The Novel HLA-DPB1*1790:01 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-DPB1*1790:01 differs from HLA-DPB1*02:02:01:01 by a single non-synonymous nucleotide change in exon 2.
Humans↗
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The Novel HLA-DPB1*1730:01 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-DPB1*1730:01 differs from HLA-DPB1*107:01:01:01 by a single non-synonymous nucleotide change in exon 4.
Humans↗
The Novel HLA-C*08:294 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-C*08:294 allele differs from HLA-C*08:01:01:01 by a single non-synonymous nucleotide change in exon 3.
Humans↗
The Novel HLA-DQB1*06:528 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-DQB1*06:528 differs from HLA-DQB1*06:09:01:01 by a single non-synonymous nucleotide change in exon 2.
Humans↗
The Novel HLA-B*13:187 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-B*13:187 differs from HLA-B*13:01:01:01 by a single non-synonymous nucleotide change in exon 3.
Humans↗
The Novel HLA-A*33:284 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-A*33:284 differs from HLA-A*33:03:01:01 by a single non-synonymous nucleotide change in exon 4.
Humans↗
Hemizygous Amplification and Sanger Sequencing of HLA-B*35:433 From an Umbilical-Cord Blood Sample.
HLA-B*35:433 was fully characterised using sequence-based typing after haplo-specific amplification.
Humans↗
The Novel HLA-A*24:668 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-A*24:668 differs from HLA-A*24:02:01:01 by a single non-synonymous nucleotide change in exon 2.
Humans↗
The Novel HLA-A*02:1259 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-A*02:1259 differs from HLA-A*02:07:01:01 by two non-synonymous nucleotide changes in exon 3.
Humans↗
The Novel HLA-C*07:640:02 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
HLA-C*07:640:02 differs from HLA-C*07:640:01 by a single non-synonymous nucleotide change in exon 3.
Humans↗
The Novel HLA-B*46:106 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
The HLA-B*46:106 allele differs from HLA-B*46:01:01:01 by one nucleotide substitution in codon 66 in exon 2.
Humans↗
The Novel HLA-C*03:712 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.
The HLA-C*03:712 allele differs from HLA-C*03:03:01:01 by one nucleotide substitution in codon 61 in exon 2.
Humans↗
Margaret Sanger and the birth control movement.
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Contraception↗
Margaret Sanger labeled 'racist'.
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Family Planning Services↗
DNA sequencing of the MHC class II region and the chromosome 6 sequencing effort at the Sanger Centre.
The human Major Histocompatibility Complex (MHC) is located on the short arm of chromosome 6 (6p21.3) and spans about 4 Mb. According to different gene families the MHC is subdivided into a class I, class II and class III region and many of its gene products are associated with the immune system and the susceptibility to various diseases. To date, we have sequenced about 40% (400 kb) of the class II region between HLA-DP and HLA-DQ and a coordinated effort to sequence the entire MHC is well underway. Analysis of the sequence revealed several novel genes and provides new insights into the molecular organisation and evolution of the MHC. All our data are publicly available via the MHC database (MHCDB) which allows rapid access, retrieval and display in the context of other MHC associated data. MHCDB is online available at (http:(/)/www.hgmp.mrc.ac.uk/) and, together with all our sequences also via anonymous ftp (ftp.icnet.uk/icrf-public).
Animals↗
The chromosome 6 sequencing project at the Sanger Centre.
Chromosome 6 is probably best known for encoding the major histocompatibility complex (MHC) which is essential to the human immune response. In addition, it has been shown to be associated with many diseases such Schizophrenia, Diabetes, Arthritis, Haemochromatosis, Narcolepsy, Epilepsy, Retinitis Pigmentosa, Deafness, Ovarian Cancer, and many more. Chromosome 6 is about 180 Mb in size and is estimated to encode around 3500 genes of which only about 10% are currently known. It is our aim to map, sequence and annotate the entire chromosome in close collaboration with the chromosome 6 community.
Chromosomes, Human, Pair 6↗
Frederick Sanger--winner of 2 Nobel prizes.
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Biochemistry↗
Genomics. Sanger will sequence zebrafish genome.
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Academies and Institutes↗