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PubMed2004

Lymphangitis carcinomatosa in thin section computed tomography.

High resolution computed tomography is a diagnostic method of choice in the evaluation of lung parenchyma. HRCT enables the evaluation of small interstitial changes, invisible on plain chest radiographs, and their assessment at the level of the lung lobule. The aim of the study was the assessment of typical findings in HRCT in lymphangitis carcinomatosa, enabling differential diagnosis. Material comprises a group of 18 patients with lymphangitic spread of carcinoma, in whom HRCT examination was performed. Nodular thickening of the peribronchovascular interstitium and interlobular septa are typical in lymphangitic spread of carcinoma. Smooth peribronchovascular and septal thickenings are typical in sarcoidosis, and are only seen in some patients in the lymphangitic spread of carcinoma. In lymphangitis carcinomatosa lung architecture remains unchanged, which allows differentiating from sarcoidosis.

Diagnosis, Differential↗
PubMed1991

[Pulmonary carcinomatous lymphangitis of prostatic origin, disclosed by acute respiratory insufficiency, regressing by treatment with an LH-RH agonist].

Carcinomatous lymphangitis of prostatic origin is infrequent and usually carries a poor prognosis. The authors report a case of pulmonary carcinomatous lymphangitis related to a prostatic carcinoma. This case was remarkable for its acute mode of revelation and for its favourable outcome under treatment with LH-RH agonists.

Follow-Up Studies↗
PubMed1984

[An unusual form of neoplastic lymphangitis in an irradiated field].

The authors describe an exceptional form of neoplastic lymphangitis occurring in old people some years after surgery and irradiation of a cancer (parotid, breast), the special character of which is that it draws exactly the fields of irradiation. This lymphangitis is at first smooth and later covered with neoplastic nodes which join together. Evolution is in any case the death after some weeks or months. Different pathogenetic hypotheses are discussed, involving the mechanisms of biology of cancer and radiations.

Aged↗
PubMed1981

Pattern recognition in radiographs of excised air-inflated human lungs. III Chronic interstitial and granulomatous inflammation, scars and lymphangitis carcinomatosa in non-emphysematous lungs.

To evaluate the patterns of chronic interstitial and granulomatous inflammation, scars and lymphangitis carcinomatosa in radiographs of excised air-inflated lungs at autopsy, the distribution of these findings in 89 lungs was determined histologically on 441 sections sampled systematically. Pathologic-radiologic correlations were studied on the basis of 29 sections from 18 lungs selected to represent unequivocally the features in question. Chronic interstitial pneumonia exhibited uneven, trabecular or macular densities distributed randomly. Honeycomb lung was characterized by a coarse reticular pattern with fairly regular and roundish translucencies measuring 2-20 mm in diameter. Granulomas of miliary tuberculosis and sarcoidosis appeared as roundish macular densities, 2-5 mm in diameter. The former were randomly distributed while the latter seemed to follow lobular septa. Scars appeared as randomly distributed, either trabecular, star-shaped or polygonal densities. Several larger scars contained calcified foci. Intraparenchymal scars of at least 2 mm in diameter, and even smaller subpleural scars, were visible radiographically. Lymphangitis carcinomatosa appeared as unevenly thick linear opacities.

Adult↗
PubMed1980

Lymphangitis of the anterior chest wall.

Lymphangitis of the anterior chest wall in children is an unusual finding and may be a diagnostic enigma. The following case report describes a five year old boy who presented with this condition. The diagnosis was somewhat elusive until a history of an antecedent insect bite was obtained. Lymphangitis should therefore be considered in the differential diagnosis when perplexing erythematous chest wall lesions are present in children.

Child, Preschool↗
PubMed1996

Lymphangitis carcinomatosa: a literature review.

Intrathoracic metastases occur in 30-40% of patients with malignant disease. In this group 6-8% have lymphangitis carcinomatosa. This review examines the pathogenesis, investigation and treatment of lymphangitis carcinomatosa. The 40-49 years age group is most commonly affected. In 46% of patients respiratory symptoms are the initial presentation of the underlying carcinoma. The most common underlying primary tumours are breast (33%), stomach (29%) and lung cancers (17%). Approximately 50% die within 3 months of their first respiratory symptoms but those with a prostatic primary carcinoma may have good remission with adjuvant hormonal therapy.

Adult↗
PubMed1988

Herpes simplex lymphangitis. Two cases and a review of the literature.

Lymphangitis and lymphedema are rarely reported complications of herpetic hand or genital infection. The natural history of these complications is gradual resolution over 14 to 21 days. Recognition of this presentation of herpes infection avoids unnecessary surgery and antibacterial therapy. Antiviral therapy may have a role in shortening the duration of symptoms and aborting recurrent lymphangitic episodes.

Acyclovir↗
PubMed1966

Prophylaxis of recurrent lymphangitis complicating lymphedema.

Antibiotic prophylaxis was employed in 21 patients with secondary lymphedema complicated by recurrent episodes of acute lymphangitis. Eighteen were completely free of subsequent attacks; the three others showed a marked reduction in the frequency and severity of subsequent attacks. Follow-up time averaged 30 months.

Acute Disease↗
PubMed1982

Granulomatous lymphangitis. A complication of intralymphatic immunotherapy with methanol extraction residue of BCG (MER).

Patients with thick primary melanomas, (Stage I) or regional nodal spread (Stage II) are at substantial risk for recurrence following usual definitive surgical excision of the primary tumor with or without lymphadenectomy. Trials of nonspecific adjuvant agents such as bacille Calmette Guerin (BCG) in experimental animals and man suggest that antitumor effects are greatest when the agent is injected near tumor of limited mass. We report a new approach to adjuvant therapy using preoperative intralymphatic injections and intraoperative local instillations of the nonviable methanol extraction residue of bacille Calmette Guerin (MER). Thirteen individuals with thick primaries, regional metastases, or recurrent melanoma of the extremities have entered the experimental program. We report here one complication of this immunotherapy observed in four of 13 treated individuals, granulomatous lymphangitis. The clinical presentation, course, and treatment of this complication are described. Its potential relation to the success of this therapy is discussed.

Adult↗
PubMed1985

Studies on histoplasmosis farciminosi (epizootic lymphangitis) in Egypt. Isolation of Histoplasma farciminosum from cases of histoplasmosis farciminosi in horses and its morphological characteristics.

Isolation of Histoplasma farciminosum from five horses, showing typical signs of histoplasmosis farciminosi (epizootic lymphangitis) was successfully attempted. The mycelial form of H. farciminosum was isolated on Sabouraud dextrose agar enriched with 2.5% glycerol, brain heart infusion (BHI) agar enriched with 10% horse blood and PPLO dextrose glycerol agar. The last medium proved to be the most effective, both for primary isolation and subculturing of the fungus. It was found that on primary isolation, the lag phase of the mycelial form of the fungus was relatively long, involving 4-8 weeks at 25 degrees C. Colonies of the mycelial form of H. farciminosum appeared on subculture as a yellowish, light brown to deep brown, convoluted, waxy, cauliflower-like growth tending to form scant aerial growth. Conversion of the mycelial form to the yeast form of H. farciminosum was successful by subculturing either on BHI agar with 5% blood or on Pine's medium and incubating at 35-37 degrees C. Complete conversion to the yeast form was achieved only after 4-5 repeated serial transfers onto fresh media every 8 days. The yeast colonies were flat, raised, slightly or deeply wrinkled, white to light gray to grayish brown, and were pasty in consistency.

Animals↗
PubMed1985

Use of enzyme-linked immunosorbent assay for the diagnosis of equine Histoplasmosis farciminosi (epizootic lymphangitis).

An enzyme-linked immunosorbent assay was evaluated for the detection of antibody in sera of equine naturally infected with Histoplasma farciminosum 'epizootic lymphangitis'. Ten sera from naturally infected horses were tested. A hydrogen peroxide ABTS mixture constituted the substrate. The reactions were read as the absorbance values measured at 405 nm using a spectrophotometer. The standard deviation and the average percentage of the absorbance values of the different serum samples were considered in the interpretation of the results. All sera were proved positive with variations in the different samples. Ground preparation of four weeks old growth of the fungus in a phosphate buffer saline was used as antigen. A peroxidase labeled goat anti-equine IgG was used as a conjugate.

Animals↗
PubMed2004

Two cases of acute respiratory failure due to carcinomatous lymphangitis in HIV patients.

In HIV-infected patients, acute respiratory failure is usually due to infectious pneumonia. In this report, we describe two cases of acute respiratory failure in HIV patients with clinical presentation suggesting infectious pneumonia. In both cases, the clinical condition deteriorated and death occurred after several days despite therapy. In both cases bronchial biopsies confirmed bronchogenic carcinoma responsible for carcinomatous lymphangitis.

AIDS-Related Opportunistic Infections↗
PubMed1975

Traumatic lymphangitis of penis.

The appearance of a firm, nodular, cord-like structure in the coronal sulcus of the penis has heretofore been considered and reported in the urologic literature as thrombophlebitis of the superficial veins. Further study and review of the literature reveal this condition to be a traumatic lymphangitis which is directly related to sexual trauma and runs a short, asymptomatic, self-limited course.

Adult↗
PubMed2004

A cross-sectional study of epizootic lymphangitis in cart-mules in western Ethiopia.

A cross-sectional study was conducted to determine the prevalence of epizootic lymphangitis (EL) in 309 cart-mules (cart-pulling mules) in Bako and Ejaji towns, Western Ethiopia using clinical and microbiological examinations, between November 2002 and April 2003. The overall prevalence was 21% (CI=16.6-26%). The clinical, histological and mycological characteristics of EL in a cart-mule were similar with those in a horse. There was significant (chi2=133.5, P=0.001) association between tick infestation and EL lesions in study cart-mules. Amblyoma coherence and Boophilus genera were the ticks collected from lesions of cases of EL, and thus played a predisposing role. In conclusion, our results showed that EL has high prevalence in cart-mules in the two towns.

Animals↗
PubMed2005

Preliminary trial on the reproducibility of epizootic lymphangitis through experimental infection of two horses.

Epizootic lymphangitis (EL) was experimentally reproduced in four horses that had been purchased from an EL-free district. Two horses were injected with either 0.2 mL of the yeast form of Histoplasma capsulatum var. farciminosum (HCF) in pus (Horse 1), or 0.2 mL (ca. 20 mg) of a suspension in saline of the mycelial form (Horse 2), both into the pre-scapular and pre-femoral lymph nodes, with scarification of the skin of the left hind limb, conjunctiva of the right eye and the nasal membrane of the right nostril. The two other horses served as controls. Nodular lesions of EL appeared during the fourth week of infection at all sites in the horse infected with the yeast form. Lesions only appeared in the lymph nodes and skin scratches of the horse infected with the mycelial suspension after three months. The control horses showed no clinical signs. The yeast form was recovered from the lesions of both infected horses. Similarly, the mycelial form was isolated from both horses on Sabouraud's Dextrose Agar. This experiment showed the reproducibility of clinical EL through experimental infection, and has laid the groundwork for the evaluation of the potency of a vaccine against EL using a vaccination and challenge experiment.

Animals↗
PubMedDate not supplied

[Nonvenereal sclerosing lymphangitis of the penis: presentation of a clinical case].

Nonvenereal sclerosing lymphangitis of the penis is an infrequent process that affects the distal lymphatics of this organ. It is characterized by the sudden appearance of a translucent and indurated cord on the coronal sulcus. Its etiology is unknown, although it has been related to microtraumas in the area after intense sexual activity. It is a benign, self-resolving process, so it is not necessary to perform a biopsy in early stages, and initial treatment should be conservative. We present a new case of this disease and discuss its etiopathogenic, clinical, diagnostic and therapeutic characteristics.

Humans↗