Halcinonide (Halog)--another new topical steroid.
Explore the source record for details and available documents.
Acetals↗
SEARCH · Search PubMed
Results for “Halcinonide”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Clinical evaluation of a new halcinonide-antifungal combination.
Explore the source record for details and available documents.
Administration, Topical↗
Topical treatment of inflammatory dermatoses and cutaneous candidiasis with a new cortico-steroid -antibiotic combination: halcinonide-neomycin-amphotericin.
Explore the source record for details and available documents.
Administration, Topical↗
[Comparative studies with Halcinonide and fluocortolone in local administration].
Explore the source record for details and available documents.
Administration, Topical↗
The influence of topical steroid application on tuberculin skin reactions in healthy persons.
Thirty-seven healthy persons were studied in order to evaluate the influence of topical steroid application on tuberculin skin reactions. Four areas measuring 4 cm in diameter were each treated with 50 micrograms of hydrocortisone cream 1%, or 50% micrograms of halcinonide (Halog) cream 0.1%, or 50 micrograms of unguentum cetacei simplex (cold cream), or not treated. The creams were applied once daily for 3 days before and one day after a tuberculin skin test. After 24 and 48 hours the area of induration were measured. We observed that application of unguentum cetacei simplex increased the size of the induration at the 24-hour reading, but not after 48 hours. Hydrocortisone cream 1% gave the same effect, whereas halcinonide cream (Halog) 0.1% caused ischaemia of the skin and reduced the induration of the skin test after 24 hours, but not after 48 hours. In 12 persons we found that simple rubbing of the skin with halcinonide cream base did not affect the size of the tuberculin skin reaction. In the present study we found that even very potent local steroid application on intact skin could only delay the development of tuberculin skin reactions, but could not diminish their size.
Administration, Topical↗
Psoriasis: treatment with a new topical corticosteroid.
A total of 60 patients was treated for psoriasis in a double-blind, paired comparison study of 0.1% halcinonide with an active corticosteroid comparison drug as topical creams. An overall evaluation of comparative responses clearly demonstrated the superiority of halcinonide in a greater number of patients. Separate evaluation of the overall therapeutic responses also favored halcinonide, with a good to excellent response in 80% of patients compared to 65% with the control drug.
Administration, Topical↗
Evaluation of topical anti-inflammatory steroid formulations in an Arthus model of inflammation.
Formulations of a number of steroids were evaluated after topical application in a reversed passive Arthus test (RPA) in rabbits. Four 21-chlorosteroids in the same cream base were investigated. The preparations of SQ 18,566 (halcinonide) and SQ 20,811 showed anti-edema activity, but those of SQ 15,361 and SQ 20,589 were less active. Ointment formulations of halcinonide also reduced edema in the RPA. These results, coupled with previously reported clinical data, suggest that the RPA might be utilized to distinguish good from poor formulations of anti-inflammatory steroids prior to screening tests or clinical trials in humans.
Administration, Topical↗
[Thermographic study of the percutaneous absorption of corticosteroids].
The results of a study on the percutaneous absorption of two corticosteroids, Halcinonide at 0.1% and Triamcinolone acetonide at 0.1%, employing an original thermographic method, are reported. In a first group of subjects treated with one application of the two corticosteroids a stronger activity of the Halcinonide was found than in a second group of subjects, after repeated applications, resulting progressively more evident and of longer duration in comparison with Triamcinolone.
Administration, Cutaneous↗
[Comparison of 3 corticoid preparations with the vasoconstriction and erythema test].
The efficacy of a new topic preparation of the corticosteroid Halcinonide containing 5% Urea has been examined and then compared with two commercial preparations of Halcinonide and Betamethasonevalerate respectively. Although these two corticosteroids usually do not belong to the same class of potency, there could not be found any significant difference neither with the vasoconstriction assay nor with the Pyrexal erythema. The influence of the three most important parameters, that are vehicle, occlusion and skin condition, is a subject of discussion.
Administration, Topical↗
Topical glucocorticoids modulate the lesion interface after cerebral cortical stab wounds in adult rats.
A lesion interface, consisting of a glia limitans lined by a laminin-rich basal lamina and leptomeningeal cells, forms within 2-3 weeks after penetrating wounds to the adult mammalian central nervous system (CNS). This interface prevents the growth of axons across the lesion. We have examined the effects of topically applied steroids on the formation of such an interface after stab wounds to the adult rat cerebral cortex. Immediately after lesioning, the surface of cortex in the region of the wound was treated with a topical application of either 0.1% halcinonide or 0.05% betamethasone dipropionate or their respective placebos. Cryostat sections through the lesioned area were obtained 3 weeks later and assessed by immunofluorescence. Steroid treatment attenuated all components of the lesion. The continuous anti-laminin labeling along the lesion in untreated rats became patchy after steroid treatment. The number of leptomeningeal cells that infiltrated into the wound was reduced in the laminin-negative regions in steroid-treated rats. In addition, astrocytic processes in the laminin-negative regions after steroid treatment were loosely arranged, compared with the tightly packed parallel processes forming the glia limitans in laminin-positive regions in controls. The mechanism of steroid-mediated attenuation of the lesion interface was examined in vitro. Betamethasone but not halcinonide reduced laminin secretion slightly in leptomeningeal cell cultures, but both steroids reduced cell proliferation. These results suggest that steroids modulate the formation of the lesion interface after CNS injury, at least in part by decreasing leptomeningeal cell proliferation. Such modulation of the lesion interface by steroids or other agents may permit the growth of axons across the lesion site and thus could enhance the overall degree of axon regeneration if other factors such as neurotrophic support and neutralization of axon growth inhibitory molecules are optimized.
Animals↗
Psoriasis: topical corticosteroid therapy.
Fifty-nine patients with bilateral psoriatic lesions were subjects in a double-blind paired comparison of halcinonide cream and fluocinonide cream. They applied the corticosteroid creams twice a day for 14 days without occlusive dressings. Objective and subjective assessment of response to therapy was made four or five days, one week, and two weeks after starting treatment. The results were analyzed by statistical methods. At the second visit (day 4 or 5), there was little difference between the two compounds, but at visits three and four, reduction of inflammation was significantly better with halcinonide than with fluocinonide.
Adult↗
Induction of glycosuria and hyperglycemia by topical corticosteroid therapy.
A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion. A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. Two additional patients with midly abnormal responses to glucose tolerance tests showed no evidence of altered glucose metabolism when treated with halcinonide cream in a similar manner.
Administration, Topical↗
Influence of the base on the results of clinical trials with topical corticosteroids.
A comparative trial between betamethasone valerate and halcinonide has shown the former to be superior, thus contradicting the results from other trials. It is thought that the discrepancy is due to differences in the nature of the preparations used in the various studies. It is suggested that note is made of the base used in trials before final conclusions about the efficicacy of steroids are made.
Administration, Topical↗
Comparative merits of two topical corticosteroid antimicrobial drugs.
The anti-inflammatory and antimicrobial activities of two topical creams, one containing halcinonide, neomycin and nystatin (HNN), and the other betamethasone valerate, gentamicin, iodochlorhydroxyquin and tolnaftate (BGI), were compared in a randomized, parallel study of 154 patients (eighty-seven secondarily infected eczematous dermatoses; sixty-seven cutaneous candidiasis). Repeated clinical assessments showed that the two creams produced equivalent therapeutic responses both in patients with infected eczematous lesions and candidiasis. HNN and BGI creams eradicated the bacterial pathogens isolated prior to treatment in 80% and 76%, respectively, of the patients with eczematous dermatoses. The organism most frequently isolated in these patients was S. aureus. Local irritation prompting discontinuance of therapy occurred in just one patient receiving HNN, and two patients receiving BGI.
Administration, Topical↗
A trial of the Actiderm dermatological patch and topical corticosteroids in the treatment of psoriasis vulgaris. The Actiderm Multi-Center Study Group.
The use of the Actiderm dermatological patch in conjunction with topical corticosteroids was evaluated in a multi-centered, paired-comparison study of 189 patients with chronic psoriasis. In each patient, two lesions of comparable severity were selected for treatment. One plaque was treated with a twice-daily application of a steroid cream (triamcinolone acetonide 0.1 percent, betamethasone valerate 0.1 percent, or halcinonide 0.1 percent) while the second plaque was treated with a forty-eight hour application of the same steroid cream under Actiderm. At follow-up visits during the three-week treatment period and at four weeks post-treatment, the lesions were evaluated for the following parameters: erythema, induration, scale, and fissuring. For each of the three steroid preparations, the Actiderm and steroid therapy produced significant improvement in all parameters compared to the steroid therapy alone. This improvement was sustained through the post-treatment phase (p is less than 0.05 in all groups). No measurable differences in therapeutic efficacy were identified among the three steroid groups. Reports of adverse experiences in the Actiderm and steroid groups were infrequent. We conclude that the Actiderm and steroid combination is a safe and highly effective treatment for psoriasis.
Administration, Topical↗
[The effect of urea in a topical corticoid preparation on vasoconstriction].
It was checked by vasoconstriction tests, whether a new topical preparation containing 0.1% halcinonide in combination with 10% urea possibly caused an increase in vasoconstriction. There was no significant difference found between the preparations with and without urea.
Administration, Topical↗
Differential borohydride assay for conjugated ketosteroids: improvement with propylene glycol.
A previously developed differential UV assay for 3-one-4-ene steroids involving reduction with sodium borohydride was frequently found to be less than 100% complete. Such incomplete reduction can be mimicked by additions of sodium metaborate, a product of the hydrolysis of sodium borohydride, to the reaction system. Complete reduction can be achieved by adding propylene glycol to the reduction system. The phenomenon was studied using halcinonide as a model.
Administration, Topical↗
Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments.
Simple laboratory methods for quantitating the topical anti-inflammatory activity of steroidal ointments are described. One is of croton oil ear edema in rats and the other is a new method using homologous passive cutaneous anaphylaxis (PCA) in rats. In order to avoid problems such as the animals' licking and/or rubbing the ointment at the applied sites, which might result in oral uptake, each rat was housed individually and fitted with a plastic collar in the croton oil experiment. The sites of ointment application in the PCA experiment were covered with adhesive plaster. Optimal experimental conditions were as follows. In the former method, ointments were applied to the inside surface of the ear 5 min after the irritant treatment and anti-edematous activity was determined after 6 h. In the latter, ointments were applied 3 h before the antigenic challenge to the dorsal area of animals which had been passively sensitized by anti-serum, and inhibition of the increased permeability was determined 45 min after the challenge. These methods were found to be reliable with respect to sensitivity and reproducibility of data. Ointments of halcinonide, betamethasone-17-valerate, hydrocortisone-17-butyrate, fluocinonide, flumethasone-21-pivalate and beclomethasone-17,21-dipropionate were evaluated by these methods.
Administration, Topical↗