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At least 55 records · Page 3Linked to original sources
PubMed2006

Management of a case of primary vaginal cancer with irreducible massive uterine prolapse--a case report.

Primary cancer of the vagina constitutes 1-2% of all malignant genital tract tumors in women. As one of the most complicated therapeutic problems in gynecological oncology, this disease had been deemed to be untreatable until the end of 1930s. Presently, as a result of technological improvements in radiotherapy and radical surgery, more favorable prognoses are known to be achieved even in advanced cases. In the present case, a woman with vaginal cancer and Stage IV massive uterovaginal prolapsus, which could not be repositioned under general anesthesia, was repositioned by surgical intervention prior to radiotherapy to avoid any potential vesicovaginal fistula formation. The cervix was bilaterally suspended to the pectineal ligaments by polypropylene mesh.

Aged↗
PubMed1983

[Clinical course and radiotherapy of primary vaginal cancer (362 cases)].

362 cases of primary vaginal carcinoma were treated at the Irradiation Department of the University Clinic for Obstetrics and Gynaecology, Vienna, from 1950 to 1977. As method of choice an individually dosed, fractioned and protracted radium-telecobalt therapy was employed. An overall 5-years' survival rate of 39.8% could be achieved, a value which is above the average reported in world literature. Comparing the last period analysed in the present study (1971 to 1977) with another period 20 years earlier (1951-1956), the following differences can be observed: the fraction of stages III and IV rose markedly from 57.2% to 68.7%; associated with this change was an increase of the percentage of older patients (greater than 60a) from 53.6% to 70.7%. These two developments had an impact on the survival rate: in the total population, it was 39.8% as compared to 32% for the period from 1971 to 1977. The 5-year-survival rate in stage I (n = 60) was 75%, in stage II (n = 95) 45.3%, in stage III (n = 145) 30.3% and in stage IV (n = 62) 19.3%. The incidence of rectovaginal or vesico-vaginal fistulas amounted to 8%. The importance of gynaecological screening for old age patients is emphasized being the only possibility for reducing the high percentage of progressed stages.

Adult↗
PubMed1975

Immunotherapy of non-clinical vaginal cancer.

In six women who had had a hysterectomy and three or more vaginal smears positive for malignant cells but no symptoms, a course of immunotherapy, based on delayed hypersensitivity reaction to dinitrochlorobenzene, was tried. Repeat smears done every three months have all been normal, and the patients were well when last seen 2-35 months after treatment.

Dinitrochlorobenzene↗
PubMedDate not supplied

Successful pregnancy after vaginal cancer treated with interferon.

A 25-year-old white woman with a vaginal invasive epidermal carcinoma was treated with interferon-alpha 2b (3,000,000 U intralesional, every two days for a total of 18 applications). Follow-up with Papanicolaou and colposcopy showed complete regression of the vaginal lesion, After three years the patient got pregnant. The prenatal course was uneventful and a vaginal delivery was performed. She is currently in follow-up without any signs of recurrence.

Adult↗
PubMed1997

[Clinical evaluation of radiation complications with various methods of radiotherapy for vaginal cancer].

The investigation was concerned with complications development in 133 cases of primary vaginal carcinoma (VC) who had been treated with combined (distance and contact treatment) or low-dosage (LD), medium-dosage (MD) or high-dosage (HD) contact irradiation. Time-dose-fractionation (TDF), cumulative radiation effect (CRE) and linear-quadratic (LQ) ("extrapolated dose of response") were used to evaluate normal tissue response. Early- and late-onset radiation injuries of vaginal mucosa, urinary bladder and rectum were compared vis-a-vis dosage which was calculated on the basis of HDF model. Dosage exceeding the limits of connective tissue tolerance was responsible for the development of early-onset epithelitis, cystitis and rectitis in cases of LD- or MD-brachytherapy of vaginal carcinoma or when the latter was conducted in conjunction with distance therapy. However, early-onset epithelitis and cystitis might appear when dosage remained within tolerance limits. This occurred as a result of HD-contact treatment or when the latter was used as a component of combined therapy. Most late-onset moist vaginal epithelites, rectites and recto-vaginal fistuals were caused by dosage in excess of tolerance. Late- and early-onset vaginal epithelitis was observed with tolerable dosage, too, if HD-brachytherapy alone was used or as a component of combined treatment.

Dose-Response Relationship, Radiation↗
PubMed1983

CO2 laser for the treatment of invasive vulvar and vaginal cancer.

In a material of 21 patients including 7 primary and 6 recurrent vulvar carcinomas, 5 vaginal carcinomas, 1 urethral carcinoma and 2 preinvasive vulvar carcinomas operation was performed with a CO2-laser scalpel. In 9 radical and 3 partial vulvectomies no primary closing of the wounds was performed. In the remaining primary closing was performed. The operative bleeding and healing process with laser scalpel and electrosurgical scalpel using open wound technique were about the same. The surgical time was longer with the laser technique but the operative specimens were better preserved. Healing of the primary closed wounds were uncomplicated.

Carbon Dioxide↗
PubMed1984

Vaginal cancer after hysterectomy for benign disease: value of cytologic screening.

Of 87 patients who were treated at the author's institution for primary cancer of the vagina, 31 had undergone total hysterectomy for benign disease. In this group of 31 patients, vaginal bleeding was the most common presenting symptom, although there were eight patients who were entirely asymptomatic and were diagnosed on routine examination. The stage of cancer was more advanced in the symptomatic patients than in the asymptomatic patients. There were seven patients with stage 0 disease, and four of these were asymptomatic and diagnosed by routine Papanicolaou smear. Overall, Papanicolaou smears were positive in 12 of 19 patients tested, a sensitivity rate of 63%. The authors recommend that patients who have a hysterectomy for benign disease continue to have Papanicolaou smears taken from the vaginal vault at regular intervals.

Adenocarcinoma↗