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Complete resolution of CMV-associated acute hydramnios by single large volume reduction amniocentesis and maternal indomethacin. A case report.

Acute hydramnios is a rare complication of pregnancy, usually of idiopathic etiology and associated with a very poor perinatal prognosis. In this single case report, acute hydramnios at 21 weeks' gestation, associated with fetal CMV infection, was treated by a single large volume reduction amniocentesis combined with maternal indomethacin therapy and result in delivery of a near term survivor.

Adult↗

Chorioangioma with hydramnios and intra-uterine fetal death.

Chorioangiomas are benign placental tumours derived from fetal vessels, that occur with a frequency of approximately 1%. Often they are associated with hydramnios and intra-uterine fetal death. Based on a case of multiple chorioangiomas with a fatal course for the baby, aspects of the pathogenesis of hydramnios are discussed. Future development in ultrasounc technology may facilitate antenatal diagnosis.

Adult↗

[Fetal pseudohypoaldosteronism: a rare cause of hydramnios].

PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition. However a growth deficiency (-2 SDS) persists at follow-up.

Female↗

[Fetal pseudohypoaldosteronism: rare cause of hydramnios].

PHA is a rare cause of hydramnios, characterized by increased amniotic fluid levels of aldosterone and sodium. Two distinct genetic entities (PHA type I and PHA type II) are included. Both are stemmed by a target organ defect with diminished renal tubular responsiveness to aldosterone. The AA present a case in which pregnancy resulted in a preterm infant with severe hydramnios, metabolic acidosis, hyponatriemia, hyperkaliemia. Salt and fluid replacement significantly improved clinical and metabolic condition. However a growth deficiency (-2 SDS) persists at follow-up.

Adult↗

Hydramnios associated with congenital mesoblastic nephroma: case report.

A case is reported of hydramnios due to excessive fetal urine production associated with congenital mesoblastic nephroma. Rapid growth of a right renal tumor and excessive fetal urine production were detected by measuring the size of the tumor and hourly fetal urine production during the development of hydramnios between 28-34 weeks of gestation. A female infant weighing 2200 g was born at 34 weeks' gestation. She lost 18% of her birth weight in the first 48 hours because of neonatal polyuria. Right nephrectomy and ureterectomy were performed 2 days after birth. After the operation, the neonatal polyuria improved dramatically. The right renal tumor was identified histologically as a mesoblastic nephroma. The importance is stressed of early and correct antenatal diagnosis of a renal tumor and precise estimation of urine production for postnatal management of hemodynamic change in cases of mesoblastic nephroma.

Adult↗

Hydramnios with hydrops fetalis and disseminated fetal neuroblastoma.

A white primigravida with acute toxemia and hydramnios delivered a hydropic male infant who died. A neuroblastoma of the right adrenal gland was found with metastic spread to the liver and other organs. The placental capillaries contained tumor cells. Pathogenesis of hydrops, hydramnios, and maternal toxemia and the consequence of tumor cells in the placenta are discussed.

Adrenal Gland Neoplasms↗

[Hydramnios as evidence of Steinert's congenital myotonic distrophy (author's transl)].

The authors describe a case of Steinert's disease. It was tracked down because of three anomalies of pregnancy: a lessening in active movements of the fetus, breech presentation and hydramnios, and it was diagnosed by neurological and electromyography of the mother. The existence of hydramnios should make it possible to avoid maternal trauma during the delivery, knowing that the child will be born with a very severe form of the illness, which is likely to be lethal. Those few cases that survive are severely mentally handicapped.

Adult↗

Monozygotic twins discordant for urinary tract anomalies and presenting as hydramnios.

This report describes premature monozygotic twins, 1 of whom had an unusual clinical manifestation of a rare congenital anomaly, the other being normally developed. Hydramnios had been suspected during pregnancy and, because of the severity, amniocentesis was attempted. However, it became evident that the hugely distended abdomen did not indicate hydramnios, the pregnancy actually being complicated by oligohydramnios. Pulmonary hypoplasia was the cause of the immediate neonatal demise of 1 twin; the other expired after prolonged therapy for meconium aspiration. No similar cases have been reported in the literature which is reviewed briefly. Particular attention is given to discordant anomalies in monozygotic twins, the mode of their placentation, and the development of amnion nodosum.

Abnormalities, Multiple↗

[Hydramnios and fetal malformations. Use of estimating the level of alpha-fetoprotein and of bilirubin in the amniotic fluid during the last trimester of pregnancy (author's transl)].

Alpha-fetoprotein (AFP) levels in amniotic fluid have been measured by electro-immunodiffusion methods in the last trimester of pregnancy. 122 samples have been taken by abdominal amniocentesis during 58 pregnancies without hydramnios and 51 pregnancies with hydramnios. The level of AFP was always less than 1.2 mcg/ml when the children were normal in the latter group. On the other hand levels were higher than 1.2 mcg/ml in 17 out of 19 abnormal children. These had 5 neural tube abnormalities, 1 hydrocephalus, 3 duodenal atresias, 1 oesophageal atresia, 1 hare lip, 1 omphalocoele and 5 different malformations. The two abnormal children who had levels of AFP within normal limits were hydrocephalic. The diagnostic value of measuring bilirubinaemia which was also measured in 22 cases has been demonstrated.

Amniocentesis↗

Severe pseudohypoaldosteronism in a pair of twins not associated with hydramnios.

A pair of non-identical twins with severe pseudohypoaldosteronism (PHA) were followed over a period of 4 years. The diagnosis was based on dehydration, hyponatremia, hyperkalemia, high urine sodium/potassium ratios, and high serum concentrations of aldosterone and renin. Sweat and saliva electrolyte concentrations were high, suggesting multifocal target-organ unresponsiveness to mineralocorticoids. No hydramnios was observed during pregnancy. Despite continuous treatment with sodium chloride and sodium bicarbonate (< or = 20 g/day) and cation exchange resin (Kayexalate, sodium polystyrene sulfonate, < or = 4 g/kg per day), the children had repeated episodes of dehydration, hyponatremia, and hyperkalemia. Growth velocity was normal in both twins. Catch-up growth was observed following infancy in the first twin. Normalization of plasma aldosterone, electrolytes, and renin concentrations was achieved at the age of 9 months.

Body Height↗

[Fetal macrosomy and hydramnios. Intrauterine symptoms of a combination of Sturge-Weber-Krabbe- and Klippel-Trenaunay syndrome].

The authors report on a case where the Klippel-Trenaunay symptom complex was combined with a Sturge-Weber-Krabbe syndrome, which, however, was only noticeable during pregnancy by fetal macrosomy and hydramnios. The child was delivered on term by Caesarean section and presented no paediatric problems; however, during the first few years of its life mental retardation became clearly evident.

Adult↗

Fetal swallowing and voiding in relation to hydramnios.

Fetal swallowing and voiding were measured using colloidal gold and an ultrasonic scanner, respectively. Subjects in the study were in their 38-40th week of pregnancy. Cases were divided into 3 groups: normal, hydramnios, and oligohydramnios. The normal group had a mean swallowing rate of 198 ml/day and a mean voiding rate of 23.6 ml/hr. No significant differences were found among these rates and the corresponding rates in the other 2 groups. It is concluded that mechanisms other than fetal swallowing and voiding can contribute to the control of amniotic fluid volume at term.

Amniotic Fluid↗

Hydramnios and gastrointestinal atresias: a review.

Hydramnios occurs in approximately 1:244 pregnancies. It has a known high association with congenital anomalies. Gastrointestinal atresias are common. The incidence, etiology, disease features, treatment, mortality, and prenatal diagnosis of gastrointestinal atresias are discussed here, along with other associated anomalies.

Abnormalities, Multiple↗

Severe fetal distress with hydramnios due to chorioangioma.

A case is described of antenatal detection of a placental mass by ultrasound in a patient with hydramnios due to chorioangioma and who had a sinusoidal-like pattern and positive oxytocin challenge test (OCT). The importance of frequent fetal heart rate monitoring in cases of suspected chorioangioma is emphasized.

Adult↗