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At least 55 records · Page 3Linked to original sources
PubMed2002

Effect of Maytenus ilicifolia Mart. on pregnant mice.

Maytenus ilicifolia Mart. is used in Brazilian herbal medicine particularly for stomach disorders, but it is also used, as in other parts of South America, for fertility control. To verify its potential as an abortifacient, the lyophilized hydroalcoholic extract of its leaves was administered orally at a dose of 1000 mg/kg/day to mice between the first and third day of pregnancy (DOP), between the forth and sixth DOP, or between the seventh and ninth DOP. The extract caused a pre-implantation embryonic loss, but it did not have an effect on implantation or organogenesis. Morphological alterations of the reproductive system, not an embryotoxic effect, were not found. Estrogenic activity of the extract, exhibited by an uterotrophic effect, suggests that it may be interfering with the uterine receptivity to the embryo.

Abortifacient Agents↗
PubMed2003

Absolute configuration and complete assignment of 13C NMR data for new sesquiterpenes from Maytenus chiapensis.

Five new dihydro-beta-agarofuran sesquiterpenes (1-5) were isolated from the leaves of Maytenus chiapensis. The structures of 1-5 were determined by means of 1D and 2D NMR techniques. A semiselective HMBC technique was applied in order to obtain complete (13)C NMR assignments. Absolute configurations were determined by CD studies and chemical correlations and on biogenetic grounds. Compound 4 showed weak activity against a multidrug-resistant Leishmania tropica line.

Animals↗
PubMed2004

Insecticidal sesquiterpene pyridine alkaloids from Maytenus chiapensis.

The new sesquiterpene pyridine alkaloids chiapenines ES-I (1), ES-II (2), ES-III (3), and ES-IV (4), in addition to the known alkaloids wilfordine (5), alatamine (6), wilforidine (7), alatusinine (8), euonine (9), euonymine (10), ebenifoline E-I (11), forrestine (12), mayteine (13), and 4-hydroxy-7-epi-chuchuhuanine E-V (14), were isolated from the leaves of Maytenus chiapensis. Their structures were elucidated by 1D and 2D NMR spectroscopy, including homonuclear and heteronuclear correlation (COSY, ROESY, HSQC, and HMBC) experiments. Wilfordine, alatusinine, and euonine exhibited strong antifeedant activity against Spodoptera littoralis.

Alkaloids↗
PubMed2004

Four new triterpenoids from Maytenus ilicifolia.

Four new triterpenoids with various skeletons, maytefolins A-C (1-3) and uvaol-3-caffeate (4), were isolated from the leaves of a Brazilian medicinal plant, Maytenus ilicifolia, together with five known triterpenoids. Of these triterpenoids only erythrodiol exhibited significant cytotoxicity against KB/S, KB/VJ300, and KU 19-20 cells.

Antineoplastic Agents, Phytogenic↗
PubMed2004

An arabinogalactan isolated from the medicinal plant Maytenus ilicifolia.

An arabinogalactan was obtained from the leaves of Maytenus ilicifolia by hot aqueous 2% KOH extraction, followed by a freezing-thawing process and anion-exchange chromatography. It consisted of arabinose, galactose, galacturonic acid, and rhamnose in a 69:20:6:5 molar ratio. Methylation analysis, partial acid hydrolysis, and (13)C NMR spectroscopy indicated that it was an arabinogalactan containing a (1-->4)-linked beta-Galp main chain, substituted at O-6 with Ara units, which were in turn substituted at O-5 (Araf) and/or O-4 (Arap), O-3, O-3,5, and O-2,5. This arabinogalactan is probably linked to O-4 of some Rhap units of a type I rhamnogalacturonan, formed by repeating (1-->4)-alpha-D-GalpA-(1-->2)-alpha-L-Rhap groups.

Brazil↗
PubMed2004

Chemical constituents from the Colombian medicinal plant Maytenus laevis.

The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.

Antineoplastic Agents, Phytogenic↗
PubMed2004

DNA polymerase beta lyase inhibitors from Maytenus putterlickoides.

During a survey of plant secondary metabolites for DNA polymerase beta lyase inhibitors, we found that a crude methyl ethyl ketone extract prepared from Maytenus putterlickoides showed strong inhibition of the lyase activity of DNA polymerase beta in an in vitro assay. Bioassay-guided fractionation of the extract, using an in vitro assay, resulted in the discovery of a new active principle, 30-(4'-hydroxybenzoyloxy)-11alpha-hydroxylupane-20(29)-en-3-one (1), as well as a known compound, (-)-epicatechin (2). Compounds 1 and 2 exhibited DNA polymerase beta lyase inhibitory activity with IC50 values of 62.8 and 18.5 microM, respectively. Compound 2 was capable of potentiating the action of the monofunctional methylating agent methyl methanesulfonate in cultured human cancer cells, consistent with the possible utility of inhibitors of this type in vivo.

Antineoplastic Agents, Phytogenic↗
PubMed2005

Lupane triterpenoids from Maytenus species.

Five new lupane triterpenes (1-5), in addition to 24 known ones, were isolated from Maytenus cuzcoina and M. chiapensis. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (COSY, ROESY, HSQC, and HMBC) experiments. The compounds were assayed for antimicrobial and cytotoxic activities, with 3-epi-betulinic acid and 28,30-dihydroxy-3-oxolup-20(29)-ene showing moderate cytotoxicity.

Animals↗
PubMed2006

A polysaccharide from a tea (infusion) of Maytenus ilicifolia leaves with anti-ulcer protective effects.

Maytenus ilicifolia is a medicinal plant used as a tea (infusion) for treatment of stomach ulcers. This tea furnished a polysaccharide after several purification steps, consisting of a freezing-thawing process, Fehling precipitation, ultrafiltration, and dialysis. It consisted of arabinose, galactose, galacturonic acid, 4-O-methylglucuronic acid, rhamnose, and glucose in a 42:41:6:5:4:2 molar ratio. Methylation analysis, controlled Smith degradation, and NMR spectroscopy indicated that it was a type II arabinogalactan containing a (1-->3)-linked beta-d-Galp main chain, substituted at O-6 by (1-->6)-linked beta-d-Galp chains, which were mainly substituted at O-3 by (1-->5)- and (1-->3)-linked alpha-l-Araf chains, and nonreducing end-units of alpha-l-Araf and 4-O-Me-GlcpA. This polysaccharide significantly inhibited ethanol-induced gastric lesions in rats with an ED(50) of 9.3 mg/kg, suggesting that the arabinogalactan liberated from the infusion has a protective anti-ulcer effect.

Anti-Ulcer Agents↗
PubMed2004

Two cangorosin A type triterpene dimers from Maytenus chuchuhuasca.

Two new cangorosin A type triterpene dimers, which composed of two triterpene units jointed by two ether linkages between the A and B rings, were isolated from the Brazilian medicinal plant "xuxuá" (Maytenus chuchuhuasca). Structures of new isolates, xuxuasins A (1) and B (2), were established based on several spectroscopic evidences.

Maytenus↗
PubMed2004

Nine regioisomeric and stereoisomeric triterpene dimers from Maytenus chuchuhuasca.

Nine regioisomeric and stereoisomeric triterpene dimers, namely xuxuarine Falpha (1), isoxuxuarine Falpha (2; cangorosin B), 7,8-dihydroisoxuxuarine Falpha (3), isoxuxuarine Gbeta (4), 7,8-dihydroisoxuxuarine Galpha (5), isoxuxuarine Ebeta (6), 7alpha-hydroxyisoxuxuarine Ealpha (7), 7',8'-dihydroxuxuarine Aalpha (8), and 7',8'-dihydroxuxuarine Dbeta (9), were isolated from the Brazilian medicinal plant "xuxuá" (Maytenus chuchuhuasca). Their structures have been elucidated based on several spectroscopic analyses including 2D-NMR experiments, MS spectra and CD spectral studies.

Dimerization↗
PubMed1996

Antibiotic phenol nor-triterpenes from Maytenus canariensis.

The new phenols 6-oxo-tingenol, 3-O-methyl-6-oxo-tingenol and 6-oxo-iguesterol were isolated from the root bark of Maytenus canariensis. Their structures were determined by 1H and 13C NMR spectroscopic studies, including HMQC, HMBC, DEPT and ROESY and chemical transformations. The synthesis of 6-oxo-tingenol was achieved from tingenone. These compounds exhibit antibiotic activity against Gram-positive bacteria.

Anti-Bacterial Agents↗
PubMed1991

Antiulcerogenic effects of two Maytenus species in laboratory animals.

Leaves of Maytenus species are commonly used in Brazil for the treatment of gastric ulcers, dyspepsias and other gastric problems. The present study evaluated the antiulcerogenic potential of a boiling water extract of equal parts of M. aquifolium and M. ilicifolia leaves against ulcer lesions induced by indomethacin and cold-restraint stress in rats. Ranitidine and cimetidine were used as reference drugs. The oral and intraperitoneal administration of the extract had a potent antiulcerogenic effect against both types of ulcers. The extract was shown to cause an increase in volume and pH of gastric juice of the animals with the pH effects comparable to those of cimetidine. The results tend to confirm the popular use of the plant.

Administration, Oral↗
PubMed1996

Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae).

Scutione (1), a new norquinonemethide triterpene with a netzahualcoyene type skeleton, has been isolated from the root bark of Maytenus scutioides (Celastraceae) by bioactivity-directed fractionation. The structure of 1 has been elucidated by means of 1H and 13C NMR spectroscopic studies, including 1H-13C heteronuclear correlation (HETCOR), a long-range correlation spectrum with inverse detection (HMBC) and ROESY experiments. Compound 1 showed antibiotic activity against Gram-positive bacteria and modest cytotoxic activity against HeLa, Hep-2 and Vero cell lines. Fluoride derivatives 2-4 were prepared and assayed for bioactivity, where 2 showed slight improvement of the cytotoxic potency.

Animals↗
PubMed1998

Effect of Maytenus ilicifolia Mart.ex. Reiss on spermatogenesis.

The effect of the ethanolic extract of Maytenus ilicifolia Mart.ex. Reiss leaves on spermatogenesis was studied in Swiss mice by evaluating morphological characteristics by light and electron microscopy. The extract was administered at a dose of 200 mg/kg/day intraperitoneally for 20 days, and at a dose of 800 mg/kg/day orally for 30 days. Structural analysis of the germ epithelium showed that treated animals were not noticeably different from control animals. The alterations included some exfoliated immature germ cells, occasional germ cell death (recognized as pyknotic nuclei) and a few vacuolized seminiferous tubules. Ultrastructurally, enlarged lipid droplets were found in Sertoli cells and swollen acrosomes occurred in early spermatids of animals treated with the higher dose. Sperm production indicated that the ethanolic extract of M. ilicifolia leaves did not contain substances sufficient to arrest spermatogenesis.

Acrosome↗
PubMed2000

Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris.

Maytenus aquifolium (Celastraceae) and Salacia campestris (Hippocrateaceae) species accumulate friedelane and quinonemethide triterpenoids in their leaves and root bark, respectively. Enzymatic extracts obtained from leaves displayed cyclase activity with conversion of the substrate oxidosqualene to the triterpenes, 3beta-friedelanol and friedelin. In addition, administration of (+/-)5-(3)H mevalonolactone in leaves of M. aquifolium seedlings produced radio labelled friedelin in the leaves, twigs and stems, while the root bark accumulated labelled maytenin and pristimerin. These experiments indicated that the triterpenes once biosynthesized in the leaves are translocated to the root bark and further transformed to the antitumoral quinonemethide triterpenoids.

Chromatography, High Pressure Liquid↗
PubMed2000

Assessment of the effect of Maytenus ilicifolia (espinheira santa) extract on the labeling of red blood cells and plasma proteins with technetium-99m.

We are trying to develop a model to assess properties of products utilized in popular medicine. Maytenus ilicifolia is used in herbal medicine. Red blood cells (RBC) labeled with technetium-99m (99mTc) are employed in nuclear medicine. This labeling procedure depends on a reducing agent and stannous chloride is used. There is evidence that this labeling may be altered by drugs. We have investigated the possibility of M. ilicifolia extract being capable to alter the labeling of blood elements with 99mTc. Blood was incubated with M. ilicifolia extract. Stannous chloride solution and Tc-99m were added. Blood was centrifuged and plasma (P) and blood cells (C) were isolated. Samples of P or C were also precipitated, centrifuged and insoluble (IF) and soluble (SF) were separated. The percentages of radioactivity (%ATI) in C, IF-P and IF-C was calculated. The %ATI decreased on C from 93.6+/-2.3 to 29.0+/-2.7, on IF-P from 77.6+/-1.2 to 7.5+/-1.0 and on IF-C from 80.0+/-3.4 to 12.6+/-4.8. Once in RBC labeling procedure with 99mTc depends on the presence of stannous (+2) ions, the substances of the M. ilicifolia extract could increase the valence these ions to stannic (+4). This fact would decrease the %ATI on blood elements and indicate the presence of oxidant agents in the M. ilicifolia extract.

Blood Proteins↗