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At least 55 records · Page 3Linked to original sources
PubMed1998

Identifying influential families using regression diagnostics for generalized estimating equations.

The Generalized Estimating Equations (GEE) is an approach to analyze correlated data. It is applied here to data from an epidemiological study of oesophageal cancer in a high incidence area in China to investigate familial aggregation. Regression diagnostics for mean structures and association structures are used to identify families that influence estimates of these structures. It is shown that most of the families influencing the mean structure have a low age of disease onset in common. Most families identified by regression diagnostics for the association structure influence the parent correlation. It is concluded that regression diagnostic techniques can be used to identify clusters influencing mean and association structures of the models.

China↗
PubMed1999

Identifying influential individuals in linkage analysis: application to a quantitative trait locus detected in the COGA data.

Once linkage is detected to a quantitative trait locus (QTL), the next step towards localizing the gene involved may be to identify those families, or individuals, in whom the putative mutations are segregating. In this paper, we describe a jackknife procedure for identifying individuals (and families) who contribute disproportionately to the linkage. Following initial detection of linkage to a QTL, the strategy involves sequentially removing each individual (or each family) from the analysis and recomputing the lod score associated with the linked region using data from all remaining subjects (or families). This procedure can be used to determine if particular observations have substantial impact on evidence for linkage. Identification of such observations may provide insights for further efforts to localize the QTL.

Alcoholism↗
PubMed1976

Time course of nigrostriatal degeneration in parkinson's disease. A detailed study of influential factors in human brain amine analysis.

It could be shown that the post mortem analysis of biogenic amines, precursors and metabolites in the human brain are influenced by various parameters. 1. The patient's medical history; long term observations of the course of the disease; age; sex. 2. Terminal illness; duration of terminal illness. 3. Previous treatment with drugs; last drugs. 4. Time interval between last drug treatment and death; time of day and date of last drug consumption. 5. Rapidity of death; time of death; duration of coma. 6. Changes occurring in tissues before death; patients' constitution during terminal illness. 7. Changes in concentration of the biogenic amines, precursors, and metabolites depending on the patient's age. 8. Time between death and necropsy. 9 Dissection of specimen. 10. Period of storage; temperature of storage. 11. Chronbiological rhythm of substances. 12. Methods of assayL 13. Homogeneity of all mentioned parameters in the control group and patient's group. For the first time it could be demonstrated that the time course of nigrostriatal degeneration, independent of the age of the parkinsonian at the beginning of the illness, is linear for the last stage and the denervation progressively increases as the duration of illness progresses.

Age Factors↗
PubMed1993

Graft isometricity in unitunnel anterior cruciate ligament reconstruction: analysis of influential factors using a radiographic model.

A radiographic model was developed to investigate the influence of three surgical variables on the change in attachment point distance (CAPD) of a hypothetical graft using the unitunnel technique of anterior cruciate ligament (ACL) reconstruction. Using three different femoral target points, we tested the hypothesis that varying the angle of knee flexion between 70 degrees and 110 degrees and varying the tibial starting point over a 4-cm range do not result in a significant variation in CAPD. We also tested the hypothesis that the CAPD from 0 degrees to 135 degrees is greater than the CAPD from 0 degrees to 90 degrees. There was a statistically significant correlation (r = 0.8465, P < 0.0001) between radiographically estimated and isometer-measured values of CAPD. The tibial starting point and the femoral target point were found to affect the CAPD significantly (P < 0.005). A more proximal tibial starting point was associated with a lower CAPD. Both the center of the anatomic femoral attachment of the ACL, and a point 1 mm medial to the junction of the roof and lateral wall of the femoral intercondylar notch and 6 mm anterior to its posterior margin, were associated with lower CAPD values than a target point 5 mm superior and posterior to the center of the femoral ACL attachment. The angle of knee flexion did not significantly affect the CAPD. The CAPD [0 degrees-135 degrees] was significantly greater than the CAPD [0 degree-90 degrees] for all combinations of variables (P < 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)

Anterior Cruciate Ligament↗
PubMed2001

[Ethical conflicts in involuntary treatment of schizophrenic patients; decision-making and in influential factors in three prototype cases].

Three case reports of patients with schizophrenia were presented to a sample of 520 persons (25.1% psychiatrists, 3.7% psychologists, 8.1% social workers, 14.6% nurses, and 48.6% others). The decisions for involuntary admission to a psychiatric hospital and involuntary treatment were questioned. In case 1 (young man, first episode, delusions, extreme social withdrawal), 71.7% supported admission to hospital and 62.7% were in favor of neuroleptic treatment. In case 2 (woman with disorganized syndrome beating her 74-year-old mother), 84.6% supported hospitalization and 78.8% neuroleptics. In case 3 (relapsed multi-episode patient, increasingly neglected, delusional, and socially withdrawn), 56.3% supported hospitalization and 52.7% neuroleptics. Generally, psychiatrists' decisions were very similar to those of other professionals and laypersons, while social workers more often rejected involuntary treatment. After professional status, multivariate analyses revealed older age as the most significant variable for support of involuntary treatment. Frequency of experience with mentally ill persons were only weak predictors or not significant.

Adolescent↗
PubMed2001

Investigating Influential Factors on Bacterioplankton Community Composition: Results from a Field Study of Five Mesotrophic Lakes.

In order to investigate which biotic and abiotic factors may have an impact on the community composition of bacterioplankton, five mesotrophic lakes were studied. The composition of the bacterioplankton communities was determined by denaturing gradient gel electrophoresis (DGGE) of 16S rDNA. Multivariate statistical analyses of the gel patterns, in relation to each other and to the chemical, biological, and physical parameters of the lakes, were performed. The analyses showed that the import of allochthonous bacteria and the interaction with other plankton organisms (for example, grazing) in the lakes probably had an impact on the composition of the communities.

Journal Article↗
PubMed1996

Both alpha and beta chain polymorphisms determine the specificity of the disease-associated HLA-DQ2 molecules, with beta chain residues being most influential.

We compared the peptide binding specificity of three HLA-DQ molecules; HLA-DQ(alpha1(*)0501, beta1(*)0201), HLA-DQ(alpha1(*)0201, beta1(*)0202), and HLA-DQ(alpha1(*)0501, beta1(*)0301). The first of these molecules confers susceptibility to celiac disease and insulin-dependent diabetes mellitus, while the two latter molecules, which share either the alpha chain or the nearly identical beta chain with HLA-DQ(alpha1(*)0501, beta1(*)0201), do not predispose to these disorders. The binding of peptides was detected in biochemical binding assays as inhibition of binding of radiolabeled indicator peptides to affinity-purified HLA-DQ molecules. Binding experiments with several peptides demonstrated a clear difference in peptide binding specificity between the three HLA-DQ molecules. Further, single amino acid substitution analyses indicated that the HLA-DQ molecules have different peptide binding motifs. The experimental data were corroborated by computer modelling analysis. Our data suggest that the three HLA-DQ molecules prefer large hydrophobic residues in P1 of peptides with subtle differences in side-chain preferences. HLA-DQ(alpha1(*)0501, beta1(*)0201) and HLA-DQ(alpha1(*)0201, beta1(*)0202) both prefer large hydrophobic residues in P9, whereas HLA-DQ(alpha1(*)0501, beta1(*)0301) prefers much smaller residues in this position. HLA-DQ(alpha1(*)0501, beta1(*)0201) and HLA-DQ(alpha1(*)0201, beta1(*)0202), in contrast to HLA-DQ(alpha1(*)0501, beta1(*)0301), prefer negatively charged residues in P4 and P7. A less prominent P6 pocket also appears to differ between the three HLA-DQ molecules. Our results indicate that polymorphic residues of both the alpha and the beta chain determine the peptide binding specificity of HLA-DQ(alpha1(*)0501, beta1(*)0201), but that the beta chain polymorphisms appears to play the most important role. The information on peptide residues which are advantageous and deleterious for binding to these HLA-DQ molecules may make possible the prediction of characteristic features of peptide that bind to HLA-DQ(alpha1(*)0501, beta1(*)0201) and precipitate celiac disease.

Amino Acid Sequence↗
PubMed1985

A robust microcomputer routine for the identification of outlying and influential points in radioimmunoassay standard curves.

This paper describes a suite of robust logit-log optimization routines for the fitting of a linear relation to laboratory data. The microcomputer routines assign a weighting value to each data point corresponding to the relative importance of that point. This procedure ensures that the routines identify and deal with any outlying data points. The routines are designed to generate the results of both a standard, unweighted least-squares algorithm and a robust, weighted algorithm thus providing the laboratory analyst with invaluable information concerning the data and the fitted relation. The routines are thoroughly tested on "perfect" and perturbed laboratory data.

Biometry↗
PubMed2002

Factors influential in making an injury severity difference to older drivers involved in fixed object-passenger car crashes.

To identify factors influencing severity of injury to older drivers in fixed object-passenger car crashes, two sets of sequential binary logistic regression models were developed. The dependent variable in one set of models was driver injury severity, whereas for the other it was the crash severity (most severe injury in the crash). For each set of models, crash or injury severity was varied from the least severity level (no injury) to the highest severity level (fatality) and vice versa. The source of data was police crash reports from the state of Florida. The model with the best fitting and highest predictive capability was used to identify the influence of roadway, environmental, vehicle, and driver related factors on severity. Travel speed, restraint device usage, point of impact, use of alcohol and drugs, personal condition, gender, whether the driver is at fault, urban/rural nature and grade/curve existence at the crash location were identified as the important factors for making an injury severity difference to older drivers involved in single vehicle crashes.

Accidents, Traffic↗
PubMed1997

Influential factors of caregiver behavior at mealtime: a study of 24 child-care programs.

OBJECTIVE: To measure the nutrition knowledge and attitudes of caregivers in child-care programs and to observe the behaviors of caregivers as they interact with children at mealtime. DESIGN: A nonexperimental research design. Nutrition knowledge and attitudes toward nutrition were measured using survey methodology designed for this study. Observers measured caregiver behavior by means of observation and quantified it using a behavior checklist. Interrater reliability was 98%. Instruments were piloted and content validity was established. Using Cronbach's alpha, reliability was .69 and .67, respectively. SUBJECTS/SETTING: Participants were 113 caregivers in 24 licensed child-care programs in three counties in Illinois. STATISTICAL ANALYSES PERFORMED: The independent variables (caregiver nutrition knowledge, caregiver nutrition attitudes, years of teaching, prior nutrition training, and education level) were correlated to the dependent variable (caregiver behavior), using the Pearson product moment correlation. The combination of variance from all independent variables was analyzed using the general linear regression model. RESULTS: Although caregivers held beliefs that should have a positive influence on children's eating behaviors, they demonstrated low knowledge of nutrition and displayed behaviors at mealtimes that were inconsistent with their beliefs and expert recommendations. Positive correlations were found between nutrition knowledge and behavior at mealtime, nutrition knowledge and attitudes, and attitudes and caregiver behavior. APPLICATIONS: These instruments can be used to assess and teach nutrition practices through self-assessment, training, and coursework. Results also begin to define the role of the caregiver in children's nutrition practices. Results demonstrate that caregiver behavior can be enhanced by addressing nutrition knowledge and attitudes.

Adolescent↗
PubMed2001

Laser supraglottoplasty for laryngomalacia: are specific anatomical defects more influential than associated anomalies on outcome?

OBJECTIVE: To evaluate different CO2 laser procedures on children with various types of laryngomalacia and determine the role of associated anomalies on the outcome. DESIGN: Retrospective chart review. SETTING: Academic tertiary referral center. PATIENTS: Twenty-three children who underwent laser supraglottoplasty for laryngomalacia between 1991 and 1998 at the UC Davis Medical Center. INTERVENTIONS: CO2 laser vaporization of redundant supraglottic mucosa of the aryepiglottic fold, arytenoid, and the epiglottis, or modification of the latter, either individually or in combination, based on the obstructing anatomy. OUTCOME MEASURES: Immediate, short term, intermediate and long term relief of respiratory symptoms, feeding difficulties, effect of associated anomalies on outcome, effect of specific anatomic obstructing site and surgical procedure performed on outcome, and the incidence of complications inherent to the procedure. RESULTS: Children without associated anomalies invariably did very well, with 78% immediately resolving their respiratory symptoms and 100% within a week. Twelve of the 14 patients with unfavorable immediate results (P<0.01) and all ten with short term unfavorable results (P<0.05) had neurologic or anatomic associated anomalies. Seven patients, all with associated anomalies, were considered surgical failures (P<0.05). These patients also had a significantly longer hospital stay (P<0.01). The presence of associated anomalies was significant (P<0.01) in determining surgical treatment of reflux or the need for an NG tube in treating feeding problems. The anatomic site of abnormality and the specific procedure performed did not affect the outcome. There were no serious complications inherent to this procedure. CONCLUSIONS: Laser supraglottoplasty, in its different modalities, is a safe and effective treatment for all types of laryngomalacia, but children with associated neurologic or anatomic anomalies will have a more complicated immediate and short term course, as well as a significant incidence of failure. Gastroesophageal reflux is an important associated condition that requires investigation in these patients, and in severe cases will merit surgical procedures to manage. The high incidence of associated neuromuscular anomalies suggests that this component has an important role in the etiology of laryngomalacia.

Child↗
PubMed1999

Evaluation of urinary cadmium and lead as markers of background exposure of middle-aged women in Korea: dietary intake as an influential factor.

The study was conducted to examine the validity of urinary cadmium (Cd) and lead (Pb) in comparison with the metals in blood as a biological marker of non-occupational exposure of general populations. Participants in four survey sites in Korea (107 non-smoking Korean women aged 30-49 years) offered peripheral blood, morning spot urine, and 24-h total food duplicate samples. Analysis of Cd and Pb was accomplished by graphite furnace atomic absorption spectrophotometry. The analyse levels were evaluated on an individual basis (n = 107) and also on a survey site basis, i.e. in terms of geometric means for the groups in the survey sites (n = 4). Cd in urine (as observed, or after correction for creatinine concentration or a specific gravity) correlated with Cd in blood on an individual as well as survey site basis, and tended to correlate with Cd in food duplicates on the survey site basis. Correlation of Pb in urine with Pb in blood was weaker than that of Cd in urine with Cd in blood both on the individual and survey site basis. Pb in urine correlated with Pb in food duplicates either weakly or even negatively when examined on a survey site basis. It was concluded that Cd in urine can be most probably employed as a biological marker of environmental Cd exposure of general population, whereas less support was obtained for Pb in urine as an exposure marker.

Adult↗
PubMed1992

Influential factors in cemented acetabular cup loosening.

To delineate further the cause of acetabular loosening in a group of 238 total hip arthroplasties performed between 1980 and 1982, the authors subjected those total hip arthroplasties to a multifactorial analysis utilizing the log normal model. Data collected on each patient consisted of age, sex, weight at the time of surgery, diagnosis, cement thickness between zones 1 and 2 and between zones 2 and 3, polyethylene thickness, lateral tilt, and metal backing of the acetabular components. The acetabulum was considered a failure by radiographic loosening with migration greater than 5 mm, revision in patients younger than 60 years of age (P = 0.154), or when the acetabular cup was metal-backed (P = .001).

Aged↗
PubMed1999

Attitudes and Approaches of Influential Role Models in Clinical Education.

The influence of a role model is a frequently cited factor in choosing a specialty choice among medical students, particularly primary care oriented students. While many studies have looked at role modeling from students' perspectives, very few have considered role modeling characteristics from the perspective of the role models. This study, using the principles of Bandura's social learning theory, determined and illuminated the characteristics and teaching methods associated with positive role modeling in clinical education from the perspective of the role model. A qualitative approach employing interviews and observations was used. Five themes emerged: the role models' approaches to teaching, their attitudes towards teaching and learning, their emphasis on clinical competence in their teaching, their roles external to their specific responsibilities, and their general affect. We found that role models were similar in their views of teaching and working with students. Also, their teaching characteristics were similar to the recommended approaches found in the literature and adhered to the principles of social learning theory. Role models were attentive to the needs of the students and tailored their teaching appropriately. They provided students with ample patient interaction so that students could apply their classroom knowledge. They also demonstrated how rewarding being an effective physician can be.

Journal Article↗