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[Principles and value of lymph node excision in tumors of the pancreatobiliary system].

Malignancies of the gallbladder, bile ducts and pancreas have a very bad prognosis compared with other gastrointestinal malignomas. Lymph node metastasis has frequently been identified as an important prognostic factor. This leads to some surgeons to embark on an extremely aggressive resectional strategy, including wide lymphadenectomy. So far, reported results of these procedures have varied considerably and concomitant morbidity has often exceeded that of standard resections. Until there is unequivocal proof of the benefit of an extended lymphadenectomy in controlled studies this strategy cannot be recommended generally.

Biliary Tract Neoplasms↗

[Initial experiences and outcome of gasless laparoscopic pelvic lymph node excision combined with Schauta vaginal radical hysterectomy in stage IB cervix carcinoma].

In 11 patients with a cervical cancer stage IB a gasless laparoscopic pelvic lymph node dissection in combination with a vaginal radical Schauta-Amreich-hysterectomy was performed. The technique of the gasless lymph node dissection with the Laparolift (ORIGIN Medsystems, Menlo Park) is described. Because of the advantages of this technique (ability to use conventional and endoscopic instruments, perform irrigation and suction, dot with sponge sticks, change instruments quickly, prepare and remove lymph nodes without influence on visibility) it was possible to obtain a radicality (45 lymph nodes-median value) according to oncological standards for an abdominal radical Wertheim hysterectomy. If the radicality is equivalent to a Wertheim hysterectomy the combination of the radical vaginal Schauta-Amreich-hysterectomy and the gasless laparoscopic pelvic lymph node dissection offers a real alternative to the abdominal Wertheim hysterectomy because of low postoperative morbidity and quick mobilisation.

Adenocarcinoma↗

[Value of laparoscopic pelvic lymph node excision in inguinal vulvar carcinoma metastasis].

We performed a laparoscopic pelvic lymphadenectomy in three patients with vulvar cancer FIGO stage II or III and positive inguinal lymph nodes. Computertomographical and lymphographical findings of pelvic lymph nodes did not correlate with the histological findings in two patients: Surgical staging up-graded the clinical stage in one patient. No intra- or postoperative complications were encountered. Laparoscopic pelvic lymphadenectomy in inguinal metastasizing vulvar cancer is a valuable method with low peri- and postoperative morbidity.

Carcinoma, Squamous Cell↗

Lymph node excision as a simple diagnostic aid in rare lipidoses.

Autopsy material from a case of Niemann-Pick disease was subjected to lipid analysis. Among the six tissues investigated, lymph nodes exhibited the greatest storage of several lipids. Since lymph nodes are relatively easy to obtain by biopsy, they may be utilized for chemical diagnosis of this type of lipidosis.

Child↗

[A case of multiple hepatocellular carcinoma complicated with N3 regional lymph node metastases preventing tumor progression by gradual introduction of lymph node excision and high-dose chemotherapy using percutaneous isolated hepatic perfusion].

We experienced a case of multiple hepatocellular carcinoma (HCC) complicated with N3 regional lymph node metastases. The gradual introduction of lymph node excision and high-dose chemotherapy using percutaneous isolated hepatic perfusion (PIHP) was effective in preventing progress of the tumor. The patient was a 63-year-old male who underwent a thorough medical examination because of elevated AFP at a local hospital. He was referred to our hospital. The preoperative laboratory results showed the elevation of AFP (729 ng/ml) and PIVKA-II (2,110 mAU/ml). CT scan of the liver revealed tumors in segment 4, 5 and 6, and lymph node metastases from the pancreas to the hepato-duodenal ligament. The enlarged lymph nodes were excised and the tumor in segment 5 was resected for pathological examination. Adriamycin was administered in doses of 100 mg/m2 and 80 mg/m2 using PIHP two and three months after the operation. According to the results of laboratory studies conducted 14 months after the operation, AFP was 12 ng/ml and PIVKA-II was within the normal range. CT scan of the liver showed the liquefaction degeneration of the remaining HCC. Although surgery is not generally indicated in a patient with multiple HCC complicated with N3 regional lymph node metastases, it should be considered in combination with PIHP in those with resectable extrahepatic lesion.

Antineoplastic Agents↗

[A risk score for operated endometrial cancer and its importance for adjuvant radiotherapy (histopathology and results of treatment based on 208 cases with pelvic lymph node excision)].

In a retrospective study of 208 surgically treated cases of endometrial cancer with pelvic lymphadenectomy, histomorphology with subtypes, tumour grading, infiltration of the myometrium, blood- and lymphatic vessel invasion and pelvic lymph node metastases, were analysed. Typical adenocarcinomas had lymph node involvement in 9% of the patients, whereas unfavourable subtypes showed in 27%. In patients with tumour grading I, the lymph nodes were involved in only 4.5% and with grading 3 in 31.4%, respectively. If the carcinoma was limited to the endometrium, no lymph node metastases could be detected. If the inner half of the myometrium was involved, pelvic nodes were positive in 9.2% with deeper infiltration in 27.3% of the cases. With obvious invasion of blood or lymph vessels, lymph nodes were positive in 43.2% of the cases. A simple score for these histopathological risk factors is proposed, enabling the allocation to patient groups of similar risk on the basis of a point system for individual prognostic factors. With a score of 1-2 points (13.5% of the cases) the prognosis is good and adjuvant irradiation does not seem necessary. With 3-4 points (34.1% of the cases), local vaginal irradiation is recommended. With 5 or more points, we recommended, in addition to vaginal irradiation, aggressive irradiation of the small pelvis, 52.4% were in this group, from which 85% were symptom-free at the critical 5 year point. In case of positive pelvic lymph node, 67% of the patients survived after adequate adjuvant follow-up irradiation.

Adenocarcinoma↗

[Endoscopic axillary lymph node excision--results of a pilot study].

OBJECTIVE: Assessment of axillary nodal status with reduced shoulder-arm-morbidity remains a major challenge for primary surgery of breast cancer patients. In a pilot study endoscopic axillary lymph node dissection was evaluated. MATERIAL AND METHODS: In 30 breast cancer patients axillary lymphadenectomy was performed after liposuction using an endoscopic approach. During a learning phase of 15 cases an open revision was routinely carried out. Later complete endoscopic lymph node dissection was performed. The exposition of anatomical landmarks, the number of resected lymph nodes, postoperative lymphorrhea, histopathological signs of traumatisation were assessed as well as intra and postoperative complications. RESULTS: In any case we found excellent exposure of anatomical landmarks. Following a learning curve of 15 cases the average number of resected lymph nodes was equal to the average number of lymph nodes resected with conventional techniques (18.2 vs. 18.4, median 17 vs 18). Minimal intraoperative complications were observed. Postoperative lymphorrhea and seroma rate were not remarkably reduced in comparison with open procedures. CONCLUSIONS: Our study demonstrates, that endoscopic lymph node dissection may be performed with a low complication rate and with identical accuracy as achieved by open techniques.

Axilla↗

[Lymph node excision in stomach cancer--a statistical analysis of survival and surgical mortality].

Between January, 1st, 1980 and December, 31st, 1993 all patients with curative removed gastric carcinoma were registered to evaluate the effect of an extended lymph node dissection on prognosis and perioperative risk. Therefore an analysis of all resected lymphatic nodes in 260 patients could be performed. Referring to the depth of tumor infiltration and the extension of the lymph node dissection (< 10 vs > 10 tumor negative lymph nodes) a significant difference could be found only for the pT 2 group. In this group the average survival time could be improved from 21 to 62 months (p < 0.018) by extended lymph node dissection, without increasing the perioperative morbidity. In our experience the extended lymphadenectomy offers a significantly improved survival for patients with non invasive gastric cancer without enhanced perioperative risk or mortality.

Adult↗

[Urinary fistula after radical hysterectomy with lymph node excision].

In 908 radical hysterectomies including dissection of pelvic lymph nodes, 13 (= 1.43%) urogenital fistulas were seen. They occurred postoperatively between the 7th and 15th day. In 12 cases it was a uretero-vaginal and once a vesico-vaginal fistula. The operation report of 7 cases with uretero-vaginal fistula reveals difficulties in separating the ureter in its prevesical part proceeding from tumour spread, endometriosis, scar or bleeding. Since 1985 a percutaneous nephrostomy has been performed (5 cases). 4 fistulas were cured spontaneously, one of them had a percutaneous nephrostomy. In all cases, urography was normal. In 7 cases, ureterocystoneostomy had to be performed. This was done once with fixation of the psoas muscle and 6 times according to Boari. All patients were cured without any complications and with an undisturbed drainage assessed 1 year later by urography. 1 patient, who refused any follow-up, died subsequently. The only vesico-vaginal fistula has been closed by Latzko's procedure. In recent years the problems concerning urogenital fistulas resulting from surgery of cervical cancer have receded. However, if patients adopt an offensive attitude against surgical therapy of stage T2b, the rate of incidence of this complication can be expected to increase.

Adult↗