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Results for “Vitamin B Complex”

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PubMed1985

B complex vitamins activate rat guanylate cyclase and increase cyclic GMP levels.

Since B complex vitamins and the intracellular messenger cyclic guanosine monophosphate (GMP) have similar effects of promoting growth, DNA and protein synthesis, the present investigation was designed to determine if the B complex vitamins' mechanism of action might involve cyclic GMP. All of the B complex vitamins increased rat cyclic GMP tissue levels. The cause of these increased cyclic GMP levels was activation of the enzyme guanylate cyclase [E.C.4.6.1.2.] which was increased significantly (P less than 0.001) in a variety of tissues at the l nmol l-1 concentration of these vitamins. The maximal activation of this enzyme required the presence of manganese ion. The present investigation suggests that the guanylate cyclase-cyclic GMP system may play a role in the mechanism of action of B complex vitamins at the cellular level.

Animals↗
PubMed1988

Effect of vitamin B complex on the immunodeficiency produced by surgery of gastric cancer patients.

We studied the effect of vitamin B complex (vitamin B1, B6 and B12 complex) on the immune responsiveness in gastric cancer patients who underwent surgery. The depression of blastogenic responses to both PHA and PWM was observed 2 weeks after surgery in half of the patients treated with Vitamedin but the degree was significantly less than that in the control patients without vitamin B treatment whose lymphocyte responses were depressed. Moreover, the blastogenic responses were induced by vitamin B administration 2 or 4 weeks after surgery in 5 of the 8 stage III-IV patients whose lymphocytes had not responded prior to surgery. Four weeks after surgery, the patients without vitamin B treatment showed only a tendency of recovery of their lymphocyte responses, whereas the recovery of blastogenic responses in the patients treated with vitamin B was significant. Essentially similar results were obtained with skin reactions to PHA and PPD. These results suggest that the administration of vitamin B1, B6 and B12 complex is useful for the protection against and the recovery of immune dysfunction produced by surgery in cancer patients.

Humans↗
PubMedDate not supplied

[Effect of carbon and nitrogen sources and complex B vitamins on the synthesis of alkaline protease by different strains of Bacillus mesentericus and Bacillus subtilis].

The effect of different sources of carbon, nitrogen, amino acids and vitamins on the synthesis of alkaline proteases by the stock and mutant strains of Bacillus mesentericus and by the natural strain of Bacillus subtilis-12 has been investigated. The maximum synthesis of alkaline protease has been obtained in the media containing starch or its hydrolysates--dextrine and maltose as the carbon source. Ammonium phosphate and casein as the nitrogen source prove to be optimal for Bac. mesentericus and Bac. subtilis, respectively. Complex B vitamins added to the nutrient medium accelerate the enzyme synthesis 2.5-4-fold.

Ammonia↗