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45 records · Page 3Linked to original sources
PubMed1986

Local variation in cutaneous and subcutaneous blood flow measured by CdTe(C1) minidetectors in normal and psoriatic skin.

The accuracy of the 133Xe washout method and the validity of newly developed cadmium telluride CdTe(Cl) minisemiconductor detectors were estimated by performing comparative, simultaneous measurements of both cutaneous (CBF) and subcutaneous (SBF) blood flow using 2 conventional scintillation sodium iodide NaI(Tl) and CdTe(Cl) detectors over the same radioactive depot in each of 10 individuals. The accuracy of the 133Xe washout method was found to be 13-15% (C.V.) for the CBF measurements and 9-12% (C.V.) for the SBF measurements. The CdTe(Cl) detectors, which have a weight of 20 g and were attached directly over the radioactive depot, may replace stationary NaI(Tl) detectors placed 20 cm from the depot for measurements of both CBF and SBF. Two CdTe(Cl) detectors were used for estimations of the local variation in CBF and SBF within a distance of 5 cm in normal skin of 10 individuals. The C.V. was 7% for the CBF measurements and 18% for the SBF measurements. Measurements of CBF and SBF were performed in 6 psoriatic patients who, after about 1 week of antipsoriatic treatment with beech tar, developed typical Woronoff rings. The local CBF differed significantly from the center of psoriatic plaques to the margin, in the Woronoff ring, and in nonlesional skin. In contrast, SBF was remarkably equal within the plaque and in the Woronoff ring. The color of the Woronoff ring cannot be ascribed to a local cutaneous vasoconstriction. Cutaneous blood flow in chronic stable, lesional psoriatic skin was significantly lower than previously published values for active lesional psoriatic skin, but significantly higher than CBF in normal individuals. Measurements of CBF in tetrahydrofurfuryl nicotinic acid (Trafuril)-treated skin showed higher values than measurements of CBF in the postischemic hyperemia period both in normal and in lesional psoriatic skin. Trafuril induced a significant increase of CBF in both lesional and nonlesional skin. The high CBF rates in lesional psoriatic skin are not due to a maximally, passively dilated vascular bed.

Adult↗
PubMed1979

Relationship between intensities of skin test reactions to glass-fibres and chemical irritants.

A total of 98 workers at a glass-wool factory were patch tested with glass-fibres and six chemical irritants. A rubbing test with the fibres, a Trafuril test and provocation of dermographism were also performed. The subjects with strong patch test reactions to one quality of fibres also reacted strongly to the other types of fibres but did not show an increased sensitivity to other tests. The subjects with intense skin reactions to rubbing with the fibres showed an increased skin reactivity to Trafuril. A tendency towards increased reactivity to the patch tests with fibres was found in persons with fair skin and blue eyes.

Adolescent↗
PubMed1981

Chronic bullous dermatosis of childhood.

A study of 16 patients with chronic bullous dermatosis of childhood (CBDC) is reported. They were followed up for 0.5 to 4.5 years. Histological and immunofluorescent (IF) study of the skin and local provocation of skin lesions by Trafuril test were carried out in every case, intestinal biopsy in twelve cases. Four patients were found to have IgG, and three IgA, along the skin basement membrane. In nine patients, no immunoglobulins were detectable; these IF negative cases seemed to be pseudonegative. Repeated biopsy and immunoelectronmicroscopic study of the skin may be helpful. In the three patient groups classified on the basis of skin IF studies, there was no difference in the clinical and histological picture, in reaction to Trafuril test and in the result of treatment. The small intestinal mucosa was abnormal in three of twelve patients. A gluten-free diet introduced in two patients had no effect on the course of the disease. CBDC with negative or positive IF, juvenile pemphigoid and IgA linear dermatosis seem to be a common clinical entity, different in severity and with individual variations. The condition is not identical with dermatitis herpetiformis Duhring.

Basement Membrane↗
PubMed1975

Capillary pH and blood gas determinations in asthmatic children.

Earlobe capillary pH and blood gases in asthmatic children were compared to arterial values. Hyperemia of the earlobe was produced by applying thurfyl nicotinate (Trafuril). Approximately 15 min later capillary blood was obtained simultaneously with a radial arterial sample. Earlobe capillary PO2, PO2, and pH correlated well with arterial values. This technique is simple, safe, and appears to be a satisfactory substitute for arterial blood in normotensive asthmatic children.

Adolescent↗
PubMed1979

Does occupational exposure to glass-fibres increase the general skin reactivity to irritants?

A total of 33 workers at a glass-wool factory were tested (patch tests with glass-fibres and chemical irritants, epicutaneous tests with Trafuril and intracutaneous tests with histamine) before starting to work at the factory and then re-tested after at least 4 weeks of exposure to glass-fibres. No statistically significant differences in the intensity of the skin reactions before and after exposure were found. Thus no general increased irritancy of the normal skin was induced by the continuous exposure to glass-fibres.

Adolescent↗
PubMed1968

Use of capillary blood in measurement of arterial PO2.

In this study we investigated the possibility of obtaining accurate values of arterial Po(2) from specimens of capillary blood stored in glass capillary tubes and measured in an oxygen microelectrode. It has been shown that Po(2) measurements made on the Radiometer oxygen microelectrode are as accurate as those made on the macroelectrode and that the storage of blood is as satisfactory in glass capillary tubes as in glass syringes. The important feature in obtaining accurate values for arterial Po(2) is the choice of the capillary bed and its method of preparation for sampling. If the ear lobe is massaged with thurfyl nicotinate (Trafuril) it is possible to obtain values of Po(2) from the capillary blood which are in close agreement with arterial Po(2) in normal, hyperoxic, and shocked vasoconstricted patients.

Arteries↗
PubMed1982

Arachidonic acid metabolism in skin: experimental contact dermatitis in guinea pigs.

The cutaneous metabolism of exogenous arachidonic acid and endoperoxide (PGH2) to prostaglandins and hydroxy-fatty acids was investigated in experimental contact dermatitis in guinea pigs and compared to normal skin, unsensitized animals treated with the allergen dinitrochlorobenzene, and Trafuril-induced irritant dermatitis. The main alterations of cutaneous arachidonate metabolism in contact dermatitis comprise: (1) an inhibition of PGD2 synthesis; (2) a switch from predominant PGD2 production to a predominance of PGE2 and (3) a marked inhibition of the lipoxygenase activity.

Animals↗
PubMed1984

Skin irritancy from propylene glycol.

Two sensitive methods for the assessment of skin irritancy reactions to propylene glycol (PG) have been used: laser Doppler flowmetry in man for erythema and skin fold thickness measurements in man, guinea pigs and rabbits for edema. Single (open and occlusive) and repeated (open) exposures were used. Trafuril was used as positive control for the flowmetric studies. In man an increased blood flow was recorded only when PG was applied under occlusion. A statistically significant increase in skin fold thickness was observed from day 7 in the guinea pig, but not in man (daily exposures for 36 days). It is concluded that occlusion seems to be a crucial factor and that skin fold thickness measurements in guinea pigs and rabbits is a useful, complementary method for the detection and prediction of marginal irritants.

Animals↗
PubMed1979

Skin reactivity in workers with and without itching from occupational exposure to glass fibres.

98 workers at a glass-wool factory were divided into three comparable groups: those with persistent troublesome itching from the fibres, those without itching, and those who had become 'hardened' to the itching. The three groups were compared with respect to the results of patch testing with glass fibres and six chemical irritants, a rubbing test with fibres, the Trafuril test, and provocation of dermographism. Anamnestic data with respect to atopy, itching from wool and synthetic fibres, sweating, and reactions to the sun were evaluated, as also was the general skin pigmentation. No statistically significant differences between the three groups were found in respect of any of these tests or factors except for a subjectively increased sensitivity in the rubbing test with fibres for the itching group. It is possible that similar itch-provocation tests might be useful for pre-employment assessment to predict severe occupational itching from glass fibres.

Allergens↗