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At least 55 records · Page 3Linked to original sources
PubMed1988

Studies on dressings for treatment of mucous membranes of oral cavity. Part 2: Influence of hydrophilizing substances on properties of hydrogel dressings comprising Kunitz protease inhibitor.

Resistance of the dressings against washing out depends upon concentrations of methylcellulose or sodium salt of carboxymethylcellulose, and upon concentrations of glycerol, 1,2-propylene glycol and polyoxyethylene glycol 400. For the determined group of dressings the ratio of washing out times in 0.9% sodium chloride solution to washing out times in distilled water remains constant. A similar relation has been observed for washing out times of the dressings in vivo compared to those in vitro in 0.9% solution of sodium chloride. The pharmaceutical availability of the Kunitz type protease inhibitor depends upon composition of the gel forming and hydrophylizing substances in the dressings. The rheological characteristics of the dressings comprise a flow limit and thixotropic properties. The initial clinical examinations proved that the dressings alleviated symptoms of paradontopathy.

Bandages↗
PubMed2004

Meta-analysis of randomized controlled trials on hydrocolloid occlusive dressing versus conventional gauze dressing in the healing of chronic wounds.

Chronic wound management is a difficult area in surgical practice. A wide range of dressings have been recommended for the management of chronic wounds. The present meta-analysis was undertaken to determine the effectiveness of hydrocolloid dressing (HCD) in the healing of chronic wounds compared with conventional gauze dressing. All available controlled clinical trials published before December 2001 that compared HCD to conventional gauze dressing in the healing of chronic wounds were systematically reviewed. We identified and analysed 12 randomized trials (11 published; 1 unpublished) comprising 693 patients with 819 ulcers. The overall odds ratio under the fixed effect model was 1.72, that is, 72% more ulcers healed completely with HCD than with conventional gauze dressing. This result was both clinically and statistically significant.

Bandages↗
PubMed1995

A new silicone rubber dressing used as a temporary dressing before delayed split skin grafting. A prospective randomised study.

In cases of split skin grafting after wide local excision of malignant melanoma or other tumours, the graft is often delayed for one or two days to reduce bleeding underneath it. Paraffin gauze and an absorbent dressing may be used as a temporary dressing before the application of the skin graft. Paraffin gauze, however, has the disadvantage that it often adheres to the wound bed making removal time-consuming and causing pain and bleeding. A new, fine-mesh polyamide netting covered with silicone (Mepitel, Mölnlycke) was therefore tested in a randomised prospective study with paraffin gauze as the control. There were significant differences between the two groups in terms of the adherence of the dressing, the time needed to remove the dressing, pain, and bleeding. Mepitel was superior to paraffin gauze because it adhered less to the wound bed, the time needed to remove the dressing was shorter, and it caused less pain and less bleeding.

Adult↗
PubMed1992

Studies on dressing for dental surgery use. Part 2. Influence of Kunitz' protease inhibitor on properties of dental gelatinous dressings.

To increase resistance of gelatinous dressings to the etching action of trypsin in vitro, the Kunitz' protease inhibitor has been added. It has been found that the etching rate of the dressings was reduced in proportion to the inhibitor added. Addition of plasticizers in the presence of an inhibitor reduces the etching rate of the dressings and the effect depends on the type and concentration of the plasticizer added. Thermally sterilized dressings have an average of 10% less resistance to the etching action of trypsin. The liberation of the inhibitor from the dressings follows first order kinetics, whereas its liberation rate depends upon the type of the plasticizer used.

Gels↗
PubMed1988

Studies on dressings for mucosa of oral cavity. Part 1: Influence of hydrophilizing substances on xerogel properties of dressings comprising Kunitz protease inhibitor.

2% methylcellulose gel solutions containing Kunitz protease inhibitor and increasing concentrations of glycerol or 1,2-propylene glycol were spread on semipermeable membrane. After evaporation of water from the gel solutions, dressings consisting of 1 or 2 mg of methylcellulose have been prepared. In these dressings, the ratio of hydrophilizing agent to methylcellulose ranged from 0.5:1 to 8:1. The thickness of the dressings is proportional to methylcellulose and hydrophilizing substance concentration/cm2 surface area. Water diffusion rates fo the dressings are similar and concentrations of hydrophilizing agent per surface unit area have not significant influence on the process. Kunitz protease inhibitor is liberated in two stages and follows first order reaction kinetics in dependence upon the hydrophilizing agent used. With the dressings, containing 100 micrograms inhibitor/cm2, peridontosis was treated within 2 weeks without any irritating effects on gingival mucosa.

Bandages↗
PubMedDate not supplied

A randomized study comparing IV 3000 (transparent polyurethane dressing) to a dry gauze dressing for peripheral intravenous catheter sites.

Patients with an intravenous catheter on a cardiology unit were prospectively randomized to receive a transparent polyurethane dressing (N = 49) or sterile gauze (N = 31) dressing to compare security of fixation, dressing condition, skin condition, and rates of inflammation. The mean age of patients was 63 years of age (standard deviation, 12.57), and the average length of cannulation was 18 hours. The only significant difference between the two groups was the dressing condition in the transparent group was significantly better (P = 0.006) than that of the gauze group. The results suggest that gauze dressing may be a viable option to cover i.v. exit sites for patients requiring short-term cannulation.

Adult↗
PubMed1998

Hair tie-over dressing. A simple dressing for hair-bearing scalp wounds.

OBJECTIVE: To describe a temporary dressing for Mohs micrographic surgery wounds of the hair-bearing scalp. METHOD: The technique of using hair at the wound edges to hold down the dressing is described. RESULTS: This is an effective, simple, comfortable, and inexpensive scalp dressing, which our patients have found to be very acceptable. CONCLUSION: We consider that the hair tie-over dressing is an ideal temporary dressing for Mohs micrographic surgery wounds of the hair-bearing scalp.

Bandages↗
PubMed1990

Occlusive dressings. Does dressing type influence the growth of common bacterial pathogens?

We studied the effect of different occlusive dressings and of air exposure on the growth of four pathogenic bacteria in wounds. Partial-thickness wounds on domestic pigs were inoculated with Staphylococcus aureus, Clostridium perfringens, Bacteroides fragilis, or Pseudomonas aeruginosa. Each wound was covered with three dressings (DuoDERM, Opsite, or Vigilon), or left exposed to air. Groups of wounds were sampled at 24, 48, and 72 hours. Staphylococcus aureus reached high levels beneath all of the dressings and in the air-exposed wounds. The numbers of C perfringens and B fragilis were greatly reduced in the air-exposed wounds and slightly reduced in the Opsite-covered wounds. The numbers of P aeruginosa were greatest in the Opsite- and Vigilon-covered wounds. The results indicate that occlusive dressings are not indicated in wounds that clinically appear to be grossly contaminated or that may contain anaerobic organisms.

Animals↗
PubMed1981

[Transparent adhesive tape as postoperative dressing. Randomized, clinical study for comparison with a conventional dressing technic].

To evaluate the effect of a thin, transparent, adhesive and elastic polyurethane drape permeable only to gas and water vapor molecules but not to bacteria in comparison to a conventional drape for postoperative dressings, a randomized trial was conducted in 90 male and female patients. 44 patients had the transparent adhesive drape and 46 a conventional dressing. Both groups were reasonably well matched according to age, sex, height, weight and type of operation. There was no difference in healing of skin wounds. But reddening around the stitches was seen more often in patients with the conventional dressing than in those with the polyurethane drape (p less than 0.05). Surprisingly, most of the patients with the transparent drape (42 of 44) accepted it. The transparent adhesive drape was found to be much less expensive than the conventional dressing.

Adult↗
PubMed1999

New cytokine dressings. I. Kinetics of the in vitro rhG-CSF, rhGM-CSF, and rhEGF release from the dressings.

Wound repair-stimulatory activities of various cytokines and growth factors depend on successful delivery of these factors to the injured sites. Here were present the design and preparation of the new collagen- and polyurethane-based dressings containing the recombinant human cytokines-rhG-CSF, rhGM-CSF or rhEGF. To test the efficacy of the retrieval of the incorporated cytokines, their controlled release from the dressings was carried out over three consecutive days using polyurethane sponge as a collector of the extracts. The maximum quantities of the released rhG-CSF, rhGM-CSF and rhEGF reached approximately 25, 50, and 10%, respectively, of the total cytokine contents of the dressings, as assessed by the specific ELISA tests. These data indicate that collagen- and polyurethane dressings containing rhGM-CSF and rhG/CSF may serve as effective tools for the topical delivery of cytokines to wounded tissues.

Bandages↗
PubMed2005

Removable rigid dressings versus soft dressings: a randomized, controlled study with dysvascular, trans-tibial amputees.

This study compares a standard soft dressing (SSD) with a removable rigid dressing (RRD) in a randomized, controlled trial using 50 dysvascular trans-tibial amputees. Both dressing types were applied immediately post-operatively and were only removed for wound dressing changes. Half the subjects were allocated prospectively by ballot to either the RRD group or the SSD group. There was a strong trend indicating that primary wound healing of the stump occurred almost 2 weeks earlier in subjects using the RRD (RRD = 51.2 days +/- 19.4; SSD = 64.7 days +/- 29.5; P= 0.07; RRD: n =17; SSD: n = 14.) There were no significant differences between the other parameters measured which included time to prosthetic fitting, length of hospital stay, incidence of stump breakdown, and time taken for stump volume to stabilize. The incidence of stump damage due to falls was also recorded, the results indicating that RRDs may protect the new stump from trauma.

Aged↗
PubMed1996

Dressed to heal: new options for graft site dressing.

To ensure the close apposition and immobilization required for survival of full thickness skin grafts, the traditional method is to use pexing sutures or tie-over pressure dressings. In certain areas, such as around the eye, other methods are required because either a concave or convex surface prevents adequate pressure, or the use of sutures as ties produces distortion of anatomical free margins. Alternative dressing methods include; telfa chips kept in place by a pressure pad; calcium alginate (which has the advantages of assisting haemostasis and absorbing serous discharge) under a pressure pad; and extra thin hydrocolloid dressings which decrease slough and are less conspicuous than other dressings.

Absorption↗
PubMedDate not supplied

Dressing selection: use of combinations of wound dressings.

There are many wound dressing products available. In certain circumstances they are used in combination. In order to protect the patient, the use of dressing combinations should have a clear purpose and the support of the manufactures. Inappropriate combinations are costly and ineffective and serve only to perpetuate practice that does not have a sound research base. This article highlights the issues surrounding dressing selection and offers guidance on appropriate dressing combinations.

Bandages↗
PubMed1997

A study to compare two film dressings used as secondary dressings.

Dressings manufactured from adhesive polymeric films have been used extensively in wound management for about 20 years. This report describes the results of a trial designed to compare the performance of two such dressings, used as secondary dressings, in a multi-centre randomised controlled community study involving 100 patients. Independent analysis of the study data revealed that, after adjusting for other effects, no genuine difference was demonstrated between the dressings in terms of their ability to resist wrinkling or prevent maceration (the primary outcome variable).

Adult↗
PubMed1986

Investigation of dressings designed for treatment of alveolitis sicca dolorosa ("dry socket"). Part 3: Influence of mannitol and sorbitol on properties of tablets and dressings comprising acetylsalicylic acid, mefenamic acid and aseptin P.

In the dressings for dry tooth sockets, mannitol and sorbitol as solid hydrophilizers have been applied. Increase of concentrations of these hydrophilizers in the tablets results in dressings with increased swelling ability and pharmaceutical availability but decreased viscosity and resistance to washing out. These properties of the dressings are also influenced by medicinal substances present. The dressing fills the tooth socket within several min, removes pain and remain there for 24-48 h.

Anti-Infective Agents↗
PubMed1986

Investigation of dressings developed for the treatment of alveolitis sicca dolorosa. Part 2: Influence of glycerol and PEG 200 on the properties of tablets and dressings comprising mefenamic acid and Nipagin P.

Some hydrogel dressings have been investigated to determine their utility for the treatment of painful dry tooth-socket (Alveolitis sicca dolorosa). As drugs mefenamic acid and Nipagin P have been applied. Hydrophilized methylcellulose, 5-15% glycerol or 5-20% PEG 200 were the filling and gel building material. It has been found, that the properties of the dressings depend on the content of the hydrophilizers. The half liberation time of the drugs under study ranges from 0.5 to 11 h, the swelling degree amounts to 366-400%, the washing out time runs to 80-140 min and the period of activity of the dressings inside the tooth-socket amounts to 24-48 h. The dressings show thixotropic properties and a high flow limit.

Bandages↗
PubMed1991

Comparison of the effects of semi-occlusive polyurethane dressings and hydrocolloid dressings on dermal repair: 1. Cellular changes.

The effects on dermal repair of two wound dressings, one the semi-occlusive polyurethane sheet Opsite, the other the hydrocolloid Granuflex, were compared in full-thickness excised lesions on porcine skin during the period from 5 d to 6 months after injury. Quantitative studies were made of changes in the populations of polymorphonuclear leucocytes, macrophages, fibroblasts, and endothelial cells. The progress of repair in the wounds covered with the semi-occlusive dressing showed a decrease in the number of inflammatory cells (polymorphonuclear leukocytes and macrophages) from 5 to 60 d, whereas the number of proliferative phase cells (fibroblasts and endothelial cells) increased from 5 to 7 d. The total cellularity per unit area showed an increase between 5 and 7 d, that is, during the proliferative phase of repair, and then progressively decreased as the proliferative phase was succeeded by the remodeling phase. In contrast, the repair process in the hydrocolloid-dressed wounds was more complex. The number of inflammatory cells remained relatively high throughout and there were consistently fewer endothelial cells present throughout. Fibroblast number showed an initial fall from 5 to 14 d but then started to increase in number from 21 to 60 d. This chronic inflammatory reaction appeared to be in response to particulate matter that had been incorporated into the wound bed and hypodermis, and was still apparent 6 months after injury, when hydrocolloid particles were detectable microscopically in the hypodermis.

Animals↗
PubMed1997

Retention dressings: a new option for donor site dressings.

Split skin graft donor site dressings should be cheap, easy to apply and remove, reduce pain, provide a moist wound healing environment, be easy to care for and cause minimal interference in the patient's daily activities. Adhesive retention dressings seem to provide these features and are a new option for donor site dressings.

Humans↗