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Results for “Pentosephosphates”

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[Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations].

Under conditions of acute and chronic stress carbohydrate metabolism was decreased in muscles and liver tissue, increased in adrenal glands and unaltered in brain. cAMP at concentration 10(-5)M decreased the rate of glycolysis in liver tissue and increased it slightly in adrenal glands. The inhibitory effect of cAMP was not decreased by 2',3'-AMP and was reversed completely by the protein inhibitor of proteinkinase. cAMP inhibited hexokinase (HK) isoenzymes 2 and 3 as well as glucose-6-phosphate dehydrogenase (G6PD) isoenzymes 1 and 2, activities of HK 1 and G6PD 3 and 4 were unaltered. The decrease in activities of HK and G6PD appears to be related to phosphorylation of proteinkinase; lack of the effect of cAMP in adrenal glands was apparently due to absence of corresponding cAMP-dependent proteinkinase in this tissue.

Adrenal Glands↗