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PubMed2004

Morphology and axonal projection pattern of neurons in the telencephalon of the fire-bellied toad Bombina orientalis: an anterograde, retrograde, and intracellular biocytin labeling study.

The connectivity and cytoarchitecture of telencephalic centers except dorsal and medial pallium were studied in the fire-bellied toad Bombina orientalis by anterograde and retrograde biocytin labeling and intracellular biocytin injection (total of 148 intracellularly labeled neurons or neuron clusters). Our findings suggest the following telencephalic divisions: (1) a central amygdala-bed nucleus of the stria terminalis in the caudal midventral telencephalon, connected to visceral-autonomic centers; (2) a vomeronasal amygdala in the caudolateral ventral telencephalon receiving input from the accessory olfactory bulb and projecting mainly to the preoptic region/hypothalamus; (3) an olfactory amygdala in the caudal pole of the telencephalon lateral to the vomeronasal amygdala receiving input from the main olfactory bulb and projecting to the hypothalamus; (4) a medial amygdala receiving input from the anterior dorsal thalamus and projecting to the medial pallium, septum, and hypothalamus; (5) a ventromedial column formed by a nucleus accumbens and a ventral pallidum projecting to the central amygdala, hypothalamus, and posterior tubercle; (6) a lateral column constituting the dorsal striatum proper rostrally and the dorsal pallidum caudally, and a ventrolateral column constituting the ventral striatum. We conclude that the caudal mediolateral complex consisting of the extended central, vomeronasal, and olfactory amygdala of anurans represents the ancestral condition of the amygdaloid complex. During the evolution of the mammalian telencephalon this complex was shifted medially and involuted. The mammalian basolateral amygdala apparently is an evolutionary new structure, but the medial portion of the amygdalar complex of anurans reveals similarities in input and output with this structure and may serve similar functions.

Animals↗
PubMed2004

Experimental study of the connections of the telencephalon in the rainbow trout (Oncorhynchus mykiss). II: Dorsal area and preoptic region.

In this study and the accompanying article (Folgueira et al., 2004a), the fluorescent carbocyanine dye 1,1'-dioctadecyl 3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) was used in fixed tissue to comprehensively analyze the connections of the different regions of the telencephalic lobes and the preoptic region of the rainbow trout. Here, we analyze the connections of the dorsal area (D; pallium) of the telencephalon, and the preoptic region, as well as the telencephalic connections of several structures in the diencephalon and brainstem of juvenile trout. The dorsal plus dorsolateral pallial zone of D (Dd+Dl-d) receives afferents from contralateral Dd+Dl-d, the ventral area of the telencephalon, preoptic nucleus, suprachiasmatic nucleus, medial thalamus, preglomerular complex, anterior and lateral tuberal nuclei, posterior tuberal nucleus, posterior hypothalamic lobe, superior raphe nucleus, and the rhombencephalic central gray and reticular formation, and projects to the central zone of D (Dc), medial thalamus, and some caudomedial hypothalamic regions. The medial zone of D (Dm) maintains reciprocal connections with the preglomerular complex and also receives afferents from the preoptic nucleus, suprachiasmatic nucleus, anterior tuberal nucleus, preglomerular tertiary gustatory nucleus, posterior tubercle, superior raphe nucleus, locus coeruleus, and the rhombencephalic central gray, and reticular formation. Dc receives fibers mainly from Dd+Dl-d, preoptic nucleus, preglomerular complex, and torus semicircularis and projects to several extratelencephalic centers, including the paracommissural nucleus, optic tectum, torus semicircularis, thalamus, preglomerular complex, posterior tubercle nuclei, and inferior hypothalamic lobes. The posterior zone of D (Dp) is mainly connected with the olfactory bulbs, the ventral and supracommissural nuclei of the ventral area (subpallium), the preoptic nucleus, and the preglomerular complex and projects to wide hypothalamic and posterior tubercular regions. The preoptic nucleus projects to the olfactory bulb, to most regions of the telencephalic lobes, and to several diencephalic and brainstem structures. These results reveal complex and specialized connectional patterns in the rainbow trout dorsal telencephalon and preoptic region. Most of these connections have not been described previously in salmonids. These connections indicate that the salmonid telencephalon is involved in multisensorial processing and modulation of brain activity.

Animals↗
PubMed1993

Retinal projection to the olfactory tubercle and basal telencephalon in primates.

The retinal projection to the basal telencephalon was studied in eight species of primates from the suborders Strepsirhini and Haplorhini, including one anthropoid primate, the gibbon. Animals received an intraocular injection of tritiated amino acids and the distribution of retinal fibers and terminals was demonstrated by autoradiographic techniques in horizontal and coronal sections. In all species a discrete group of labeled retinal fibers is observed to branch off from the dorsolateral aspect of the optic tract at the level of the suprachiasmatic nucleus. These fibers, destined to the basal telencephalon, are topographically distinct from the retinal fibers which innervate the suprachiasmatic nucleus and medial hypothalamic regions. The fibers of the retinotelencephalic tract course dorsally above the supraoptic nucleus through the lateral hypothalamic area and then proceed further rostrally and laterally below the diagonal band of Broca towards the olfactory tubercle. Within the olfactory tubercle, terminal distribution of label is observed in the mediocaudal region along the granular cell layer II. In the macaque this cellular layer shows a characteristic thickening in the region of retinal terminals which is evident in both coronal and horizontal section. In some species this labeled region is seen within the superficial bulge of the tubercle on the ventral aspect of basal telencephalon. In all primates the retinal projection to olfactory tubercle is bilateral. In prosimians label is predominantly contralateral to the injected eye, in New World monkeys label is equally distributed on both sides of the brain and in Old World monkeys label is mainly found ipsilaterally. Retinal fibers were also seen in the periamygdaloid region but never extended as far as piriform cortex. These results, in addition to previous studies in other mammalian orders, confirm that the basal telencephalon, and in particular the olfactory tubercle, constitutes a region of visual and olfactory convergence. This sensory integration may be related to photic and chemosensory modulation of reproductive physiology and behavior.

Animals↗
PubMed1988

Developmental-stage-dependent radiosensitivity of neural cells in the ventricular zone of telencephalon in mouse and rat fetuses.

Pregnant ICR mice were treated with single whole-body X-radiation at a dose of 0.24 Gy on day 10, 13, or 15 of gestation. Fetuses were obtained from mothers during 1 and 24 hours after irradiation. Pyknotic cells in the ventricular zone of telencephalon were counted in serial histological sections. Incidence of pyknotic cells peaked during 6 and 9 hours after irradiation in each gestation day group. Then, dose-response curves were obtained 6 hours after 0-0.48 Gy of irradiation. All three dose-response curves showed clear linearity in the dose range lower than 0.24 Gy. Ratios of radiosensitivity estimated from the slopes of dose-response curves in day 10, 13, and 15 groups were 1, 1.4, and 0.4, respectively. These demonstrated that ventricular cells in the day 13 fetal telencephalon were the most radiosensitive among the three different age groups. In order to confirm the presence of the highly radiosensitive stage common to mammalian cerebral cortical histogenesis, pregnant F344 rats were treated with single whole-body gamma-irradiation at a dose of 0.48 Gy on day 13, 14, 15, 17, or 19 of gestation. The incidence of pyknotic cells in the ventricular zone of telencephalon was examined microscopically during 1 and 24 hours after irradiation. The peak incidence was shown 6 hours after irradiation in all the treated groups, and the highest peak incidence was shown in day-15-treated group. The developmental stage of telencephalon of day 15 rat fetuses was comparable to that of day 13 mouse fetuses. Thus, the highest radiosensitivity in terms of acute cell death was shown in the same developmental stage of brain development, i.e., the beginning phase of cerebral cortical histogenesis, in both mice and rats.

Animals↗
PubMed1998

The dispersion of clonally related cells in the developing chick telencephalon.

Lineage analysis in the chick telencephalon was carried out using a library of retroviral vectors. Clones were analyzed in posthatch day 14-21 animals for the phenotype and final locations of sibling cells. Clones often contained multiple types of neurons and glia. Clones of more than four cells almost always crossed functional boundaries. They were dispersed primarily along the rostrocaudal axis or in multiple directions, e.g., along the rostrocaudal and mediolateral axes. In order to begin to understand how the final patterns of dispersion were reached, embryonic tissue was examined. Radial migration, apparently supported by radial glial cells, occurred within the proliferative zones in all clones. In contrast to the migration of cells in the mammalian telencephalon, no tangential migration within the proliferative zones was observed at any age examined. However, beginning at embryonic day 4.5, tangential migration in the mantle zone in multiple directions was observed among the majority of clones. This type of migration occurred as soon as a mantle zone became apparent. It appeared that the tangential migration was not along radial glial processes. As in the mammalian telencephalon and chick diencephalon, dispersion among clonally related cells in the chick telencephalon is frequent, is extensive, and results from tangential migration in a variety of directions.

Animals↗
PubMed2000

Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures.

The use of genetics to study the development of the telencephalon and derivatives such as the cerebral cortex has been limited. The telencephalon begins to form midway through gestation, and targeted mutations in genes suspected of playing roles in its development often lead to early phenotypes that preclude analysis of their role at later stages. This problem can be circumvented using a Cre/loxP recombination system. A mouse line was produced in which cre was targeted to the Foxg1 (BF-1) locus, a gene expressed specifically in the telencephalon and discrete head structures. Crosses between Foxg1-Cre mice and three separate loxP reporter mice generated embryos with recombination patterns matching that expected from the normal pattern of Foxg1 expression. Recombination occurs invariably in the telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches. Recombination in some animals also occurs less efficiently in tissues not known to express Foxg1. We show that the genetic background of the parental mice and the loxP target allele can each contribute to differences in the exact pattern of recombination. Collectively, these data show that Foxg1-Cre mice should be useful in the deletion or ectopic expression of any floxed target gene in a Foxg1-like pattern.

Alkaline Phosphatase↗
PubMed1994

Projections of the olfactory bulb in an elasmobranch fish, Sphyrna tiburo: segregation of inputs in the telencephalon.

We have previously shown that the morphological compartmentalization of the elasmobranch olfactory bulb is accompanied by a topographical arrangement of the primary olfactory projections onto the bulb. If this spatial arrangement is significant for the processing of the information, one would expect it to be preserved in the secondary olfactory centers of the telencephalon. In this paper, we describe the elasmobranch secondary projections from the olfactory bulb to the telencephalon, focusing on their spatial arrangements within the forebrain. Results show that the olfactory input onto the telencephalon are segregated. The medial olfactory tract projects rostrally onto the superficial layer of the dorsal pallium and onto the lateral pallium. The lateral olfactory tract projects caudally onto the lateral pallium, the striatum and the area superficialis basalis. Thus, the secondary olfactory projections are segregated within the telencephalon, with an overlapping of the secondary fibers in the main projection area, the lateral pallium.

Animals↗
PubMed2004

Altered gene expression with abnormal patterning of the telencephalon in embryos of diabetic Albino Swiss mice.

AIMS/HYPOTHESIS: Several studies have shown that maternal diabetes increases the risk of congenital malformations in various organ systems including the neural tube. The present study analysed molecular and morphological changes in the forebrain of embryos from diabetic Albino Swiss mice. METHODS: Maternal diabetes-induced morphological changes in the forebrain were examined histologically. Cell proliferation index was assayed by BrdU labelling. In situ hybridisation and quantitative real-time PCR were used to analyse the expression of genes coding for sonic hedgehog ( Shh), Nkx2.1, brain factor-1 ( BF-1) and bone morphogenetic protein-4 ( Bmp4) that control forebrain patterning. RESULTS: There were no distinguishable abnormalities in the forebrain of embryos from diabetic pregnancies on embryonic day 0.5. At embryonic day 11.5, embryos of diabetic pregnancies displayed a fusion and thickening of the ventral telencephalic neuroepithelium and a partial absence of the dorsal telencephalon, indicating a severe patterning defect in the dorsoventral axis of the telencephalon. The cell proliferation index was also higher in the ventral telencephalon of these embryos. Molecular analyses indicated that expression of Shh, Nkx2.1 and BF-1 was increased and their expression domains expanded dorsally in the ventral telencephalon in embryos of diabetic mice at embryonic day 11.5. The expression of Bmp4 was reduced in the dorsal forebrain of these embryos. At embryonic day 8.5, only Shh expression was increased. CONCLUSIONS/INTERPRETATION: Altered expression of various genes involved in dorsoventral patterning of the forebrain is associated with forebrain malformations in embryos of diabetic mice.

Animals↗
PubMed2001

Interference with the GABAergic system in the dorsolateral telencephalon and modulation of the electric organ discharge frequency in the weakly electric fish Gymnotus carapo.

The functional role of the dorsal portions of dorsolateral telencephalon in modulating the stable electric organ discharge was determined by microinjection of an agonist or antagonist GABAergic drug in the awake weak electric fish, Gymnotus carapo. The dorsolateral telencephalon, which is interconnected with the preglomerular complex and the dorsocentral telencephalic area was microinjected through a guide cannula previously implanted, with different doses of bicuculline, muscimol and saline. Microinjection of bicuculline into the dorsolateral telencephalon induced a complex response consisting of increase, decrease and abrupt interruptions in the frequency of electric organ discharges and an increase in motor activity. Motor activity and modulations in the electric organ discharge are dose dependent. The somatic, but not the electric, effect is abolished under anesthesia by urethane, suggesting that the two responses are parallel but unrelated in terms of occurrence. These data, together with former neuroanatomical findings by this laboratory, suggest two parallel pathways by which the blockage of GABAA receptors in the dorsolateral telencephalon causes modulations in the firing of the medullary pacemaker nucleus. A possible route for the motor effect through reticular projection from the torus semicircularis dorsalis is discussed.

Animals↗
PubMed1980

Neurotransmitter enzymes in telencephalon, brain stem and cerebellum during the entire life span of the mouse.

Neurochemical analysis of neuronal function was undertaken by measuring the activities of cholinacetyltransferase (CAT), acetylcholinesterase (AChE), and glutamic acid decarboxylase (GAD), in the telencephalon, brain stem and cerebellum of the mouse. Cholinergic activity was first expressed in the 10-day embryonic brain stem, which showed a relatively high CAT activity at birth. Postnatal brain stem development was characterized by a rapid and parallel increase in CAT and AChE. Although AChE peaked at 1 month, CAT activity was no achieved until 1 year. Acetylcholine synthesis was initiated in the 12-day embryonic telencephalon and a steady age-related increase in CAT was maintained until birth. A lag in both CAT and AChE activities was recorded during the first week of postnatal telencephalon development. Cerebellar CAT was low at birth, and increased irregularly to reach a maximum by 1 month. In contrast, postnatal cerebellar AChE activity increased steadily over the same time period. The GABA-ergic neuronal system matured rapidly in each brain region, and was unaffected by aging. Although the brain stem precociously expressed cholinergic activity, it wa the region most susceptible to deterioration during aging. Telencephalon CAT activity was unaffected by aging and in the cerebellum, a significantly reduced level of CAT was only found in truly senescent animals. The decreased cholinergic function during senescence was not due to either increased proteolysis or to alteration in the molecular form of the cholinergic enzymes.

Acetylcholinesterase↗
PubMed1996

Adult neurogenesis in the telencephalon of a lizard: a [3H]thymidine autoradiographic and bromodeoxyuridine immunocytochemical study.

A qualitative and quantitative evaluation of adult neurogenesis in the telencephalon of a lizard was conducted using [3H]thymidine autoradiography and immunocytochemical detection of 5'-bromodeoxyuridine (BrdU). The sites of cell proliferation, the fate, and the phenotype of cells born in adulthood were determined by short and long survival experiments (7 and 30 days). Adult specimens of the Moorish gecko, Tarentola mauritanica (Sauria, Gekkonidae), received subcutaneous injections of either BrdU or [3H]thymidine. Seven days after BrdU administration most labelled cells were in the walls (ventricular zone; VZ) of the lateral ventricles, particularly close to the sulcal zones. Labelled cells in the VZ of other ventricles were practically absent. Following 30 days, labelled cells outside the VZ were seen in most telencephalic regions: olfactory bulbs (OB), medial, dorsal, and lateral cortices (MC, DC, LC), anterior dorsal ventricular ridge (ADVR), nucleus sphericus (NS), and striatum (St). Electron microscopic examination of [3H]thymidine labelled cells found in these areas revealed their neuronal identity. No labelled neurons were detected in the dorsomedial cerebral cortex (DMC), septum (Sp), or elsewhere in the telencephalon. We conclude that neurogenesis occur in most regions of the adult lizard telencephalon. The most intense neuronal production occurs in the MC. Other telencephalic regions, such as the OB, ADVR, and NS, also show a considerable rate of adult neurogenesis. We infer from our results that the new neurons are born in the walls of the lateral ventricles and then migrate to their destinations. Furthermore, we report some evidence suggesting that neurons formed in adulthood in the olfactory bulbs are generated in the distant proliferative VZ. The functional significance of neurogenesis in the telencephalon of adult lizards is unclear, but it seems to be restricted to areas that have been implicated in olfactory plasticity, learning, and memory.

Age Factors↗
PubMed1984

Enkephalin-like immunoreactivity within the telencephalon of the reptile Caiman crocodilus.

Immunohistochemical methods were used to characterize the distribution of staining for leucine enkephalin-like and methionine enkephalin-like immunoreactivities in the telencephalon of Caiman crocodilus. Very similar distributions of both leucine enkephalin-like and methionine enkephalin-like immunoreactivity were observed. The greatest accumulations of enkephalin-like immunoreactive material were observed within the ventrolateral area of the telencephalon, a region considered comparable to the mammalian corpus striatum and avian paleostriatal complex (i.e. basal ganglia) on the basis of embryological, anatomical and histochemical criteria. Within the ventrolateral area, many small immunoreactive neuron cell bodies were observed, particularly within the rostromedial small-celled component of the ventrolateral telencephalic area. A rich plexus of fibers displaying enkephalin-like immunoreactivity invests the entire ventrolateral area including the large-celled subdivision. A system of thick, coarse, radially-directed immunoreactive fibers running between medial and dorsal portions of the ventrolateral area and more ventral portions was observed in this study. Other structures in the caiman telencephalon, containing large numbers of neural elements displaying enkephalin-like immunoreactivity, were the ventral paleostriatum (a region considered comparable to the ventral pallidum of mammals), the lateral septal nucleus and the nucleus accumbens. The corticoid areas contained far fewer elements displaying enkephalin-like immunoreactivity, although immunoreactive fibers and cell bodies were observed within the medial, dorsal and lateral corticoid areas, particularly at caudal levels. The dorsal ventricular ridge contains the lowest number of immunoreactive cells and fibers of any structure within the caiman telencephalon although occasional neurons displaying enkephalin-like immunoreactivity were encountered in the dorsal ventricular ridge. The results are compared to the distribution of enkephalin within the cerebral hemispheres of mammals, birds and other reptiles.

Alligators and Crocodiles↗
PubMed2003

Topographical projections to the nucleus prethalamicus from the cerebellum, optic tectum, and telencephalon in holocentrid teleosts.

Fiber connections of the nucleus prethalamicus (PTh) were investigated by biocytin injections into the corpus cerebelli, optic tectum, and telencephalon in holocentrids. The present study revealed the corpus cerebelli projections to the plexiform layer of the contralateral PTh, optic tectum to the marginal and large cell layers of the ipsilateral PTh, and telencephalon to the small cell layer of the ipsilateral PTh. Large cells of the PTh project fibers back to the telencephalon. These observations suggest that projections of the corpus cerebelli, optic tectum, and telencephalon to the PTh are topographically organized.

Animals↗
PubMed2005

Proliferation zones in the salmon telencephalon and evidence for environmental influence on proliferation rate.

Cell proliferation occurs in the brain of fish throughout life. This mitotic activity contributes new neurons to some brain subdivisions, suggesting potential for plasticity in neural development. Recently we found that the telencephalon in salmonids (salmon, trout) is significantly reduced in fish reared in hatcheries compared to wild fish, and that these differences resulted in part from rearing conditions. Here, we describe localized areas of cell proliferation in the telencephalon of juvenile coho salmon (Oncorhynchus kisutch) and begin to explore whether mitotic activity in these areas is sensitive to environmental conditions. Using the 5-bromo-2'-deoxyuridine (BrdU) cell birth-dating technique, we localized proliferating cells in the telencephalon to three distinct zones (proliferation zones 1a, 1b, and 2). We measured the volumes of these zones and showed that they grew at different rates relative to body size. We also found that variation in environmental rearing conditions altered the density of BrdU-labeled cells in proliferation zone 2, but not in zones 1a or 1b. However, this change in mitotic activity did not generate a difference in telencephalon size. These results suggest that environmental conditions, and associated changes in swimming activity or social structure, may influence rates of cell proliferation in the fish forebrain.

Animals↗
PubMed2006

Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon.

Our understanding of the cellular and molecular mechanisms underlying the adult neural stem cell state remains fragmentary. To provide new models on this issue, we searched for stem cells in the adult brain of the zebrafish. Using BrdU tracing and immunodetection of cell-type-specific markers, we demonstrate that the adult zebrafish telencephalon contains self-renewing progenitors, which show features of adult mammalian neural stem cells but distribute along the entire dorso-ventral extent of the telencephalic ventricular zone. These progenitors give rise to newborn neurons settling close to the ventricular zone within the telencephalon proper. They have no equivalent in mammals and therefore constitute a new model of adult telencephalic neural stem cells. In addition, progenitors from the ventral subpallium generate rapidly dividing progenitors and neuroblasts that reach the olfactory bulb (OB) via a rostral migratory stream and differentiate into GABAergic and TH-positive neurons. These ventral progenitors are comparable to the mammalian neural stem cells of the subependymal zone. Interestingly, dorsal and ventral progenitors in the adult telencephalon express a different combination of transcription factors than their embryonic counterparts. In the case of neurogenin1, this is due to the usage of different enhancer elements. Together, our results highlight the conserved and unique phylogenic and ontogenic features of adult neurogenesis in the zebrafish telencephalon and open the way to the identification of adult neural stem cell characters in cross-species comparative studies.

Age Factors↗
PubMed2003

A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon.

Regionalization of the neural plate and the early neural tube is controlled by several signaling centers that direct the generation of molecularly distinct domains. In the developing telencephalon, the anterior neural ridge (ANR) and the roof and floor plate act as such organizing centers via the production of Fgfs, Bmps/Wnts, and Shh, respectively. It remains largely unknown, however, how the combination of these different signals is used to coordinate the generation of different telencephalic territories. In the present study, we report on telencephalic development in Pdn mutant mice, which carry an integration of a retrotransposon in the Gli3 locus. Homozygous mutant animals are characterized by a partial dorsal-to-ventral transformation of the telencephalon and by an increased size of the septum. On a molecular level, these alterations correlate with a reduction and/or loss of Bmp/Wnt expression and a concomitant expansion of Fgf8 transcription. Finally, we provide evidence that the ectopic activation of Fgf signaling in the dorsal telencephalon provides an explanation for the ventralization of the Gli3 mutant telencephalon as application of Fgf8-soaked beads to dorsal telencephalic explants led to the specific induction and repression of ventral marker and dorsal marker genes, respectively.

Animals↗
PubMed1997

Postnatal neurogenesis in the telencephalon of turtles: evidence for nonradial migration of new neurons from distant proliferative ventricular zones to the olfactory bulbs.

Postnatal neurogenesis in the the turtle telencephalon was investigated by using bromodeoxyuridine immunocytochemistry and [3H]thymidine autoradiography. Red-eared slider turtles Trachemys scripta elegans (Cryptodira, Emydidae) 2-3 months old were injected with the thymidine analogue 5'-bromodeoxyuridine (BrdU) and allowed to survive for 7, 30, 90, and 180 days. Results indicate that cells in the walls of the lateral ventricles continue to proliferate postnatally. Shortly after BrdU treatment (seven days) most labelled cells were found in the walls of the lateral ventricles (ventricular zone: VZ). Labelled cells were particularly abundant in and around the ventricular sulci. The same pattern of labelling was found in the telencephalon of juvenile turtles (> two years old) injected with BrdU and killed seven day later, suggesting that the proliferative activity continues in the telencephalic VZ of turtles during juvenile stages of life and possibly into adulthood. With longer survival periods after BrdU administration (30, 90, and 180 days), the VZ of the telencephalon showed a similar pattern of labelling to that found at seven days. Furthermore, with survival periods of 90 and 180 days labelled cells resembling neurons were found in most telencephalic regions. The largest numbers of these putative neurons were found in the olfactory bulbs. By using [3H]thymidine autoradiography combined with electron microscopy these postnatally generated cells were confirmed as neurons. We conclude that postnatal neurogenesis occurs in the turtle telencephalon. This process is most prominent in the olfactory bulbs. From the pattern of proliferation of neuronal precursors in the VZ we infer that neurons recruited postnatally into the olfactory bulbs come from distant proliferative VZs in the walls of the lateral ventricles.

Animals↗
PubMed1999

Reciprocal connections between the preglomerular complex and the dorsolateral telencephalon in the weakly electric fish, Gymnotus carapo.

The diencephalic preglomerular complex of gymnotiform fish receives inputs from several sensory areas. By employing anterograde and retrograde tracing techniques, we studied the afferent and efferent connections of the dorsolateral area (dorsal subdivision) of the telencephalon with the preglomerular nuclei in the weakly electric fish, Gymnotus carapo. Neurons of the medial preglomerular nucleus project to intermediate and deep portions of the middle (commissural) level of the dorsolateral telencephalon, and neurons located in the lateral preglomerular nucleus project to superficial portions of the middle levels of the dorsolateral telencephalon. Therefore, we observed a spatial distribution pattern of connectivity between dorsolateral telencephalon and preglomerular complex.

Animals↗