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[Paranoid disorders in the debut and further course of late schizophrenia].

A study of 60 schizophrenic patients permitted to clinically analyze the state of late paranoic psychoses, which is difficult for differential diagnosis due to pronounced age syndromological atypicity. The allocation of these prevalently slowly progressive forms to late schizophrenia is based on studies of the regularity of the disease, particular clinico-psychopathological traits of the paranoic syndrome as well as on the hereditary loading data, premorbid traits and signs of mental abnormality in the past. The data obtained indicate a relationship between pronounced age atypicity of the psychoses and the degree of progression of the schizophrenic process.

Age Factors↗

Folie à famille: shared paranoid disorder in a Vietnam veteran and his family.

Reports of folie à famille are rare; this may be the first reported case involving a Vietnam veteran. Expression of his paranoid schizophrenia involved delusions and hallucinations relating to Vietnam, and his wife and children shared his paranoia. Typical of folie à famille were the dominant family member, the threat of violence, and the family's social isolation, frequent crises, and stable membership. Although the veteran's intrusive recollections of his Vietnam experience were typical of posttraumatic stress disorder, he acted on rather than avoided them. Treatment focused on the entire family, partly to minimize future problems in the children.

Adolescent↗

[Induced litigious-paranoid disorders with onset at an advanced age].

In some old patients with a psychogenic quarrelsome paranoiac symptom complex the latter develops by the mechanism of psychic induction. Pathological quarrelling shows a number of clinical dynamic peculiarities in patients in whom it has been induced as against those who have initiated it.

Aged↗

Evolutionary perspectives on paranoid disorder.

Certain subtypes of DD may represent abnormal forms of previously well-characterized, content-specific behaviors that represent evolved adaptations to challenges of social interaction and mating. Such rare delusional states may be manifestations of an adaptive hypersensitivity to important environmental threats or opportunities, or may be a byproduct of behavioral misfiring triggered by unfamiliar environmental cues or perceptions.

Adaptation, Psychological↗

[Unusual hallucinatory forms of paranoid disorders in late schizophrenia].

The authors studied 62 patients with late schizophrenia with the predominance of elementary misperceptions. The main variants of such psychoses with auditory, olfactory and tactile perceptive disturbances have been identified. The authors also ascertained common typological signs distinguishing these psychoses from the classical paranoids of late age. A possible role of the age and environmental factors in the formation of the above psychoses is considered.

Age Factors↗

Psychiatric illness in first-degree relatives of schizophrenic and surgical control patients. A family study using DSM-III criteria.

This report examines the risk for psychiatric illness in 723 first-degree relatives of schizophrenics and 1,056 first-degree relatives of matched surgical control patients. Diagnoses in patients and relatives were made "blind" to one another, using DSM-III criteria. Information on relatives was obtained from personal interview and/or hospital records. Results were analyzed using two levels of diagnostic certainty and with or without relatives on whom only hospital records were obtained. In all analyses, the risk for schizophrenia was significantly greater (at least 18-fold) in the relatives of schizophrenics v controls. Evidence was also found for an increased risk in relatives of schizophrenics for schizoaffective disorder, paranoid disorder, and atypical psychosis but not for unipolar disorder, anxiety disorder, or alcoholism. As defined by DSM-III, schizophrenia is a familial disorder; however, the increased risk for psychotic illness in relatives of schizophrenics does not appear to be confined to schizophrenia alone.

Adolescent↗

Familial links between schizophrenia and other disorders: application of the multifactorial polygenic model.

A substantial number of patients do not meet diagnostic criteria for schizophrenia yet exhibit psychotic phenomena characteristic of that disorder (e.g., schizophreniform disorder, schizoaffective disorder, paranoid disorder, atypical psychosis). The relationship between schizophrenia and these disorders is poorly understood. This paper describes how the two-threshold multifactorial model of familial transmission can be applied to test the hypothesis that these disorders share a multifactorial etiology with schizophrenia. The procedure is illustrated using data from a blind family study of the major psychoses. Results support the hypothesis that the disorders under examination share a common multifactorial familial etiology. Methodological issues are discussed along with suggestions for future research in this area.

Adult↗

A study of thought disorder in paranoid and non-paranoid schizophrenia.

Thought disorder was studied in 21 paranoid and 24 non-paranoid schizophrenics fulfilling the research diagnostic criteria using the Thought, Language and Communication Scale. Chronic paranoid schizophrenics more often had tangentiality. Other thought disorders were similar in paranoid and non-paranoid schizophrenics.

Adolescent↗

Genetic associations between delusional disorder and paranoid schizophrenia: A novel etiologic approach.

OBJECTIVES: Genetic associations between delusional disorder and paranoid schizophrenia are not well understood, although involvement of biological factors has been suspected. We investigated the incidence of human leukocyte antigen (HLA) class I alleles in patients with delusional disorder and paranoid schizophrenia, first, to explore a possible immunogenetic etiology of these paranoid disorders and, second, to determine whether they share similar etiologic mechanisms. METHOD: We employed a nested case-control study design. Psychiatric reference data were available for 38,500 patients attending a hospital-based psychiatric outpatient department between 1998 and 2005. We enrolled 100 patients with delusional disorder and 50 patients with paranoid schizophrenia as the subject cases, using DSM-IV criteria. We considered equivalent numbers of healthy volunteers matched for age and ethnic background as control subjects. All subjects came from an India-born Bengali population. We applied the polymerase chain reaction-based molecular typing method to all patients and healthy subjects. RESULTS: The HLA-A*03 gene is significantly associated with delusional disorder as well as with paranoid schizophrenia. This HLA gene alone or in linkage disequilibrium with other HLA genes or other closely linked non-HLA genes may influence susceptibility to delusional disorder and paranoid schizophrenia. CONCLUSIONS: The study reveals important associations between HLA genes and paranoid disorders. Delusional disorder and paranoid schizophrenia may share similar etiologic mechanisms. This preliminary observation may help our understanding of the genetic basis of these paranoid disorders.

Adult↗

Induced delusional disorder. a review of the concept and an unusual case of folie à famille.

Induced delusional disorder (or shared paranoid disorder), also known as folie à deux, is a fairly uncommon disturbance characterized by the presence of similar psychotic symptoms in two or more individuals. Most often the symptoms are delusional. Usually the 'primary' case, i.e. the individual who first develops psychotic symptoms, can be distinguished from one or more 'secondary' cases, in whom the symptoms are induced. We discuss the concept of shared paranoid disorder and consider various aetiological, clinical and diagnostic issues related to the disturbance. We also describe a case of folie à famille, this condition being a type of shared paranoid disorder. The case involves a couple and their 12-year-old son. The boy's father is the 'primary' case, whilst the boy and his mother are both 'secondary' cases. The boy was admitted to our child and adolescent psychiatric unit for in-patient treatment. Treatment success was moderate in terms of improving the features of folie à famille in the three individuals involved.

Child↗

Paranoid (delusional) disorders in the light of a long-term follow-up study.

A large sample of first-admitted hospitalized patients with delusional psychoses were personally followed up after a mean of 10 and 30 years. At last follow-up 42% showed good overall functioning and 44% were in ordinary work. Patients with affective disorder according to DSM-III had most homogeneous and favorable outcome, while a striking heterogeneity of outcome was noticed in schizophrenia, schizophreniform and paranoid disorder. Along with other reports the study showed that precipitating events indicated favorable prognosis for patients with schizophreniform, schizoaffective and paranoid disorder. Moreover, in the total sample the findings indicated that short duration of symptoms prior to admission was a good prognostic sign, indicating that early intervention is important for delusional patients.

Adult↗

Assessment of potential violence in the paranoid worker.

Violence in the workplace is sometimes a manifestation of an untreated psychiatric disorder. Paranoid personality disorder, paranoid schizophrenia, and delusional (paranoid) disorder are three psychiatric syndromes in which paranoid ideation is a prominent feature. While the vast majority of people with these conditions are not violent, paranoid workers can exhibit violent behavior as a reaction to beliefs that co-workers or supervisors are threatening or persecuting them. Three cases are described to illustrate the clinical presentation of these disorders and their management in an occupational setting.

Adult↗

The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events.

OBJECTIVE: The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing. METHOD: The Trauma History Questionnaire and the PTSD module of the Structured Clinical Interview for DSM-III-R were administered to 180 male and female outpatients with a diagnosis of one or more DSM-III-R personality disorders. Path analysis was used to evaluate the relationship between borderline personality disorder and PTSD. RESULTS: High rates of early and lifetime trauma were found for the subject group as a whole. Compared to subjects without borderline personality disorder, subjects with borderline personality disorder had significantly higher rates of childhood/adolescent physical abuse (52.8% versus 34.3%) and were twice as likely to develop PTSD. In the path analysis of the relationship between borderline personality disorder and PTSD, none of the different types of paths (direct path, indirect paths through adulthood traumas, paths sharing the antecedent of childhood abuse) was significant. The associations with both trauma and PTSD were not unique to borderline personality disorder; paranoid personality disorder subjects had an even higher rate of comorbid PTSD than subjects without paranoid personality disorder, as well as elevated rates of physical abuse and assault in childhood/adolescence and adulthood. CONCLUSIONS: The associations of personality disorder with early trauma and PTSD were evident, but modest, in borderline personality disorder and were not unique to this type of personality disorder. The results do not appear substantial or distinct enough to support singling out borderline personality disorder from the other personality disorders as a trauma-spectrum disorder or variant of PTSD.

Adolescent↗

[Non-cognitive aspects of dementia].

OBJECTIVE: To observe the frequency of various psychiatric disorders (depressive disorders, anxiety state and paraphrenic-paranoid disorders). PATIENTS AND METHODS: This study includes the 'cases' of dementia detected in an epidemiological field study done door-to-door, double phased and including non-institutionalized persons aged over 69 years in a rural area. All diagnoses were done by CAMDEX and on these criteria. RESULTS: Depressive disorder was diagnosed in 26.5% studied, paraphrenic or paranoid disorder in 14% and anxiety state in 6.5%. Depression and paraphrenic-paranoid disorder were not associated with the severity of the dementia, whilst anxiety state was more commonly seen in mild dementia. Paraphrenic-paranoid disorders were commoner in women than in men. CONCLUSION: The considerable prevalence of other psychiatric diagnoses in persons with dementia shows that non-cognitive symptoms are common in these patients.

Aged↗

[Group cognitive behavior therapy in the routine care at a Psychiatric Ward of Diagnosis and Treatment].

OBJECTIVE: To describe a preliminary evaluation of a group CBT approach which has been fully integrated into the routine care for acute psychotic inpatients, admitted to a typically overburdened inner-city psychiatric general hospital unit. DESIGN: The design is pre-post. A comparison of some indicators between the years preceding (1997) and following the beginning of the group therapy (1998) has been carried out. SETTING: Psychiatric ward of S. Filippo Neri in Rome, in 1998. METHOD: The study compared the rate of rehospitalization, the rate of compulsory admission, the use of physical restraints, the episodes of violent behaviour and the escape from the ward. During the last three months of 1998 patients' satisfaction was also measured. RESULTS: Overall 385 patients attended the group therapy, 79% of all inpatients in the period, with an average number of 4 sessions per patient. 59% of participants in the group in 1998 had a diagnosis of schizophrenia or paranoid disorder. The total compulsory admissions declined by 1/3 (p < 0.001), the "revolving door" patients declined by 1/3 (p < 0.05), compulsory admissions in "revolving door" patients declined by 3/4 (p < 0.005), violent episodes by almost half (p < 0.001), physical restraints and patients escape from the ward almost disappeared. Patients' opinion about the participation to the group was excellent. CONCLUSIONS: It is likely, but not sure, that the improvements were directly attributable to the introduction of the group treatment. Moreover, the group was clearly found to be useful by the majority of the participants. Some asked for further help of this type on discharge. These preliminary results are promising and make us confident they will act as stimuli for other colleagues to implement and evaluate this approach in other settings.

Adult↗

Earlier psychiatric morbidity in patients with Alzheimer's disease.

The medical charts of 188 Alzheimer patients and a comparison group of 80 nondemented patients matched for age and sex were retrospectively reviewed for history of psychiatric morbidity. The Alzheimer patients were more likely to have had a psychiatric illness earlier in life (chi 2 = 8.5238, df = 1, P less than .001) with unipolar depression and paranoid disorder being the two most frequent psychiatric disorders. Possible explanations for these findings include underreporting, facility bias, functional psychiatric features as prodromal states of Alzheimer's disease, and vulnerability to psychiatric morbidity in those who go on to develop Alzheimer's disease. The likelihood of each of these explanations is discussed.

Aged↗