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Effects of visible signs of contagious ecthyma on mass and survival of bighorn lambs.

External signs of contagious ecthyma became common in a population of Rocky Mountain bighorn sheep (Ovis canadensis) in Alberta, Canada, after it attained high density. Between 1990 and 1993, we studied effects of this disease on mass gain and survival of lambs. Prevalence and severity were independent of lamb sex. Lambs with large sores and scabs gained less mass than other lambs and were lighter the following spring as yearlings. There was no significant effect of the disease upon lamb survival, and contagious ecthyma did not appear to play a primary role on the dynamics of the study population.

Analysis of Variance↗

[Pseudomonas sepsis with ecthyma gangrenosum in an acute myeloid leukemia patient].

A 56-year-old woman with acute myeloid leukemia had two rapidly growing necrotizing nodules with ulcer formation on her head after the first course of consolidation therapy. Clinical features corresponding to sepsis (e.g., fever) appeared following the development of the skin lesion. Pseudomonas aeruginosa was isolated from the blood as well as pus of the lesion. Based on these findings, a diagnosis of ecthyma gangrenosum was made. Treatment with ciprofloxacin and gamma-globulin dramatically improved the patient's clinical features. Since Pseudomonas sepsis with ecthyma gangrenosum is associated with a high mortality rate, it is important to start immediate treatment with appropriate antibiotics.

Anti-Infective Agents↗

Atypical contagious ecthyma in a sheep after extensive cutaneous thermal injury.

An atypical case of contagious ecthyma in a wether, following severe thermal injury to the skin, is reported. Histologically, extensive verrucous growths at the edges of the burned skin were areas of severe epidermal hyperplasia and hyperkeratosis. Intracellular viral particles were present, and sections of skin were positive for ovine contagious ecthyma virus by a fluorescent antibody test.

Animals↗

[Ecthyma of sheep and goats].

Contagious pustular dermatitis (CPD, contagious ecthyma, Orf) is a highly contagious viral disease afflicting sheep and goats. The infectious agent is a parapoxvirus which is widespread and also contagious for humans (zoonosis). Recently the disease in sheep and goats is marked by increased incidence and severe cases which cause many losses especially among lambs in fattening farms. The immunity of once infected animals is based on cellular defense mechanisms which are very unstable. The most suitable method for the prevention of ecthyma is parenteral vaccination with attenuated live vaccines. Effective vaccination programmes should enclose the whole animal population at intervals of 6-8 months.

Animals↗

Attempted reactivation of contagious ecthyma in Dall sheep.

Dexamethasone was administered to 2 Dall ewes that had clinically recovered from contagious ecthyma in an attempt to reactivate contagious ecthyma in the sheep. Clinical signs of disease were not detected within 24 days after corticosteroid injection, and virus was not detected in tissues collected at necropsy.

Animals↗

Camel contagious ecthyma (pustular dermatitis).

In 1979, pustular dermatitis caused by a virus belonging to the family Poxviridae , genus Parapoxvirus , was observed among camels in some areas of Mongolia . The morbidity in adults ranged from 10 to 80%, of 2 to 3-month-old suckling camels between 50-70% and it reached 100% in 1-year-old animals. In the beginning, pustules developed around the mouth followed by papular elevations and scab formation. The virus designated camel contagious ecthyma (CCE) grew on the chorionallantoic membrane (CAM) of 11-day-old chick embryos (CE). The disease was transferred to the scarified skin of 2 to 3-month-old camels. Vaccination with the material containing CCE virus seemed to be promising. In contrast, camels were not protected after immunization with vaccinia virus and with a vaccine against sheep and goat contagious ecthyma.

Animals↗

[Ecthyma contagiosum epidemics in Turkey].

In the years 1979 and 1980 after the religious holidays of the "Feast of Sacrifice" in Izmir (Turkey), there was an epidemic-type of outbreak of 31 cases of ecthyma contagiosum. On the occasion of the sacrificial feast day the amateur butchers, their helpers, housewives, and others came into direct contact with virus-infected parts and were infected with the ecthyma contagiosum virus, which includes the paravaccinia group.

Adolescent↗

Pseudomonas cepacia endocarditis and ecthyma gangrenosum.

A case of right-sided Pseudomonas cepacia endocarditis in a heroin addict is presented in which septic cutaneous vasculitis (ecthyma gangrenosum) is a prominent feature. Ecthyma gangrenosum, most commonly associated with sepsis due to P aeruginosa, has not been previously described with P cepacia septicemia.

Adult↗

Ecthyma gangrenosum in a burned child.

The history of ecthyma gangrenosum has been presented, as well as its pathological diagnosis, prognosis and natural history. The history of forms of treatment has been outlined and the grave prognosis is emphasized. A case presentation introduces the experience at the Cincinnati Shriners Burns Institute. From a review of the literature and the experience at the Shriners Burns Institute, a suggestion for optimal treatment has been proposed. The particulars of this treatment include: early recognition, general nutritional and metabolic support, as well as high-dose aminoglycoside and semi-synthetic penicillin therapy, administered parentally and by sub-eschar clysis. Despite the grave prognosis, attention to these factors should result in optimal survival of patients with ecthyma gangrenosum.

Burns↗

Ecthyma gangrenosum in an AIDS patient with normal neutrophil count.

Ecthyma gangrenosum is the cutaneous manifestation of Pseudomonas aeruginosa septicemia, typically affecting immunosuppressed patients, particularly those with neutropenia. Association with HIV disease has been rarely reported. We describe an unusual presentation of solitary ecthyma gangrenosum on the face of a non-neutropenic patient with AIDS.

AIDS-Related Opportunistic Infections↗

Ecthyma gangrenosum as a manifestation of Pseudomonas sepsis in a previously healthy child.

We present a case of Pseudomonas aeruginosa sepsis heralded by ecthyma gangrenosum in a previously healthy 15-month-old child. Pseudomonas infection and its uncommon skin manifestation are rarely encountered in an immunocompetent child. This case highlights the critical importance of identifying ecthyma gangrenosum to institute optimal antimicrobial therapy.

Anti-Bacterial Agents↗

Ecthyma gangrenosum caused by disseminated Exserohilum in a child with leukemia: a case report and review of the literature.

We report an 8-year-old boy with acute leukemia who developed ecthyma gangrenosum secondary to infection with Exserohilum spp., a rare cause of human disease. The skin, paranasal sinuses and lungs were involved. To the best of our knowledge, this is the first report of ecthyma gangrenosum caused by Exserohilum spp. This case emphasizes the importance of prompt skin biopsy for early diagnosis and treatment of this life-threatening infection.

Child↗

Harlequin baby with ecthyma gangrenosum.

Pseudomonas aeruginosa bacteremia or sepsis often occurs in hospitals, affecting mainly children with underlying disease. Ecthyma gangrenosum is classically considered a pathognomonic sign of sepsis by P. aeruginosa. The harlequin baby, a severe variant of ichthyosis, occurs rarely, and these infants are at high risk of cutaneous infections and sepsis. We herein report a harlequin baby who developed ecthyma gangrenosum.

Diagnosis, Differential↗

Ecthyma gangrenosum associated with aplastic anemia.

Ecthyma gangrenosum is a characteristic skin lesion of systemic infection due to Pseudomonas aeruginosa. It has a high incidence in patients with chronic disease and impaired defense mechanisms. Early diagnosis and appropriate systemic antibiotic therapy is crucial since its mortality rate is very high. We report a case of ecthyma gangrenosum in aplastic anemia.

Adult↗

[Gangrenous ecthyma of the diaper area in infants].

Ecthyma gangrenosum due to Pseudomonas aeruginosa is a skin infection in which necrotic ulcerations surrounded by a red areola develop. The diaper area is the region most often involved in infants. Typically, ecthyma gangrenosum occurs in patients with septicemia and risk factors (chemotherapy, neutropenia). However, transient bacteremia or an infection confined to the skin may be the cause in some patients, with maceration in the diaper area and previous antibiotic therapy as risk factors.

Diagnosis, Differential↗

[Properties of the contagious ecthyma virus used for vaccine production].

Experiments were carried out to establish the effect of some antibiotics and merthiolate on the vaccinal Phylaxia strain of ecthyma contagiosa. Besides, followed up was the effect of these antibiotics on concomitant microflora that had multipled in the virus suspension. Trials were also made to titrate the vaccinal strain on lambs through scarification. Titration was carried out by the method of Schmidt. Virus dilutions of 10-1 were applied following scarification on the the thighs and fore limbs of two lams. A scarified site was also left without application to check up the effect. Each treatment needed two lambs. It was found that the antibiotics nistatin, kanamycin, oxacillin, tetraolean, oleandomycin, oxitetracyclin and chloramphenicol did not lower the activity of the vaccinal virus Phylaxia. The antibiotics tested at the respective concentrations had no sterilizing effect on the crust media regard to the concomitant bacteria. It is pointed out that the method of virus treatment can be employed to determine the biologic potential of productional batches of ecthyma contagiosa vaccine.

Age Factors↗

Pseudomonas aeruginosa O-11 folliculitis. Development into ecthyma gangrenosum in immunosuppressed patients.

Six immunocompromised patients were shown to exhibit Pseudomonas aeruginosa folliculitis in apocrine regions similar to "swimming pool" folliculitis. The lesions evolved within 24 hours as severe ecthyma gangrenosum. The source of the P aeruginosa, serotype O-11, was found in the water system of the hospital. Clinical identification of the lesions and early treatment is important to prevent severe manifestations.

Adult↗

Ecthyma gangrenosum occurring at sites of iatrogenic trauma in pediatric oncology patients.

We report two cases of ecthyma gangrenosum which occurred at sites of iatrogenic trauma. The first case developed due to metastatic seeding with Pseudomonas aeruginosa during an episode of septicaemia and the second case occurred as a primary skin lesion. Both required prolonged courses of antibiotics and one patient died. The different pathogenic mechanisms and outcomes associated with this condition are discussed.

Anemia, Aplastic↗