Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “psoriasis”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 55 records · Page 3Linked to original sources
PubMed2026

Integrated multi-omics strategies for identifying novel therapies in psoriasis.

MOTIVATION: Psoriasis is a chronic, immune-mediated disorder with an unmet need for effective treatments. To systematically prioritize therapeutic targets, we integrated proteome-wide Mendelian randomization (MR) with expression validation in blood/skin, genetic susceptibility analysis, differential gene expression (DGE) from bulk and single-cell RNA sequencing (scRNA-seq), colocalization, pathway enrichment, and protein-protein interaction analyses. RESULTS: Proteome-wide MR identified 29 candidate protein targets (Bonferroni-corrected), all replicated in independent datasets. Fifteen targets showed significant expression associations in blood or skin. Eleven proteins-UBLCP1, IL23A, ASF1A, RARRES2, ICAM1, PRSS53, ICAM5, GCA, IL2RA, DBI, and NFKB1-exhibited consistent directional effects with their genes. Genetic susceptibility analysis confirmed 20 target-specific polygenic scores for psoriasis and five for psoriatic arthritis. DGE analysis identified 13 targets in bulk and 13 in scRNA-seq-primarily in keratinocytes and immune cells-with IL2RA, COMP, and A2ML1 dysregulated across both. Colocalization analysis implicated shared causal variants for psoriasis in ASF1A, CD8A, CTF1, IL7R, MMP12, RARRES2, XCL2, DBI, IL23A, IL2RA, SGSH, and TIMD4. Enrichment analyses highlighted involvement in cytotoxicity, immune regulation, and JAK-STAT signaling. Eighteen targets interacted with approved anti-psoriasis drugs. Notably, drugs targeting IL2RA, IL7R, CTF1, ICAM1, MMP12, NFKB1, CD8A, DDX58, IL12A, SGSH, and FAP are approved or in trials for other diseases, suggesting repurposing potential. Our integrative multi-omics approach prioritized 29 high-confidence targets, including 13 novel candidates (RARRES2, ASF1A, CTF1, DBI, B3GNT2, CD8A, TIMD4, CRTAM, SGSH, XCL2, DAPK2, A2ML1, and FAP). Several high-priority targets-such as IL2RA, IL23, MMP12, RARRES2, IL7R, and ICAM1-were supported across analytical layers. These findings provide a robust foundation for psoriasis drug development. AVAILABILITY AND IMPLEMENTATION: The code used for the analyses in this manuscript has been archived in Zenodo at [DOI: 10.5281/zenodo.19692128].

Psoriasis↗
PubMed1979

Aseptic (avascular) necrosis of the femoral head in psoriasis.

Aseptic (avascular) necrosis of the femoral head associated with psoriasis is reported. The clinical histories of nine patients with avascular necrosis of the femoral head and one patient with bilateral humeral head osteonecrosis are summarized. Psoriasis was the only associated condition found in three of the patients. Only two patients had received systemic corticosteroids in significant amounts (greater than 1 gm of prednisone). Four patients had received methotrexate therapy for psoriasis. Other possible contributing factors including serum uric acid levels are discussed. Psoriasis should be added to the list of systemic diseases associated with aseptic (avascular) necrosis. Avascular necrosis of the femoral head should be considered in any patient with psoriasis and pain in the hip or thigh.

Adult↗
PubMed1979

Effect of 8-methoxypsoralen plus UVA on psoriasis leukotactic factor.

The effect of psoralen phototherapy on the chemotactic activity of psoriasis leukotactic factor (PLF) was studied. The chemotactic activity of PLF extracted from psoriasis scales was evaluated using modified Boyden chambers. Treatment of (1) psoriasis lesions, (2) psoriasis scale and (3) extracted PLF with 8-methoxypsoralen plus UVA irradiation reduced the chemotactic activity of PLF. These results may help define the mechanism of psoralen phototherapy in psoriasis.

Adult↗
PubMed1977

Lymphocyte activation by streptococcal antigens in psoriasis.

Cell-mediated immune responses in 28 hospitalized patients with psoriasis and in 36 healthy controls were studied using the two-step leukocyte migration agarose test. Specific cell-mediated immunity to A-streptococcal cell wall and cell membrane antigens occurred significantly more often in patients with psoriasis than in the control group. A statistically significant correlation between psoriasis-associated antigens of the HLA-B locus and cellular immune reactivity to A-streptococcal antigens or clinical course was not found. When patients with guttate psoriasis were compared separately with the control group, leukocyte migration inhibition induced by cell-free supernatants of A-streptococcal antigen-exposed mononuclear cell cultures was found to be more frequent than in other forms of psoriasis.

Adolescent↗
PubMed1978

Psoriasis in an unselected series of twins.

The relative importance of genetic factors in the origin, age at onset, clinical type, course, and severity of psoriasis was evaluated on the basis of an unbiased sample of twins, ie, the Danish Twin Register, which covers the total population of twins born in Denmark. All verified and probable cases of psoriasis in twins, born 1891 through 1920, were ascertained. Results are presented of an examination of all members of index pairs in which both partners were alive on a certain date. Fourteen monozygotic and 22 dizygotic, like-sexed pairs were found to include at least one partner with unquestionable psoriasis. Zygosity determination was mainly based on extensive serological examinations. The analyses show that the manifestation of psoriasis depends almost exclusively on the presence of the specific genotype. The age at onset, clinical type, course, and severity are also mainly determined by the genetic constitution. Association with certain HLA antigens of the B series has been confirmed, but the fact that many of the twins (including several of the concordant monozygotic pairs) possess neither of these antigens shows the corresponding genes to be important, but not decisive, elements in the predisposition. We conclude that psoriasis is a genetically determined disorder that may, to a limited extent, be modified by environmental influences.

Adolescent↗
PubMed1976

HLA antigens in psoriasis. A family study.

HLA antigens were determined in 14 Finnish families with psoriatic members. The pedigrees of all families are presented. The results showed a clear association between HLA B13 and inheritable psoriasis, for all the 14 HLA analysed psoriatic patients in four families had B13. In one family all five psoriatic patients had the haplotype HLA-A10, Bw17; in two other families the association between Bw17 and psoriasis was less obvious. In three families six of the eight children with the haplotype A1, Bw37 had psoriasis. In all these families one parent had psoriasis or psoriatic relatives and the other parent contributed A1, Bw37. It is suggested that Bw37, in association with other genetic factors, indicates a high risk of developing psoriasis. In one family both the father with psoriatic arthritis and the son with post-urethritic Reiter's disease had A2, B27. This haplotype was also possibly associated with psoriatic arthritis in two families.

ABO Blood-Group System↗
PubMed1979

Photochemotherapy for psoriasis. A clinical cooperative study of PUVA-48 and PUVA-64.

A clinical cooperative study involving 14 centers evaluated photochemotherapy (psoralen and high-intensity long-wave ultraviolet light [PUVA]) for psoriasis. Results from 465 patients treated with a PUVA-48 unit (equipped with 48 high-intensity UVA bulbs) and 110 patients treated with a PUVA-64 unit (equipped with 64 high-intensity UVA bulbs) confirmed the effectiveness of photochemotherapy for psoriasis. Clearing of psoriasis occurred in 85% of patients on PUVA-48 therapy. Mean number of treatments, joules per square centimeter, to clear, and total joules at clearing were similar to other reported trials. The plateau method of clearing resulted in lower joules per square centimeter at clearing, total joules per square centimeter, and number of treatments than the nonplateau method. Maintenance therapy groups were mainly M1 (once weekly) or M4 (no treatment for more than 60 days). No meaningful laboratory abnormalities were detected and ophthalmologic examinations showed a few abnormal results following PUVA. Short-term side effects were mainly erythema, nausea, and pruritus. The effectiveness and short-term safety of PUVA for psoriasis has now been confirmed by a second large cooperative study.

Adolescent↗
PubMed1979

Tar gel-phototherapy for psoriasis. Combined therapy with suberythemogenic doses of fluorescent sunlamp ultraviolet radiation.

To determine the efficacy of suberythemogenic ultraviolet phototherapy in conjunction with administration of a tar gel (SEUV TG), patients with widespread psoriasis were treated by application of a tar gel preparation followed after 12 hours by suberythemogenic doses of fluorescent sunlamp irradiation. In paired comparison studies, therapeutic effects of the following treatments were evaluated: SEUV-TG, a more conventional erythemogenic tar gel phototherapy regimen (modified Goeckerman), the tar gel alone, and SEUV irradiation following application of gel vehicle. Response to therapy was monitored with a severity score system. In patients with psoriasis responsive to phototherapy, smaller quantities of UV energy administered in combination with a tar gel were at least as effective as larger erythemogenic doses. Production of erythema with fluorescent sunlamp radiation does not appear to be necessary to improve psoriasis. Both UV radiation and tar gel have beneficial effects on psoriasis, but the combination is superior.

Adolescent↗
PubMed1978

[About the regression of psoriasis capitis after mechanical epilation (relations between the psoriatic efflorescence and the follicular proliferation) (author's transl)].

The pathomorphological and pathophysiological reactions of the spontaneous and artificially induced skincycle in psoriasis capitis-lesions were clinically and histologically investigated. 1. After the epilation in the psoriasis capitis-lesion a healing of the psoriatic efflorescence was observed. 2. Histologically a close correlation between the induced anagen and the regression of the psoriasis existed: As a cause of this phenomenon an interaction between the dermis, the follicular proliferation and the epidermal proliferation of psoriasis is assumed.

Adult↗
PubMed1977

Ultrastructure of the capillary loops in the dermal papillae of psoriasis.

Electron microscopy was used to define the ultrastructure of the capillary loops in the dermal papillae of psoriatic lesions. Pustular psoriasis of von Zumbusch and psoriasis vulgaris were studied before and after treatment with the Goeckerman regimen. Capillary loops were reconstructed from 1-mum plastic-embedded sections. Ultrathin sections were taken at intervals for correlation with the 1-mum sections. There were no ultrastructural differences between the capillary loops in psoriasis vulgaris and pustular psoriasis. The intrapapillary portion of the loop was predominantly a venous capillary. Four basic ultrastructural loop patterns were recognized which can serve as markers in studying the responses of psoriatic loops in various experimental situations. Following 3 weeks of Goeckerman therapy, the morphology of psoriatic capillary loops changed from venous capillaries to arterial capillaries which are found in the papillae of normal skin. This transformation was observed to begin 48 to 72 hr after the initiation of therapy.

Biopsy↗
PubMed1978

Two tris urea mercaptoethanol extractable polypeptides found uniquely in scales of patients with psoriasis.

This study was designed to chemically characterize the principal structural proteins of psoriatic scales. Cornified cells were obtained from 40 patients with psoriasis, 21 patients with other scaly diseases, and 13 normal individuals. Cells were washed with Tris-HCl buffer and incubated in 8 M urea containing 2-mercaptoethanol (pH 9.0) at 30 degrees C for 7 hr. Extracted proteins were subjected to SDS polyacrylamide gel electrophoresis and protein patterns from normal and diseased scales were compared. The 67,000 dalton constituent of normal cornified cells could not be identified in protein from psoriatic scale and instead, a pair of polypeptides of approximately 54,000 and 57,000 daltons appeared. These extra bands were not found in protein extractions from other skin diseases, uninvolved skin of psoriasis patients, or normal skin. In order to analyze further normal and psoriatic scale proteins, the immunoreaction of rabbit antisera to human 67,000 dalton polypeptide with extracted psoriasis protein and with frozen biopsy sections, was studied using immunoprecipitation tests and indirect immunofluorescence microscopy. Both techniques demonstrated the existence of the 67,000 dalton protein in psoriasis, but as a minor component. These results indicate that additional unique urea mercaptoethanol soluble proteins are formed in psoriatic lesions, and this unusual protein synthesis may reflect the morphological changes in this disease.

Humans↗
PubMed1978

Chemokinetic and chemotactic factors in psoriasis scale extracts.

Soluble solutions of psoriasis scale were prepared by extracting scales in 6 m urea and removing urea by dialysis. Extracts were tested for chemokinetic and chemotactic activity for human polymorphonuclear leukocytes and mononuclear cells in vitro using the migration under agarose assay. Five of 6 extracts demonstrated significant chemotactic activity for polymorphonuclear leukocytes, and 4 or 6 were also chemotactic for mononuclear cells. All extracts augmented random migration of polymorphonuclear leukoyctes (chemokinesis). Checkerboard epxeriments showed extracts were truly chemotactic as well as chemokinetic. The kinetics of polymorphonuclear leukocyte and mononuclear cell chemotaxis toward psoriasis scale extracts were similar to kinetics of chemotaxis toward a bacteria-derived chemotactic factor and zymosan-activated serum. Since zymosan-activated serum and purified C5a were not chemokinetic, psoriasis scale extract was more like a bacteria-culture supernate than these complement factors in augmenting random migration of polymorphonuclear leukocytes. Substances in psoriasis scale may be capable of influencing the inflammatory response.

Cell Movement↗
PubMed1976

HL-A antigens in patients with guttate psoriasis.

Tissue typing was performed on lymphocytes of sixty-two patients with guttate psoriasis, in forty-four of whom this was the first manifestations of the disease. In 84% of cases, the guttate psoriasis was preceded by a clinical infection. A highly significant excess of antigen W17 (HLA-BW17) was found in patients when compared with healthy population. In common with some other studies antigens HL-A13 (HLA-B13), W15 (HLA-BW15) and W21 (HLA-BW21) were found in excess but these became non-significant after correction for the number of antigens studied. 68% of patients who had guttate psoriasis de novo, subsequently developed persistent plaque psoriasis.

HLA Antigens↗
PubMed1976

HLA antigens and susceptibility to psoriasis vulgaris in a non-Caucasian population.

Fifty-four unrelated Japanese patients with psoriasis vulgaris were tissue typed using the Sixth International Histocompatibility Workshop antisera. Two control groups were included in this study: Thirty-one pustulosis palmaris et plantaris and 17 seborrheic dermatitis as a disease control and 66 normal, healthy, unrelated Japanses as a reference. HLA-Al (P = 0.0065) from the A locus and HLA-BW37 (P = 0.0164) from the B locus were found to occur with increased frequency in patients with psoriasis vulgaris. No significant difference in antigen frequencies in pustulosis palmaris et plantaris was found, however, HLA-AW30 and/or AW31 and HLA-B12 occurred with increased frequency in seborrheic dermatitis. No linkage between psoriasis and HLA was observed in eight families. Therefore our findings in Japanese do not confirm the previous observation made in Caucasians of an association between psoriasis vulgaris and HLA-B13 or BW17.

Adult↗
PubMed1977

The HLA system and the arthropathies associated with psoriasis.

Histocompatibility typing was carried out in 74 patients with psoriasis and an inflammatory arthropathy. In 40 patients with peripheral arthropathy characterized by distal interphalangeal joint involvement, 13 (32-5%) were HLA-B27 positive, significantly higher than the control frequency (P = 5-8 X 10 (-6). 26 of the 40 patients did not have ankylosing spondylitis or radiological sacroiliitis and 7 were HLA-B27 positive, also significantly higher than in controls (P = 0-0049). All 7 patients with psoriasis and ankylosing spondylitis without peripheral arthropathy were HLA-B27 positive. The 10 patients with ankylosing spindylitis or radiological sacroliitis who were HLA-B27 negative all had peripheral arthropathy. It is suggested that being HLA-B27 positive increases the risk of a psoriatic patient developing both peripheral arthropathy and ankylosing spondylitis. In addition, some of the genes involved in susceptibility to psoriasis also have a role in the pathogenesis of both types of arthropathy. A hypothesis is put forward that some of the genes for psoriasis may be aetiologically important in some HLA-B27 negative patients with ankylosing spondylitis.

Adult↗
PubMed1978

Peritoneal dialysis for psoriasis. An uncontrolled study.

Remissions of long-standing psoriasis have been reported in patients starting either chronic hemodialysis or peritoneal dialysis for renal failure. To see if dialysis influences the course of psoriasis in the absence of renal failure, we selected three patients with severe, refractory, long-standing psoriasis to undergo weekly peritoneal dialysis treatments. Two began to improve after the first dialysis, with nearly complete resolution after four and nine treatments, respectively. The third patient showed no objective changes after four dialyses. These findings add to increasing anecdotal reports of psoriasis improving with dialysis and extend the observations to patients without renal disease.

Adult↗
PubMed1976

[The immunological mechanisms of psoriasis].

The occurrence of ANA in eluates of lymphocytes and polymorphonuclear leucocytes obtained in five untreated psoriasis patients could be demonstrated by means of the indirect immunofloruescence technique. These antibodies appear to be mainly directed against the nuclei of the basal cell layer, however, ANA directed against the nuclei of epidermal and dermal cells have also been encountered. The immunological mechanisms in psoriasis may therefore be looked upon as the result of an alteration in the structure of nucleic acid or nuclear protein of the basal layer cells. Finally psoriasis may be the result of an interplay of various exogenous factors and a special genetical make-up leading to the release of certain nuclear proteins initiating a delayed type immune response at the onset and an Arthus type reaction located in the upper layers of the epidermis at a later stage of the disease, and as a secundary phenomenon the derailment of keratinization. Moreover a slightly decreased mean percentage of circulating lymphocytes forming rosettes with sheep erythrocytes have been found in the patients studied. This slight decrease suggests a diminution of the T-lymphocyte control facilitating the antibody production by B-lymphocytes. The course of events in psoriasis is a self perpetuating inflammatory process.

Antibodies, Antinuclear↗
PubMed1979

Significance of HLA antigens and the mixed lymphocyte reaction in psoriasis.

Human Major Histocompatibility (HLA) complex antigens B13, BW16, BW17, CW6 and D-MA are increased in frequency in patients with psoriasis. Of these, the strongest association is with HLA-CW6 and D-MA, with a relative risk of 10.4. Since no strong association with any HLA-A locus antigen is seen, it seems likely that the disease susceptibility gene for psoriasis lies close to the HLA-D locus, which is defined by the use of the mixed lymphocyte reaction (MLR). In the mouse, the Immune response (Ir) genes are found in the MLR region and it is thought that Ia antigens lie at a corresponding location in man. Recently, we have demonstrated that human epidermal cells cause stimulation in the mixed lymphocyte reaction. Lymphocyte antigens which stimulate in this reaction are known to be products of HLA genes and anti-HLA-D sera block stimulation by epidermal cells. It is possible that these antigens may be involved in the regulation of cell--cell communication. Psoriasis is a disease characterized by epidermal hyperproliferation. It is possible, therefore, that an HLA-linked deficiency of recognition between epidermal cells exists in patients with psoriasis and that this defect allows abnormal cellular proliferation to occur.

Animals↗