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Speaking Fo and cepstral periodicity analysis of conversational speech in a 105-year-old woman: variability of aging effects.

We investigated speaking fundamental frequency and periodicity of voicing during conversational speech in a 105-year-old woman. Analyses revealed higher mean speaking fundamental frequency compared to previously published data obtained from elderly women. In the absence of normative data, the results of cepstrum analyses performed on vowels produced during connected speech revealed less periodicity for the 105-year-old woman's voice than for a 35-year-old woman's voice. The main finding of this study indicates that previously reported group trends regarding aging effects on mean speaking fundamental frequency of the female voice cannot simply be attributed to all elderly individuals. These results stress the importance, for clinical and research purposes, of recognizing the existence of considerable intra- as well as intersubject variability in the effects of aging on the voice.

Adult↗

[The neuropathology of neonatal period: analysis of 1616 autopsies].

The lesions of the central nervous system represent an important cause of morbid-mortality in the neonatal period. This is due to the vulnerability of the brain to several adverse conditions during gestation and after birth. This study analyses the prevalence and pattern of central nervous system lesions in neonates autopsied at Hospital de Clínicas - Curitiba. There were 5743 pediatric autopsies performed in the Sector of Anatomic Pathology from 1960 to 1995 with 2049 cases corresponding to death during neonatal period. These later autopsies were reviewed and all cases with central nervous system lesions were selected and classified according to sex, age and pattern of central nervous system lesion. The central nervous system was affected in 1616 (78,87%) of neonatal autopsies and there was predominance of intracerebral hemorrhages (73,39%), congenital malformations (4,27%) and infections (3,59%). The hypoxic hemorrhages are the most prevalent central nervous system lesions in the neonatal period, affecting mainly premature babies. There was predominance of central nervous system malformations in the female neonates.

Age Distribution↗

Attentive and pre-attentive periodicity analysis in auditory memory: an event-related brain potential study.

In an event-related potential (ERP) study we presented human subjects with streams of repetitive white noise (semi-periodic noise) under attend and ignore conditions to investigate whether the perception of the periodicity with short cycle-lengths is due to lower level, pre-attentive sensory memory processing or higher level, attentive working memory processing. The ERPs of both conditions reveal N1-like deflections that are time locked on the semi-periodic noise suggesting that the processing of the periodicity is due to a pre-attentive rather than an attentive process. The topography of the deflections suggests that its generators are located in the supratemporal plane. Additionally, the ERPs elicited by infrequent disruptions in the periodicity show differences between the conditions suggesting that the detection of disruptions in periodicity is facilitated by attention.

Adult↗

Effect of Quinapril on the Circadian Blood Pressure Pattern Evaluated by Periodic Analysis of Covariance.

The effects of quinapril on casual blood pressure (BP) and circadian variations in 24-h blood pressure (24ABPM) were studied in patients with essential hypertension. Twenty-six patients were enrolled in the study (mean age 59 plus minus 11 years). After a 4-week washout period, patients, were treated with quinapril 5 mg, 10 mg, or 20 mg once a day until casual blood pressures become optimal within 8--10 weeks. The 24ABPM was performed before and after treatment at 30-min intervals using an ABPM-630 in patients during usual daily activities on the work days. Measured BP was fitted to a periodic regression curve with 24-h and 12-h harmonics. Quinapril significantly decreased casual blood pressure but had no effect on pulse rate. It exhibited an excellent antihypertensive effect throughout 24 h; this effect, however, was stronger during the day than at night, resulting in no excessive nocturnal hypotension. The level of the periodic regression curves for systolic and diastolic blood pressures was significantly decreased following treatment but that of the pulse rate was not affected by this drug. The drug caused changes in the pattern of the periodic regression curve for blood pressure and pulse rate. This was attributed to the more prominent antihypertensive effect of quinapril in the afternoon and evening. To evaluate the efficacy of this drug semiquantitatively, the hyperbaric indices were compared before and after the treatment, and those indices for both systolic and diastolic blood pressures were significantly decreased. Adverse effects occurred in four patients (15.4%), all of which were mild and thought to be clinically insignificant. It was concluded that quinapril, 5--20 mg day(minus sign1), was considered to be useful for patients with mild to moderate essential hypertension.

Journal Article↗

[Evolution of the degrees of influenza vaccine (flu shot) coverage in Spain throughout the 1993-2001 period. Analysis by Autonomous Communities].

BACKGROUND: Influenza (flu) is a disease involving a high morbidity which takes a high toll on healthcare costs for which there is an effective vaccine available. This study is aimed at evaluating the evolution of the different degrees of influenza vaccine (flu shot) coverage in Spain by Autonomous Communities during the 1993-2001 period. METHODS: A total of 42,123 cases from the National Health Survey (NHS) for the years 1993 (n=21,051) and 2001 (n=21,072) were analysed, all of which corresponded to non-institutionalised Spanish adults over 15 years of age. Both surveys are representative at the Autonomous Community level. RESULTS: For the total sample, a vaccine coverage of 17.94% (CI 95% 17.42-18.46) in 1993 and of 19.30% (18.77-19.83) en 2001 was estimated. In the logic regression model, adjusted by age, sex and related chronic disease, significant improvements were found in the degrees of coverage of individuals over 64 years of age (OR = 1.28 CI 95% 1.10-1.50) for Spain as a whole and for five of the seventeen Autonomous Communities between 1993 and 2001. However, no significant changes were found in the degrees of coverage for the group under age 65 with related chronic disease entailing an indication for being administered the vaccine. CONCLUSIONS: A slight yet insufficient improvement in the degrees of coverage among the high-risk groups studied were found to exist both nation-wide in Spain as a whole as well as in the majority of the Autonomous Communities between 1993 and 2001. Degrees of coverage varied greatly among Autonomous Communities. The individual under age 65 with related chronic diseases heightening the risks of suffering from flu-related complications have not improved their degrees of coverage regarding this vaccine during the period studied. The difficulty involved in improving the degrees of coverage among this type of patients might lead us to consider the alternative and potential benefit of lowering the age limit of the current influenza vaccine (flu shot) indication-related recommendations in Spain.

Aged↗

Empyema thoracis during a ten-year period. Analysis of 72 cases and comparison to a previous study (1952 to 1967).

In this series of 72 cases of empyema, 28 patients (38.8) had anaerobes isolated from their pleural fluid cultures. In 22 patients, anaerobes were the only isolates, and in six there were also aerobes. This observed frequency (38.8%) of anaerobic empyema is notably greater than the frequency noted in an earlier study (1952 to 1967) from the Veterans Administration Medical Center, Wood, Wis, while the contribution of various pathogenetic mechanisms was similar. Although closed chest tube drainage was instituted initially in 51 patients, 18 patients (35%) subsequently required additional procedures. The case-fatality ratio was 51.4% in this study compared with 46.6% in the earlier study. Twenty-two patients died during the same hospitalization period while the empyema was an active problem. Six (8.3%) of these empyema-related deaths occurred in patients without underlying disease, while 16 (22.2%) were in patients with underlying diseases.

Adult↗

Period analysis of the electroencephalogram.

A program is described which utilizes the Digital Equipment Corporation LINC-8 computer with 4K of memory to process the electrical activity of the brin into a set of meaningful statistics. The program provides an efficient methol of obtaining spectoral information concerning the EEG without the associated cost or complexity of conventional power spectrum techniques. The combination of utilization of a small laboratory computer with an easily programmable method provides an approach for automated EEG analysis which is within the financial and technical scope of most small hospital EEG laboratories;

Computers↗

Impaired coronary vasodilator reserve in the immediate postcoronary angioplasty period: analysis of coronary artery flow velocity indexes and regional cardiac venous efflux.

The ratio of peak hyperemic/basal mean coronary flow velocity, an index of coronary vasodilator reserve, immediately after coronary angioplasty normalizes in less than 50% of patients. To evaluate other indexes of coronary vasodilator capacity, both intracoronary arterial velocity and cardiac venous efflux were measured at rest and during vasodilator-induced coronary hyperemia (intracoronary nitroglycerin and papaverine) before and after angioplasty in 27 patients; 17 patients had measurements of intracoronary velocity alone and 10 had thermodilution measurements of great cardiac vein flow. Coronary flow velocity responses were also measured in 6 angiographically normal segments in patients undergoing angioplasty and in 10 normal left coronary artery segments in patients with normal coronary arteries or isolated right coronary artery disease. Despite significant angiographic (72 +/- 12 to 23 +/- 11% diameter narrowing) and hemodynamic (49 +/- 12 to 19 +/- 12 mm Hg aortocoronary gradient) improvement, coronary vasodilator reserve ratios for both arterial velocity and venous flow after angioplasty were only minimally affected. Angioplasty did not significantly increase rest coronary vein flow or artery flow velocities, but did result in significantly higher papaverine responses after angioplasty. Mean and phasic coronary velocity, diastolic coronary flow velocity integral and measured great cardiac vein flow ratios were significantly lower when compared with those in 16 angiographically normal coronary artery segments. These data indicate that maximal hyperemic coronary flow velocity is increased after angioplasty, but the reserve ratios, calculated by any of several flow velocity indexes, remain minimally improved. Angiographic correlations (percent coronary diameter, absolute diameter or cross-sectional area) with variables of coronary blood flow or velocity suggest that no single variable is useful in assessing angioplasty results. However, postangioplasty arterial mean velocity and diastolic flow velocity integral are nearly normalized in most patients, whereas relative changes remain attenuated. These findings are important in studies assessing coronary vasomotor responses in patients with atherosclerotic coronary disease, especially after angioplasty.

Adult↗