Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “GLYCERIN”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Onset and duration of positive responses to the glycerin test in patients with Menière's disease.

The onset and duration of positive responses to the glycerin test were studied in 28 patients with Menière's disease who had positive responses to the test. The responses were measured for three hours at 30-minute intervals after the ingestion of glycerin. Positive responses were found as early as 30 minutes after ingestion of glycerin. The responses had often become negative by two to three hours. Testing of patients with Menière's disease only at the end of a three-hour interval after ingestion of glycerin will produce a large proportion of false-negative responses, as evidenced by a 39 per cent negative response rate three hours after ingestion of glycerin.

Glycerol↗
PubMed1999

Plasticising effect of water and glycerin on human skin in vivo.

Application of water and glycerin is known to influence skin mechanics. The kinetics of these processes are of great interest. A study was performed to show the immediate changes in skin-mechanics. A Dermaflex machine (R) was used to study 23 healthy volunteers. Water or glycerin was applied to the flexorside of the forearm, and readings were made after 3, 6, 9, 12 and 15 min. Regional untreated skin served as baseline. In agreement with earlier studies both substances influenced hysteresis. Water caused a significant increase in hysteresis after 12 and 15 min of hydration (P<0.01). Glycerin caused significantly increased hysteresis after 3 min (P<0.05) and the effect continued to the end of the observation period. No significant differences were seen in the distensibility. The onset of action is rapid for both substances, and the effects are therefore supposed to take place in the outermost layers of epidermis. The effect of glycerin on the hysteresis is more rapid in onset than that of water. Comparing the permeability coefficients, the effect on the mechanical properties of the skin does not appear to be determined by the permeability coefficients as water has a higher permeability coefficient but induces smaller changes than glycerin. Water alone does not appear to be the optimal plasticiser of human skin and other substances soluble in both water and lipids may have an even greater influence on skin mechanics in vivo.

Adult↗
PubMed2003

Comparative trial between sodium tetradecyl sulfate and glycerin in the treatment of telangiectatic leg veins.

BACKGROUND: Thirteen patients were treated with either sodium tetradecyl sulfate (STS) or glycerin to compare the efficacy and adverse sequelae of each agent. OBJECTIVE: To determine the relative safety and efficacy of two sclerosant solutions. METHODS: Each patient's leg veins that were from 0.2 to 0.4 mm in diameter and that did not have incompetence from the saphenofemoral junction and whose feeding reticular veins had been already treated in a prior sclerotherapy session were randomly treated with either 0.25% STS or 72% glycerin solution. Patients were evaluated from 2 to 6 months postsclerotherapy for overall clinical improvement and incidence of adverse sequelae. RESULTS: Glycerin was comparable to STS in discomfort of injection but demonstrated a significant decrease in bruising, swelling, and postprocedural hyperpigmentation. Glycerin also demonstrated a better, more rapid clearance of treated telangiectasias. CONCLUSIONS: Seventy-two percent glycerin is a safe and effective sclerosant with fewer side effects and more rapid clearance of telangiectatic leg veins than STS.

Adult↗
PubMed2002

A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients.

Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to apply the cream at least once daily for 30 days. Adverse skin reactions and changes in skin dryness were assessed by the patient and a dermatologist. Adverse skin reactions such as smarting (a sharp local superficial sensation) were felt significantly less among patients using the 20% glycerin cream compared with the urea-saline cream, because 10% of the patients judged the smarting as severe or moderate when using glycerin cream, whereas 24% did so using urea-saline cream (p < 0.0006). No differences were found regarding skin reactions such as stinging, itching and dryness/irritation. The study showed equal effects on skin dryness as judged by the patients and the dermatologist. In conclusion, a glycerin containing cream appears to be a suitable alternative to urea/sodium chloride in the treatment of atopic dry skin.

Administration, Topical↗
PubMed1995

Antimicrobial activity of glycerine-ichthammol in otitis externa.

The clinical efficacy of glycerine-ichthammol in otitis externa may be due to an anti-inflammatory action of ichthammol or a dehydrating effect of glycerine on the oedematous ear canal. Its antimicrobial activity, if any, against the common organisms in otitis externa is not well known. A study of the antibacterial property of glycerine-ichthammol as measured by a growth inhibition test and a modified cidal assay, showed inhibition of selected gram positive organisms (Streptococcus pyogenes and Staphylococcus aureus) by ichthammol and glycerine-ichthammol combination, but only negligible antibacterial activity against Pseudomonas aeruginosa and Escherichia coli. Candida albicans was also weakly inhibited. As the activity against gram negative organisms is minimal, incorporation of an anti-gram negative antibiotic such as gentamicin in the glycerine-ichthammol compound to enhance its antibacterial spectrum is suggested.

Anti-Bacterial Agents↗
PubMed2005

Heterotopic transplantation of glycerin-preserved trachea: effect of respiratory epithelium desquamation on acute rejection.

An effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 +/- 0.43, P < or = 0.001) when compared to the autograft and glycerin-preserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerin-preserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens.

Animals↗
PubMedDate not supplied

The ability of electrical measurements to predict skin moisturization. I. Effects of NaCl and glycerin on short-term measurements.

Non-invasive methods to evaluate skin hydration by measuring electrical properties are widely used in the cosmetic industry. However, there is still some controversy about factors that affect measurement. For example, concerns have often been expressed about the possible confounding effect of salts, either in the formulation or on the skin. Ionized salts on the skin may increase electrical conductivity and may lead to changes in electrical properties that are not related to increased water content. We have performed a systematic study of the effects of salt, i.e., sodium chloride, and glycerin on the electrical properties of skin as measured by the three most commonly used instruments, the Nova DPM 9003, the Corneometer CM 825, and the Skicon 200. Formulations containing salt from 0-3% and glycerin from 0-10% were tested for their effects at one and two hours after a single application. Salt lowered the readings in the absence of glycerin and increased the reading in the presence of glycerin. For all three instruments, there was a linear correlation between the measurement and the glycerin level in the presence or absence of salt.

Administration, Topical↗
PubMed1992

[Epidural administration of bupivacaine in glycerine solution can prolong analgesia].

Glycerine has long been used with phenol as a drug depot in control of intractable pain. However, through our literature review, glycerine has never been used to prolong the pharmacological effects of a local anesthetic, such as bupivacaine. Our study is an attempt to use the same mechanism to further extend the pharmacologic effects of a popular long lasting anesthetic in a commonly used technique. Fifteen adult patients with cancer pain received 0.125% bupivacaine via a chronically implanted epidural catheter. In a blind study of pain control: Group I, consisting of 8 patients, received 5 ml 0.125% bupivacaine in normal saline; group II, consisting of 7 patients, received the same amount of the same strength anesthetic dissolved in 50% glycerine. The pharmacological effect was assessed by evaluation of intensity and duration of sensory as well as motor blockade. Our preliminary experimental experience revealed that significant prolongation (11.8 +/- 2.3 h vs 7.6 +/- 1.8 h, p less than 0.01) of analgesia was observed with the glycerine solution as compared to the saline solution. There was no motor blockade or other adverse effects or complications. This markedly prolonged analgesic effect is attributed to the slow release of the local anesthetic agent from the glycerine base which functions as a drug depot. Other clinical applications of this novel approach in pain relief are currently under investigation.

Adult↗
PubMed2006

[The diagnostic value of TEOAE-glycerine test in patients with vertigo on the first attack].

OBJECTIVE: To investigate the diagnostic value of transiently evoked otoacoustic emissions (TEOAE) combined with glycerine test in patients with vertigo on the first attack. METHOD: PTT and TEOAE-glycerine test were conducted on the 28 patients who suffered the first attack of vertigo without hearing loss, tinnitus or a sensation of fullness in the ear. At the same time, history and clinical manifestation of the patients were not supportive for the non-Meniere's disease. RESULT: Among the 28 cases, four of them had nothing changed on the PTT and TEOAE parameters after glycerol administration, all of the indexes were in the normal range. Among the 20 positive cases in the TEOAE-glycerine test (unilateral ear 16 cases, bilateral ears 4 cases), TEOAE for 2 cases were not evoked before glycerol administration, while it was evocable after glycerol administration. For the positive ears, all of the parameters of TEOAE were lower than those in the normal standard before and after glycerol administration; there were 4 positive cases in the PTT glycerine test, however, both TEOAE were not evoked before and after glycerol administration. CONCLUSION: TEOAE-glycerine test can be used as a routine method for the early diagnosis of Meniere's disease and differentiating diagnosis in the patients who suffer vertigo on the first attack with normal hearing.

Adolescent↗
PubMed1991

Marginal adaptation with glass-ceramic inlays adhesively luted with glycerine gel.

The purpose of this study was to examine the effectiveness of glycerine gels in preventing the formation of an oxygen-inhibition layer during the polymerization of composite resin materials. Sixteen glass-ceramic inlays were adhesively luted with and without the application of glycerine gels on the inlay margins before the polymerization of the luting composite resin material. To remove the oxygen-inhibition layer, the inlays were brushed with acetone. Replicas were obtained before and after acetone brushing, and a computerized quantitative marginal analysis was carried out under the scanning electron microscope. Statistical analysis revealed significant differences between the polymerization with and the polymerization without the use of a glycerine gel. The inlay margins polymerized after the application of a glycerine gel showed better marginal adaptation than did the inlay margins polymerized without it, suggesting that oxygen inhibition during polymerization can be prevented by the application of glycerine gels to the surface of composite resin materials.

Ceramics↗
PubMed1983

Glycerin and urea tests in Meniere's disease. A multifactorial analysis using a quantification method.

By using the quantification method for multidimensional qualitative data, 13 variables were analyzed. The younger the patient, the stronger was the correlation between age and positive glycerin and urea tests. At ages over 50 years no correlation with positive test results was found. The longer the duration of disease, the stronger was the correlation between this duration and a positive urea test. The glycerin test showed no correlation with the duration of the disease. Hearing losses of 40 to 69 dB. were correlated with both a positive glycerin test and a positive urea test. Greater hearing losses were correlated only to a positive glycerin test. Hearing losses less than 39 dB. were not correlated with positive results in either the glycerin or the urea test.

Adult↗
PubMed1985

A comparative study of suture materials: chromic gut and chromic gut treated with glycerin.

Histologic and mechanical properties of chromic gut and glycerin-treated chromic gut were evaluated. Zero gauges of both materials were implanted for 7 days to evaluate inflammatory response. No difference was found in the degree of inflammatory response. Scanning electron micrographs showed a more uniform surface for the glycerin-treated chromic gut. Regular chromic material was stronger in unknotted tensile strength and fracture load for all gauges. The 1-0 gauge glycerin-treated chromic gut stabilized with the knot configuration of 1 = 1 = 1 = 1; and the 1,2-0, and 3-0 gauges reached knot security at 1 = 1 = 1. The in vivo studies showed marked difference in the tensile strength of stable knots between the two materials. Only with five throws (1 = 1 = 1 = 1 = 1) did the strength of glycerin-treated chromic gut overlap that of regular chromic gut.

Animals↗
PubMed1994

Placement of calcium hydroxide in simulated canals: comparison of glycerin versus water.

Calcium hydroxide (Ca(OH)2) is an intracanal medicament used as an antimicrobial agent, temporary obturant, and for apexification. Placement should be controlled for the maximum biological effect. This study evaluated and compared the effectiveness of delivery of Ca(OH)2 mixed with water or with glycerin as to (a) length of placement and (b) density of fill at different levels. Fifty-six simulated canals with moderate curvature were prepared to #60 using the step-back technique. Ca(OH)2 was mixed with either water (28 canals) or glycerin (28 canals) into a thick paste and placed with lentulo spirals. Radiographs were made and blindly assessed. Results showed that glycerin was statistically significantly superior (p < 0.05) to water as to (a) length of fill and (b) density in the coronal, middle, and apical thirds. Of particular interest was the apical third, in which 0% of water and 50% of glycerin Ca(OH)2 pastes were completely dense.

Calcium Hydroxide↗
PubMed2003

Influence on pH of vehicle containing glycerin used with calcium hydroxide.

- The pH values of the external aqueous medium, relative to the roots of 41 human premolar teeth filled with Ca(OH)2 in to several vehicles, were evaluated in the present study. After root canal biomechanical preparation and smear-layer removal, the teeth were stored individually, immersed in flasks containing 800 ml of ultra-pure deionized water for a period of 118 days. A pH meter was used to analyse the pH values as a function of time. The measurements were divided into phase 1: dissolution, in which all canals remained empty and open in the absence of medicament for 48 days, and phase 2: diffusion, in which the specimens were divided into 10 groups which consisted of three control groups: group 1, water control; group 2, sealing control; and group 3, opened canal dissolution control, and seven experimental groups, with five teeth each, whose canals were filled with Ca(OH)2 paste associated with the following vehicles: group 4, saline solution; group 5, polyethylene glycol (Calen); group 6, glycerin and parachlorophenol (PMCC); group 7, PMCC; group 8, glycerin; group 9, glycerin and formo cresol (FC); and group 10, anesthetic solution. This phase lasted for 70 days. A total of 1058 measurements of the pH values were made. Regression analysis was used for statistical evaluation. The results show that all groups containing polyol in the composition of the paste had a trend to acidification in the interval between filling and 14 days later (therapeutic period) and, at the end of the experiment (1687 h to 70 days after canal filling), the pH was slightly alkaline. We conclude that polyhydroxy alcohol (glycerin and polyethylene glycol, Calen) diffusion enhances acidification of the aqueous medium.

Calcium Hydroxide↗
PubMed1972

Inhibitory effect of glycerin on Vibrio parahaemolyticus and Salmonella.

In a study of the effect of glycerin in transport media on Vibrio parahaemolyticus and Salmonella, it was found that a concentration of 30% glycerin was highly inhibitory for V. parahaemolyticus and to a lesser degree for Salmonella. The incorporation of peptone or human feces in media did not reduce the inhibitory effect of glycerin. In media with 15% glycerin, viable counts of V. parahaemolyticus and Salmonella increased after 24 hr of incubation both in the presence and absence of feces. Due to the concurrent increase in the total bacterial count in the media containing feces, no enrichment effect was noted.

Bacteriological Techniques↗
PubMed1983

Loss of Ca2+-dependent regulation in glycerinated skeletal muscle contraction.

Glycerinated muscle fiber from rabbit psoas muscle often lost Ca2+-dependent regulation of its contraction with long-term extraction in a 50% glycerol solution containing 5 mM EGTA at -20 degrees C, designated as Ca2+-insensitive muscle fiber (CaIS-fiber). About 30 or 40% of glycerinated muscle fibers were CaIS-fibers after 1 to 3 months in the glycerol solution. We investigated the cause of the loss of Ca2+-sensitivity of the glycerinated muscle fiber by tension mechanogram and SDS polyacrylamide gel electrophoresis. This natural CaIS-fiber showed a new band of 30K daltons peptide on SDS gels. On the other hand, Ca2+-sensitive fiber (CaS-fiber) changed to CaIS-fiber by trypsin digestion for 40 sec. The tryptic CaIS-fiber had no troponin C and 30K daltons peptide bands in the electrophoretograms. Incubating with 2 mM CaCl2 for 40 hr at 25 degrees C, CaS-fiber changed easily to CaIS-fiber which had 30K daltons peptide and faint troponin T and I bands, as in natural CaIS-fiber. All CaIS-fibers could recover their Ca2+-dependent regulation by incubating with native tropomyosin from rabbit skeletal muscle for 2 days at 4 degrees C. These results indicate that the loss of Ca2+-dependent regulation of glycerinated muscle fiber is due to degradation of regulatory protein system by endogenous Ca2+-activated proteolytic enzymes.

Animals↗
PubMed2000

Homogenous implant in rat tibias of matrix preserved in 98% glycerin: histomorphologic study.

As a chemical medium for preservation of tissues, glycerin has shown good results because it maintains the cellular integrity despite the tissue dehydration it causes. Taking advantage of the osteoinducing properties of the osseous matrix and glycerin as a proper medium for tissue preservation, osseous matrix was implanted in rat tibias. Twenty-four rats were used, each receiving two surgical wounds. In one of the wounds an osseous matrix preserved in 98% glycerin was implanted and the other received a matrix without preservatives. Six animals were sacrificed on days 10, 20, 30 and 60 post-implant. After routine histological processing, the specimens were stained in hematoxylin-eosin and Masson's trichrome. The results showed that the matrixes preserved in glycerin presented faster resorption with replacement by newly formed tissue.

Animals↗
PubMed2001

Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis.

BACKGROUND/AIMS: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin. METHODS: Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist. RESULTS: No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition. CONCLUSIONS: Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis.

Adult↗