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Results for “Erysipelothrix Infections”

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PubMed1988

Valvular endocarditis associated with experimental Erysipelothrix rhusiopathiae infection in the opossum (Didelphis virginiana).

Intravenous inoculation of a wild type isolate of Erysipelothrix rhusiopathiae in opossums resulted in valvular endocarditis in all infected animals. Opossums were inoculated once a week for 3 weeks. Lesions became visible with cardiac ultrasound by week four post-inoculation. Opossums remained clinically normal throughout the experiment, and preinfection body weight was maintained. Other lesions of chronic erysipelas including skin necrosis and arthritis were not found in infected opossums.

Animals↗
PubMed2002

Hyaluronidase is not essential for the lethality of Erysipelothrix rhusiopathiae infection in mice.

To investigate the role of hyaluronidase in the pathogenicity of Erysipelothrix rhusiopathiae, transposon Tn916 was transferred from Enterococcus faecalis CG110 to a virulent strain of E. rhusiopathiae, and hyaluronidase-deficient mutants were isolated. A virulence assay in the mice showed that of the seven hyaluronidase-deficient mutants tested, six mutants were avirulent, but that one mutant, designated AST121, was as virulent as its parental strain. Western immunoblotting with a monoclonal antibody specific to the capsule, a major virulence factor of the organism, revealed that all of the avirulent mutants had lost the capsular antigen, whereas the mutant AST121 did not. These results suggest that the lack of virulence of the six hyaluronidase-negative mutants could be due to a loss of the capsule and that hyaluronidase does not contribute to the lethality of E. rhusiopathiae infection in mice.

Animals↗
PubMed1988

Mechanism of protection induced in mice against Erysipelothrix rhusiopathiae infection by treatment with porcine antiserum to the culture filtrate of an attenuated strain.

The mechanism of protection induced in mice against challenge with a virulent strain of Erysipelothrix rhusiopathiae by porcine antiserum to the culture filtrate (CF) of an attenuated strain was investigated. Death and bacterial growth in the spleens of mice challenged with the virulent strain were completely prevented by treatment with the antiserum. The protective effect of the serum was markedly decreased in mice in which polymorphonuclear leucocytes (PMN) were depleted by cyclophosphamide (CY) treatment but not in mice in which macrophages were blocked selectively by carrageenan (CG). The phagocytic rate of PMN and the number of bacteria ingested by PMN were significantly higher in mice treated with the antiserum than in mice treated with normal serum. These results indicate that anti-CF serum exerts its protective effect by opsonic activity and that opsonized E. rhusiopathiae are eliminated mainly by PMN.

Agglutination Tests↗