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[An initial assessment of therapeutic value of strontium 85 isotope in treatment of chronic osteomyelitis in adults].

An initial assessment of treatment of chronic osteomyelitis in 16 adults with Strontium 85 is presented. A dose 3.5-5 times greater than standard scintigraphic one was administered. In 3 cases the dose has been repeated because of the persistence of infection. The radionuclide was well tolerated. In 14 cases ceasing of osteomyelitis have been achieved. Laboratory tests showed no abnormalities.

Adult↗

Potential of inductively coupled plasma mass spectrometry for trace element metabolism studies in man.

A new inorganic mass spectrometric technique is described which allows sensitive, rapid and economic determination of trace element concentrations and isotope ratios in aqueous samples. This paper illustrates the potential of the technique in one particular application area, namely the measurement of strontium isotope ratios in human blood and urine following ingestion of an enriched stable strontium isotope. The data from a human volunteer experiment illustrate the viability of the analytical method, with measurement precisions of +/- 0.2% (1 sigma) achieved for the isotope ratio in urine samples, which contained approximately 300 ng 86Sr in the volume required for analysis. Measurement precision is limited by counting statistics.

Humans↗

Strontium-89 and strontium-90 levels in breast milk and in mineral-suplement preparations.

Strontium-90, strontium-89 and S.U. values were determined in human milk before and after the resumption of atmospheric nuclear testings in 1961, and the levels were compared to cows' milk values reported during the same time. S.U.(90) levels in human milk were approximately one-fifth of those found in cows' milk. Assuming an average dietary intake of 11-13 S.U.(90) during the period tested, the mean strontium/calcium ratio of 1.78 found in human milk represents an Observed Ratio milk-diet of approximately 0.14-0.16. Although strontium-89 was present in cows' milk already in September 1961, it did not appear in human milk until November 1961. It seems, therefore, that there was a two-month lag period between the appearance of fresh fallout in cows' milk and human milk. Calcium-supplement mineral preparations used by pregnant and lactating women were tested to find their strontium-89, strontium-90 and S.U. levels, because strontium isotopes, if present in these products, will be transferred to the fetus and to breast-fed infants. The compounds tested had S.U.(90) levels of 0.13-2.62; in none of the preparations was Sr(89) present.

Animals↗

Strontium biokinetics in humans: influence of alginate on the uptake of ingested strontium.

Radioactive isotopes of strontium, mainly 90Sr, released into the environment due to nuclear accidents may contribute significantly to the internal radiation exposure of members of the public after ingestion of strontium with contaminated foodstuffs. The committed radiation dose is significantly dependent on the fraction of the ingested activity that crossed the gut wall (f1 value). In tracer kinetic investigations, the effect of sodium alginate on the gastrointestinal absorption of strontium was studied in human subjects. Sodium alginate was proven to be a potent agent for reducing strontium absorption with high efficiency and virtually no toxicity. The data obtained show that the uptake of ingested strontium from milk was reduced by a factor of nine when alginate was added to milk. It is concluded that alginate preparations are a suitable antidote against radiostrontium.

Administration, Oral↗

Isotopes, ice ages, and terminal Proterozoic earth history.

Detailed correlations of ancient glacial deposits, based on temporal records of carbon and strontium isotopes in seawater, indicate four (and perhaps five) discrete ice ages in the terminal Proterozoic Eon. The close and repeated stratigraphic relationship between C-isotopic excursions and glaciogenic rocks suggests that unusually high rates of organic carbon burial facilitated glaciation by reducing atmospheric greenhouse capacity. The emerging framework of time and environmental change contributes to the improved resolution of stratigraphic and evolutionary pattern in the early fossil record of animals.

Animals↗

Modelling the Phanerozoic carbon cycle and climate: constraints from the 87Sr/86Sr isotopic ratio of seawater.

A numerical model describing the coupled evolution of the biogeochemical cycles of carbon, sulfur, calcium, magnesium, phosphorus, and strontium has been developed to describe the long-term changes of atmospheric carbon dioxide and climate during the Phanerozoic. The emphasis is on the effects of coupling the cycles of carbon and strontium. Various interpretations of the observed Phanerozoic history of the seawater 87Sr/86Sr ratio are investigated with the model. More specifically, the abilities of continental weathering, volcanism, and surface lithology in generating that signal are tested and compared. It is suggested that the observed fluctuations are mostly due to a changing weatherability over time. It is shown that such a conclusion is very important for the modelling of the carbon cycle. Indeed, it implies that the conventional belief that the evolution of atmospheric carbon dioxide and climate on a long time scale is governed by the balance between the volcanic input of CO2 and the rate of silicate weathering is not true. Rather carbon exchanges between the mantle and the exogenic system are likely to have played a key role too. Further, the increase of the global weathering rates with increasing surface temperature and/or atmospheric CO2 pressure usually postulated in long-term carbon cycle and climate modelling is also inconsistent with the new model. Other factors appear to have modulated the weatherability of the continents through time, such as mountain building and the existence of glaciers and ice sheets. Based on these observations, a history of atmospheric carbon dioxide and climate during Phanerozoic time, consistent with the strontium isotopic data, is reconstructed with the model and is shown to be compatible with paleoclimatic indicators, such as the timing of glaciation and the estimates of Cretaceous paleotemperatures.

Atmosphere↗

Investigating the sources of the labile fraction in sediments from silicate-drained rocks using trace elements, and strontium and lead isotopes.

Elemental concentrations of the trace elements Rb, Sr, Th, Pb, Zn, Cu, Ni, Cd and Sb, as well as Sr and Pb isotopic compositions, were determined on the labile fraction (called acid-extracted matter AEM, Négrel et al., Chem. Geol. 166 (2000) 271-85) of soil and sediment along two small rivers located in the centre of France, one flowing from basalt, the other one on granite-gneiss. Oxide-mineral form in AEM (i.e. Fe-Mn oxides), acts as the main carrier phase. Analysis of the relationships between the trace elements, and lead and strontium isotopes allows the origin of the elements (i.e. natural and anthropogenic) and their history, both in the sediment and soil from the small watersheds to be assessed. Lead-isotope compositions in AEM display large fluctuation in the two watersheds and show a large scatter between natural input (basalt and granite), atmospheric input from gasoline, and input from past mining activities. On the basaltic watershed, Pb and other trace elements like Sb deriving from past mining waste are mainly related to atmospheric origin, while on the granitic terrain Pb originates from mineralization. The Sr-isotope compositions of AEM, water and residues are similar in the watershed draining basalt. On the watershed draining granite, AEM and streamwater shows 87Sr/86Sr ratios similar in the upstream part of the watershed and a divergence between the two ratios appears in the downstream part of the watershed implying that oxides have precipitated upstream and are not re-equilibrated during their transport downstream.

France↗

Biostratigraphic and chemostratigraphic correlation of Neoproterozoic sedimentary successions: upper Tindir Group, northwestern Canada, as a test case.

Recent advances in Proterozoic micropaleontology and sedimentary isotope geochemistry suggest that improved interbasinal correlation of Neoproterozoic (1000-540 Ma) successions is possible. Because widely varying interpretations of its age have been suggested and no reliable radiometric dates or paleomagnetic data are available, the upper Tindir Group of northwestern Canada provides an opportunity to test this hypothesis. The age of these strata is of paleontological importance because silicified carbonates near the top of the group contain disc-shaped-scale microfossils that may provide insights into the early evolution of biomineralization. A reinterpretation of upper Tindir microfossil assemblages suggests a late Riphean age. Although diagenesis and contact metamorphism have altered the isotopic compositions of some carbonates, least altered samples indicate that delta 13C of contemporaneous seawater was at least +4.7%, typical of Neoproterozoic, but not Cambrian, carbonates. Strontium isotopic compositions of the least altered samples yield values of approximately 0.7065, which can be uniquely correlated with late Riphean seawater. Together, micropaleontology and the isotopic tracers of C and Sr constrain the upper Tindir carbonates and their unique fossils to be late Riphean, likely between 620 and 780 Ma.

Animals↗

Persistence of rock-derived nutrients in the wet tropical forests of La Selva, Costa Rica.

We used strontium isotopes and analysis of foliar and soil nutrients to test whether erosion can rejuvenate the supply of rock-derived nutrients in the lowland tropical rain forest of La Selva, Costa Rica. We expected that these nutrients would be depleted from soils on stable surfaces, a result of over one million years of weathering in situ. In fact, trees and palms in all landscape positions derive a relatively high percentage (> or =40%) of their strontium from bedrock, rather than atmospheric, sources. The fraction that is rock-derived increases on slopes, but with no detectable effect on plant macronutrient concentrations. These results differ from those in a similar ecosystem on Kauai, Hawaii, where plants on uneroded surfaces derive almost all of their foliar Sr from atmospheric, rather than bedrock, sources. The results from La Selva challenge the assumption that tropical Oxisols in general have low nutrient inputs from bedrock, and support the hypothesis that erosion can increase the supply of these nutrients in lower landscape positions.

Costa Rica↗

Kinetics of isotopic exchange between strontium polymolybdate and strontium ions in aqueous solution.

A heterogeneous isotopic exchange reaction of strontium polymolybdate in strontium chloride solution was studied using 90Sr as a tracer. The effects of low and high strontium chloride concentration on the rate and mechanism of the isotopic exchange reaction were investigated. It was found that, at high concentrations, the rate is independent of strontium concentration, but, at low concentrations, the rate is proportional to the strontium concentration. These results support a hypothesis that, at low concentrations, the rate is controlled by film diffusion, whereas at high concentrations it is controlled by particle diffusion. Experiments were performed at 293, 303 and 313 K. Activation energy of isotopic exchange reaction and thermodynamic parameters deltaH*, deltaS*, and deltaG* were calculated using the Arrhenius and Eyring equations. The results also indicated that recrystallization is a predominant factor in the present exchange reaction.

Kinetics↗