (SD), and CO (cooperativeness) and therefore in general are capable of coping with their somatic problems.

Adolescent↗

Character education as a prevention strategy in school-related violence.

Prevention education is seen as a key component in addressing school violence. Three hundred and three fourth grade students in 9 elementary schools in a predominantly rural community were provided a specialized program of character education as a prevention tool to reduce the potential for deviant behavior. Students in 3 schools were in the no treatment control condition. Students in the remaining 6 schools received a school-based and curriculum driven character education program; two of the schools were in the curriculum only condition while in four of the schools students were randomly selected to receive a protocol-driven summer academic (6 weeks) and experiential education/program. The intervention results suggest that the students who received the academic/camp intervention had the greatest increases in social competence, the largest gains in reading achievement, and the largest increase in parental interaction. Recommendations for prevention education are discussed at the primary, secondary and tertiary levels.

Age Factors↗

Self-mutilation in substance-dependent patients and relationship with childhood abuse and neglect, alexithymia and temperament and character dimensions of personality.

OBJECTIVE: Aim of this study was to evaluate the prevalence of self-mutilation (SM) in Turkish male substance-dependent patients, and to investigate the relationship of SM with childhood abuse and neglect, alexithymia and temperament and character dimensions of personality. METHODS: Participants were 136 consecutively admitted males with substance dependence (96 alcohol and 40 drug). Substance dependence was diagnosed by means of the Structured Clinical Interview for DSM-IV (SCID-I), Turkish version. Patients were investigated with the childhood abuse and neglect questionnaire, Toronto alexithymia scale (TAS-20) and temperament and character inventory (TCI). RESULTS: Among substance-dependent patients 34.6% was considered as a group with SM. Rates of being single and unemployed, histories of physical and sexual abuse and suicide attempts were higher in the SM group. Current age, age at first substance use and age at regular substance use were lower in the group with SM. Mean of TAS-20 and 'difficulty in identifying feelings' (DIF) and 'difficulty in describing feelings' (DDF) subscales of TAS-20 were higher in SM group. There were no significant differences between groups in terms of TCI subscales. Age, childhood physical abuse and suicide attempt history predicted SM in logistic regression. CONCLUSIONS: Young substance users with childhood physical abuse histories could be the target population to prevent self-mutilating behavior. This study also suggests that whenever self-mutilating behavior is present, the possibility of childhood abuse, alexithymia and suicide attempts must be evaluated.

Adolescent↗

Temperament, character and symptoms of anxiety and depression in the general population.

Few studies have investigated the relationship of temperament and character, as conceptualized in the Temperament and Character Inventory-Revised (TCI-R), to symptoms of depression and anxiety in the general population. In this study a random sample of subjects (20 to 70 years), in two Finnish cities, were surveyed with the TCI-R, Beck Depression and Anxiety Inventories, plus questions related to diagnosed lifetime mental disorders, health care use for psychiatric reasons during the past 12 months, and history of mental disorders in first-degree relatives. Altogether 347 subjects (38.6%) responded. Of the TCI-R dimensions, Harm Avoidance correlated with symptoms of depression (r(s)=0.555, p<0.001), anxiety (r(s)=0.560, p<0.001), self-reported lifetime mental disorder (r(s)=0.272, p<0.001), health care use for psychiatric reason during the past 12 months (r(s)=0.241, p<0.001) and family history of mental disorder (r(s)=0.202, p<0.001). Self-directedness correlated negatively with symptoms of depression (r(s)=-0.495, p<0.001), anxiety (r(s)=-0.458, p<0.001), lifetime mental disorder (r(s)=0.225, p<0.001) and health care use (r(s)=-0.135, p=0.013). Overall, Harm Avoidance and Self-directedness seem to associate moderately with depressive and anxiety symptoms, and somewhat predict self-reported use of health services for psychiatric reasons, and lifetime mental disorder. High harm avoidance may associate with a family history of mental disorder.

Adult↗

Temperament and character in patients with classical myotonic dystrophy type 1 (DM-1).

This study was designed to investigate personality in classical Myotonic Dystrophy (DM-1). Forty-six patients with DM-1 (25 women and 21 men), 31 healthy controls and 37 subjects in a contrast group, consisting of patients with other muscle disorders (spinal muscular atrophy, facioscapulohumeral dystrophy and limb girdle muscular dystrophy), completed the Temperament and Character Inventory (TCI) (Cloninger, 1994). We aimed to establish whether CTG triplet repeat size correlated with ratings of personality dimensions in the TCI. The DM-1 patients scored significantly higher on the TCI dimension Harm avoidance and lower on Persistence, Self-directedness and Cooperativeness. Signs of a personality disorder were found in 20% of the DM-1 patients. No correlation was found between the number of CTG repeats and scores in the TCI. This study indicates deviant personality in classical DM-1 regarding temperament and character, both in comparison to healthy controls and to patients with other muscle disorders with no known brain disorder.

Adolescent↗

Temperament and character in couples with fertility disorders: a double-blind, controlled study.

OBJECTIVE: To evaluate the personality features of infertile patients. DESIGN: A double-blind, controlled study. SETTING: An outpatient facility for diagnosis and care of infertility. PATIENT(S): We assessed 142 infertile couples with obstetric-gynecologic clinical and instrumental examinations. The couples were divided into three groups: organic infertility, functional infertility, and infertility of uncertain origin. The third group was excluded. INTERVENTION(S): Organic infertility and functional infertility were ascertained with gynecologic and andrologic clinical examinations, seminal liquid examination, postcoital testing, progesterone assay, hysterosalpingography, biopsy of endometrium, and laparoscopy. Personality traits were assessed with the Temperament and Character Inventory (TCI). MAIN OUTCOME MEASURE(S): Results of the Temperament and Character Inventory. RESULT(S): Infertile women showed lower Cooperativeness than control women. Women with functional infertility had lower scores in Cooperativeness and Self-Directedness than women with organic infertility. Men belonging to the functional infertility group had a lower Novelty Seeking score than did those of the organic infertility group. Men and women in the functional infertility group showed higher Harm Avoidance than those in the organic infertility and control groups. CONCLUSION(S): The results emphasize that the study of personality in the diagnostic and therapeutic assessment of infertility might provide useful predictive elements for functional infertility.

Adult↗

Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution.

BACKGROUND: Little is known as to whether or not the seven personality dimensions of Cloninger's theory, particularly the three character dimensions newly included in the theory, are independent of the states of depression. METHODS: One hundred and eight patients with major depression filled out the Temperament and Character Inventory (TCI) before and after a 16-week antidepressant treatment. RESULTS: The level of depression, as assessed by the Hamilton Rating Scale for Depression, was correlated positively to the harm avoidance score and negatively to the self-directedness and cooperativeness scores. During the treatment, the scores on these three dimensions significantly changed toward normal values in treatment-responders, but were stable in treatment-nonresponders. The changes in these dimensions were significantly explained by the change in the depression severity during treatment. Scores on novelty seeking, reward dependence, persistence, and self-transcendence were not correlated significantly to the level of depression and did not change significantly during the treatment in either treatment-responders or nonresponders. LIMITATIONS: The changes in the TCI scores during treatment in this study may reflect a non-specific tendency for the scores to change on retest. CONCLUSIONS: The results suggest that a depressive state can significantly affect assessments of harm avoidance, self-directedness, and cooperativeness in major depression. The administration of the TCI during a depressive episode may elevate the HA score, and may lower the SD and C scores. These findings highlight the importance of considering the state of depression before drawing conclusions about the TCI personality traits, when a patient with major depression is still experiencing a depressive episode.

Adult↗

Normative data and factor structure of the Temperament and Character Inventory (TCI) in the French version.

We explored the psychometric features of the French Temperament and Character Inventory (TCI) in a 602-subject community sample (263 men and 339 women), representative of the French population. The factor structures of the temperament and character dimensions, explored separately, were in agreement with the hypothesized constructs, except for the scales Novelty Seeking NS1 (exploratory excitability), Persistence, and Self-Directedness SD4 (self-acceptance). The internal consistency of the main dimensions was good (Cronbach alpha coefficients between 0.68 and 0.82), but weak for Persistence (0.49). The mean scores of the temperament dimensions were notably different from those published in other normative data - especially lower for Novelty Seeking (16.4+/-5.6) and higher for Harm Avoidance (16.1+/-7.2) when compared with US data - suggesting cross-cultural differences in personality assessment, and the necessity to use specific normative values with each translated instrument.

Adult↗