An investigation of new fluorine compounds in anaesthesia.
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The concentration of fluoride in superficial layers of enamel of permanent teeth was studied in 14-year-old children residing in Szczecin and Bialystok-two cities differing regarding the level of environmental fluorine pollution. It was found that higher environmental pollution with fluorine favors the accumulation of this element in superficial layers of enamel in the form of structural fluoride. Total and structural fluoride concentration decreased with layer depth.
The molecular mechanism for regulating nucleotide contents depends on the activity of numerous enzymes during glycolysis, pentose cycle and oxidation reduction system. Special attention was paid to the consequences of indirect effects of fluorine on ATP, ADP and AMP contents, nucleotide pool, energetic charge and the amount of 2,3 DPG. The effects of fluorine on ATP-ase activity are also described.
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Novel fluoroalkylated products where a CF(2)COOEt group was introduced at the alpha-position of alpha,beta-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF(2)COOEt and alpha,beta-unsaturated ketones with Et(2)Zn in the presence of RhCl(PPh(3))(3) depending on the solvents. Furthermore, the novel alpha-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (R(f)-X) instead of BrCF(2)COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-beta-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO(4) . 7H(2)O, selectively.
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