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Results for “GASTROINTESTINAL DISEASES”

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At least 55 records · Page 3Linked to original sources
PubMed1993

Manifestations of gastrointestinal disease on chest radiographs.

Diseases of the gastrointestinal tract may result in radiographic changes in the thorax. An abnormal chest radiographic finding is often the initial clue to the diagnosis of gastrointestinal disease. This article presents the commonly recognized and some unusual thoracic manifestations of significant primary esophageal diseases including achalasia, diverticula, carcinoma, duplication cysts, varices, esophageal perforation, and postoperative changes. Intraabdominal gastrointestinal processes such as pancreatitis or pseudocysts, gastric and colonic abnormalities, pneumoperitoneum, liver abnormalities, intraabdominal abscesses, and diaphragmatic hernias, which are frequently associated with intrathoracic abnormalities, are also reviewed. Awareness of changes on the chest radiograph produced by gastrointestinal disease allows prompt diagnosis and facilitates the appropriate confirmatory diagnostic study, such as esophagography or computed tomography.

Digestive System Diseases↗
PubMed2004

The role of mast cells in common gastrointestinal diseases.

The gastrointestinal tract is a rich source of mast cells with an enormous surface area that permits a high degree of interaction between the mast cell and the intestinal contents. The active metabolic products of the mast cell influence gastrointestinal secretion, absorption, and motility through paracrine effects of local mast cell activation and also cause systemic effects through the release of cellular products into the bloodstream. Recent advances in our knowledge of the immune system and the recognition that the gastrointestinal immune function might be partially mediated through gastrointestinal mucosal mast cells has opened mast cell research to the field of gastroenterology. Local gastrointestinal proliferation of mast cells in response to recognized or obscure stimuli can alter gastrointestinal function and induce systemic symptoms. Symptoms can arise from the increased number of mast cells, overproduction of specific mast cell mediators, and hyperactivity of the enteric nervous system that induces mast cell activation. The diseases mentioned in this review represent a small proportion of areas where mast cell function might play an important role in the response to disease and generation of symptoms.

Female↗
PubMed1999

Oral manifestations of gastrointestinal disease.

A variety of gastrointestinal diseases can be associated with lesions of the oral cavity. The lesions usually correlate to active intestinal disease, but they may present prior to any other evidence of the disease and even be used to initiate diagnosis and treatment. This paper reviews the more common oral manifestations of gastrointestinal disease and their dental management.

Gastrointestinal Diseases↗
PubMed2004

T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice.

BACKGROUND & AIMS: Eosinophil-associated gastrointestinal diseases are frequently associated with extraintestinal features, including bronchopulmonary manifestations. The factors predisposing to bronchial hyperresponsiveness in eosinophil-associated gastrointestinal diseases are unknown. To elucidate the mechanistic link between eosinophil-associated gastrointestinal diseases and bronchial hyperresponsiveness, we used murine models of eosinophil-associated gastrointestinal diseases and eotaxin-1/transgene-induced eosinophil-associated gastrointestinal diseases. METHODS: Mice were sensitized and orally challenged with ovalbumin-coated encapsulated particles to induce eosinophil-associated gastrointestinal disease, and bronchial responsiveness was examined. Furthermore, transgenic mice expressing eotaxin in the intestine (with the rat fatty acid-binding promoter) were used to specifically elucidate the contribution of this chemokine in eosinophil-associated gastrointestinal disease-associated bronchial hyperresponsiveness. RESULTS: The induction of allergen-induced eosinophil-associated gastrointestinal disease was directly correlated with the development of bronchial hyperresponsiveness. The development of bronchial hyperresponsiveness in mice with allergen-induced eosinophil-associated gastrointestinal disease was dependent on eotaxin expression in the gastrointestinal tract. Expression of eotaxin in the gastrointestinal tract of transgenic mice was sufficient to promote bronchial hyperresponsiveness. Bronchial hyperresponsiveness was shown to be directly linked to the aberrant CD4(+) T helper 2 lymphocyte production of interleukin-13. It is interesting to note that transgenic expression of eotaxin was linked with enhanced T helper 2 lymphocyte/cytokine synthesis (interleukin-4, -5, and -13) and the production of mucosal immunoglobulin G1 in the gastrointestinal lumen. We also showed that eotaxin treatment of CD4(+) T cells enhanced interleukin-13 production in vitro. CONCLUSIONS: These studies suggest that increased expression of eotaxin in the gastrointestinal compartment can lead to increased CD4(+) T cell-derived T helper 2 lymphocyte-cytokine production that drives aberrant immunophysiological responses in distant noninflamed mucosal tissue (the lung). These results provide a possible explanation for the altered lung function seen in some patients with inflammatory gastrointestinal disorders.

Animals↗
PubMed1997

[Hypertension and gastrointestinal diseases].

Essential hypertension and gastrointestinal disease are two of the most common diagnoses made in the doctor's office. Since they may occur simultaneously, the differential therapeutic aspects of the respective therapies are of importance for every general practitioner. However, complex interactions between hypertension and gastrointestinal diseases often make the choice of the most suitable drug difficult. The present article provides an overview of the most common therapeutic regimens, identifies possible interactions, and should help the doctor to select the optimal treatment for the individual patient.

Antihypertensive Agents↗
PubMed2002

Hepatic manifestations of gastrointestinal diseases. Inflammatory bowel disease, celiac disease, and Whipple's disease.

The gastrointestinal tract and the liver are closely related anatomically, physiologically, and pathologically. Some disease associations are well documented, such as PSC in association with IBD, whereas others are less well defined. A heightened clinical suspicion is required in these patients who do not present with the classical disease associations. The underlying causes of their diseases are the subject of much debate and research, and their diagnosis and management remain challenging.

Animals↗
PubMed2001

Lower gastrointestinal disease in women.

Gastrointestinal disease is common in women and therefore a commonly encountered entity in gynecologic practice. A new understanding of the underlying pathophysiology of the most common condition, irritable bowel syndrome, is changing both diagnosis and therapy.

Colonic Diseases, Functional↗
PubMed1988

Common gastrointestinal diseases in the elderly.

Gastrointestinal diseases, such as gastroesophageal reflux (GER) and peptic ulcers, are prevalent in the elderly. These disorders have been found to develop because of an imbalance between aggressive and defensive physiologic factors, but specific causes remain unknown. If neglected or improperly treated, gastrointestinal disease can cause serious complications, particularly in the elderly. Pharmacologic therapy has proven effective for treating both GER and peptic ulcers.

Aged↗
PubMed1996

Tissue spectroscopy for gastrointestinal diseases.

Tissue spectroscopy for gastrointestinal diseases has made rapid strides in methodology and technology, with recent studies showing very promising results for the detection of pre-cancers and cancers. Laser-induced fluorescence spectroscopy, elastic scattering spectroscopy, and Raman spectroscopy have all shown favorable results in the diagnosis of malignancies and dysplasia in a number of small studies, both in vitro and in vivo. While technical limitations have been encountered with each of the techniques, significant advances have been made in the last year that may allow a highly sensitive and specific diagnosis to be generated within seconds, allowing directed or guided biopsies or therapy during a single procedure. Large multicenter trials will be necessary to demonstrate the efficacy, usefulness, and efficiency of these new tools.

Biopsy↗
PubMed1979

Diet therapy in gastrointestinal disease: a commentary.

Dietary regimens in gastrointestinal disease can be divided into two categories: First, those of proven value include: (a) Disaccharide elimination for disaccharidase deficiency and exclusion of monosaccharides for sugar malabsorption; (b) gluten-free diet for celiac/sprue; (c) elimination of certain allergens because of food allergies; (d) protein restriction for portal systemic encephalopathy; (e) low-carbohydrate diet for dumping syndrome; (f) low-fiber diet for diarrheal syndromes; and (g) low-fat diet for steatorrhea. Second, controversial diets include a bland diet for acid-peptic disorders, a high-fiber diet for colonic disorders, and a low-fat diet for gallbladder disease. It is important to separate facts from fancy in the dietary management of patients with gastrointestinal disease and base the recommendations for a particular diet on available objective evidence, not on traditional or fashionable trends.

Carbohydrate Metabolism, Inborn Errors↗