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PubMed2005

'Projective transidentification': an extension of the concept of projective identification.

Questions about the concept of projective identification still persist. The author presents the following hypotheses: Klein's traditional view and Bion's extension and revision of it can be thought of as occupying a continuum in reverse. He postulates that Bion's concept of communicative intersubjective projective identification (which the author renames 'projective transidentification') is primary and inclusive of Klein's earlier unconscious, omnipotent, intrapsychic mode but includes Bion's 'realistic' communicative mode as well. The author hypothesizes, consequently, that intersubjective projective identification constitutes both the operation of an unconscious phantasy of omnipotent intrapsychic projective identification solely within the internal world of the projecting subject--in addition to two other processes: conscious and/or preconscious modes of sensorimotor induction, which would include signaling and/or evocation or prompting gestures or techniques (mental, physical, verbal, posturing or priming) on the part of the projecting subject; followed by spontaneous empathic simulation in the receptive object of the subject's experience in which the receptive object is already inherently 'hard-wired' to be empathic with the prompting subject.

Consciousness↗
PubMed1977

The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. VI. The projection onto longitudinal zones of the paramedian lobule.

Microinjections (30-50 nl) of a horseradish peroxidase (HRP) suspension of 25% (wt./vol.) were made in different folia of the paramedian lobule of cats, and the sites of occurrence of labeled cells in the inferior olive were precisely determined. In each case only a small number of cells are labeled, aggregated in a minute area. The labeled cells are found within three only of the four olivary areas previously determined (Brodal et al., '75) to project onto the paramedian lobule (fig. 1): one area in the rostral half of the medial accessory olive, another in the dorsal accessory olive (except its caudalmost part), and a third in part of the caudal half of the dorsal lamella of the principal olive. Labeled cells were never found in the fourth area, the ventral lamella. A distinct zonal pattern in the projection is demonstrated (figs. 3, 5B): a middle longitudinal zone of the paramedian lobule receives olivary afferents from the area in the medial accessory olive, a medial zone from part of the projection area in the dorsal accessory olive, a lateral zone from part of the projection area in the dorsal lamella. This zonal projection appears to extend throughout the length of the paramedian lobule (the two caudalmost folia could not be studied). tthe somatotopical pattern in the projections from the accessory olives described previously (Brodal et al., '75) is confirmed. The pattern of a zonal projection obtained with the HRP-method (fig 5B) is simpler than that deduced by Armstrong et al ('74) from recordings of antidromic potentials in the olive (fig 5A). Concerning main points there is satisfactory agreement. The phenomenon that following microinjections of HRP in superficial parts of the folia labeled cells occur within parts only of the regions of the olive which contain labeled cells following large HRP-injections in the paramedian lobule is discussed.

Afferent Pathways↗
PubMed1978

The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. VII. The projection to lobulus simplex, crus I and II.

The olivocerebellar projection to lobulus simplex, crus I and II in the cat was investigated by means of retrograde axonal transport of horseradish peroxidase (HRP). The distribution of labeled cells in the inferior olive following HRP injections in lobulus simplex, crus I and II confirmed the findings by Brodal ('40b) that the rostral half of the principal olive projects to these areas of the cerebellar hemisphere. However, concerning details there are some differences in so far as the heaviest contribution to crus I comes from the medial parts of the ventral and dorsal lamella, that to crus II from its lateral part, especially the ventral bend. The present findings show that in addition the rostral part of the medial and the rostromedial part of the dorsal accessory olive project to these areas of the cerebellar cortex. Further details in the projection are shown in figure 8B. The findings agree fairly well with the electrophysiological results of Armstrong et al. ('74) and the experimental anatomical data of Groenewegen and Voogd ('77a,b). An attempt is made to correlate the findings with the pattern of longitudinal zonal subdivision of the cerebellum. There is evidence for a topical organization within the projection to crus I and II and parts of their projection areas in the principal olive. The distribution of the labeled cells which project to lobulus simplex, crus I and II is discussed in relation to afferent pathways to the inferior olive.

Animals↗
PubMed1993

Organization of visual corticostriatal projections in the cat, with observations on visual projections to claustrum and amygdala.

Electrophysiological mapping criteria were employed to identify visual areas 20a, 20b, 21a, 21b, PMLS, AMLS, ALLS, PLLS, DLS, VLS, and PS in the cat, and to guide placement of tracer deposits. Anterograde tracer methods were used to study the corticostriatal projections of these extrastriate visual areas. The experiments demonstrate that all 11 extrastriate areas send projections to two distinct regions within the striatum, an extensive longitudinal zone within the caudate nucleus, and a more compact region within the posterolateral putamen. Cortical visual projections to the putamen terminate in relatively compact sheets or slabs, and appear to overlap extensively, while those to the caudate nucleus are irregularly patchy and more widely dispersed. Retrograde tracer deposits into the visual recipient zone of the caudate nucleus reveal substantial convergence of other cortical inputs to this same domain. Aspects of visuotopic organization are preserved in the visual projections to both the putamen and the caudate nucleus, but unequivocal retinotopic organization could not be inferred from the available material. Ten of the eleven extrastriate visual area also project topographically onto the visual zone of the claustrum. Area PS does not appear to contribute to the corticoclaustral projections. Five of the extrastriate visual areas (ALLS, PLLS, DLS, VLS, PS) also send sparse projections to the amygdaloid complex.

Amygdala↗
PubMed2000

Deciding Whether to Complete or Terminate an Unfinished Project: A Strong Test of the Project Completion Hypothesis.

The primary purpose of this research was to subject Conlon and Garland's (1993; Garland & Conlon, 1998) project completion hypothesis to a stronger test than it has faced in the past. We conducted an experiment in which we manipulated the degree of completion, sunk-cost amount, and anticipated sales price for a hypothetical real estate development project. The sales price information allowed participants to calculate the economic value of the project. Participants were also held "accountable" in the sense that they had to explain the reasoning behind their decisions to the experimenter. Together, the sales price information and accountability stipulation created an inducement to engage in an economically rational decision process. In spite of this inducement, participants were unduly affected by the project's closeness to completion. In fact, when the project was close to being finished, they often recommended completing the project even when it was economically unwise to do so. While the effects of the project completion manipulation were surprisingly strong, the sunk-cost manipulation had virtually no effect. Implications of these results and directions for future research are discussed. Copyright 2000 Academic Press.

Journal Article↗
PubMed1980

The ponto-cerebellar projection in the rat: differential projections to sublobules of the uvula.

Microinjections of horseradish peroxidase (HRP) were made in different sublobules of the uvula (lobule IX, a, b, and c of Larsell, 1952) of the cerebellar cortex in the rat. These injections resulted in retrograde labeling of cells located in the pontine nuclei. Sublobule IXa receives a predominant input from a single column of cells situated in a dorsointermediate position in the caudal pontine nuclei. Sublobules IXb and IXc receive a pontine projection from two different columns of cells, one medial and one lateral. The location of the labeled cells in the lateral part of the caudal pons suggests a topographic projection to the subdivisions of the uvula. Sublobule IXa receives a projection from a distinct dorsointermediate region and sublobule IXb and IXc receive a projection from partially overlapping ventral regions. The cells of origin in the medial pons are organized such that more dorsally located cells project to sublobule IXb and ventrally located cells project to sublobule IXb with extensive overlap. These differential patterns of projections to the sublobules of the uvula along with other data in the literature suggest that sublobule IXa may be involved with different functional correlates than sublobules IXb and IXc.

Animals↗
PubMed1978

An investigation of the cerebellar cortico-nuclear projections in the rat using an autoradiographic tracing method. I. Projections from the vermis.

The topography of the projections from the vermis of the cerebellar cortex to the intracerebellar nuclei (excluding the vestibular complex) was newly investigated in the rat using an autoradiographic technique. The projection were strictly ipsilateral and the majority terminated in nucleus fastigus although there were small projections to the medial pole of nucleus interpositus. The only portion of fastigius which was never heavily labelled was the dorsolateral protuberance. Some rostrocaudal localisation was evident with lobules II-V projecting to rostral fastigius (Fm), lobules VI-VIII projecting mainly more caudally (Fcm and Fm) and lobule IX projecting to the caudoventral tip of fastigius. Nevertheless, even the densest portions of the terminal fields often overlapped heavily, suggesting that, in the rat, in contrast to some other species, the rostrocaudal localisation is such that individual lobules do not possess private termination fields of any extent. Such an arrangement should provide ample opportunity for integration by individual nuclear neurones of input from extensive areas of cortex. In the mediolateral plane, localisation was more evident, with the medial vermis projecting to the medial pole of fastigius and the lateral portion to lateral fastigus and less heavily to medial interpositus.

Animals↗
PubMed1990

Quantitative re-evaluation of descending serotonergic and non-serotonergic projections from the medulla of the rodent: evidence for extensive co-existence of serotonin and peptides in the same spinally projecting neurons, but not from the nucleus raphe magnus.

A quantitative analysis of serotonin (5-HT) and spinally-projecting neurons was re-evaluated in the rodent. The findings indicate that most (nearly 90%) of the medullary 5-HT neurons projected to the lumbar spinal cord, and most (up to 85%) of the spinally projecting neurons within the distribution of the serotonergic neurons contained 5-HT immunoreactivity. However, in nucleus raphe magnus (NRM) only about two-thirds of the projection cells were 5-HT immunoreactive. These data support two general conclusions: (1) the raphe-spinal system consists primarily of an extensive 5-HT pathway with neuronal subsets containing the co-localized peptides. Only the NRM contains a major non-5-HT projection. (2) As most of the medullary 5-HT neurons project to the caudal spinal segments of the rodent, collateralization of individual 5-HT neurons is extensive and widespread, existing to different spinal cord levels, as well as to other medullary nuclei, e.g., cranial nerve and inferior olivary nuclei. These findings argue that although differences are present within the 5-HT distributions, the raphe-spinal system as a whole should be considered to be a relatively homogeneous pathway containing 5-HT as the common element rather than as separate populations containing major projections of 5-HT alone, 5-HT co-localized with peptides and peptides without 5-HT.

Animals↗
PubMed1986

Distribution of neurons in the main cuneate nucleus projecting to the inferior olive in the cat. Evidence that they differ from those directly projecting to the cerebellum.

The distribution in the main cuneate nucleus of cells projecting to the inferior olive and the intermediate zone of the cerebellar anterior lobe were compared by means of double retrograde labeling methods in the cat. The tracer combinations were either Fast Blue and Diamidino Yellow Dihydrochloride; or horseradish peroxidase conjugated to wheat germ agglutinin and Diamidino Yellow Dihydrochloride. Neurons in the caudal, middle and rostral subdivisions of the main cuneate nucleus project to the inferior olive. Differences exist, however, in its number and location along the rostrocaudal extent of the nucleus. Cells projecting to the inferior olive predominate in the caudal and middle subdivisions, where they concentrate ventrally. No cells in the "clusters region" project to the inferior olive. Main cuneate nucleus neurons projecting to the cerebellum concentrate rostral to the obex, bordering the external cuneate nucleus and partially intermixing with the rostrally located cells projecting to the inferior olive. However, no double-labeled cells were found. The results indicate that the main cuneate nucleus projections to the inferior olive and cerebellar anterior lobe originate from different populations of neurons with high specific locations within the nucleus. This finding is in agreement with previous studies suggesting that each of the main cuneate nucleus targets receives its input from a distinct population of neurons within the nucleus.

Animals↗
PubMedDate not supplied

An inbred epilepsy-prone substrain of BALB/c mice shows absence of the corpus callosum, an abnormal projection to the basal forebrain, and bilateral projections to the thalamus.

BALB/c mice lack a corpus callosum in about 11% of the population. Two inbred substrains of BALB/c mice, epilepsy-prone (EP) and epilepsy-resistant (ER), have been examined to determine whether these substrains differ in regard to corpus callosum morphology. Further, this study addressed the issue of whether misrouted cortical axons form an aberrant pathway instead of the corpus callosum. Initial studies that examined fresh brain tissue of adult animals revealed normal corpora callosa in all ER mice but deficient or absent corpora callosa in all EP mice. Subsequently, Dil crystals were placed in the motor cortices of aldehyde-fixed brains of 2-week-old animals to investigate cortical projections in both inbred substrains of mice. Fluorescent microscopy revealed that all of the ER animals had normal corpora callosa, whereas all EP animals exhibited either reduced corpora callosa (partially callosal) or an absence (acallosal) of this structure. Both acallosal and partially callosal EP mice displayed an extensive, aberrant projection to the basal forebrain as well as bilateral projections to midline and intralaminar thalamic nuclei. The fibers projecting to the basal forebrain arose from the cortex, coursed toward the midline before turning ventrally along the midline, and appeared to terminate in the medial septal nucleus and the nucleus of the diagonal band. ER animals lacked this aberrant cortical projection to the basal forebrain. Electron microscopic results obtained from EP mice indicated that labeled axons in this aberrant pathway formed axosomatic, axodendritic, and axospinous synapses with the neurons in the medial septal/diagonal band complex. The function of the aberrant projection to the basal forebrain remains unknown but it may provide an abnormal excitatory input to a region that provides cholinergic and GABAergic input to the cerebral cortex and hippocampus. The additional projections to midline and contralateral intralaminar thalamic nuclei in EP mice may function to intensify the synchronization of bilateral discharges.

Agenesis of Corpus Callosum↗
PubMed2006

Characteristics of Project Liberty clients that predicted referrals to intensive mental health services.

OBJECTIVE: The authors describe characteristics of Project Liberty crisis counseling recipients that predicted referral to more intensive professional mental health treatments over the two-year period after the terrorist attacks on the World Trade Center. METHODS: Random-effects ordinal regression models were applied to data from 684,500 logs of Project Liberty service encounters for individual counseling sessions. RESULTS: Overall, about 9 percent of individual counseling visits ended with a referral to professional mental health services. Individuals needing intensive mental health treatment continued to enter Project Liberty for two years after the World Trade Center attacks. The strongest predictor of referral was having reactions to the attack that fell into a greater number of the four domains assessed-behavioral, emotional, physical, or cognitive domains. Individuals with reactions in four domains were most likely to be referred. Those who had greater attack-related exposure were also more likely to be referred. CONCLUSIONS: It is important to provide long-term access to brief counseling and triage services and to target these interventions specifically to individuals displaying greater distress or impairment and having more traumatic exposure.

Affective Symptoms↗
PubMed1989

[Afferent projections to the uvula in the cat. I. Climbing fiber projections].

The inferior olive afferents to the cerebellar uvula were studied by means of retrograde axonal transport of horseradish peroxidase (HRP) in the cat. Following large and small injections of HRP into the uvula, the distributions of labeled cells in the inferior olive were investigated. As to the climbing fiber projection, it is revealed that there are six longitudinal parasagittal zone extending throughout the dorsal and ventral uvula. That is, the caudal aspect of the nucleus beta projects to a most medially oriented zone (caudal beta zone), the rostral aspect of the nucleus beta projects to a zone (rostral beta zone) oriented lateral to the caudal beta zone, the caudal aspect of the medial accessory olive (MAO) projects to a zone oriented lateral to the rostral beta zone, the dorsomedial cell column projects to a zone (dorsomedial cell column zone) oriented in the intermediate part of the uvula, the ventral lamella of the principal olive (vlPO) projects to a more lateral zone (vlPO zone), and the rostral aspect of the MAO projects to the most lateral zone (rostral MAO zone).

Afferent Pathways↗
PubMedDate not supplied

Project Salsa: development and institutionalization of a nutritional health promotion project in a Latino community.

PURPOSE: Project Salsa was a community-based effort seeking to promote health through nutritional behavior change in a Latino community of San Diego, California. The purpose of this article is to report on program factors related to long-term institutionalization of Project Salsa interventions. DESIGN: Project Salsa was a demonstration rather than an experimental project. To ensure maximum sensitivity to the needs and values of the community, Project Salsa began with an extensive health needs assessment, including development of an advisory council, telephone survey, archival research, and key informant interviews. SETTING: Project Salsa interventions took place in San Ysidro, California, located near the U.S.-Mexico border adjacent to Tijuana from 1987 to 1992. SUBJECTS: The intervention community had 14,500 residents, of which nearly 83% were Latino. INTERVENTIONS: Interventions included coronary heart disease risk factor screenings, meal preparation classes, newspaper columns, point-of-purchase education, school health and cafeteria programs, and breast-feeding promotion. MEASURES: Institutionalization of intervention components. RESULTS: Two of the interventions, the risk factor screenings and school health programs, are still in operation 4 years after the end of project funding. CONCLUSIONS: Four factors common to institutionalized components are presented in the paper.

Adult↗
PubMedDate not supplied

Evaluation of the Heart To Heart Project: lessons from a community-based chronic disease prevention project.

PURPOSE: To present an evaluation of a 5-year, community-based, chronic disease prevention project managed by a state health department to determine whether the department could replicate similar previous projects that had received more funding and other resources. DESIGN: The evaluation used a matched comparison design and a review of archive and interview data. SETTING: Florence, South Carolina (population: 56,240). SUBJECTS: A random sample of 1642 persons in Florence (and 1551 in the comparison) who responded to a risk factor questionnaire and underwent a physical assessment; 70.7% of baseline subjects participated in the postintervention. Forty key persons were interviewed concerning project effectiveness. INTERVENTIONS BY PROJECT: Walk-a-thons, a speakers' bureau, media messages, restaurant food labeling, and cooking seminars. More than 31,000 participants were involved in 585 activities. MEASURES: Questionnaires focused on hypertension, obesity, high cholesterol, smoking, and exercise. Physical assessments determined lipid, lipoprotein, apolipoprotein, and blood pressure levels. Analysis of covariance was used for baseline and postintervention comparisons. Content analysis was used on archive and interview data. RESULTS: The project had a slightly favorable intervention effect on cholesterol and smoking, but failed to have an effect on other risk factors for cardiovascular disease. The project influenced community awareness, enlisted influential community members, and fostered linkages among local health services. CONCLUSIONS: Health departments can be instrumental in community risk reduction programming; however, they may not replicate projects having greater resources.

Cardiovascular Diseases↗
PubMed1999

Projecting retirement income of future retirees with panel data: results from the modeling income in the near-term (MINT) project.

Cross-sectional data capture only a point in time and miss individual changes in earnings, labor force participation, marriage, fertility, and health. Because panel data follow individuals over time, they do not have this problem. The problems or concerns with cross-sectional data may be compounded when these data are used to make projections. Iams and Sandell (1997) found that using panel data on earnings explained much more variation in future earnings than using cross-sectional survey data. Panel data are also needed to estimate Social Security benefits, especially for women. Because of auxiliary benefits paid to spouses, ex-spouses, and widow(er)s of entitled workers, an individual's Social Security retirement benefit depends not only on his or her earnings history, but also on his or her marital history and the earnings histories of current and previous spouses. When we compare projected unreduced Social Security benefits with what they would be if we didn't have marital history or earnings history data for men, we find that: Benefits computed using only earnings histories are not very different from benefits computed using both earnings and marital histories. Benefits computed using only current earnings and marital histories underestimate benefits for those in earlier birth cohorts and overestimate benefits for those in the most recent birth cohort. Benefits computed without either marital or earnings histories underestimate benefits for all birth cohorts, but by much more for earlier cohorts than for more recent cohorts. For women we find that benefits computed without marital or earnings histories underestimate benefits in all birth cohorts. The largest differences are for women in earlier birth cohorts. Using both marital and earnings histories to estimate unreduced Social Security benefits, we find that men are projected to continue receiving higher benefits than women, although the gap is expected to narrow as the baby boomers near retirement age. We also look at the composition of projected total income available at retirement for those with incomes in the 45th-55th percentiles of the income distribution and find that: Total income at retirement is projected to be larger for men than for women in every birth cohort. Women are projected to receive the largest share of their total income from Social Security benefits. Men are projected to receive the largest share of their total income from other income sources, although this share declines as the baby boomers near retirement age.

Cohort Studies↗
PubMed1985

Development of the ipsilateral retinothalamic projection in the frog Xenopus laevis. I. Retinal distribution of ipsilaterally projecting cells in normal and experimentally manipulated frogs.

The distribution of ipsilaterally and contralaterally projecting cells within the retina in Xenopus laevis was studied by injection of horseradish peroxidase into the thalamus on one side of the brain and subsequent determination of the locations of retrogradely labeled cells in both retinas. In normal animals, contralaterally projecting cells were found throughout the retina. Ipsilaterally projecting cells, in contrast, were most frequent in temporoventral retina and largely absent from dorsonasal retina as well as from a region surrounding the nerve head. A similarly restricted distribution of ipsilaterally projecting cells was observed in retinas of animals after regeneration of one optic nerve as well as in animals from which one eye was removed prior to the time when the ipsilateral projection first develops. The restricted distribution of ipsilaterally projecting cells in normal animals raises the possibility that these cells may be produced relatively late in development. This hypothesis is explored in the following paper (Hoskins, S.G., and P. Grobstein (1985) J. Neurosci. 5: 920-929). The fact that similar distributions were seen in normal and experimental animals implies that organization of the ipsilateral retinothalamic projection in X. laevis is not critically dependent either on particular patterns of axonal organization which may be present during normal development or on interactions among fibers from the two eyes.

Animals↗
PubMed1980

Patterns of organization of comments on the corticopontine projection in the cat with the pontocerebellar projection.

Following lesions of various parts of the cat cerebral cortex, the distribution of degenerating fibers in the pontine nuclei was mapped in drawings of serial transverse and horizontal sections of Fink and Heimer. All parts of the cerebrum give rise to the corticopontine fibers and each functionally uniform area has its particular projection zones in the pons. Thus, it has been shown that the pontine projection zones from the sensorimotor, auditory, orbital, cingulate and "association" cortices are arranged in longitudinal columns throughout the pons, mostly in well delimited columns, while those from the visual cortex reveal columns oriented transversely in the rostral part of the pons. When the distribution of the pontine afferents from various parts of the cortex are compared in detail, it is evident that there are differences in locations of the columns, clustered in continuous zones of terminations, among different pontine projections, although there are partial overlaps among these projection zones. The present as well as the previous findings of the corticopontine projection are correlated with observations of the pontocerebellar projection obtained by other investigators with the horseradish peroxidase and the autoradiographic methods, and a possible propagation of different modalities of sensations from the cerebral cortex, via the pons, to the cerebellum is discussed with reference to some physiological data. The present study largely confirms and extends the previous data of the corticopontine projection and reveals that the cortico-ponto-cerebellar pathways are more cmplexly organized than was previously assumed.

Afferent Pathways↗
PubMed1995

Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area.

Locations of pontomesencephalic cholinergic projection neurons from the laterodorsal tegmental (LDTg) and pedunculopontine tegmental (PPTg) nuclei to midbrain dopaminergic nuclei were mapped. Stereotaxic microinjections of Fluoro-Gold- or rhodamine-labeled microspheres were made either to substantia nigra (SN) or ventral tegmental area (VTA) in rat. Choline acetyltransferase was visualized immunohistochemically. Labeled cells were digitally mapped at multiple levels of the nuclei using an interactive computer/microscope system. SN-projecting neurons were distributed predominantly ipsilaterally in distinct regions of the PPTg: either at its rostral pole or caudally in an area ventromedial to the superior cerebellar peduncle. Few SN-projecting neurons were found in LDTg. VTA-projecting neurons were distributed bilaterally throughout the cholinergic group, primarily in the densest regions of the LDTg and caudal PPTg. Neurons were not strictly segregated into these patterns. Scattered cells belonging to either projection could be found throughout the cholinergic group on either side. Hierarchical log-linear analysis showed these differences in topographic distribution to be statistically significant. Subtraction of cell density images demonstrated well delineated regions of the cholinergic group where the projections were predominately either to SN or VTA. These data indicate a high degree of internal organization within the pontomesencephalic cholinergic group based on the location of efferent projections to SN or VTA. These findings support the concept that this cholinergic group is functionally organized in a manner which selectively innervates motor (SN) and limbic (VTA) dopaminergic nuclei.

Animals↗