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[Combined acupuncture reflexotherapy and hypnosis in treating neuroses].

Observed were 117 patients with different neuroses (neurasthenia, hysteria, obsessive) involving intense vasoautonomic paroxysms of sympathetic-adrenal, vagoinsular and combined nature. Unfavorable course of such neuroses was noted. Combined one-session acupuncture and hypnosis treatment is put forth and the increased hypnogenicity phenomenon was demonstrated under acupuncture therapy. Both techniques benefited from their combination. The possibility of eliciting hypnoid states under the physical methods of treatment is discussed together with their therapeutic application and arising deontological problems.

Acupuncture Therapy↗

[The nature of the neurohormonal reorganizations in patients with neuroses].

Neurohormonal balance was studied in patients suffering from neurasthenic, hysteric of obsessive-phobic neuroses. The peculiarities of functional restructuring in sympathoadrenal, opioid and pituitary-adrenal cortex systems were considered as related to clinical form or stage of the disease. Irrespective of the neurosis clinical form, a considerable rise in the endorphin blood levels with increasing sympathoadrenal and adrenocortical activities were typical of its initial stages. With long-lasting neuroses, the neurohormonal shifts characteristic of chronic emotional stress were detected.

Adult↗

Perspectives in the study of neuroses in contemporary psychiatric practice.

Although DSM III has removed the category of neurosis, the implied fragmentation of the generic concept has been regretted by some investigators. Since its introduction in 1769, when the term was used to denote conditions which had a hysterical and hypochondriacal character, the technical use of the term has undergone revisions and reinterpretations which at one extreme have been embedded in psychoanalytic theory, and at the other have resulted in the replacement of the single concept by a proliferation of operationally defined syndromes. The present paper discusses some of the nosological problems implicit in recent trends. Whereas depression appears in 10 ICD9 categories does the psychiatric/neurotic dichotomy in relation to depression still have meaning in the absence of the generic term 'neurotic'? The hierarchical principle is widely accepted as a basis for classification, and yet the hierarchically minor syndromes may be a source of major distress. The paper reviews epidemiological studies of prognosis and follow-up of neuroses, and shows a significant excess of mortality, which is both behavioural and organic in origin. One important difficulty with the loss of the generic term is the potential loss of generic research where, for example, evaluation of treatment of panic disorder is considered distinct from other types of anxiety and phobia. The paper argues for the practical and theoretical benefits of retaining an umbrella term such as 'neuroses'.

Depressive Disorder↗

[Dynamics and outcome of obsessive neuroses with onset in childhood and adolescence in the light of follow-up studies].

A total of 52 patients (28 males and 24 females from 16.5 to 21.5 years of age) observed in childhood because of obsessional neuroses were studied. All the studied cases were divided into 3 groups: patients with obsessional movements and actions, patients with obsessional fears and patients with obsessions of the mixed type. Follow-up studies of the patients demonstrated that the prognosis of obsessional states with an onset in childhood and adolescency should not be based only on the duration of the disease. It depends on the combination of a number of factors: the clinical form of neuroses, type of development, traits of the "basis", stage of psychophysical development, determing evolution of the disease and degree of social adaptation.

Adolescent↗

[Causes and conditions for the development of protracted neuroses].

The follow-up findings were studied in 102 patients with long-standing (2-17 years) neuroses (neurasthenia, 49 cases, hysterical neurosis, 53 cases) and compared with those in 40 patients with acute forms of these diseases. The results of the study point out to factors predisposing to an unfavourable course of the illness. Ii is noted that in most cases, protracted neuroses develop in individuals with definite personality characteristics and numerous variants of "biological insufficiency", such as aggravated heredity, frequent colds in childhood, attendant somatic pathology, etc. Some risk factors have been emphasized including a prolonged influence of psychotraumatic circumstances on these patients, their late application for help to the psychiatrist and late initiation of the adequate treatment.

Adult↗

[Patient catamnesis in neuroses with systemic somatic disorders].

Using the clinico-catamnestic method (supplemented with some laboratory examinations) the author observed 126 patients with neuroses, in the clinical picture of which systemic disorders were prevalent. It was found that among patients with the neuroses accompanied with vegetative dystonia and cardiac disturbances those suffering from neurasthenia were predominant, while among patients with neurotic respiratory and gastrointestinal disturbances most were suffering from hysteria. In the latter patients a great variability of the neurotic syndromes was noted. Pathogenetic psychotherapy of that pathology appeared to be sufficiently effective: 75.4% of the patients recovered or showed a stable improvement. Any direct participation of the neurotic somatic disorders in development of organic impairments in the respective somatic systems was not revealed.

Adult↗

[Clinicopsychological study of the "internal picture of the disease" in neuroses in the process of their psychotherapy].

Using clinical and experimental psychological methods a number of characteristics of the disease insight was studied in 72 patients with neuroses. An analysis of the time course of the patients' attitude to their disease and treatment has enabled the author to disclose the peculiarities of understanding the disease cause by the patients as a criterion of psychotherapy efficacy. The most characteristic variants of psychological defence in various forms of the neuroses, as well as the inner personal conflicts in the patients and their self-estimation are described. On the basis of the data obtained peculiarities of the psychotherapeutic strategy contributing to improvement of the therapy efficacy are indicated.

Adult↗

[Evaluation and prognosis of the mental work capacity of flight personnel with neuroses].

Features of psychic functions and mental performance of flight personnel suffering from various neuroses were examined by clinical and psychological methods. The most severe and persistent changes in mental performance were found in neurasthenics. Higher mental productivity was detected in 80% of subjects with other neuroses (neurotic states and reactions, asthenic state, emotional-vegetative instability) (P less than 0.001). These findings can be regarded as important diagnostic and prognostic criteria in expertise and performance evaluations.

Aerospace Medicine↗

[Basis disturbances in depressive neuroses and psychosomatic disorders].

Applying the concept of the "basic fault" (Balint) to depressive neuroses and psychosomatic disorders the author reports some analogies in the dynamic processes of both diseases. Both are based on a pre-verbel deficiency in communication which has an influence on further conflict-organisation. In the case of psychosomatic diseases this leads to a fixation on the pre-verbel, vegetative object-relation. At the stage of the re-activated psychovegetative basic fault only somatic reactions and satisfactions may be accepted by the patients. This impedes the working alliance, consolidates somatisation as a resistance mechanism, and may require discontinuation of psychoanalytic treatment. In the case of depressive neuroses the stage of the basic fault is characterised by a paradox form of sell-object-relationship which is both object-relation and narcistic isolation as well. Though at this stage verbal communication is less important the analist may advance dissolving of this paradox relationship by means of empathetic interventions.

Depressive Disorder↗

[Classification of neuroses in the practice of occupational health physicians].

The author discussed current opinions on classification of neuroses. She stressed the diversified and complicated terminology which has been developed in this regard for the requirements of psychiatrists and statistics. The description of individual types of neuroses, useful for occupational health service physicians and based on a concise definition of major symptoms, is proposed.

Humans↗

[The participation of cerebral hypoxia in the pathogenesis of neuroses (a new concept)].

The data are presented concerning the state of vascular brain system during experimental neurosis in Wistar rats, the intricate cerebral hemodynamical disturbances, shifts in activity of the crucial enzymes of the mitochondrial respiratory chain, and activation of the lipid peroxidation processes. The positive results on treatment of the experimental and clinical neuroses with antioxidants which have antihypoxic properties are presented. Results on increase of resistance to stress in rats under the influence of negatively charged air ions with expressed antihypoxic are discussed. The general outline is given of the molecular neurochemical processes which accompany the development of neurotic diseases as well as of reversal of these processes due to the antioxidant therapy. The concept concerning the cerebral hypoxia in neuroses is based on the obtained evidence. This concept opens the principally novel pathogenetical approaches to treatment and prevention of these diseases.

Adult↗

W. H. R. Rivers and the war neuroses.

W. H. R. Rivers was the most famous member of the Cambridge Expedition to the Torres Strait. At the time, he was a physician and had an international reputation as a researcher in physiological psychology. The expedition signaled the beginning of his career in social anthropology, but also a long hiatus in his activities in medicine. His clinical interests revived during World War I. As an officer in the Royal Army Medical Corps (RAMC), Rivers became a leading proponent of "psychological medicine." Today, his war-time psychiatry is remembered mainly in association with his patient, Siegfried Sassoon. This article focuses on his wartime activities, his clinical practices, and his theories concerning the war neuroses and the unconscious. The currently popular view of Rivers as a quasi-Freudian humanist is challenged.

Combat Disorders↗

Specific features of the erythroid hemopoietic stem in CBA/CaLac mice with neuroses demonstrating good and poor learning capacities.

We studied changes in the erythroid hemopoietic stem in CBA/CaLac mice with experimental neuroses demonstrating good and poor learning capacities (conflict situation and paradoxical sleep deprivation followed by training in a 3-arm T-maze). The animals with different learning capacities exhibited pronounced hyperplasia of the erythroid hemopoietic stem in response to neurosis. Activation of the erythron in good learners was related to acceleration of division and maturation of erythroid precursors and enhanced formation of cell complexes containing central macrophage. In poor learners hyperplasia of the erythroid hemopoietic stem under conditions of conflict situation manifested in activation of proliferation and differentiation (against the background of decreased count of erythroid and mixed complexes in the bone marrow), while after paradoxical sleep deprivation followed by T-maze training this hyperplasia was associated with increased formation of additional hemopoietic islets (against the background of desynchronization of division and maturation of erythroid precursor cells).

Animals↗

Mechanisms of regulation of erythropoiesis during experimental neuroses.

We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and alpha- and beta-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.

Adrenergic Uptake Inhibitors↗

Monoaminergic regulation of the pool of erythropoietic stem cells in active and passive mouse in experimental neuroses.

We studied monoaminergic mechanisms of regulation of the pool of erythropoietic precursors in active and passive mice under conditions of conflict situation and during paradoxical sleep deprivation. It was found that in animals with different behavior subjected to experimental neuroses the regulatory effects of CNS monoamines on proliferation and differentiation are mediated via adrenergic and erythropoietin-sensitive structures on erythroid stem cells. The revealed intergroup differences in precursor proliferation and differentiation rates (and erythrokaryocyte content in the bone marrow) are related to peculiarities in the activity of monoaminergic system and their interaction with peripheral structures on erythropoietic precursors.

Animals↗

Are experimental neuroses pathological states?

This paper argue that experimental neuroses are true pathological states. They can be caused by misconditioning or false learning and lead subsequently to failure of adaptation and other broad reactions of the organism. There seem to be two variants: in one case the experimental neurosis is due to the arousal and conditioning of anxiety that is of such intensity that it is very resistant to extinction. The other is the outcome of neural overload resulting in failure to perform required tasks.

Adaptation, Psychological↗

Comparison of therapeutic efficacy of neuroses between CM6912 (ethyl loflazepate) and diazepam in a double-blind trial.

1. The therapeutic efficacy on several neuroses between CM6912 and diazepam (DZP) was comparatively investigated by means of intergroup comparison method in a double-blind trials. CM6912 was given to CM-1 group on the basis of twice daily dose of 1 mg each in the morning and evening and to CM-2 group on the basis of once daily dose of 2 mg only in the evening and DZP was given to another group on the basis of three times each dose of 2 mg. 2. As for the overall evaluation, no significant differences were found in the percentages of final global improvement rating among three groups. It resulted in "markedly improved" by 22% in CM-2 group, 18% in CM-1 group and 15% in DZP group in order, and "more than moderately improved" by 62% in CM-2 group, 56% in DZP group and 51% in CM-1 group in order. 3. As for the overall safety rating, no differences were found in the incidence of adverse reactions. 4. As for the global utility rating, it resulted in "extremely useful" by 22% in CM-2 group, 14% in CM-1 group and 8% in DZP group in order, showing significant superiority of CM-2 group to DZP group (p less than 0.05). It resulted in "more than useful" by 58% in CM-2 group, 52% in DZP group and 50% in CM-1 group in order.

Anti-Anxiety Agents↗

Developmental differentiation of anxiety and affective neuroses.

One hundred and fifty anxiety neurotic and neurotic depressive twin probands were differentiated into three groups by means of discriminant analysis, 50 in each group. The groups were named pure anxiety neurosis, mixed anxiety-depression and pure neurotic depression. Childhood environmental factors seemed important in the development of pure neurotic depression, while mixed anxiety-depression seemed to be determined by environmental factors in adult life. Further investigation showed that loss of a parent before the age of 16, and moving before the age of 14 seemed important in the development of pure neurotic depression. Loss, or threat of loss, of love objects appeared to be the most common precipitating event for the neurotic depression and mixed anxiety-depression groups, while pregnancy and childbirth seemed to be of great significance in the development of pure anxiety neuroses. Furthermore, unmarried status was most frequent in the mixed anxiety-depressive group of probands.

Adult↗