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PubMed2006

Laboratory productivity and the rate of manual peripheral blood smear review: a College of American Pathologists Q-Probes study of 95,141 complete blood count determinations performed in 263 institutions.

CONTEXT: Automated laboratory hematology analyzers are capable of performing differential counts on peripheral blood smears with greater precision and more accurate detection of distributional and morphologic abnormalities than those performed by manual examinations of blood smears. Manual determinations of blood morphology and leukocyte differential counts are time-consuming, expensive, and may not always be necessary. The frequency with which hematology laboratory workers perform manual screens despite the availability of labor-saving features of automated analyzers is unknown. OBJECTIVE: To determine the normative rates with which manual peripheral blood smears were performed in clinical laboratories, to examine laboratory practices associated with higher or lower manual review rates, and to measure the effects of manual smear review on the efficiency of generating complete blood count (CBC) determinations. DESIGN: From each of 3 traditional shifts per day, participants were asked to select serially, 10 automated CBC specimens, and to indicate whether manual scans and/or reviews with complete differential counts were performed on blood smears prepared from those specimens. Sampling continued until a total of 60 peripheral smears were reviewed manually. For each specimen on which a manual review was performed, participants indicated the patient's age, hemoglobin value, white blood cell count, platelet count, and the primary reason why the manual review was performed. Participants also submitted data concerning their institutions' demographic profiles and their laboratories' staffing, work volume, and practices regarding CBC determinations. The rates of manual reviews and estimations of efficiency in performing CBC determinations were obtained from the data. SETTING: A total of 263 hospitals and independent laboratories, predominantly located in the United States, participating in the College of American Pathologists Q-Probes Program. RESULTS: There were 95,141 CBC determinations examined in this study; participants reviewed 15,423 (16.2%) peripheral blood smears manually. In the median institution (50th percentile), manual reviews of peripheral smears were performed on 26.7% of specimens. Manual differential count review rates were inversely associated with the magnitude of platelet counts that were required by laboratory policy to trigger smear reviews and with the efficiency of generating CBC reports. Lower manual differential count review rates were associated with laboratory policies that allowed manual reviews solely on the basis of abnormal automated red cell parameters and that precluded performing repeat manual reviews within designated time intervals. The manual scan rate elevated with increased number of hospital beds. In more than one third (35.7%) of the peripheral smears reviewed manually, participants claimed to have learned additional information beyond what was available on automated hematology analyzer printouts alone. CONCLUSION: By adopting certain laboratory practices, it may be possible to reduce the rates of manual reviews of peripheral blood smears and increase the efficiency of generating CBC results.

Blood Cell Count↗
PubMed1994

Imposed work and oxygen delivery during spontaneous breathing with adult disposable manual ventilators.

BACKGROUND: Manual ventilators (resuscitators) are used primarily to ventilate the lungs of patients lacking spontaneous ventilatory effort. However, in many settings patients are allowed to breathe through the manual ventilator. Although many aspects of manual ventilator function have been studied, very little has been reported on the use of manual ventilators during spontaneous breathing. The purpose of this study was to evaluate inspiratory and expiratory imposed work of breathing and oxygen delivery during spontaneous breathing through disposable manual ventilators. METHODS: Simulated spontaneous breathing was established with a two-chambered test lung, with one chamber serving as the test chamber and the other as the driving chamber. Imposed work of breathing was evaluated with decelerating inspiratory flow at a rate of 20 breaths/min at tidal volume (VT) 0.25 1 and peak flow 40 l/min, at VT 0.5 l and peak flow 80 l/min, and VT 0.81 and peak flow 120 l/min. Flow (integrated to volume) and pressure were measured between the manual ventilator and test lung, and inspiratory and expiratory imposed work of breathing were calculated by integration of the volume-pressure curve. Oxygen concentration was measured with an oxygen analyzer placed between the manual ventilator and the test lung at 20 breaths/min, VT 0.5 l, and flow 45 l/min. An oxygen flow of 15 l/min was added to the device for all evaluations. Two of the manual ventilators had built-in positive end-expiratory pressure valves, and imposed work was evaluated at 10 cmH2O with these. RESULTS: There were significant differences in imposed work between inspiration and expiration (P < 0.001) and among the three levels of ventilatory demand (P < 0.001). For each ventilatory demand, there was a significant difference in work between manual ventilator brands for inspiratory work and expiratory work (P < 0.001). At a VT of 0.5 l and peak flow of 80 l/min, the pooled inspiratory imposed work for all manual ventilators was 0.44 +/- 0.12 J/l, and the pooled expiratory imposed work was 0.29 +/- 0.05 J/l. With 10 cmH2O positive end-expiratory pressure, the inspiratory imposed work was very high (> 1 J/l). Four of the devices were unable to deliver more than 0.85 oxygen concentration at the spontaneous ventilatory pattern evaluated. CONCLUSIONS: Adult disposable manual ventilators produce a substantial imposed work of spontaneous breathing, which is increased with the addition of positive end-expiratory pressure. With some manual ventilators, a high oxygen concentration may not be delivered during spontaneous breathing. We recommend that patients not be allowed to spontaneously breathe through disposable manual ventilators.

Adult↗
PubMed1995

One-session therapist directed exposure vs two forms of manual directed self-exposure in the treatment of spider phobia.

Fifty-two patients with spider phobia, fulfilling the DSM-III-R criteria for simple phobia, were assessed with behavioral, physiological and self-report measures. They were randomly assigned to five different treatment conditions: (1) one session therapist-directed exposure (maximum 3 hours), (2) specific manual-based treatment in the home, (3) specific manual-based treatment at the clinic, (4) general manual-based treatment in the home and (5) general manual-based treatment at the clinic. The results show that therapist-directed one-session treatment was significantly more effective than three of the manual-based treatments, both at the post-treatment and follow-up stages. Specific manual-based treatment at the clinic was significantly more successful than the other manual-based treatments, but only at follow-up. The proportion of clinically significant improved patients at follow-up was 80% in the therapist-directed group compared to 63% for the specific manual-based treatment at the clinic, 10% for specific manual-based treatment in the home, 9% for general manual-based treatment in the home, and 10% for general manual-based treatment at the clinic. The conclusion that can be drawn is that one-session therapist-directed treatment is the treatment of choice for spider phobia but manual-based treatment is a good alternative in some cases.

Adolescent↗
PubMed2000

Training primary care physicians to give limited manual therapy for low back pain: patient outcomes.

STUDY DESIGN: Randomized controlled study of standard manual therapy given by 31 generalist physicians to 295 patients, in primary care practice. OBJECTIVES: To determine whether training primary care physicians in techniques of limited manual therapy would result in improved outcomes for their patients with acute low back pain. SUMMARY OF BACKGROUND DATA: Controversy continues regarding the benefit of spinal manual therapy and the role of highly trained manual therapists in the care of low back pain. Continuing medical education in manual therapy is frequently offered to generalist physicians, but nothing is known of the value and effectiveness of this training. METHODS: Thirty-one primary care physicians were trained to provide optimal low back care (enhanced care) and a sequence of eight standard manual therapy techniques. Two hundred ninety-five patients were randomized into two treatment groups: enhanced care alone and enhanced care with manual therapy. Main outcome measures included the Roland-Morris functional disability scale measured over time and patient-reported time to functional recovery, time to complete recovery, and satisfaction with care. RESULTS: No differences were found in Roland-Morris scores over time, mean functional days to recovery, days absent from work, or patient satisfaction. More patients receiving manual therapy (21; 14%) had completely recovered after the first visit compared with the control group (8; 6%; P = 0.01). Patients who received more intense manual therapy (four or more maneuvers) had a more rapid return to functional recovery (7.8 days) compared with those who received less intense manual therapy (11.1 days; P = 0.02). CONCLUSION: Limited training in manual therapy techniques offers very modest benefit compared with high-quality (enhanced) care for acute low back pain. Outcomes may have been modified by failure of some participant physicians to undertake the required sequence of maneuvers. Intensity of manual therapy may be a factor in improving patient outcomes and needs further study.

Disability Evaluation↗
PubMed2006

Comparison of manual and digital measurements in adolescent idiopathic scoliosis.

STUDY DESIGN: Comparison of manual and digital measurement of radiographic parameters in patients with adolescent idiopathic scoliosis (AIS). OBJECTIVE: To assess the reliability of digital measures as compared to manual measures in the evaluation of AIS. SUMMARY OF BACKGROUND DATA: Radiographic parameters are critical to the evaluation of patients with AIS, and are frequently used to monitor curve progression and guide treatment decisions. The reliability of many of the more common radiographic measures has only recently been elucidated for both manual and digital measures. However, a comparative analysis of manual versus digital measures has been performed only for coronal Cobb angles. The inter-technique reliability of these parameters will have increasing importance as digital radiographic viewing and analysis become commonplace. METHODS: There were 2 independent, blinded observers that measured 30 complete sets of preoperative (posterior-anterior, lateral, and both side-bending) and postoperative (posterior-anterior and lateral) radiographs on 4 different occasions. For the first 2 iterations, manual measurements were taken using the same pencil and protractor. For the last 2 iterations, measurements of digitized radiographs were taken on a software measurement program (PhDx, Albuquerque, NM). Coronal measures included the main thoracic and thoracolumbar/lumbar standing and side-bending Cobb angles, apical vertebral translation, coronal balance, T1 tilt angle, lowest instrumented vertebrae angle, angulation of the disc inferior to the lowest instrumented vertebrae, apical Nash-Moe vertebral rotation, and Risser grade. Sagittal parameters included T2-T5 and T5-T12 regional thoracic kyphosis, T2-T12 thoracic kyphosis, T10-L2 thoracolumbar junction sagittal curvature, T12-S1 lumbar lordosis, and global sagittal balance. The technique-dependent measurement variability and the inter-technique (manual vs. digital), intraobserver reliability were evaluated for each radiographic parameter (within 3 degrees ). RESULTS: Digital measurement showed decreased intraobserver variability for many (9 of 15) of the radiographic parameters assessed. Likewise, digital measures indicated good or excellent correlation with the absolute values obtained with manual measurement for many (10 of 15) parameters. All but 1 of those parameters having moderate-to-poor correlation had been previously shown to have poor reliability, regardless of measurement technique. Statistically significant differences between measurement variability were noted for 6 measures, including 2 favoring digital and 4, manual. Significant differences in the absolute values were noted for 5 measures, determined at a difference of 3 degrees . However, the differences in both parameter variability and absolute values tended to be small and of little clinical significance for manual versus digital measurement. CONCLUSIONS: Digital measurement showed improved measurement precision and good correlation with manual measurements for the majority of AIS parameters. Absolute differences between manual and digital measurements were generally small. Therefore, digital measures are acceptable as a valid technique for scoliosis evaluation. The importance of digital versus manual measurement reliability will increase as digital radiographic viewing becomes more prevalent.

Adolescent↗
PubMed1997

Comparison of manual and automated cell counts in EDTA preserved synovial fluids. Storage has little influence on the results.

OBJECTIVE: To determine the precision and agreement of synovial fluid (SF) cell counts done manually and with automated counters, and to determine the degree of variability of the counts in SF samples, kept in the tubes used for routine white blood cell (WBC) counts--which use liquid EDTA as anticoagulant--at 24 and 48 hours at 4 degrees C, and at room temperature. METHODS: To determine precision, cell counts were repeated 10 times--both manually and by an automated counter--in a SF sample of low, medium, and high cellularity. The variances were calculated to determine the interobserver variation in two manual (M1,M2) and two automated cell counts (C1,C2). The agreement between a manual (M1) and automated counter (C1) results, was analysed by the Bland and Altman method and the difference against the mean of the two methods was plotted. Then, the mean difference between the two methods was estimated and the standard deviation of the difference. To determine the effects of storage, SF samples were kept in a refrigerator at 4 degrees C, and at room temperature; cell counts were done manually (M1) and automatically (C1) at 24 and 48 hours and the changes analysed by the Bland and Altman method. The variances were compared using an F test. RESULTS: (1) Precision. With the manual technique, the coefficients of variation were 27.9%, 14%, and 10.7% when used for counting the SF with low (270), medium (6200), and high cellularities (25,000). With the automated technique the coefficients of variation were 20%, 3.4%, and 2.9% in the same SF samples. In the fluids of medium and high cellularity, the variances of the automated cell counts were significatively lower (F test, p < 0.002) than those of the manual counts. (2) Interobserver variation. The variance between C1 and C2 (25 SF) was significatively lower (F test, p < 0.002) than that of the manual counts (41 SF). (3) Agreement between the two techniques (100 SF). For cellularities above 2000 cells/mm3, the manual method gave results between +10% to -34% of the results obtained by the coulter. For cellularities below 2000 cells/mm3, manual cell counts were between +60 to -1280 cells/mm3 of those obtained by the automated counter. (4) Influence of storage. The coulter counts of SF samples preserved at 4 degrees C showed less variance (F test, p < 0.05) than the manual counts. The worst results were obtained in manual counts of SF samples kept at room temperature; these samples at 48 hours showed a variation between -47% to 42% of the initial results. CONCLUSIONS: Automated cell count of the SF offers advantages: it gives higher precision and consumes less time. The stability of the samples preserved in the EDTA tubes used for routine WBC counts is of additional interest, because if delay cannot be avoided, the results of the WBC counts are still accurate at 24 and even at 48 hours, at least for clinical purposes.

Blood Preservation↗