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The pattern of memory loss resulting from intravenously administered diazepam.

A word recognition task was designed to determine the stage in memory affected by a single 10-mg intravenous injection of diazepam and the duration of the effect. Injection in three experimental subjects produced an anterograde amnesia for the 14 to 24-minute period immediately after injection. Memory loss resulted from impaired storage, the stage during which information is entered into memory. Retention and retrieval stages of memory were unaffected. This temporary amnesia may result from increased inhibition in the hippocampal system produced by diazepam, which shares many properties with the inhibitory neurotransmitter gamma-aminobutyric acid.

Amnesia

A computerised past medical history.

A patient questionnaire has been devised which is amenable to computer analysis, storage and retrieval. The computer prints out two copies of the condensed information, one for the patient and one for the doctor. The scheme has been tested in 100 patients in one practice and patient acceptability is 97 percent. The cost is between $2.50$2.50 and $10.00 per patient. The advantages of such a scheme to the patient, general practitioner, specialist and hospital are discussed.

Attitude to Health

Data storage and retrieval system for a nuclear medicine department.

A mark sense IBM data card was designed specifically for the nuclear medicine department. The data card functions as a flow sheet with coded information added in sequence by secretary, technician, and physician. Statistical information, patient identification, quantitative results, physician interpretation, and discharge diagnosis can be easily coded and entered on the card by the appropriate individual. The completed card can be punched, filed, and retrieved by machine. Filing and retrieving can also be done by hand for flexibility. The stored data can easily by programmed and converted to computer handling and storage. The card is inexpensive to produce. Card design is extremely flexible for varying needs. If sorting and punching equipment is not available, this can be contracted for in the community as low cost.

Information Systems

A dynamic graph for documentation of gestational age.

A graphic format is presented for the display and storage of data relating to gestational age. The graph permits rapid retrieval and synthesis of often confusion information and is thereby useful in the management of complicated pregnancies.

Female

Computer-assisted collection and analysis of pathology data.

At the National Center for Toxicological Research, long-term experiments with mice requiring the collection, storage, retieval, and analysis of an inordinate amount of data necessitated the development of an automated pathology information system. The system included automatic collection of mouse body and organ weights and hematologic findings; the use of mark-sensitive forms for the collection of gross and microscopic findings; and the use of computers for the storage, retrieval, and analysis of pathology data.

Animals

On-line computer storage, retrieval, and reporting of coded angiographic data.

Interpretations of angiographic images have been coded and stored using an on-line computer terminal for seven years. Decoded angiographic information is incorporated in computer-generated reports which are printed on demand after completion of cardiac catheterization procedures. Currently, almost 5,500 cases are stored in an off-line data base which has been designed to help identify patterns with prognostic potential. Also, the program has helped standardize angiographic nomenclature, saved much clerical time, and virtually eliminated clerical errors. The program interacts with other software in the hospital, avoiding repetitious entries. The advantages and shortcomings of the program and commonly used approaches to computer storage/retrieval of radiographic information are described.

Angiography

Research data integrity: a result of an integrated information system.

The toxicologic problems of today frequently require long-term, multidisciplinary experimentation involving large numbers of animals. In order to provide the extensive safety evaluation necessary to produce data that can be reasonably extrapolated to humans, automated research support systems have transcended the position of useful tools and have become an integral part of the total design of experimental protocols. For an automated information system to fully represent the reality of the experiment, it must be able to assure integrity, as well as provide for the storage, calculation, and retrieval of data values of the quality and quantity necessary for fulfilling protocol requirements. Guarantees against error and loss of data, in addition to flexibility and easy access, must be an inherent part of the system if the acceptance and condifence of the investigator are to be obtained. This paper discusses the criteria, philosophies, and benefits of integrated data systems that ensure integrity of toxicologic research support.

Computers

A computer system automatic analysis of vectorcardiograms.

This computer system performs the analysis of orthogonal electrocardiograms for vectorcardiographic (VCG) display and classification. The data acquisition can be performed 'on-line' with the complete analysis in 'real-time', or off-line by processing a magnetic tape. The original computational methods for beat averaging and wave recognition are described. Some features, such as the quality of the visual display of the VCG traces, the availability of a measurement matrix allowing the quantitative analysis of the VCG and the use of a data bank for storage, retrieval and statistical studies make this system very efficient for clinical purposes, introducing the concept of 'Computer Assisted Vectorcardiography'.

Diagnosis, Computer-Assisted

Gas chromatographic-mass spectrometric-computer methods in the study of drug metabolism.

The computer-assisted interpretation of repetitively scanned mass spectra can be of great value in the analysis of a complex mixture even in the absence of a library of reference spectra. We have written a set of interpretation programs for a PDP11/45 laboratory computer. A file structure is used that combines economy of storage with ease of creation and retrieval. User interaction is by a simple command language implemented by an interpreter. The program structure is such that additional functions can be added easily.

Chromatography, Gas

An interactive toxicological data handling system for a PDP-12 computer.

This paper describes a program developed for the cataloguing, storage and retrieval of toxicological data. The user can, through dialogue with the program, enter and update data, and request reports with statistical analyses. The system is written in the FOCAL-12 language for a PDP-12 laboratory computer, and is suitable for a larger number of moderately-sized experiments.

Computers

Computer assisted monitoring in intensive medicine.

Intensive Medicine is always associated with the problem of handling the mass and assuring the quality of information on vital signs, fluid and blood balance, laboratory data, physiological calculations, etc., required in patient care. A computer based monitoring system for intensive care was introduced in 1973 at the Academic Hospital in Leuven. The basic software was developed at the Peter Bent Brigham Hospital of the Harvard Medical School and the medical division of the Hewlett Packard Company; the computer used was a H.P. 2100 central processor with 32K of core memory. Initially, the program allowed mainly acquisition, storage and retrieval of bedside monitored and manual data of cardiac and circulatory function. Very soon however, the software was extended and modified by the division of "Medical Informatics" in order to meet new or different requirements. In the present situation our vision on the use of computer-assisted monitoring has changed and our present program has been extended as follows : 1. On-line collection and retrieval of bedside monitored data including heart rate, arterial blood pressure (systolic-diastolic-mean) left atrial pressure, central venous pressure, pulmonary artery pressure, intracranial pressure. Trend analysis of those data, with calculation of mean values, standard variation and corresponding t-tests. 2. Computer assistance in performing time consuming calculations on off-line data such as : -- clearance-values (renal function), -- temperature-correction of blood-gasvalues, -- hour-to-hour fluid balance, including calculation of in-sensible losses, -- blood-balance. 3. Data transmission of laboratory results as soon as available in the central laboratory through a direct link between laboratory and I.T.U. 4. Computer assisted E.C.G. analysis. The three first objectives are realised, on-line E.C.G.-analysis is being developed. The same computer serves the remotely located medical and coronary care units and one bed in the emergency department. An assessment of computer assistance in intensive therapy, on nursing labor and on quality of patient care is made.

Clinical Laboratory Techniques

Computer data processing of medical diagnoses in pathology.

Modes of insertion of pathology diagnoses into a computer data storage and retrieval system are reviewed. The conversion of free-flowing diagnostic sentences into internal code is considered, and the advantages of coding are discussed from two aspects: (a) to minimize storage, and (b) to help alleviate difficulties in retrieval of synonymous terminology. Methods of manually pre-coding diagnoses into Systemized Nomenclature of Pathology (SNOP) code are discussed. Data encoding produces a fixed format record which provides significant economy in data handling. The potential use of a real-time visual display unit in data gathering and automatic coding is presented.

Diagnosis, Computer-Assisted