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Transillumination laryngoscopy: a new way of evaluating vocal fold and hypopharyngeal lesions.

Conventional methods of observing the larynx and the hypopharynx use reflected light to illuminate the larynx. The aim of this study was to see whether transilluminating the larynx was possible in subjects with and without disease. The larynx and the hypopharynx were observed by means of a rigid scope with a low-light charge-coupled device camera without the light guide inserted. Illumination was provided by a second rigid scope attached to a light source that was held at the neck by an assistant. The larynx and hypopharynx were observed by transillumination using both constant lighting and stroboscopy in 3 subjects with pharyngeal or laryngeal lesions and in 4 normal controls. The tumors were translucent or nontranslucent in appearance. A translucent polyp became nontranslucent when overlapping the vocal fold, thus indicating that a lesion the size of a polyp could be evaluated with this method. Mucosal waves could be observed during stroboscopy with transillumination, thus allowing observation of waves and lesions that cannot be observed with conventional stroboscopy.

Adult↗

The development of a system for transillumination computed tomography.

A transillumination computed tomography system has been developed for studies of the breast, testes, neonatal skull and peripheral limbs. Initial experiments on test objects have emphasised the problems of scattering and geometrical dependence of lesion detection that are likely to be encountered in conventional diaphanography, but have demonstrated the feasibility of computed tomography as a means of improving the sensitivity of the transillumination technique. The problems of transillumination computed tomography have been addressed and further areas of research identified.

Humans↗

Transillumination in breast cancer detection: screening failures and potential.

This prospective study of 1265 women referred to a multimodality breast diagnostic center compares the sensitivity for breast cancer detection of state-of-the-art transillumination light scanning and film-screen mammography. Of 33 biopsy-proven cancers, transillumination light scanning detected 58%, while mammography detected 97% of the cancers. Light scanning did detect 55% of the nonpalpable breast cancers, and 30% of those tumors smaller than 1 cm. Detection of breast cancer by light scanning was affected by breast size, but not architecture, and was directly related to tumor size. Although transillumination light scanning can detect some small curable breast cancers (smaller than 1 cm), it does not do so at a sensitivity adequate for screening. An example is illustrated in which light scanning detected an occult breast cancer before the development of recognizable mammographic changes.

Adult↗

Transillumination for the diagnosis of pneumoperitoneum.

Transillumination of the abdomen with a cold fibreoptic light source was used for the rapid diagnosis of pneumoperitoneum in a sick premature infant with necrotising enterocolitis. The diagnosis was confirmed at laparotomy. The neonate survived the surgical procedure of resection and anastomosis of the perforated gut. Although additional diagnostic investigations such as X-rays and paracentesis of the abdomen were also positive in this case, transillumination of the abdomen proved to be a useful tool for early diagnosis. Transillumination thus is a valuable modality for early diagnosis of pneumoperitoneum, especially where facilities for in-house X-rays are not available.

Enterocolitis, Necrotizing↗

Normalized transillumination of fluorescent proteins in small animals.

We investigated the capacity of normalized transillumination methods in imaging fluorescent proteins in visible light, in phantoms and in live mice. We demonstrate significant imaging improvements over epi-illumination imaging, as commonly applied today. Of particular importance is the significant betterment in contrast achieved, due to minimization of the influence of autofluorescence and the enhancement of depth sensitivity compared to epi-illumination imaging. Although normalized transillumination does not match the accuracy and quantification capacity of tomographic imaging, it nevertheless attains key advantages over other planar optical imaging methods while preserving implementation simplicity. Due to the balance achieved between simplicity and accuracy, normalized transillumination approaches could serve as an important alternative molecular imaging method.

Animals↗

Transillumination in neonatal diagnosis.

Transillumination is a safe, nonionizing, and noninvasive diagnostic technique that is particularly well-suited for use in the newborn. In addition, its portability, minimal expense, and facility make it a useful and necessary tool for the neonatal intensive care unit. This article reviews the principles of transillumination, describes equipment currently in use, and summarizes the clinical applications of transillumination.

Abdomen↗

Percutaneous arterial sampling using transillumination.

Percutaneous arterial sampling was performed using transillumination. A success rate of 96% was obtained when sampling the radial, ulnar, posterior tibial, and dorsalis pedis arteries. Although small hematomas were produced despite pressure, no serious complications of infection, thrombotic obstruction, or thermal injury occurred. We conclude that the use of transillumination for arterial sampling is a safe technique that permits rapid sampling of very superficial peripheral arteries, allows visual confirmation of the Allen test for estimation of collateral flow, and would perhaps aid in arterial cannulation. Pediatrics, 59:1032-1035, 1977, TRANSILLUMINATION, ARTERIAL SAMPLING.

Arteries↗

[Diaphanoscopy in surgery. Presentation of a cold-light loop for various surgical uses, particularly for the choledochus and retrocavities of the epiploa. Comparison with an earlier system using traditional transillumination].

An account is given of the creation of an autoclavesterilisable, cold-light, transilluminating loop for surgical use following personal endoscopic experience with personally divised instruments, some of which were presented at the Turin Medical and Surgical Meetings held in 1954. It is considered that much valuable can be made of the intense luminous ray, which can be aseptically transfered into the surgery site for direct or transparent viewing. A description is given of a guided, flexible gastroduodenal sound used for obtaining material, insufflation and transillumination, and of a sterilisable, semi-rigid, metal loop used for conventional (hot light) illumination and diaphanoscopy. Lastly, the features of the new (cold-light) optical-fibre metal loop are explained. Its curvature is adaptable for the illumination and transillumination of even deep cavities. Useful employment of the new loop in the surgery of the choledochus and retro-cavities of the epiploa is referred to.

Common Bile Duct↗

Dissecting microscope versus magnifying loupes with transillumination in the preparation of follicular unit grafts. A bilateral controlled study.

BACKGROUND: The increasing importance that hair transplant surgeons are placing on maintaining the integrity of the naturally occurring follicular unit has generated great interest in finding the ideal method of graft dissection. OBJECTIVE: The present study attempts to compare two popular dissecting techniques: the dissecting microscope, and magnifying loupes with transillumination, in the preparation of follicular unit grafts. METHODS: Donor strips from 41 patients were used in a prospective, bilateral controlled fashion to compare the two different dissecting techniques. RESULTS: Microscopic dissection produced a 17% greater yield of hair as compared with magnifying loupes with transillumination. CONCLUSION: The results of this study show an increase in the yield of follicular unit grafts, as well as the total amount of hair harvested from the donor strip, when using the dissecting microscope as compared with magnifying loupes with transillumination. This increase was observed when only the latter part of the dissecting procedure was studied. When complete microscopic dissection is used, the advantage should be even more significant.

Alopecia↗

Transillumination of the skull in premature infants.

Transillumination of the skull in infants is a simple technique which can be used to detect several major abnormalities of the central nervous system. The usefulness of transillumination has been limited, however, by the lack of standard techniques for its performance and by the absence of normal values, especially in premature infants. In healthy premature infants, there is a progressive increase in transillumination with increasing gestational age over three sites--the anterior fontanelle, the frontotemporal fossa, and the parieto-occipital eminence.

Analysis of Variance↗

Identification of anterior uveal tumor border by transscleral transillumination and an ophthalmic endoscope.

PURPOSE: To report a method for identifying the borders of anterior uveal tumors in deeply pigmented eyes. METHOD: The borders of the anterior uveal tumors were marked by transscleral transillumination with a fiberoptic light and observed from the vitreous cavity using an ophthalmic endoscope. RESULTS: The ophthalmic endoscope disclosed a bright orange spot by transscleral transillumination of a normal uvea in deeply pigmented eyes. Two anterior uveal melanomas and one adenocarcinoma of the nonpigmented ciliary epithelium did not transmit light through the tumors. CONCLUSION: With an ophthalmic endoscope and transscleral transillumination, the borders of ciliary body tumors can be identified and clearly demarcated, even in deeply pigmented eyes.

Adenocarcinoma↗

In vivo transillumination biomicroscopy and photography of meibomian gland dysfunction. A clinical study.

Meibomian gland transillumination biomicroscopy and infrared photography were performed on 18 patients with clinically evident meibomian gland dysfunction (MGD) and dermatologic rosacea, 22 patients having MGD without evidence of dermatologic rosacea, and 15 unaffected individuals who served as controls. All patients having clinical signs of MGD demonstrated morphologic abnormalities of their meibomian glands by transilluminated biomicroscopy. Patients without dermatologic rosacea were noted to have varying degrees of gland distortion. Moreover, infrared photography documented a loss of the normal grape-like clusters of dark spots that represent the gland, suggesting a loss of glandular acini. Patients with dermatologic rosacea had more severe alterations, including marked distortion and loss of normal gland anatomy. There were no such abnormalities in clinically unaffected individuals. These data demonstrate that transilluminated biomicroscopy and infrared photography have the ability to identify a spectrum of morphologic alterations of the meibomian glands in MGD patients. The authors suggest that these techniques could be used to classify clinical MGD based upon the presence or absence of identifiable meibomian gland abnormalities.

Eyelid Diseases↗

Failure to transilluminate the stomach is not an absolute contraindication to PEG insertion.

Percutaneous endoscopic gastrostomy (PEG) tubes are now a well established method of enteral feeding. With the introduction of nurse endoscopists it has been possible to site PEG tubes with only one member of medical staff being present. Furthermore transillumination of the stomach is considered by many to be essential prior to gastric puncture. We present a series of 62 consecutive PEG tube sitings performed by the same nurse endoscopist/doctor team without transillumination of the stomach prior to gastric puncture. Sixty of the 62 patients (97%) had successful PEG tube insertion. There were no immediate complications. There were two failures, neither of which related to the technique. It is concluded that failure of transillumination is not an absolute contraindication to PEG tube insertion.

Adolescent↗

Transillumination spatially modulated illumination microscopy.

The diagnostic utility of a conventional transillumination microscope, the most common imaging modality in clinical use today, is limited by the microscope's resolution. It is, however, possible to achieve lateral resolution well beyond the classical limit by using laterally structured illumination in a wide-field, nonconfocal microscope. In this method, the spatially modulated illumination (SMI) makes high-resolution information that is normally inaccessible visible in the observed image. Previously presented SMI microscopy systems operated in epifluorescence mode. We describe the design, construction, and testing of a novel transillumination SMI microscope. As transillumination is necessary for most medical applications, such as histopathologic evaluation of biopsy tissue and chromosomal analysis, such a system should have a significant diagnostic effect.

Algorithms↗

Use of infrared videography to detect and record iris transillumination defects.

We have developed a technique of detecting and recording iris transillumination defects using an infrared sensitive video camera. This method is useful for assessing the loss of posterior iris pigment in patients with the pigmentary dispersion syndrome and pigmentary glaucoma. Some patients with no transillumination defects on slit-lamp examination were noted to have discrete defects on infrared videography. This technique is a rapid, convenient, and reproducible method of permanently recording posterior iris pigment changes. These high-quality video images can then be followed to determine the natural course and the results of therapy in these patients.

Glaucoma, Open-Angle↗

Simulation of time-resolved breast transillumination.

A Monte Carlo simulation has been developed to predict the quality of time-resolved images of the breast by transillumination. The smallest diameter of a detectable carcinoma located in the breast has been computed. The simulation suggests that time-resolved imaging of the breast is possible and invaluable in the near infra-red (NIR) by transillumination. The enhancement of the transfer function by the introduction of time-resolved detection is limited by the contribution of noise at short integration times. The estimated diameter of the smallest detectable sphere is derived from the image quality index (IQI) theory and its value is around 4 mm. The simulated images of an absorbing sphere (approximating the carcinoma) within a homogeneous medium (approximating the surrounding tissue) show a significant improvement of the image with short integration time.

Breast Neoplasms↗

[The transillumination technique. An alternative to conventional intubation?].

The technique of light-guided intubation is based on the principle that a source of light brought into the trachea results in clearly visible and defined transcutaneous illumination, while no illumination can be observed with the light source in the oesophagus (Fig. 1-7). The Trachlight is a reintroduced instrument for this alternative intubation technique. The essential developments are: a length-adjustable stylet with a removable internal metal wire, a brighter light source, a stable handle with tight fixation of the endotracheal tube, and a time-dependent warning device to avoid extended intubations. One hundred twenty patients (Mallampati I. ASA I-III) were included in the study (conventional intubation [group KL, n = 60]. Trachlight intubation [group TT, n = 60]. The goals of the investigation were to examine the handling, application, problems, limitations, and possible indications of the method. The recorded parameters were: number of intubation attempts: course and duration of intubation; complications; and difficulties. In 40 patients (20 in each group) the indication for invasive blood pressure measurement was given due to the surgical procedure, and circulatory parameters were recorded at defined moments during the intubation course. In group KL 55 patients were intubated in the attempt, 4 on the second, and 1 on the third (mean duration 23.6 +/- 10.4 s, range 12-60 s). Complications were: unilateral intubation (3 patients), bradycardia (2), asystole (1) and soft-tissue injury (1). Of the 60 patients in group TT. 54 were intubated successfully, the mean time needed being 29.9 +/- 14.8 s (range: 6-61 s). The remaining 6 were then intubated by the conventional method. Positive results in group TT included: easy handling and application, no injury to soft tissues or teeth, and invariably correct placement of the tube. Problems included: sufficient transillumination was achieved only after (entire) dimming of the room, insufficient control over the distal end of the tube due to an unfixed metal wire, unintentional switching off of the light while with-drawing the metal wire, difficulties in withdrawing the metal wire (too strong fixation), as well as disturbing effects of the warning device (blinking of the light 30 s after switching on). Reasons for the 6 intubation failures were introduction of the instrument into the oesophagus despite a supposed correct position, impossibility of correct placement in a patient with an extremely large goiter, and insufficiently clear transillumination in 3 extremely obese patients. The cardiovascular parameters showed no changes during laryngeal manipulation; a clear rise in heart rate and blood pressure was recorded, however, when the tube was inserted into the trachea. The cardiovascular parameters during conventional intubations were similar. The light-guided intubation technique can be regarded as a further alternative for airway management, due to the described improvement of the instrument. The indication for the technique is given in patients in whom no difficulty with intubation is expected, to avoid soft tissue damage and traumatising temporomandibular joint movements. Preclinical use may be limited due to environmental brightness. In patients with expected difficult airway management, fiberoptic intubation will remain the method of choice.

Esophagus↗

[Spectral transillumination of the female breast].

PURPOSE: Evaluation of wavelength-associated characteristics by transilluminating normal and pathological breast tissue. METHOD: 80 in vivo and 52 in vitro measurements were carried out with a Mammaspectrograph (Siemens AG, ZFE München). 31 patients had a carcinoma and 59 patients a benign breast lesion. Measurements were performed with an increment of 10 nm, wavelengths between 550-1100 nm. RESULTS: Normal and pathological breast tissue could be characterised in the area of absorption maxima of fat, water and haemoglobin. Atrophic breast tissue has a remarkable transmission minimum at 930 nm. Tumors with a high number of cells and neovascularisation showed a strong absorption over the entire "diagnostic window" and a transmission minimum at 970 nm. Below 700 nm the high concentration of haemoglobin resulted in an increase of transmission. Less wavelength-associated characteristics were seen in tumors with mastopatically-transformed surrounding tissue. CONCLUSION: To differentiate breast tissue, transillumination has to be performed in the area of absorption maxima of fat, water and haemoglobin.

Adenocarcinoma, Mucinous↗