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At least 55 records · Page 3Linked to original sources
PubMed2006

Positive inotropic effect of Murraya koenigii (Linn.) Spreng extract on an isolated perfused frog heart.

Ethanolic extract of fresh leaves of M. koenigii (MKEE) showed a dose dependent positive inotropic effect on isolated frog heart. The responses to MKEE (62.5-1000 microg) were not affected in either way by theophylline, imidazole, propranolol and sildenafil. The change in potassium and sodium concentration did not alter MKEE-induced positive inotropic effect. Lignocaine did not alter the responses to MKEE significantly. Responses to MKEE were significantly inhibited when calcium concentration was reduced to half (from 1.58 to 0.79 mM) and were significantly potentiated when calcium concentration was doubled (from 1.58 to 3.16 mM). Verapamil was found to inhibit the responses significantly. The results suggest that M. koenigii induced positive inotropic effect possibly by increasing availability of calcium from extra cellular sites.

Animals↗
PubMed1996

Biochemical response in rats to the addition of curry leaf (Murraya koenigii) and mustard seeds (Brassica juncea) to the diet.

Three groups with 12 weanling male albino rats were group fed for 90 days on a standard laboratory rat diet plus 20% coconut oil either without a supplement or with the addition of 10% curry leaf or 10% mustard seeds. Feed was offered at a level of 10% body weight. At the end of the trial, measurements were made on the total serum cholesterol, high density lipoproteins, low density lipoproteins, and very low density lipoproteins fractions, release of lipoproteins into the circulation, lecithin cholesterol acyl transferase activity and lipoprotein lipase activity. Feed intake and mean body weight of the rats on each treatment was not significantly different. Both spices resulted in a reduction in total serum cholesterol and LDL + VLDL, an increase in the HDL, lower release of lipoproteins into the circulation and an increase in the LCAT activity.

Animals↗
PubMed1990

Studies on the effect of curry leaves supplementation (Murraya Koenigi) on lipid profile, glycated proteins and amino acids in non-insulin-dependent diabetic patients.

Curry leaves powder supplementation (12g providing 2.5 g fibre) was carried out for a period of 1 month in 30 non-insulin dependent diabetes mellitus patients. The parameters monitored at 1, 15 and 30 days were fasting and 2 h post-prandial blood sugar levels, serum total cholesterol and its lipoprotein fractions, triglycerides, total amino acids, uronic acid, glycosylated serum proteins and glycosylated low density lipoprotein cholesterol fraction. The results indicated a transient reduction in fasting and post-prandial blood sugar levels at 15-day period with no appreciable changes in serum glycosylated protein levels, glycosylated low density lipoprotein cholesterol fraction, serum lipids, lipoprotein cholesterol levels, uronic acid and total amino acids were observed during the supplementation period, i.e, either at 15 days or 30 days.

Amino Acids↗
PubMed1990

[Studies on anti-implantation and hormone activity of yuehchukene, an alkaloid isolated from the root of Murraya paniculata].

Oral or subcutaneous administration of yuehchukene to female mice at the dosage of 2 or 4 mg/kg.d on day 1-3 of gestation resulted in 100% anti-implantation effect. However, yuehchukene at 4 mg/kg.d was found to have no anti-implantation effect in hamsters. Allen-Doisy test showed that yuehchukene had obvious estrogenic activity. Treatment of immature mice with yuehchukene at the dosage of 2 or 4 mg/kg.d for 3 days caused an increase of uterine weight. Combined use of yuehchukene with estradiol was shown to have synergistic effect on promoting uterine growth. Experiments showed that the estrogenic activity of yuehchukene was weaker than that of estriol. The affinity of this compound for estrogen receptor was also found to be weaker than that of estriol.

Alkaloids↗
PubMed1995

Haematological & histological studies after curry leaf (Murraya koenigii) & mustard (Brassica juncea) feeding in rats.

Whole curry leaf and mustard fed to rats at doses equal to normal human intake did not cause any adverse effect on food efficiency ratio (FER), red blood cell count (RBC), white blood cells (WBC), total count, differential counts or on the levels of blood constituents, like serum electrolytes, blood urea, haemoglobin, total serum protein, albumin-globulin ratio, fibrin level, glycosylated haemoglobin and the activity of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and alkaline phosphatase in serum. No histopathological changes were observed in the liver of rats administered curry leaf and mustard.

Animals↗