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PubMed1968

[Heart injuries].

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Heart Injuries↗
PubMed2002

Use of zafirlucast, cysteine-containing leukotriene antagonist, in epinephrine-induced heart injury.

Combination of preventive and repeated (after 12 h) injections of zafirlucast in a daily dose of 40 mg/kg to animals with epinephrine-induced heart injury essentially decreased the content of leukotriene C(4), but did not prevent the increase of leukotriene B(4)content in the blood, though decreased its content in comparison with the level observed 24 h after epinephrine injection by 11%. Two injections of zafirlucast had a favorable impact on serotonin content in the myocardium (this parameter decreased by 19%), promoted a decrease in epinephrine content and normalization of the norepinephrine/epinephrine ratio, did not change prostaglandin content and ratio, and slightly decreased histamine content in the myocardium. The effect of zafirlucast can be explained by a decrease of oxidative stress. Zafirlucast decreased blood content of myofibrillar fraction of creatine phosphokinase (by 22%) and slightly improved elastic characteristics of erythrocytes. These results suggest that zafirlucast can be added to combined therapy of necrotic, stress-induced, hypoxic, and ischemic injuries of the myocardium.

Animals↗
PubMed1998

A serial echocardiographic observation of acute heart injury associated with pheochromocytoma crisis.

There are no previous reports of serial echocardiographic findings in patients with pheochromocytoma. We report a 50-year-old woman with pheochromocytoma who developed acute heart injury. Echocardiography revealed that the acute myocardial injury started early in the base and subsequently extended to the mid-portion of the heart. The injury persisted longer in the base than in the mid-portion.

Adrenal Gland Neoplasms↗
PubMed1985

Cardiac evaluation following heart injury.

Both penetrating and blunt cardiac injuries require urgent management. Delayed sequelae and complications have been reported to occur in 4 to 56% of survivors and frequently required secondary surgical corrections. Between January 1980 and June 1984, 204 patients presented with heart injuries. One hundred twenty-eight of these patients survived. Of the 90 undergoing cardiorrhaphy in the operating room, 78 survived. Two-dimensional (2-D) and pulsed-Doppler echocardiography (echo) and/or cardiac catheterization were performed in 40 patients for suspected significant residual injury. Eight of the 40 required secondary cardiac operations. Two-dimensional echo demonstrated pericardial effusion, abnormal chamber enlargement, abnormal cardiac wall motion, intracardiac missile, and intracardiac and pleural thrombus. Pulsed-Doppler findings included ventricular septal defect, tricuspid insufficiency and right ventricular turbulence secondary to arteriovenous fistulae. Cardiac catheterization detected lesions undetected by 2-D echo in one patient with a gunshot wound. It is concluded that in the absence of cardiac bullets seen on routine chest X-ray, 2-D with pulsed-Doppler echo is an excellent screening technique. With a positive echo study or a residual bullet overlying the cardiac silhouette, cardiac catheterization is indicated in selected patients.

Adolescent↗