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PubMed1998

Wisconsin statutes regarding HIV testing in primary care: frequent questions and answers.

The authors review Wisconsin statutes related to human immunodeficiency virus (HIV) testing in primary care, including the areas of written informed consent, documentation of consent, testing without consent, testing of minors, disclosure of test results without the consent of the test subject, reporting requirements, discrimination, access by insurance companies and third-party payors to HIV test results, and civil liabilities and criminal penalties associated with violation of HIV-related state statutes. During the course of the HIV epidemic in Wisconsin, many individuals (service providers, legislators, consumers and advocates) supported the enactment of HIV-related legislation. Today, Wisconsin has some of the nation's most comprehensive HIV legislation. These laws have set a legal framework that balances the rights of individuals with protection of public's health. The relatively low seroprevalence of HIV infection in Wisconsin can be attributed, in part, to the state's HIV-related legislation. While Wisconsin HIV legislation is broadly focused, much of it is concerned with HIV testing. This article examines common questions as they pertain to HIV testing in primary care and to the following areas addressed by state statutes: counseling and referral for health and support services [Wisconsin statute s. 252 14(3)] informed consent for testing or disclosure [Wisconsin statute s. 252.15(2)] written consent to disclose [Wisconsin statute s. 252.15(3) & (4)] testing without consent of the test subject [Wisconsin statute s. 252.15(2)] confidentiality of an HIV test [Wisconsin statute s. 252.15(5)] reporting of positive test results [Wisconsin statute s. 252.15(7)] discrimination [Wisconsin statute s. 252.14(2)] civil and criminal liabilities [Wisconsin statute s. 252.14(4); 252.15(8) & (9)].

AIDS Serodiagnosis↗
PubMed1992

Superior qualities of University of Wisconsin solution for ex vivo preservation of the pig heart.

The components of the University of Wisconsin solution have the potential to enhance and extend heart preservation. We have evaluated University of Wisconsin solution by comparing it with St. Thomas' Hospital cardioplegic solution in the isolated pig heart subjected to 8 hours of ischemia at 4 degrees C (n = 6 in each). The hearts were perfused ex vivo with enriched autologous blood for the control and the postpreservation assessments. Morphologic, metabolic, and functional evaluations were performed. Left and right ventricular function as assessed by the slope values of systolic and diastolic pressure-volume relationships of isovolumically contracting isolated heart was better preserved by University of Wisconsin solution (percent reduction: left ventricular systolic, 52.4% +/- 5.5% versus 17.7% +/- 6.7% [p less than 0.001]; right ventricular systolic, 125.6% +/- 46.4% versus 65.5% +/- 31.4% [p less than 0.05]; right ventricular diastolic, 112.3% +/- 48.7% versus 40.2% +/- 31.3% [p less than 0.02] after St. Thomas' Hospital and University of Wisconsin preservation, respectively). Postischemic recovery of left ventricular rate of rise of pressure and myocardial oxygen consumption were significantly improved after University of Wisconsin preservation (percent reduction, rate of rise of pressure: St. Thomas' Hospital 39.3% +/- 8.1%; University of Wisconsin 18.1% +/- 4.6%; percent reduction, myocardial oxygen consumption St. Thomas' Hospital 55.1% +/- 6.9%, University of Wisconsin 24.8% +/- 6.7%; p less than 0.001). Microvascular functional integrity as assessed by coronary vascular resistance was well maintained throughout the postischemic period and was similar to the preischemic control value in the University of Wisconsin group. By contrast, a significant increase was found at the beginning of postpreservation reperfusion, with a progressive rise thereafter in the St. Thomas' Hospital group (p less than 0.001). Preservation of myocardial adenosine triphosphate was improved and energy charge was unchanged after 8 hours of ischemia and reperfusion in the University of Wisconsin-preserved hearts compared with the St. Thomas' Hospital-preserved hearts (p less than 0.01). Electron microscopic examination revealed substantially better preservation of the contractile apparatus after preservation with University of Wisconsin solution. Myocytes from hearts receiving University of Wisconsin solution, unlike those given St. Thomas' Hospital solution, showed relaxed myofibrils with prominent I-bands. We conclude that University of Wisconsin solution has the potential to improve the preservation of the heart and possibly prolong the ischemic period in clinical cardiac transplantation.

Adenosine↗
PubMed2000

Racial disparities in African American and white infant mortality United States and Wisconsin, 1980 to 1998.

Infant mortality is a powerful indicator for assessing the health of a population, and the extent to which society invests in its children. This paper examines infant mortality trends in the United States and Wisconsin among the African American and white populations from 1980 to 1998. Data from the National Center for Health Statistics and Wisconsin Birth and Infant Death Reports were used to examine overall infant mortality trends from 1980 to 1998 for African American and white infants. The overall infant mortality rate in Wisconsin decreased steadily from 10.3 infant deaths per 1000 live births in 1980 to 7.2 in 1998. White infant mortality followed this trend, declining from 9.6 in 1980 to 5.6 in 1998. African American infant mortality has remained about the same since 1980 at 18 infant deaths per 1000 live births, even though the overall percentage of African American live births in Wisconsin increased from 6% in 1980 to 10% in 1998. The ratio of African American to white infant mortality rates in Wisconsin increased from 2 to 1 in 1980 to 3.2 to 1 in 1998. While the Wisconsin African American infant mortality rate remained even since 1980, the US rate declined from 22.2 in 1980 to 14.1 in 1998. The Wisconsin African American rate in 1998, 17.9, surpassed the national rate. The use of 5-year running averages to smooth out year-to-year fluctuations showed statistically significant declines in Wisconsin white infant mortality rates and no change in Wisconsin African American infant mortality rates. These trends show the importance for Wisconsin to sustain its current efforts to reduce black infant mortality. At the same time, Wisconsin-based research efforts to determine strategies and factors that work should continue and influence the future design of systems, programs, and policies to eliminate the disparity.

Black or African American↗
PubMed2001

Smoking during pregnancy in Wisconsin compared to the United States, 1997.

PURPOSE: The purpose of this study is to identify disparities in maternal smoking between Wisconsin and United States women and to determine differences that explain the higher percentage of pregnant women who smoke in Wisconsin compared to the United States. METHODS: 1997 Wisconsin and US birth certificate data were compared and stratified by age, education, and race/ethnicity. The relative risks (the risk of Wisconsin women smoking during pregnancy compared to US women smoking during pregnancy) were calculated by direct standardization to the 1997 US distribution for these characteristics. RESULTS: In 1997, 17.9% of Wisconsin women smoked during pregnancy, compared with 13.2% nationally (relative risk [RR] = 1.4; Wisconsin women were 40% more likely to smoke than US women). Age and education adjusted RRs among Wisconsin women aged 20 and older were 2.3 (American Indian), 2.8 (Hispanic), and 2.2 (non-Hispanic black), while the RR was 1.2 for non-Hispanic white mothers. Among women 20 and older, the crude RR for Wisconsin was 1.5; adjusting for age, education, and race/ethnicity only slightly decreased the RR to 1.4. CONCLUSIONS: The percentage of women who smoke during pregnancy in Wisconsin continues to be above the national rate and the Healthy People 2000 goal of 10% or less. Disparities with the US average are particularly great for minority women in Wisconsin. Adjusting for age, education and ethnicity does not explain Wisconsin's higher prenatal smoking rate.

Adolescent↗
PubMed2004

Trends in maternal and child health outcomes: where does Wisconsin rank in the national context?

BACKGROUND: The infant mortality rate (IMR), low birth weight (LBW) rate, and first trimester entry into prenatal care (PNC) are indicators that reflect the health of a population. OBJECTIVE: To examine these indicators in Wisconsin from 1979 through 2001 and compare them to those of the United States, looking at trends and relative rank compared with other states. METHODS: Three-year averages for IMR, LBW, and PNC were analyzed for the periods 1979-1981, 1984-1986, 1989-1991, 1994-1996, and 1999-2001 from data sources published by the Centers for Disease Control and Prevention. Wisconsin's rank relative to other states was compared for the overall, black, and white populations. RESULTS: Wisconsin's overall IMR was consistently at, or slightly better than, the national IMR. From 1979-1981 to 1999-2001, the US black IMR decreased by 37.4%, while the Wisconsin black IMR declined 12.4%; thus, Wisconsin's rank among the states fell from third best to 32 among 34 states with a sufficient number of black births. LBW rates for Wisconsin's black population were consistently at least twice that of the white population. In 1979-1981, early entry into PNC for all Wisconsin women (82.9%) was significantly higher than that of the US population (74.1%). Wisconsin's early PNC entry rates improved slightly; as other states also improved, Wisconsin's ranking dropped. Wisconsin's relative ranks for IMR, LBW, and PNC declined for all 3 indicators from 1979-1991 to 1999-2001. DISCUSSION: Birth outcome disparities in Wisconsin pose challenges for physicians, public health, and private agencies; all must collaborate and act to improve health, housing, employment, education, and the social capital and support that makes up the fabric of our society.

Birth Rate↗
PubMed2006

Progress in reducing cigarette consumption: the Wisconsin tobacco control program, 2001-2003.

OBJECTIVES: In 2000, the Wisconsin Legislature allocated $20.8 million annually to establish a comprehensive tobacco control program. The purpose of this study was to evaluate the impact of Wisconsin's tobacco control program on reducing cigarette consumption during its first 2 years of operation. METHODS: Per capita cigarette sales were used to estimate cigarette consumption. Trends in cigarette consumption in Wisconsin between 2001 and 2003 were compared with trends in the United States as a whole, with groups of states, and with Wisconsin's peer state group. RESULTS: Cigarette consumption in Wisconsin declined 9.2% from 2001 to 2003. In the same time period cigarette consumption in the United States declined only 3.8%. Wisconsin also demonstrated a greater percent decline in its cigarette consumption rate than did 3 of the 4 state groups. Finally, compared to its peer state group Wisconsin performed better between 2001 and 2003, with a decline of 9.2% compared to only a 4.2% reduction in its peer state group. SUMMARY: Wisconsin has shown progress in reducing cigarette consumption during the first 2 years of its tobacco control program. Greater declines in Wisconsin compared to the United States, most state groups and its own peer state group suggest early effectiveness of Wisconsin's tobacco control program. Wisconsin will require continued implementation of evidence-based policy initiatives and aggressive tobacco control activities in order to maintain its progress toward decreasing the public health burden of tobacco.

Health Promotion↗
PubMedDate not supplied

The effects of Ca++ on the preservation of myocardial energy and function with University of Wisconsin solution. A 31P nuclear magnetic resonance study of isolated blood perfused Langendorff pig hearts.

We have studied the effects of adding 0.5 mmol/L CaCl2 to University of Wisconsin solution (0.08 mmol/L free Ca++) on hypothermic heart preservation. Isolated pig hearts were subjected to 8 hours of preservation at 12 degrees C; eight hearts were arrested with Ca++ free University of Wisconsin solution, and seven hearts were arrested with Ca(++)-containing University of Wisconsin solution. The recovery of contractile function was evaluated by measuring isovolumic ventricular pressure development. 31P nuclear magnetic resonance spectroscopy was used to monitor the changes in high-energy phosphates. Compared to the hearts arrested with the Ca(++)-free University of Wisconsin solution, the heart arrested with the Ca(++)-containing University of Wisconsin solution showed significantly improved (p < 0.001) contractile functional recovery. No "stone heart" or loss of high-energy phosphates was observed on reperfusion. The hearts showed an increase in diastolic pressure during infusion of the Ca(++)-containing University of Wisconsin solution, however, to show the relationship between the addition of calcium and the increase in diastolic pressure, a second protocol was performed. A 30-minute period of ischemia was induced in thirteen hearts that were arrested at 12 degrees C with either Ca(++)-containing University of Wisconsin solution (n = 8) or Ca(++)-free University of Wisconsin solution (n = 5). Diastolic pressure was monitored during ischemia while ventricular volume was maintained constant with a balloon. The hearts arrested with the Ca(++)-containing University of Wisconsin solution showed a mean rise of 5 mm Hg in diastolic pressure and a rapid decline of phosphocreatine (p < 0.001). Our results suggest that, although 0.08 mmol/L free Ca++ improves functional recovery after 8 hours of heart preservation with University of Wisconsin solution at 12 degrees C, it can increase diastolic pressure during ischemia and accelerate breakdown of the high-energy phosphate stores in the myocardium, suggesting that use of University of Wisconsin solution containing 0.5 mmol/L CaCl2 may result in a significant increase in the intracellular calcium level.

Adenosine↗
PubMed1985

A laboratory-based surveillance of human blastomycosis in Wisconsin between 1973 and 1982.

Blastomycosis appears to be prevalent in states around the Great Lakes. However, its incidence in these states has not been reported. The Wisconsin Division of Health established a laboratory-based surveillance for human blastomycosis in Wisconsin to estimate disease incidence and identify endemic areas in the state for the interval 1973 to 1982. Certified mycology and pathology laboratories in Wisconsin and at two major medical centers in Minnesota were surveyed for all laboratory isolates and identifications in tissue of Blastomyces dermatitidis obtained in Wisconsin residents during 1973-1982. A total of 235 isolates and identifications of B. dermatitidis were obtained; 214 (88%) Wisconsin laboratories participated. It was estimated that the annual incidence of blastomycosis in Wisconsin for 1973-1982 ranged between 0.32 and 0.72 cases per 100,000 total population (mean, 0.48 cases/100,000 population). Cases were reported in residents from 40 (56%) of the 72 Wisconsin counties. Residents of seven counties in northern and central Wisconsin had significantly higher incidences of blastomycosis than residents of other counties in which cases were documented. The incidence of blastomycosis in Wisconsin for 1973-1982 is similar to that noted in Mississippi, Kentucky, and Arkansas where this disease is thought to be endemic and where similar surveys have been performed.

Adult↗
PubMed2000

Welfare reform consequences for children: the Wisconsin experience.

BACKGROUND: The Temporary Assistance to Needy Families, enacted under the Personal Responsibility and Work Opportunity Reconciliation Act of 1996, is a reality for many working families. As public policies are enacted, unintended consequences for infants/children must be minimized. Child advocates in Wisconsin, leading this nation in reforming Aid to Families with Dependent Children (AFDC), are concerned about supporting eligible infants/children as safety-net programs are unlinked. OBJECTIVE: This study reviews the enrollment status of 4 linked programs over time in Wisconsin, from January 1995 to August 1998. Eligible infants/children in programs, such as Medicaid/AFDC, Medicaid/Healthy Start, and Food Stamps, were analyzed and compared with enrollment in Special Supplemental Nutrition Program for Women, Infants/children (WIC), a nonlinked program. DESIGN: A cross-sectional analysis of monthly enrollment for infants/children was subdivided into 3 periods: prewelfare reform or AFDC (January 1, 1995 to December 31, 1995), the welfare reform pilot or Pay For Performance (January 1, 1996 to August 31, 1997), and welfare reform better known as Wisconsin Works (W-2), (September 1, 1998 to August 31, 1998), periods 1, 2, and 3, respectively. PARTICIPANTS: Infants/children in Wisconsin from birth to 18 years of age enrolled in W-2 and/or other safety-net programs were monitored: AFDC or W-2, WIC, Food Stamps, Medicaid/AFDC, and Medicaid/Healthy Start. RESULTS: The average number of infants/children removed from AFDC and Medicaid/AFDC during periods l and 2 were -1210 increasing to -3128 per month, respectively, almost tripling the rates of decline during the pilot period (see ). By the end of this study, >100 000 (111 198) infants/children were removed from AFDC/W-2 enrollment and 51 559 fewer infants/children benefited from Medicaid. This rate of decline slowed during period 3, averaging -687 per month, while W-2 enrollment continued to decline significantly at a rate of -2692 per month. In contrast, Medicaid/Healthy Start enrollment, targeted to infants/children <6 years of age, increased significantly over all periods by +332, +1327, and +266, respectively. Food Stamps enrollment also declined throughout all 3 consecutive periods, -603, -2462, and -1450, respectively. However, enrollment in the WIC program did not decline significantly to the same degree as other certification-linked programs with AFDC or W-2, as indicated by the consecutive slopes of -60, -111, and -183, respectively. CONCLUSION: Wisconsin infants/children were rapidly removed from welfare rolls in unprecedented numbers during the periods January 1995 and August 1998. Comparisons of periods before W-2 implementation and 1 year after implementation support the fact that certification-linked programs, such as Medicaid and Food Stamps, were sufficiently aligned to AFDC/W-2 to significantly impact infants/children enrollment. Historically, WIC certification in Wisconsin has not been linked to AFDC, and infants/children traditionally eligible for Medicaid and Food Stamps are also eligible for WIC. Yet, contrary to the AFDC-linked safety-net programs, declines in WIC enrollment were not statistically significant during all study periods. Statewide and local interventions within Wisconsin, such as outreach activities, targeted to Medicaid/Healthy Start and more recently Title XXI (State Children Health Insurance Program), slowed the reductions of Medicaid enrollment for Wisconsin infants/children. These findings support that altering safety-net programs can result in unintended consequences if not carefully transitioned as demonstrated in Wisconsin welfare reform.

Adolescent↗
PubMed2000

Trends in smoking during pregnancy, Wisconsin 1990 to 1996.

PURPOSE: Smoking during pregnancy can be harmful to the fetus. This paper examines trends in smoking during pregnancy in the United States and Wisconsin from 1990-1996. In addition, percentage change in smoking prevalence during pregnancy by selected maternal characteristics and in all Wisconsin counties is compared for the periods 1990-1992 and 1994-1996. METHODS: Data from the National Center for Health Statistics and Wisconsin resident birth certificates were compared to examine overall smoking trends for pregnant women from 1990-1996. For Wisconsin, 3-year averages (1990-1992 and 1994-1996) were calculated to provided more stable estimates. The percentage change in smoking prevalence was examined by selected maternal characteristics, such as age, marital status, race, prenatal care and education, and by county of residence. RESULTS: Smoking rates for pregnant women in the United States have gradually decreased, from 18.4% in 1990 to 13.6% in 1996. From 1990 to 1996, maternal smoking in Wisconsin declined from 22.9% to 18.2% (significant at P < .001). In Wisconsin, smoking rates during pregnancy were higher in both 1990-1992 and 1994-1996 among women who were younger, unmarried, American Indian, or African American; received late or no prenatal care and did not graduate from high school. Out of 72 Wisconsin counties, 63 showed a decrease in smoking rates for pregnant women. CONCLUSIONS: Smoking prevalence during pregnancy in Wisconsin is above the Healthy People 2000 and Wisconsin Public Health Agenda for the Year 2000 goals of less than 10% of women smoking during pregnancy. Public health must continue its initiative to encourage healthy life styles for pregnant women.

Adult↗
PubMed2001

Trends in falls, poisoning, drowning, and burns Wisconsin: 1986-1996.

Falls, poisoning, drowning, and burns comprise the four most common causes of unintentional injury death not related to motor vehicles. We examine mortality trends for these causes of injury in Wisconsin over a 10-year period (1986-1996). While national age-adjusted rates for fall mortality have remained relatively stable, Wisconsin has experienced a sharp 38% increase. The greatest increase in fall mortality was seen in the aged. Nationally, poisoning mortality rose by approximately 50% during this same period while Wisconsin saw almost no increase in mortality (3%) from poisoning. Wisconsin did experience an increase in deaths from poisoning in middle-aged adults. Mortality from drowning decreased by about 28% both in Wisconsin and in the United States, with much of the progress occurring in children and young adults. Burn mortality also declined nationally and within Wisconsin by 30% to 35%. The Wisconsin Public Health Department's "Healthier People in Wisconsin" objectives for the year 2000 will likely be met for drowning and burns, but not for falls. Overall, unintentional injury mortality in Wisconsin is decreasing. However, specific subpopulations are not reaping the benefits of this decline, suggesting a possible focus for future efforts aimed at lowering unintentional injury mortality.

Accidental Falls↗
PubMed2004

Trends in bariatric surgery for morbid obesity in Wisconsin.

BACKGROUND: Obesity is a national epidemic with rates in Wisconsin and the United States doubling over the past decade. Research of available treatments for morbid obesity (body mass index > or = 40 kg/m2) suggests that bariatric surgery may be the only modality that provides any significant long term weight loss. METHODS: Using the data from Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System, we analyzed self-reported information on body weight and height among adults in Wisconsin. We used the WITHIN database for inpatient hospitalization and surgeries in Wisconsin to evaluate trends in gastric bypass surgery. Finally, we surveyed bariatric surgeons in Wisconsin to assess trends in bariatric surgery in the state. RESULTS: In Wisconsin, the percentage of the adults considered to be obese increased from 11% in 1990 to 22% in 2001. In 1999-2001, approximately 80,000 adults (2% of the population) were morbidly obese. The number of gastric bypass surgeries performed in Wisconsin more than doubled in 1 year, from 182 in 2001 to 426 in 2002. According to bariatric surgeons, gastric bypass accounts for approximately 90% of bariatric surgeries performed in Wisconsin. Thus, in 2002, there was roughly 1 bariatric surgery for every 200 morbidly obese Wisconsin adults. Most (84%) bariatric surgeons are planning to increase the number of procedures they perform, and 24% plan on adding an additional bariatric surgeon to their group. SUMMARY: Bariatric surgery rates are increasing in Wisconsin, yet the demand for surgery far exceeds current capacity of surgeons in the state.

Adolescent↗
PubMed2005

Births to teens in Wisconsin: targeting high-risk populations.

BACKGROUND: Adolescents giving birth represents an important public health issue with social, economic, and health-related consequences. OBJECTIVE: Compare birth rates and trends in birth rates among adolescents age 15-19 years in Wisconsin and the United States by race/ethnicity. METHODS: Teen birth rates from 1998-2002, and trends in birth rates from 1995-2002 for Wisconsin and the United States were compared by race/ethnicity using data from the Wisconsin Interactive Statistics on Health and data from the Centers for Disease Control and Prevention. RESULTS: The general statewide birth rates and birth rates for Wisconsin white teens were lower than national rates, while birth rates for black, Hispanic, and American Indian teens were well above national rates from 1998-2002. Disparities between births to minority adolescents and white adolescents were higher in Wisconsin than in the United States. Although teen birth rates in general have declined nationally and in Wisconsin, rates among Hispanics in Wisconsin have increased during the 1995-2002 period. DISCUSSION: Racial disparities in teen birth rates in Wisconsin far exceed national disparities. These disparities result from far-ranging, long-term social and environmental differences in underlying determinants of health that relate to ethnic and cultural beliefs, variation in access to health care that provides family planning and reproductive health services, decreased availability of school-based clinics, lack of role models, education, and variations in income and social status. Wisconsin should focus its teen pregnancy prevention activities on the groups at highest risk.

Adolescent↗
PubMed2005

Youth suicide in Wisconsin: mortality, hospitalizations, and risk factors.

OBJECTIVE: To review Wisconsin data on youth suicide mortality, hospitalizations from nonfatal self-inflicted injuries, and self-reported risk behaviors. METHODS: Suicide mortality data for youth (defined here as persons 10-24 years of age) were obtained from the Centers for Disease Control and Prevention (CDC) for 1995-2001 and from the Wisconsin Division of Public Health for 2002. Hospitalization data for Wisconsin from 1995-2002 were obtained from the Wisconsin Division of Public Health. Survey data on self-reported risk behaviors were obtained from the CDC for 2001. RESULTS: While the rate of youth suicide declined by 24% in the United States during the 9-year period studied, Wisconsin's rate declined only slightly (8%). Firearms accounted for 60% of completed youth suicides in Wisconsin. Medication overdoses and cutting accounted for 88% of self-inflicted injury hospitalizations for Wisconsin youth from 1995 to 2002. Wisconsin high school students reported similar rates of risk factor behaviors as youth in New Jersey (the state with the lowest suicide rates in the nation), but were more likely to use firearms (60% versus 32%). CONCLUSION: Rates of suicide mortality, attempts, and self-reported risk behaviors among youth in Wisconsin continue to be unacceptably high. Physicians can play an important role in reducing youth suicide rates by acting within their clinical practices, as leaders in community suicide-prevention activities, and as advocates for policy change.

Adolescent↗
PubMed1992

Comparison of the University of Wisconsin preservation solution and other crystalloid perfusates in a 30-hour rabbit lung preservation model.

The University of Wisconsin solution, which contains a high potassium concentration (120 mmol/L), was evaluated for rabbit lung preservation by comparing it with a modified University of Wisconsin solution with low potassium (4 mmol/L), a low-potassium dextran solution (4 mmol/L), and simple surface cooling. In the first three groups rabbit lungs were flushed in situ with the solution (n = 5 in each group); then the lung-heart block was harvested and stored at 10 degrees C for 30 hours. In the surface cooling group the lungs were harvested without flushing and then simply immersed in saline and stored. For assessment, the stored lung was ventilated with room air and perfused with fresh venous blood at a rate of 40 ml/min for 10 minutes. Assessment of lung function included gas analysis of effluent blood, mean pulmonary artery perfusion pressure, and peak airway pressure. Among these parameters, oxygen tension was most sensitive. Oxygen tension at 10 minutes' perfusion in the modified University of Wisconsin (95 +/- 6 mm Hg) and low-potassium dextran (99 +/- 4 mm Hg) groups was significantly higher than that in the surface cooling (61 +/- 7 mm Hg) and University of Wisconsin (51 +/- 7 mm Hg) groups. There was no difference between the modified University of Wisconsin and low-potassium dextran groups or between the surface cooling and University of Wisconsin groups. We conclude that the low-potassium University of Wisconsin solution is superior to the high-potassium University of Wisconsin solution and that the lactobionate and raffinose included in the University of Wisconsin solution as impermeants do not improve lung preservation in this model.

Adenosine↗
PubMed1996

Efficacy of oxygenated University of Wisconsin solution containing endothelin-A receptor antagonist in twenty-four-hour heart preservation.

BACKGROUND: The University of Wisconsin solution has been proven to be effective for prolonged heart preservation. However, 24-hour heart preservation by simple cold immersion in University of Wisconsin solution has been disappointing. We have performed hypothermic low-pressure continuous coronary perfusion with oxygenated University of Wisconsin solution for experimental prolonged heart preservation. However, the high potassium concentration of University of Wisconsin solution combined with prolonged ischemia has detrimental effects on endothelial function, which increases coronary tone during preservation and after reperfusion. The severe vasoconstriction and tissue edema result in damage to the coronary microcirculation. The purpose of this study was to determine whether hypothermic low-pressure continuous coronary perfusion technique with oxygenated University of Wisconsin solution containing a selective endothelin-A receptor antagonist (FR139317) would increase the effectiveness of the perfusion technique and improve postischemic cardiac function, both minimizing tissue edema and suppressing vasoconstriction. METHODS AND RESULTS: Preischemic and postischemic cardiac function of isolated rabbit hearts was evaluated with a Langendorff apparatus. The hearts were divided into three groups (n = 7 each): group I (hypothermic low-pressure continuous coronary perfusion with University of Wisconsin solution), group II (hypothermic low-pressure continuous coronary perfusion with oxygenated University of Wisconsin solution), and group III (hypothermic low-pressure continuous coronary perfusion with oxygenated University of Wisconsin solution containing 10 mg/L of FR139317). Preservation was performed for 24 hours. The initial perfusion pressure for continuous coronary perfusion was set at 5 mm Hg. Measurement of percentage of tissue water content and ultrastructural examination of the myocardium was then performed. In groups I, II, and III, the perfusion pressures at the end of the 24-hour preservation period increased from 5 mm Hg to 12.2 +/- 2.5, 8.1 +/- 1.3, and 5.4 +/- 0.8 mm Hg (p < 0.05), respectively. Percent recovery rate of cardiac output was 56.6 +/- 2.8, 82.3 +/- 8.2, and 93.3 +/- 6.0 (p < 0.05), respectively. And percent recovery rate of coronary flow was 55.5 +/- 8.1, 80.0 +/- 8.0, and 94.3 +/- 9.4 (p < 0.05), respectively. A significant inverse correlation was found between continuous coronary perfusion pressure at the end of preservation and the recovery rate of cardiac output (r = 0.85, p < 0.05). Tissue water content was significantly higher in group I than in groups II and III. These effects were inhibited by oxygenation of the University of Wisconsin solution (group II) and by the addition of the selective endothelin-A receptor antagonist (FR139317) (group III). Damage to coronary circulation was reduced by oxygenation and the addition of endothelin-A receptor antagonist during prolonged heart preservation. CONCLUSIONS: We concluded that hypothermic low-pressure continuous coronary perfusion technique with oxygenated UW solution containing endothelin-A receptor antagonist (FR139317) maintained coronary circulation by suppressing tissue edema and vasoconstriction during preservation, which improved postischemic functional recovery.

Adenosine↗
PubMed2002

The dental work force in Wisconsin: ten-year projections.

BACKGROUND: The national dentist-to-population ratio is expected to decline during the next decade. The Wisconsin Dental Association undertook a study to determine the impact of this decline on the future supply of and demand for dental care in Wisconsin. METHODS: Using state and national data, the researchers estimated the number of dentists leaving and entering the state for the years 2001 through 2010. Then, using multivariate regression equations, the researchers estimated expected changes in dentists' productivity, the growth of the Wisconsin population and increases in utilization of dental services for the next 10 years. From these data, they determined the number of dentists needed in 2010 to maintain the current level of access. They assessed several strategies for increasing the number of dentists in the state. RESULTS: Wisconsin will have 297 fewer dentists in 2010 than it did in 2000. However, with increases in dentists' productivity of 1.8 percent per year, a slowly growing Wisconsin population (0.42 percent per year) and modest increases in utilization (0.82 percent per year), Wisconsin will need only 194 additional dentists to maintain current levels of access to care. The authors examined several options for increasing the number of dentists and their productivity, including increasing the number of Wisconsin (vs. out-of-state) students enrolled at Marquette University School of Dentistry, Milwaukee, employing more auxiliaries and using risk-based scheduling for recall patients. CONCLUSIONS: Wisconsin will have fewer dentists in 2010 than in 2000, but current levels of access can be maintained by implementing modest changes in the selection of dental students at Marquette, in the use of dental auxiliaries and in patient scheduling. CLINICAL IMPLICATIONS: With the national dentist-to-population ratio declining, each state should assess how its supply and demand for dental care will change in the next 10 years. If substantial supply-and-demand imbalances exist, options for correcting the imbalances need to be considered.

Dental Auxiliaries↗
PubMed2001

Trends in homicide in Wisconsin, 1985-1998.

OBJECTIVE: To explore homicide trends for Wisconsin over the period 1985-1998 and assess the state's progress towards meeting its year 2000 health objectives. METHODS: Wisconsin and US homicide data from the Centers for Disease Control's Web-based Injury Statistics Query and Reporting System (WISQARS) were analyzed for the period 1985-1998. RESULTS: Homicide rates in Wisconsin rose 54% between 1985 and 1995, but since that year, a sharp reverse in trends since has erased three-fourths of the increase. While Wisconsin rates for 1998 remain 15% above their 1985 levels, US rates peaked in 1991 and have since fallen to 12% below their 1985 levels. When compared to 1985, Wisconsin homicide rates for 1998 were 24% lower among whites, but 16% higher among blacks. CONCLUSIONS: Wisconsin failed to achieve its year 2000 objective for homicide reductions, with rates remaining over 80% above the state goal. Though Wisconsin's current homicide rate is nearly half the US average, recent reductions in Wisconsin homicide have lagged behind those observed nationally.

Adolescent↗