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PubMed2006

[What causes self-control failure in delayed-cost dilemma: the role of affective expectancy and regulatory resource].

Two studies were conducted to examine the effect of affects on self-control behavior in delayed cost dilemma. Results of Study 1 suggested that long term negative affects such as regret and self-disgust might have facilitating effects on motivation of self-control if they were anticipated before delayed-cost dilemma situations, but inhibiting effects on self-efficacy of control when experienced after dilemma situations. Study 2 examined the effect of affect priming on self-control in eating behavior, as well as an interaction effect of anticipated affect and regulatory resource on it. Results indicated that participants who had enough regulatory resource succeeded in self-control, i.e. they ate less, regardless of the type of affect priming, but those who did not have sufficient resource and were not primed with long-term negative affects failed to control their behavior. It was argued that regulatory resource explanation of self-control should be expanded to the theory including anticipated affects.

Adult↗
PubMed2002

Affective percept and voluntary action: a hypothesis.

I present a hypothesis concerning the neuronal, mental and behavioral effects of all kinds of affective (emotional) stimuli, i.e., of unpleasant and pleasant stimuli. I use the term stimulus in its broad sense. Affective stimuli evoke two associated percepts: "cognitive" and "affective". A food in the mouth, for example, evokes the gustatory percept and the percept of pleasure. However, affective percepts are unstable parts of cognitive-affective compounds. Five types of affective percepts are pain, fear, pleasure, "desire" and appetite in the broad sense of these words. Desire is evoked by inadequate pleasant stimuli. Affective percepts are "lower" or "higher". The latter are not directly associated with bodily needs. Esthetic and social percepts are higher, for example. Although pain and pleasure are essentially innate, they can be modified by sensory experience. Alimentary and esthetic preferences and social values are modifiable, for example. The neurons of pain and fear and of the unpleasant components of desire and appetite motivate four types of voluntary actions. These are, respectively, escape, avoidance, "optimization" and approach actions. All these actions eliminate the motivating displeasure. In addition, avoidance actions protect from the signaled pain, optimization actions increase the existing pleasure and approach actions provide the signaled pleasure. Thus, voluntary actions associated with different percepts occur according to one universal principle. Voluntary actions are "internal" and behavioral. During internal actions a goal and then an action plan are decided. These actions often provide the images of the goal stimuli and of particular movements.

Affect↗
PubMed2001

Regional brain activation as a biological marker of affective responsivity to acute exercise: influence of fitness.

Previous research has shown that regional brain activation, assessed via frontal electroencephalographic (EEG) asymmetry, predicts affective responsivity to aerobic exercise. To replicate and extend this work, in the present study we examined whether resting brain activation was associated with affective responses to an acute bout of aerobic exercise and the extent to which aerobic fitness mediated this relationship. Participants (high-fit, n = 22; low/moderate-fit, n = 45) ran on a treadmill for 30 min at 75% VO2max. EEG and affect were assessed pre- and 0-, 10-, 20-, and 30-min postexercise. Resting EEG asymmetry predicted positive affect (as measured by the energetic arousal subscale of the Activation Deactivation Adjective Check List) postexercise. Furthermore, resting frontal EEG asymmetry predicted affect only in the high-fit group, suggesting the effect might be mediated by some factor related to fitness. It was also shown that subjects with relatively greater left frontal activation had significantly more energy (i.e., activated pleasant affect) following exercise than subjects with relatively greater right frontal activation. In conclusion, aerobic fitness influenced the relationship between resting frontal asymmetry and exercise-related affective responsivity.

Adult↗
PubMed2002

The effects of diffuse and distinct affect.

In a series of suboptimal priming studies, it was shown that both affective and nonaffective reactions to a stimulus may occur without awareness. Moreover, it was demonstrated that affective information is detected earlier than nonaffective information. Therefore, early reactions to an affect-laden stimulus (e.g., a smiling man) are cognitively unappraised and thus diffuse (e.g., "positive"), whereas later affective reactions can be more specific and distinct (e.g., "a smiling man"). Through variations of prime exposure (extremely short, moderately short) the impact of early diffuse and late distinct affect on judgment was investigated. Findings show that distinctness (and prime-target similarity) is an essential determinant of whether the effect of affect is null, assimilation, or contrast. Furthermore, whether affect priming activates diffuse or distinct reactions is a matter of a fraction of seconds.

Affect↗
PubMed1992

Genetic and environmental influences on positive and negative affect: support for a two-factor theory.

Genetic and environmental etiologies of positive and negative affect, as measured by the Bradburn Affect Balance Scale, were studied to gain understanding of a two-factor theory of well-being. It was hypothesized that negative affect would demonstrate significant genetic and environmental variance and positive affect would be explained primarily by environmental influences. Data were combined from 105 pairs of twins (ages 18-72) and 220 multigenerational families (ages 16-98). Simultaneous model fitting indicated significant heritable effects for negative affect and a significant effect of common environment for twins. Significant effects for positive affect included common environment (for parents and offspring and for twin pairs) and assortative mating. These results, documenting differential genetic and environmental influences on positive and negative affect, provide further support for their being separate components of well-being.

Adolescent↗
PubMed2006

Affective states and racial identity among African-American women with trichotillomania.

Affective correlates of hair pulling were investigated in a sample of 43 African-American women with trichotillomania. The relationship among affective correlates and dimensions of racial identity was also examined. Via phone interview, participants completed the hair-pulling survey on which they rated the intensity of 10 different affective states across three different points in the hair-pulling episode (before, during and after). Participants also completed the Multidimensional Inventory of Racial Identity, which assesses racial identity across the dimensions of centrality, regard and ideology. Univariate analyses identified the feelings of being bored, happy, anxious, guilty and relieved as reflecting a time difference. Negative correlations were found among the racial identity dimension of private regard and the affective correlates of happy and relief that were experienced during and after pulling. Negative correlations were found between the racial identity dimension of humanist ideology and relieved affect as well as humanist ideology and relieved affect during a pulling episode. In light of the results, the importance of understanding and assessing cultural factors in the affective experience of African-American women with trichotillomania is discussed.

Adult↗
PubMed1980

Affects and their non-communication.

The non-communication of affects is the most evident form of defence in a certain group of narcissistic patients. This non-communication of affects may take the direct form of a state of non-relatedness or may be disguised as the communication of false affects or affects that serve the function of inducing corresponding feelings in the object. We have examined in detail the motives for this non-communication and its implications for a more general theory of affects. Although the motives are variegated we have observed the recurrent wish to control omnipotently the affects of others. We have understood the induction of dysphoric affects in the transference and countertransference as the wish to recreate actively what has been experienced passively. It is an attempt to bring the trauma arising from the external world into the internal world and thus to create an illusion of mastery and control. This is analogous to Freud's description of the child's game in 'Beyond the pleasure principle".

Adult↗
PubMed1996

Infant affective reactions to the resumption of maternal interaction after the still-face.

To investigate infants' reactions to the Face-to-Face Still-Face Paradigm and in particular the reunion episode, 50 6-month-olds' affective, behavioral, and physiologic reactions were recorded and analyzed. Infants reacted to the still-face with negative affect, a drop in vagal tone, and an increase in heart rate. By contrast, they reacted to the reunion episode with a mixed pattern of positive and negative affect. There was a carryover of negative affect from the still-face, an increase in fussiness and crying, and a rebound of positive affect. During this episode, the infants' heart rate and vagal tone returned to initial levels. The data indicate that infant affective displays are specifically related to different interactive events, but that their physiologic reactions do not show the same level of specificity. The findings also highlight the complexity of the affective and reparatory processes that take place in mother-infant interactions.

Affect↗
PubMed1977

Occupation characteristics in affective disorders.

One hundred and fifty-four consecutively evaluated new and return psychiatric outpatients were examined by the same interviewer using a detailed, precoded questionnaire based on the diagnostic criteria for psychiatric research proposed by Feighner et al. Affective disorders were present for 75% of the patients and were associated with a history of past employment at a declared occupation, inactive occupation status, and recent occupation status change. Sixty patients with diagnoses of primary affective disorders and 56 patients with diagnoses of secondary affective disorders were identified and studied. The primary affective disorder was associated with higher level and longer held occupations with fewer changes of occupation activity status than was the secondary affective disorder. Forty-one patients with diagnoses of unipolar primary affective disorders and 19 patients with diagnoses of bipolar primary affective disorders were examined. The unipolar illness was associated with a shorter duration of occupation type and less permanent unemployment than was the bipolar illness.

Affective Symptoms↗
PubMed1998

[Affect and mimetic behavior].

The relationship between facial expression and experienced affect presents many problems. The two diametrically opposed positions proposing solutions to this problem are exemplified using the conceptions of Mandler u. Izard. The underlying premises of both conceptions still prevail in various forms. The authors reject the concepts according to which facial expression is merely correlated to the affects (see Mandler 1975) as well as the view that facial expression controls the affects (see Izard 1977). The relationship between affect and facial expression is reexamined, subjecting it to a semiotic, essentially semantic analysis similar to the Ogden and Richards' language and meaning approach. This analysis involves a critical discussion of Scherer's attempt of a purely communicational interpretation using Bühler's organon model. In the author's approach, facial expression is seen not simply as a system of signals, but as a system of representative signs which signify the affects and refer to the emotive meaning of things for the subject. The authors develop the thesis that human beings are not born simply with the ability to speak, but also with the abstract possibility of performing facial expressions. This ability develops by way of coordinating patterns of expressions, which are presumably phylogenetically determined, with affects that take on a socially determined individual form, similar to language acquisition during socialisation. The authors discuss the methodological implications arising for studies investigating the affective meaning of facial expressions.

Affect↗
PubMed1976

Bipolar course in schizo-affective illness.

The authors undertook a chart review to examine the use of the diagnosis of schizophrenia, schizo-affective type, in clinical practice. Of 27 patients given this diagnosis over a 3-year period, 13 were found to have evidence of bipolar course in their illnesses. For both the bipolar and unipolar groups, the most striking finding in first-degree relatives was the prominence of affective conditions. The bipolar group had a statistically significant earlier age for first psychiatric treatment and previous number of hospitalizations. Symptoms noted on admission were mostly affective, and the schizophrenic symptoms reported were noted by authors to be considered overinclusive or unreliable by many clinicians. Both groups received treatment with antipsychotic and antidepressant medication. Six of 13 bipolar patients and no unipolar patients were treated with lithium carbonate. Five bipolar patients met research criteria of Feighner et al. (1972) for primary affective illness and another met the criteria for schizophreniform illness. One unipolar patient met criteria for probable primary affective illness and another met the criteria for probable schizophreniform illness. The authors concluded that the diagnosis of schizo-affective illness, as used in day to day clinical practice, does not identify a group of schizophrenic patients nor a homogeneous patient group, and when both affective and schizophrenic features appear in a patient with a bipolar illness, the diagnosis of manic-depressive illness, not schizophrenia, should be given first consideration.

Adolescent↗
PubMed1997

Clinical and genetic analysis of a family affected with dominant optic atrophy (OPA1)

OBJECTIVES: To refine the dominant optic atrophy locus, OPA1, on chromosome 3q and to characterize the phenotype of a 6-generation family pedigree affected with this disease. METHODS: Fifty-six family members had a complete eye examination. Clinical records of an additional 3 patients were reviewed. Goldmann perimetry and a 21-chip subtest of the Farnsworth-Munsell 100-Hue test were performed on selected patients. Affected patients, unaffected siblings, and potentially informative spouses were genotyped with short tandem repeat polymorphisms located on chromosome 3. The genotypic data were subjected to linkage analysis. RESULTS: Thirty-four family members were found to be clinically affected. Most experienced vision loss (20/40 or poorer) in the first decade of life. Most (9 of the 16 eyes) progressed to 20/800 or poorer visual acuity by age 60 years, while 2 patients maintained visual acuities of 20/40 at that age. Affected patients had a 2- to 10-fold increase in the error score of a 21-chip subtest of the Farnsworth-Munsell 100-Hue test compared with age-matched unaffected family members. The optic nerve examination revealed temporal pallor and excavation in all affected individuals. Linkage analysis revealed significant lod scores with 9 markers. The highest lod score, 10.1 (theta = 0) [corrected], was obtained with marker D3S2305. Analysis of recombinants narrowed the disease interval to approximately 3.8 centimorgans, flanked by D3S3669 (centromeric) and D3S1305 (telomeric). CONCLUSIONS: Most patients affected with dominant optic atrophy in this family progressed to legal blindness by middle age. Color vision testing is a sensitive method for detection of affected patients. The dominant optic atrophy locus, OPA1, has been refined by the identification of new flanking markers: D3S3669 (centromeric) and D3S1305 (telomeric).

Adolescent↗
PubMed1979

Combination of lithium carbonate and haloperidol in schizo-affective disorder: a controlled study.

Lithium carbonate alone has been shown to be inferior to neuroleptics alone in the treatment of excited schizo-affective illness. However, in clinical practice, lithium carbonate and neuroleptics are often combined in this disorder. We report a double-blind five-week controlled trial of lithium carbonate plus haloperidol vs placebo plus haloperidol in the treatment of excited schizo-affective patients. Eighteen patients were studied in each treatment group. Modest but statistically significant differences in favor of lithium carbonate plus haloperidol were found by week 5, using the Brief Psychiatric Rating Scale. Lithium carbonate plus haloperidol was favored both for affective schizo-affectives and for schizophrenic schizo-affectives. Lithium carbonate benefit did not seem to be restricted to affective symptoms only. In the clinical treatment of acute schizo-affective illness, the modest benefits of added lithium carbonate must be weighed against the risks of the drug's toxicity.

Adult↗
PubMed1995

Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment.

BACKGROUND: This study examines recent suggestions from a number of investigators that signal-transducing guanine nucleotide-binding (G) proteins may be involved in the pathophysiology of bipolar affective disorder and may represent molecular targets for lithium's mood-stabilizing actions. METHODS: We used selective antibodies to quantitate the levels of the G protein alpha subunits that regulate adenylate cyclase activity (G alpha s and G alpha i2) and phosphoinositide turnover (G alpha q/11). We also quantitated levels of pertussis toxin-catalyzed phosphate 32-labeled adenosine diphosphate ([32P]ADP) ribosylation in platelet and leukocyte membranes from a group of 14 untreated (predominantly manic) patients with bipolar affective disorder, 20 lithium-treated euthymic patients with bipolar affective disorder, and 11 healthy controls. RESULTS: In both tissues, the immunolabeling of the 45-kd form of G alpha s was higher in the bipolar affective disorder group considered as a whole (treated or untreated) compared with controls, effects that reached statistical significance in the leukocyte membranes. There were no significant differences in the immunolabeling of G alpha i1/2, G alpha q/11, or pertussis toxin-catalyzed [32P]ADP ribosylation in either tissue in the untreated bipolar affective disorder group compared with controls. In both tissues, lithium-treated subjects demonstrated lower levels of G alpha q/11 and higher levels of pertussis toxin-catalyzed [32P]ADP-ribosylation, which reached significance in the platelet membranes. CONCLUSIONS: Our results are complementary to the previously reported findings of elevated G alpha s levels in postmortem brain tissue form patients with bipolar affective disorder and in mononuclear leukocytes obtained from depressed patients with bipolar (but not unipolar) affective disorder. The significantly higher levels of pertussis toxin-catalyzed [32P]ADP ribosylation in the subjects receiving long-term lithium-treatment replicates our findings in rat cortex and in healthy volunteers and adds to the growing body of evidence implicating G alpha i as a target of lithium's actions.

Adenosine Diphosphate Ribose↗
PubMed1999

Analysis and metaanalysis of two polymorphisms within the tyrosine hydroxylase gene in bipolar and unipolar affective disorders.

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, association studies of bipolar and unipolar affective disorder groups and metaanalyses of published data on the TH tetranucleotide repeat polymorphism were done. The association studies used the TH tetranucleotide repeat polymorphism in intron 1 and a PstI polymorphism at the 3' end of the gene. The study comprised 124 unrelated bipolar patients, 126 unipolar patients, and 242 controls. There was no significant association of either bipolar or unipolar affective disorder with the TH tetranucleotide repeat polymorphism. However, a weak association (chi2 = 3.946, 1 df, P = 0.047; odds ratio, allele 2 vs. allele 1 = 0.71 (95% CI, 0.51-0.996)) was observed in the unipolar sample with the TH-PstI polymorphism. Three metaanalyses of published data on the TH tetranucleotide repeat polymorphism in major affective disorder were performed: bipolar I + II vs. control using 583 cases and 745 controls; unipolar vs. control using 204 cases and 359 controls; and bipolar + unipolar vs. control using 846 cases and 823 controls. In each analysis there was no association of the TH tetranucleotide repeat polymorphism and affective disorder. These results do not support the tyrosine hydroxylase gene having a major role in the etiology of bipolar affective disorder. However, our data suggest that this locus should be examined in larger samples of unipolar affective disorder.

Adolescent↗
PubMed1996

Symptom reporting in cancer patients: the role of negative affect and experienced social stigma.

BACKGROUND: Recent research suggests that patients' appraisal of somatic symptoms is more closely related to emotional variables (particularly negative affect) than to their actual health as determined by external criteria. METHODS: Sixty surgical cancer patients who at the time of a routine follow-up examination filled out the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire-C30, which included a positive/negative affect scale and a scale tapping into experienced social stigma. Patients' health status was determined in two ways: the examining physician gave a global judgement on a standardized scale at the end of the examination, and an additional two external physicians later rated the patients based on the findings listed in the medical record. RESULTS: Patients' reports of somatic symptoms were strongly correlated with two measures of negative affect (r = 0.75 and r = 0.65, respectively) and with experienced social stigma (r = 0.51). In contrast, the correlations between reported symptoms and the examining or external physicians' ratings were considerably weaker (r = 0.31 and r = 0.19). According to a multiple linear regression with 6 predictors, negative affect was the best single predictor of symptom reporting (beta = 0.68; P < 0.001) and global quality of life (beta = 0.48; P < 0.001). Factor analysis yielded a dimension of somatopsychosocial distress that accounted for 44.1% of the variance and is comprised of reported symptoms (factor loading = 0.86), negative affect (0.90 and 0.82), experienced social stigma (0.74), and global quality of life (0.70). Physicians' ratings and positive affect constituted two additional separate factors. CONCLUSIONS: Cancer patients' reporting of somatic symptoms by means of a standardized quality of life questionnaire is closely related to emotional and social distress and is not equivalent to health status as determined from a clinical perspective. Researchers and practitioners have to be aware of this fact when interpreting quality of life data. Furthermore, negative affect deserves attention as an important signal for intervention in tumor follow-up programs.

Abdominal Neoplasms↗
PubMed2003

Relative risk of prostate cancer for men with affected relatives: systematic review and meta-analysis.

An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative risk (RR) for these associations. The purpose of our study was to identify and summarize published reports on the relationship between risk of prostate cancer and family history, which is defined as having a father, brother, any first- or second-degree relative or other relative affected with prostate cancer. A Medline and manual search from 1982 to 2000 identified 24 studies that reported RR and confidence intervals (CI) and satisfied inclusion criteria. Pooled RR estimates based upon a weighted average model were as follows: any affected family member RR = 1.93, CI 1.65-2.26; affected first-degree relative RR = 2.22, CI 2.06-2.40; affected second-degree relative RR = 1.88, CI 1.54-2.30; father with prostate cancer RR = 2.12, CI 1.82-2.51; and brother with prostate cancer RR = 2.87, CI 2.21-3.73). Statistical comparison of pooled data demonstrated that the RR is significantly higher for affected brother than for affected father (p < 0.03). A sensitivity analysis demonstrated that these results are robust with respect to population bias. This meta-analysis confirms that risk of prostate cancer is associated with family history of disease and improves the quantification of this risk.

Humans↗
PubMed2000

Uncertainty of the hazardous concentration and fraction affected for normal species sensitivity distributions.

Species in the environment vary according to their sensitivity to a toxicant. Because these differences in sensitivity are unique to the toxicant at consideration and laboratory data sets to assess this variability are very small due to cost, it is important to provide uncertainty estimates of (1) environmental quality objectives (hazardous concentrations) derived from these laboratory data and (2) fraction of species affected at given, or predicted, laboratory or environmental concentrations. This article focuses on the normal (Gaussian) distribution of species sensitivity. It examines and compares results of Problems (1) and (2) from two opposing statistical philosophies, Bayesian and Classical, leading to vastly different numerical approaches. For the normal model, both approaches lead to identical answers, numerically. Extrapolation factors for the lower, median, and upper estimates of the hazardous concentration at six levels of protection are derived. Furthermore, upper, median, and lower estimates of the fraction affected at given, standardized, logarithmic concentrations have been tabulated. This table can be used directly for risk assessment without reference to protection levels or hazardous concentrations. The confidence limits for hazardous concentration and fraction affected depend heavily on the number of species tested and are independent of the toxic substance involved (provided the model is right), due to correction for the mean and standard deviation of the toxicity data. The equivalence of confidence limits for hazardous concentration and fraction affected is captured in the law of extrapolation: the upper (median, lower) confidence limit for the fraction affected at the lower (median, upper) confidence limit of the hazardous concentration is equal to the fraction affected (e.g., 5%) used to define the hazardous concentration. The upper confidence limit for the fraction affected at the median estimate of the hazardous concentration for 5% of the species is a fixed number depending on the sample size of the toxicity data only. It amounts to 46% at n=3, down to 20% at n=10, and still 12% at n 30.

Animals↗