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PubMed2002

[Extramedullary plasmocytoma of the left tonsil. A rare cause of tonsillar asymmetry].

The plasmocytoma is a tumor, which can only rarely be found in the oropharynx. In this respective case an asymmetria of the tonsils was caused by an extramedullary plasmocytoma. Even if the asymmetria of the tonsils has a harmless nature, a tumor growth always has to be considered when thinking of the differential diagnosis. First of all, squamous-cell carcinoma has to be taken into account, more rarely with malignant lymphoma. Tonsillektomie added by immunhistological examination of the preparation brings diagnostic certainty.

Diagnosis, Differential↗
PubMed2000

Noncontiguous spinal metastases and plasmocytomas should be operated on through a single posterior midline approach, and circumferential decompression should be performed with individualized reconstruction.

BACKGROUND: In noncontiguous spinal metastatic disease, anterior or combined anterior-posterior surgery is an effective treatment. The objective of this study is to investigate whether circumferential decompression through a single-stage posterior midline approach with individualized spinal reconstruction can still achieve comparable results for functional improvement and for maintenance of spinal alignment in the absence of the risks associated with the more invasive transcavitary or combined approaches. METHOD: Seventeen patients with noncontiguous spinal metastases and plasmocytomas at one or two adjacent levels were included in this series. Circumferential decompression was obtained with anterior reconstruction and posterior fixation in ten patients, and with posterior instrumentation alone in seven patients. Postoperatively the patients were prospectively followed, and their functional status and spinal alignment were periodically evaluated. FINDINGS: Fourteen patients died from progression of their underlying cancer. Their mean survival time was 8 months (range: 1 to 21 months). Three survivors were evaluated at 10, 4 and 3 months respectively. At one month after surgery, 14 patients (82%) showed neurological improvement. Of 10 preoperative nonambulators, seven regained walking capacity. Five patients who were ambulatory with assistance improved to full functional independence. Local tumour recurrence was recorded in one patient after subtotal vertebrectomy for a plasmocytoma at L5. No other tumour recurrences were noted. In one patient a partial loss of correction occurred at T6 - without functional deterioration, however. Spinal alignment was maintained in all other patients who became or remained ambulatory. No major intra-operative complications or peri-operative deaths occurred. CSF leakage was recorded as the most common complication in four patients. INTERPRETATION: Circumferential decompression and spinal reconstruction through a single-stage posterior midline approach is feasible and effective. The extent of surgery can be individualized by means of this technique to the patient's specific problem. In patients with limited life expectancy from metastatic neoplastic disease, the results compare favourably with the more invasive anterior or combined antero-posterior procedures.

Adult↗
PubMed1991

P.O.E.M.S. syndrome with complete recovery after treatment of a solitary plasmocytoma.

The P.O.E.M.S. syndrome is a rare clinical entity that has been described mainly in Japan. It is characterized by a progressive polyneuropathy with raised CSF protein content, organomegaly, endocrinopathy, skin changes and plasma cell dyscrasia. We report a new documented case associated with a solitary plasmocytoma of the 12th thoracic vertebra. Immunopathological and ultrastructural studies of the peripheral nerve did not disclose any immune-specific changes. Surgery and radiation therapy of the plasmocytoma allowed a complete recovery, with a 5-year follow-up. This case report illustrates the need for serial full skeletal survey, including scintigraphy, in middle-aged patients with progressive polyneuropathy of obscure origin.

Bone Diseases↗
PubMed2004

[Solitary bone plasmocytoma: treatment and outcome features].

PURPOSE: - To describe natural history of solitary bone plasmocytomas (SBO) after treatment. PATIENTS AND METHODS: - Between 1975 and 1998, we retrospectively identified 13 patients with SBO treated in the department of radiotherapy at Salah-Azaïz institute of Tunis. To be included in this study, three criteria were needed: histologic confirmation and only one bone lesion without medullary infiltration (or less than 10%). Mean age was 43 years (22-64) with sex-ratio of 3,3. Tumor sites were vertebra (6), flat bones (6) and tibia (1). Megavoltage radiotherapy was given to all patients, associated to surgery in eight cases (5 excisions and 3 laminectomies) and to chemotherapy in three. RESULTS: - With a mean follow-up of 63 months, two local failures were noted at 24 and 48 months. Two patients developed multifocal lesions and one patient had an extramedullary lesion. Multiple myeloma occurred in four patients (30%) after a median follow-up 3,5 years. Unfavorable outcome could not be predicted by age, gender or site of disease but by myeloma protein. CONCLUSION: - Radiotherapy is an effective local treatment for solitary bone plasmocytoma. Prospective studies are needed to better define predictive parameters of unfavourable outcome and indications of combined chemotherapy.

Adult↗
PubMed2004

[EBV-associated cutaneous plasmocytoma in a renal transplant patient].

INTRODUCTION: Postransplant lymphoproliferative disorders are well known complications of solid organ transplant, usually associated with Epstein-Barr virus (EBV). OBSERVATION: A 25 year old renal transplant patient presented with two subcutaneous nodules on the lower limb that appeared 3 years after a second renal transplantation. Biopsy of one nodule showed an EBV associated plasmocytoma located in the subcutaneous tissue. A complete systemic evaluation showed no evidence of extracutaneous involvement. The patient was treated with anti CD20 therapy (rituximab), and complete remission was achieved. DISCUSSION: Extranodular localisations of postransplant lymphoproliferative disorders are usually reported, but cutaneous localizations are rarely described. Histological presentation are various, but plasmocytoma-type is infrequent. Initial therapy of cutaneous EBV-associated postransplant lymphoproliferative disorders without extracutaneous involvement consists in reduction of the immunosuppression therapy and/or an antiviral treatment and prolonged surveillance. Treatment with monoclonal anti-CD20 antibodies (rituximab) is proposed.

Adult↗
PubMed2005

[Plasmocytoma of the skull base revealing multiple myeloma].

We report a case of sphenoidal plasmocytoma in a 57-year-old male revealing multiple myeloma. MRI showed a tumor located in the sphenoid sinus with local extension. Diagnosis was made by histology after transsphenoidal resection. We discuss the imaging features of plasmocytomas and review the principal differential diagnoses.

Humans↗
PubMed1981

[IgD plasmocytoma: clinical and differential diagnostic features (author's transl)].

A 64-year-old man died of IgD plasmocytoma only two months after onset of first symptoms. The course of the disease was characterized by marked renal insufficiency, hypercalcaemia with cardiac arrhythmias and bone destruction, in addition to raised phosphate concentration and alkaline phosphatase activity. The electrophoresis diagram was unremarkable and had no M-peak. But immunoelectrophoretic analysis of serum demonstrated a IgD paraprotein; in addition there was a monoclonal light chain, type lambda. At post-mortem the diagnosis of plasmocytoma was made; in addition there was renal amyloidosis.

Arrhythmias, Cardiac↗
PubMed1974

Topology of repeated sequences: relationship of nuclear RNA to the repeated sequences of the main and satellite DNA in mouse plasmocytoma cells.

The topology of repeated sequences in mouse plasmocytoma DNA was studied by high-resolution CsCl density gradient centrifugation and heterogeneous nuclear RNA.DNA hybridization. Satellite region DNA of plasmocytoma cells contains additional components and hybridizes specifically with entire heterogeneous nuclear RNA molecules. A linkage is demonstrated between the A+T-rich satellite sequences and those hybridizing with heterogeneous nuclear RNA. Heavy DNA also hybridizes specifically with heterogeneous nuclear RNA molecules that show sequence similarity to heterogeneous nuclear RNA hybridized to satellite DNA. These results could suggest that part of satellite DNA became heavier after integration of some other DNA species, which could belong to a virus or to immunoglobulin repetitive genes. Dispersed, highly repetitive, short nucleotide sequences could constitute recognition sites for such a process.

Animals↗
PubMed1999

A nonhealing ulcer diagnosed as extramedullary plasmocytoma of the limb eight years after cardiac transplantation.

A 63-year-old man was hospitalized for a nonhealing ulcer of the left lower leg that appeared 8 years after orthotopic cardiac transplantation under immunosuppressive therapy including cyclosporine. Serum protein electrophoresis, immunofixation, and urinalysis revealed a monoclonal gammopathy IgG kappa. The final diagnosis of an extramedullary plasmocytoma was made by biopsy of the ulcer, which showed formations of plasmablastic cells. We report a rare case of extramedullary plasmocytoma as a posttransplantational malignancy.

Cyclosporine↗
PubMed1983

A study of some molecular and kinetic properties of two tRNA methyltransferases from mouse plasmocytoma.

A tRNA(adenine-1)methyltransferase and a tRNA(cytosine-5)methyltransferase have been partially purified from mouse plasmocytoma MOPC 173. Their apparent Mr are 200000-230000 and 110000-140000, respectively, as determined by gel filtration and density gradient centrifugation. Both enzymes exhibit maximum activity in the presence of high concentrations of monovalent cations (0.175 M and 0.25 M KCl, respectively) and in the absence of magnesium. Their kinetic constants have been determined at various KCl concentrations, with several tRNA species as substrates. These constants may differ by more than one order of magnitude, depending upon the substrate used, and they are strongly dependent upon the ionic concentration as well. The possibility that the tRNA(adenine-1)methyltransferase from mouse plasmocytoma is different from the homologous enzyme purified from a normal rat tissue [Glick, J. M. and Leboy, P. S. (1977) J. Biol. Chem. 252, 4790-4795] is discussed.

Animals↗
PubMed1985

Specific involvement of calmodulin and non-specific effect of tropomyosin in the sensitivity to ouabain of Na+,K+-ATPase in murine plasmocytoma cells.

The Kd for ouabain for inhibition of Na+,K+-ATPase isolated from murine plasmocytoma MOPC 173 cells is 120 microM, but when isolated in the presence of EDTA, it is 100-fold lower (1.2 microM). Simultaneous addition of muscle tropomyosin and calcium to sensitive membranes restored the original insensitivity (tropomyosin bound to the membranes in an irreversible and saturable manner). For comparison 86Rb influx into intact cells, mediated by the Na+,K+-pump, is half-maximally inhibited at 50 microM ouabain. Calcium converts the enzyme to an insensitive form. This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+. Addition of exogenous calmodulin to these calmodulin-depleted membranes was required, in addition to tropomyosin and Ca2+, to decrease the ouabain sensitivity. The involvement of calmodulin was further assessed by measuring the range of Ca2+ concentrations required to convert to the insensitive form. At saturating concentrations of tropomyosin, increasing free [Ca2+] up to 3 microM led to an heterogeneous population of Na+,K+-ATPase forms. The calcium dependency was a saturable process. The shift to the insensitive form was half maximal at 0.65 + 0.11 microM free Ca2+ and was abolished by the addition of troponin I or trifluoroperazine (0.1 mM). These results suggest that, in murine plasmocytoma cells, the intrinsic sensitivity of Na+,K+-ATPase to ouabain might be regulated by a calmodulin-dependent process within a submembrane contractile-like environment.

Actinin↗
PubMed1981

Solitary plasmocytoma of the vagina.

A 78-year-old woman with a plasmocytoma of the vagina is described. The diagnosis monoclonal IgG kappa-producing plasma cell tumour was based on immunohistochemical studies. Careful screening for other localizations including immunofluorescence of the bone marrow aspirate and in methyl-methacrylate embedded bone marrow biopsy specimen, yielded no evidence in favour of a multiple myeloma. To our knowledge only 5 patients with plasmocytoma of the vagina were previously reported, but only in the present case extensive immunohistochemical studies of tumour, bone marrow and blood were performed.

Aged↗
PubMedDate not supplied

Solitary plasmocytoma of the larynx.

Solitary plasmocytoma of the larynx is a rare tumor. To our knowledge there are only 73 cases reported in the world literature. We present 2 more supraglottic plasmocytomas and give a review of the relevant literature.

Aged↗
PubMed1999

Coexistence of erythrocyte agglutination and EDTA-dependent platelet clumping in a patient with thymoma and plasmocytoma.

For 8 years, EDTA-dependent pseudothrombocytopenia was observed in a 55-year-old woman with a history of rheumatoid arthritis who had undergone surgery for lymphoepithelial thymoma 11 years earlier. The clinical picture was characterized by the presence of platelet clumps and antiplatelet antibodies of the IgM class. With the recent appearance of a solitary extramedullary plasmocytoma in the right retrobulbar region and the detection of an IgGlambda monoclonal gammopathy, blood examination also revealed erythrocyte agglutinates alongside the platelet clumps and the presence of a cold IgG antibody with antiI specificity. Both phenomena were observed in vitro when the sample temperature declined to 20 degrees C to 25 degrees C, but not at 37 degrees C. While the EDTA-dependent antiplatelet antibodies did not appear to be chronologically correlated with the patient's diseases, the cold antierythrocyte autoantibodies were strictly related to the plasmocytoma and the IgGlambda monoclonal component in serum. To our knowledge, this is the first description of an association between EDTA-dependent platelet and erythrocyte agglutinates, with a clinical picture of pseudothrombocytopenia and pseudoerythrocytopenia due to cold agglutinins.

Blood Cell Count↗
PubMed1978

[Solitary secreting plasmocytoma in a femoral localization in a young man (author's transl)].

A pathological fracture in 20-year-old man led to the discovery of a right femoral plasmocytoma. Immunoelectrophoresis revealed the existence of a monoclonal Kappa IgG. After tumour reduction by radiotherapy and chemotherapy, surgical excision was possible with the insertion of a reconstructive prosthesus. Functional recovery was complete. The dysglobulinaemia completely disappeared and, with a two year follow-up, no dissemination of the plasmocytoma has been found.

Adult↗
PubMed1975

[Micro-molecular plasmocytoma: case report (author's transl)].

The histological diagnosis of an apparently solitary destructive bone lesion revealed a plasmocytoma, being suspected of generalized spreading. Thereupon performed radiological examination demonstrated multiple radiolucent skeletal lesions and supported this diagnosis. Although specific hematological and proteinchemical findings were not indicative in the first instance, a second scrutiny of protein rates succeeded to demonstrate Bence-Jones-Kappa and consequently this case could be classified as a multiple micro-molecular plasmocytoma.

Acute Disease↗
PubMedDate not supplied

Therapeutical aspects of the plasmocytoma localized at the level of head and neck.

The authors present a study on 7 cases of extramedullary plasmocytoma localized in E.N.T. area, hospitalized and solved in the E.N.T. Department of the the "Sf. Spiridon" Universitary Hospital, in the last 15 years, between 1983-1997. We insist on the last solved case, presenting a double isolated localization, a laryngeal and a rhinosinusal one. We consider that the most indicated treatment in the isolated extramedullary plasmocytoma, is the radiosurgical therapy with a good rate of survival.

Aged↗
PubMed2003

Autologous hematopoietic stem cell transplantation for mediastinal extramedullary plasmocytoma.

Extramedullary plasmocytoma (EMP) is a rare cell neoplasm most frequently localised in the upper respiratory tract. We report the case of a 43 year-old-man, with an unusual presentation of EMP developing in the mediastinum, two years after a diagnosis of solitary plasmocytoma of the bone which was successfully treated by local irradiation. In this aggressive presentation, we decided to perform an autologous hematopoietic stem cell transplantation. Two months after transplantation, CT scan showed disappearance of the mediastinal mass and immunofixation of the serum was normal. Selected cases of diffuse EMP, could benefit from intensive treatment followed by autologous hematopoietic stem cell transplantation.

Adult↗