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At least 55 records · Page 3Linked to original sources

A case of black dot ringworm with a review of Japanese cases.

Black dot ringworm (BDR), caused by Trichophyton violaceum var. glabrum (T. glabrum), was observed in a 28-year-old Japanese female who had been treated with prednisolone (22.5 mg/day) for systemic lupus erythematosus. It was successfully treated with oral terbinafine (125 mg/day) for 12 weeks. The causative fungus was identified by molecular analysis as well as morphological and biochemical examination. The chitin synthase 1 (CHS1) gene cleavage pattern of the clinical isolate with restricted enzyme HinfI was identical to that of T. violaceum. We reviewed previous reports of BDR to determine the historical trend of this infection in Japan. Since 1974, 93 Japanese cases have been reported. The age distribution was bi-modal: the higher peak consisted of children (aged 0-15 years), and the lower peak was composed of the elderly (aged 60-75 years). In the elderly group, females were predominant (M:F=1:22, p<0.001). T. violaceum, including T. glabrum, was identified as the most common causative fungus of BDR (75.3%). Sixty percent of cases showed slight erythema. In 8 families, 16 cases were found to be intrafamilial infections. A history of previous steroid treatment was described in about 40%.

Adult↗

Cutaneous 'ringworm' lesions of Scopulariopsis brevicaulis.

Scopulariopsis brevicaulis is a saprophytic fungus which is occasionally isolated as an apparent cause of toenail fungal infection, and which rarely has been reported as a cause of deep fungal granuloma. We report a case of skin infection with this organism, which was proved by culture of a pure isolate. The skin lesions had an annular ringworm appearance with pustules, they occurred initially at a site of minor injury, and they responded to treatment with terbinafine and itraconazole.

Adolescent↗

Inflammatory ringworm with unusual features.

Zoophilic dermatophyte infections are often inflammatory but severe widespread inflammatory lesions of glabrous skin, as in the female patient described, are unusual. Most cases of M. canis ringworm can be traced to an infected animal. This dermatophyte is associated with a variety of clinical presentations on glabrous skin and is being isolated with increasing frequency in some countries.

Adult↗

Experimental medication of equine ringworm due to Trichophyton equinum var. autotrophicum.

Twelve medicaments were tested for their efficacy in the treatment of Trichophyton equinum var. autotrophicum; povidone iodine, thiabendazole ointment, captan ointment and Burroughs Wellcome Ringworm Ointment gave satisfactory results but their usefulness may be limited for treatment of large numbers of horses. Aqueous washes containing 0.5% hexetidine or 0.3% chloramine-T did not prevent fungi being isolated from lesions for up to 7 days after treatment. Similarly neither etisazole nor thiabendazole suspension prevented fungi from being isolated from lesions for up to 15 days after treatment. Commonly used aqueous solution of 2.5% lime sulphur and 2% captan were least successful, as fungi could still be isolated from lesions for up to 30 days after treatment. The need to treat large numbers of horses may dictate the use of such solutions rather than ointments because of ease of application and cost factors. Treatments consisting of 10% nystatin ointment, 10% iodine fortis, 10% Medol and a proprietary ointment, Queensland Itch Dressing, were not satisfactory. Clinical appraisal and a scratch test must be used together to evaluate progress of treatment. Mass medication of large numbers of horses should be primarily aimed at reduction of spread of infection; normal hair growth should not be used as an indication of the removal of infective agents in the hair as regrowth was altered very little by medication. Hence assessments of cure on the basis of regrowth of hair alone are of dubious value.

Administration, Topical↗

An outbreak of ringworm in sheep in Ireland caused by Trichophyton verrucosum.

An outbreak of ringworm in sheep in Ireland caused by Trichophyton verrucosum is described. The flock consisted of 110 sheep and two separate groups within the flock were affected. Eleven of the first group of 23 sheep and five of the second group of 25 sheep showed lesions. Contact with infected cattle and fomites contaminated by the cattle are believed to have caused the outbreak. An excellent response was obtained in both infected groups by treatment with griseofulvin at a dose rate of 7.5 mg/kg daily for seven days.

Animals↗

Skin cancer after X-ray treatment for scalp ringworm.

Some 2,224 children given X-ray therapy for tinea capitis (ringworm of the scalp) have been followed for up to 50 years to determine cancer incidence, along with a control group of 1,380 tinea capitis patients given only topical medications. The study found a relative risk (RR) of 3.6 (95% confidence interval, 2.3-5.9) for basal cell skin cancer (BCC) of the head and neck among irradiated Caucasians (124 irradiated cases and 21 control cases), in response to a scalp dose of about 4.8 Gy. No melanomas of the head and neck have been seen, and only a few squamous cell carcinomas. About 40% of irradiated cases have had multiple BCCs, for a total of 328 BCCs. Although 25% of both the irradiated and control groups are African-American, only 3 skin cancers have been seen among them, all in the irradiated group, indicating the importance of susceptibility to UV radiation as a cofactor. Light complexion, severe sunburning and North European ancestry were predictive of BCC risk in the irradiated group, but chronic sun exposure was not. Children irradiated at young ages had the highest BCC risk. The RR for BCC risk is approximately constant with time since exposure, suggesting that risk will probably last for a lifetime.

Age Factors↗

[Natamycin-S treatment of ringworm in cattle. Epidemiological aspects (author's transl)].

At a test centre for bulls the progress of a ringworm infection was studied. By treating only the affected animals with natamycin-S the progress of the disease as well as the spreading of the infection among untreated animals could be studied. By treating only the affected animals with natamycin-S the progress of the disease as well as information could be gathered on the difference of progress of the infection in both groups and also of the role of possible immunity.

Animals↗

[Incidence and control of cattle ringworm in Scandinavia].

Clinical aspects, prophylactic as well as therapeutical vaccination with a live attenuated vaccine against Trichophyton verrucosum are dealt with in this article. Further, the epidemical and zoonotical view of the disease is described. The farmers' motives to vaccinate differ depending on type of herd. Hygienic and disinfectant measures in connection with the start of a vaccination program are emphasized. In Sweden, vaccination against ringworm is included in the "Faultless Hide" scheme as one amongst other preventative measures aiming to improve the hide quality. A beneficial effect on both frequency of diseased herds and quality of the hides is obtained.

Animals↗

An outbreak of ringworm in karakul sheep caused by a physiological variant of Trichophyton verrucosum Bodin.

An outbreak of ringworm in Karakul sheep occurred during 1973 among the flocks of at least 14 farmers in South West Africa and the northern Cape Province. Infections spread from one farm to another as a result of introducing infected stud rams. On one farm a few cattle, a goat and a horse developed lesions after being in contact with infected sheep. Some of the attendants handling infected sheep also contracted the disease. Strains recovered from infected animals resembled Trichophyton verrucosum morphologically, but when grown on laboratory media they did not require an exogenous source of vitamins, which was found to be indispensable for strains of this species studied previously.

Africa, Southern↗

Scalp ringworm among Black children in South Africa and the occurrence of Trichophyton yaoundei.

The prevalence of tinea capitis among 153 children who were selected by overt signs of scalp infestation from among 658 Black schoolchildren, was studied in two rural areas of the Transvaal. In both areas (Eastern and Northern Transvaal), Trichophyton violaceum was the predominant dermatophyte species which was isolated. Microsporum audouinii was isolated in both areas from a total of 4 children, but M. canis was the cause of only 1 infection, and that was in the Eastern Transvaal. Five infections caused by T. yaoundei, all of which occurred in the Northern Transvaal, were recorded. They are the first documented cases of endothrix scalp ringworm caused by this species in South Africa.

Black or African American↗

An analysis of infiltrating cells in human ringworm.

Immunohistochemically we examined six patients with ringworm which exhibited a well-marked erythematous edge and central resolution. To obtain a panoramic view of the immunopathological features of various evolutionary stages of skin lesion, we took a radial slice biopsy specimen extending from normal-appearing skin to central resolution. The actively involved edge had a moderate amount of dermal infiltrate of mononuclear cells which mostly consisted of T cells. The ratio of the helper T cells to suppressor T cells was 3.4. At the central resolution, the dermal infiltrate was mild, and the helper T/suppressor T ratio was 3.0. The well-marked erythematous edge showed a decrease of OKT6 positive Langerhans' cells in the epidermis, while many OKT6 positive cells were present in the upper dermis. At the central resolution, however, OKT6 positive cells increased in number in the acanthotic epidermis.

Adult↗

Ringworm-like late syphilides.

A peculiar form of late, superficial, serpiginous, non-ulcerative syphilides, leaving no visible scars, resembling clinically the ringworm of the glabrous skin, showing the granulomatous histopathological structure and relatively abundant T. pallidum, predominantly spread around the blood vessels is described.

Diagnosis, Differential↗

Natamycin treatment of ringworm in cattle in the United Kingdom.

A total of 258 cattle clinically affected with Trichophyton verrucosum (ringworm) were treated twice by spraying with a suspension containing the fungicidal antibiotic natamycin. One-hundred-and-forty-seven in-contact, but unaffected cattle were also similarly treated. Forty-one of the affected animals were examined mycologically and clinically as they were taken to be representative of the whole group. At eight weeks after the last treatment 93 per cent of the affected animals had completely recovered and the remaining 7 per cent had improved markedly; 70 per cent of the mycologically examined animals proved negative at the same time. No reinfection of the recovered animals or spread of the disease to the treated in-contact animals was seen up to six months after treatment.

Animals↗

Ringworm of the scalp in children.

Scalp scrapings were collected from 651 children in the Cape Peninsula and along the Western Cape coast to determine which dermatophytic fungi occur in these areas. Fungi were isolated from 61% of specimens, by far the commonest being Trichophyton violaceum. Only half of these specimens showed fungal elements on direct microscopy. Among patients with scaly scalp lessons of varying severity the isolation rate was 64%, but dermatophytic fungi were also isolated from 16% of 50 asymptomatic children. Carriers of fungi without obvious ringworm may play an important role in the spread of the disease.

Child↗

Vaccination of cattle against ringworm caused by Trichophyton verrucosum.

A live-trichophyton vaccine against ringworm in cattle which was based on an attenuated strain of Trichophyton verrucosum was tested in controlled challenge-exposure experiments and in field trials. On the basis of data involving approximately 400,000 vaccinated animals over a 5-year period, it was concluded that trichophytosis in cattle can be controlled by immunoprophylaxis. Side effects associated with the vaccination occur infrequently.

Animals↗

Hazards of domestic pets. Ringworm and other skin conditions.

Domestic pets may be responsible for a number of skin eruptions in man. Whilst ringworm due to Microsporum canis is one of the most common of these conditions in this country, trichophyton infection, flea bite dermatitis, cheyletiella dermatitis, canine scabies and traumatic dermatitis are by no means rare. Less frequently encountered conditions include creeping eruption, favus, fowl-mite dermatitis and allergic dermatitis.

Animals↗

Skin cancer incidence among children irradiated for ringworm of the scalp.

A series of about 2200 children who received X-ray treatment for ringworm of the scalp (tinea capitis) during the 1940s and 1950s, and a comparable group of 1400 treated without X ray, have been followed by mail questionnaire for an average of 26 years since treatment to tabulate the incidence of skin cancer. The X-ray treatment consisted of 300-380 R to five overlapping fields on the scalp, to cause complete depilation. This delivered doses of 300-600 rad to various portions of the scalp, with lower doses to the skin of the face and neck. In the irradiated group, 41 persons have had one or more basal cell carcinomas of the scalp or face while only three have been diagnosed in controls. There was a high prevalence of multiple skin cancers in the irradiated group (80 lesions among 41 cases). The minimum latent period for radiation-induced skin cancers was long--about 20 years--and this may be attributable to the young age of the population. The skin cancer risk was particularly pronounced on the face, where there would be more UVR exposure in addition to X-ray exposure. Lightness of complexion proved to be an important factor in the skin cancer risk. In addition, skin cancers were found only among caucasians, even though 25% of the study population were blacks. These findings suggest that UVR exposure levels or sensitivity to such exposure interact with ionizing radiation exposure in defining skin cancer risk.

Adolescent↗