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Active commuting to school: an overlooked source of childrens' physical activity?

The assessment and promotion of childrens' healthful physical activity is important: (i) to combat the international obesity epidemic that extends to childhood; and (ii) to establish an early habit of lifestyle physical activity that can be sustained into adolescence and adulthood. The primary focus of both assessment and promotion efforts has been on in-school physical education classes and, to a lesser extent, out-of-school structured exercise, sport and play. A potential source of continuous moderate activity, active commuting to school by means of walking or by bicycle, has been largely ignored in surveys of physical activity. Suggestive evidence of steep declines in the amount of childrens' destination walking can be gleaned from national transportation surveys. At the same time, there has been a dramatic increase in the reported use of motorised vehicles, including the use for chauffeuring children. There is very little evidence to support or refute active commuting to school as an important source of childrens' physical activity; however, this is largely because it has been overlooked in the stampede to assess time in more vigorous activities. The promotion of active commuting to school must be considered in the context of parents' real and perceived concerns for their children's personal and pedestrian safety. We certainly do not have a full understanding at this time of all the factors related to decisions about transportation mode, whether by child, parent, community, or school. Such information is necessary if successful and sustainable interventions can be implemented, important transport policy decisions can be made, and community and school designs can be modified. Practice rarely waits for research, however, and there are numerous examples of innovative programming, policies and environmental designs occurring internationally that can serve as natural experiments for enterprising researchers willing to push the envelope of our understanding of active commuting and childrens' physical activity. Since we know so little, there is much to learn.

Adolescent↗

The nature of calibrators in immunoassays: are they commutable with test samples? Must they be?

Immunoassay systems require calibration protocols that are normally more sophisticated than many analytical techniques in routine clinical use. Calibrators used in such assays may differ significantly from the analyte in clinical specimens. Differences in the properties of calibrators, or reference materials, from those of clinical specimens may include: species origin of the calibrator for an analyte; integrity of the molecular species; matrix of the calibration solution; addition of preservative agents. Owing to the large number of potential differences in the properties of calibrators and those of serum specimens that may affect immunoassay results, the concept of commutability that we originated and first applied to enzyme activity measurements can readily be applied to immunoassay determinations. We specifically examined the properties of calibration materials in nine commercial immunoassay tests for human thyrotropin. Significant non-commutability of materials was demonstrated. The measured results obtained with authentic patient sera differed by a factor of approximately two fold between the techniques exhibiting the lowest and greatest numeric results. Considerably larger intermethod biases were found for calibration materials. Multivariate analysis revealed that the patient sera formed a highly focussed pattern. The calibration materials for one instrument system also focussed in this group. Other calibrators formed three foci indicating similar patterns of commutability within each of the three groups. Clustering was independent of the amount of thyrotropin in the patient specimens, but appeared to be concentration-dependent for at least some of the calibrators. Thus the availability of a common calibration material appears feasible, but not presently available in many commercial products. A processed human serum, a candidate material for use in our proficiency testing program, was projected in the same cluster as authentic patient sera indicating that this material has intermethod properties identical to patient sera (i.e. fully commutable).

Humans↗

Commutability of calibration and control materials for serum lipase.

BACKGROUND: To effectively assess and correct for intermethod variability, calibration and control materials (CCMs) must show the same intermethod behavior as patient sera, i.e., they must be commutable. We describe the commutability of selected CCMs for lipase assays, the impact of noncommutability of CCMs in normalizing patient results, and characteristics of reagents that affect assay specificity and commutability. METHODS: Lipase was measured in 98 patient sera and in 29 commercial CCMs, with 2 commercial methods using different substrates and with 4 experimental methods using 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester as substrate and colipase as cofactor, but differing in the stabilizing proteins used and in the size of the substrate micelles. RESULTS: The noncommutability rate, i.e., the frequency of aberrant intermethod behavior of CCMs in comparison with patient sera, was 27% for liquid CCMs and 47% for lyophilized CCMs. The normalized residuals, measuring the degree of noncommutability, were -2.3 to 2.4 for CCMs with "normal" lipase activity, and -3.5 to 21.7 for CCMs with higher lipase activity. Recalculation of patient results with CCMs as calibrators decreased or increased the original bias according to whether the CCMs were commutable. CONCLUSIONS: For the lipase methods in this study, the frequency of noncommutability of CCMs is affected by assay-specific characteristics, including size of substrate micelles and the presence or absence of added proteins.

Calibration↗

CAKL: Commutative algebra k-mer learning of genomics.

Despite the availability of various sequence analysis models, comparative genomic analysis remains a challenge in genomics, genetics, and phylogenetics. Commutative algebra, a fundamental tool in algebraic geometry and number theory, has rarely been used in data and biological sciences. In this study, we introduce commutative algebra k-mer learning (CAKL) as the first-ever nonlinear algebraic framework for analyzing genomic sequences. CAKL bridges between commutative algebra, algebraic topology, combinatorics, and machine learning to establish a new mathematical paradigm for comparative genomic analysis. We evaluate its effectiveness on three tasks-genetic variant identification, phylogenetic tree analysis, and viral genome classification-typically requiring alignment-based, alignment-free, and machine-learning approaches, respectively. Across eleven datasets, CAKL outperforms five state-of-the-art sequence analysis methods, particularly in viral classification, and maintains stable predictive accuracy as dataset size increases, underscoring its scalability and robustness. This work ushers in a new era in commutative algebraic data analysis and learning.

Journal Article↗

Prior crash and violation records of pilots in commuter and air taxi crashes: a case-control study.

With a case-control design, this study examined the relationships of crash/incident history, violation history, pilot age, flight experience, and recent flight time with the likelihood of being involved in commuter aircraft and air taxi crashes. Cases (n = 725) were pilots who had been involved in commuter aircraft or air taxi crashes during 1983-88, identified from the National Transportation Safety Board aviation crash data base. From the Federal Aviation Administration (FAA) airmen information system, 1,555 pilots were randomly selected as controls. Controls were frequently-matched with cases on medical class and calendar year. Different data bases within the FAA's airmen information system were linked to ascertain information about crash/incident and violation records in the previous 3 years, age, total flight time, and flight time in the prior 6 months. Multivariate logistic regression models were fitted to estimate odds ratios and evaluate dose-response effects, non-linear relationships, and interactions. Cases had significantly higher prevalence rates of prior crash/incident and violation records. The estimated odds ratio of being involved in a commuter aircraft or an air taxi crash was 1.7 (95% confidence interval [CI], 1.3-2.4) for crash/incident history, and 1.6 (95% CI, 1.1-2.2) for violation history. A "dose-response effect" was found with both crash/incident history and violation history, with higher odds ratios for pilots with crashes versus incidents or with more serious violations. Total flight time showed a diminishing protective effect. Either very small or very large recent flight time increased the risk of being involved in a commuter aircraft or an air taxi crash.

Accidents, Aviation↗

Crashes of commuter aircraft and air taxis. What determines pilot survival?

Pilots have been recognized as an occupational group having very high work-related death rates. Commuter aircraft and air taxis are far more likely to be involved in fatal crashes than are larger airplanes. To examine the factors related to pilot survival in commuter aircraft and air taxi crashes, we analyzed National Transportation Safety Board data for the years 1983 to 1988. Case fatality rates were calculated for the pilots-in-command and odds ratios were estimated from a multivariate logistic regression model for variables related to pilots, aircraft, and circumstances. During the 6-year period, 536 people were killed and 744 injured in 888 commuter aircraft and air taxi crashes. The pilot case fatality rate was 20%. The most important determinants of pilot fatality were postcrash fire (odds ratio [OR] 8.2), off-airport location (OR 8.1), bad weather (OR 4.3), and nonuse of shoulder restraints (OR 3.7); all were significant at P < .01. Crash survival could be enhanced by more crashworthy fuel systems, aircraft seats, and use of restraint systems in commuter aircraft and air taxis. The value of shoulder restraints for pilots in these aircraft is confirmed and their use should be vigorously promoted.

Accidents, Aviation↗

Human factors in crashes of commuter airplanes.

Pilots and frequent travelers on commuter aircraft are exposed to higher risks of death or injury than those on major air carriers. To provide a better understanding of the circumstances of crashes of scheduled commuter airplanes, National Transportation Safety Board data were analyzed for all cases of death, serious injury, or major damage involving commuter airplanes during 1983-88, when 172 people were killed and 207 injured in 118 events. Three-fourths of cases involved inadequate pilot performance, notably poor handling of emergencies and improper instrument flying procedures. Pilot errors occurred disproportionately in bad weather, which played a role in 30% of crashes. Aircraft malfunctions were involved in 42% of crashes. Certain airplanes were overinvolved in gear-up landings or in crashes due to fuel mismanagement. Greater priority should be given to applying known preventive measures to the problem of commuter crashes.

Accidents, Aviation↗

Crash and violation experience of pilots involved in prior commuter and air taxi crashes: a historical cohort study.

BACKGROUND: Commuter flights and air taxis represent a major category of aviation losses in terms of both human life and economic resources. Previous studies have examined human factors involved in these crashes. A retrospective study revealed that pilots' prior crash and violation records are associated with an increased risk of being involved in a commuter aircraft or an air taxi crash. HYPOTHESIS: Pilots who are involved in crashes are at increased risk of involvement in future crashes and violations. METHODS: Pilots who had been involved in and survived commuter aircraft or air taxi crashes during 1983-88 (crash group, n = 580) and a random sample of pilots who were flying for these commercial operations (control group, n = 1555) were followed up for 3 yr. The crash/incident and violation experience during the 3 yr of follow-up was compared between the two groups at univariate level and at multivariate level. RESULTS: During the 3 yr of follow-up, the incidence rate of crashes/incidents was significantly higher for the crash group than for the control group (12.4% vs. 7.2%, p < 0.01). The crash group also was more likely to have a violation record than the control group during the 3 yr of follow-up (8.6% vs. 3.7%, p < 0.01). These differences were not changed by adjusting for pilot age, total flight time and medical class. CONCLUSIONS: Pilots who were involved in commuter aircraft or air taxi crashes have significantly higher subsequent crash and violation rates than their counterparts. In order to develop effective prevention strategies, environmental and psychosocial factors that predispose pilots to increased risk of involvement in aviation crashes and violations should be examined.

Accident Proneness↗

Home environmental consequences of commute travel impedance.

The physical and perceptual dimensions of commuting travel impedance were again found to have stressful consequences in a study of 99 employees of two companies. This quasi-experimental replication study, which focuses here on home environment consequences, investigated the effects of physical impedance and subjective impedance on multivariate measures of residential satisfaction and personal affect in the home. Both sets of residential outcome measures were significantly related to the two impedance dimensions. As predicted, gender was a significant moderator of physical impedance effects. Women commuting on high physical impedance routes were most negatively affected. Previously found subjective impedance effects on negative home mood, regardless of gender, were strongly replicated with several methods and were buttressed by convergent results with objective indices. The theoretical conjecture that subjective impedance mediates the stress effects of physical impedance was supported by the personal affect cluster but only for one variable in the residential satisfaction cluster. Traffic congestion has increased in metropolitan areas nationwide, and commuters, families, and organizations are absorbing associated hidden costs. The results are reviewed in terms of our ecological model, and the moderating effects of gender are discussed in terms of choice and role constraints.

Adult↗

Occupational, commuting, and leisure-time physical activity in relation to risk for Type 2 diabetes in middle-aged Finnish men and women.

AIM/HYPOTHESIS: Leisure-time physical activity can reduce the risk of Type 2 diabetes, but the potential effect of different types of physical activity is still uncertain. This study is to examine the relationship of occupational, commuting and leisure-time physical activity with the incidence of Type 2 diabetes. METHODS: We prospectively followed 6898 Finnish men and 7392 women of 35 to 64 years of age without a history of stroke, coronary heart disease, or diabetes at baseline. Hazards ratios of incidence of Type 2 diabetes were estimated by levels of occupational, commuting, and leisure-time physical activity. RESULTS: During a mean follow-up of 12 years, there were 373 incident cases of Type 2 diabetes. In both men and women combined, the hazards ratios of diabetes associated with light, moderate and active work were 1.00, 0.70 and 0.74 (p=0.020 for trend) after adjustment for confounding factors (age, study year, sex, systolic blood pressure, smoking, education, the two other types of physical activity and BMI). The multivariate-adjusted hazards ratios of diabetes with none, 1 to 29, and more than 30 min of walking or cycling to and from work were 1.00, 0.96, and 0.64 (p=0.048 for trend). The multivariate-adjusted hazards ratios of diabetes for low, moderate, high levels of leisure-time physical activity were 1.00, 0.67, and 0.61 (p=0.001 for trend); after additional adjustment for BMI, the hazards ratio was no longer significant. CONCLUSIONS/INTERPRETATION: Moderate and high occupational, commuting or leisure-time physical activity independently and significantly reduces risk of Type 2 diabetes among the middle-aged general population.

Adult↗

Matrix effects in clinical analysis: commutability of control materials between the Ektachem, Beckman and SMA 12/60 glucose and urea methods.

The effects of the protein matrices of selected human and animal based control materials on the Ektachem, Beckman and SMA 12/60 glucose and urea methods have been investigated by means of commutability studies. The commutability of control materials between the Ektachem and SMA 12/60 was greater than that between the Ektachem and Beckman methods and was similar to that reported for conventional methods. No trends were apparent amongst control sera from different species nor with different total protein levels. Some variation in commutability was found with different batches of Ektachem glucose and urea slides. In addition the effect of lyophilisation of fresh human serum on its analytical behaviour with different experimental batches of Ektachem glucose/urea slides was studied and found to be negligible.

Autoanalysis↗

Bus commuters' coping strategies and anxiety from terrorism: an example of the Israeli experience.

This study examined the use of three coping strategies: (1) emotion-focused coping (calming-distraction); (2) problem-focused coping (checking-behavior); and (3) denial (reduced perceived vulnerability), and their relationship to anxiety from terrorism among 50 Israeli bus commuters. Their mean age was 31 years (60% females). Commuting frequency was negatively correlated, and problem-focused coping was positively correlated with anxiety from terrorism. Ratios of problem-focused coping/denial and of problem-focused/emotion-focused coping were each positively correlated with anxiety from terrorism. Coping ratios accounted for 15% of the variance in anxiety from terrorism, after considering commuting frequency. Combining minimal problem-focused preventative acts with distraction and reduced perceived vulnerability may be beneficial.

Adaptation, Psychological↗

Relation between commuting, leisure time physical activity and serum lipids in a Chinese urban population.

PRIMARY OBJECTIVE: To analyse the association between both commuting and leisure time physical activity and serum lipids in a Chinese population. POPULATION: A total of 1786 males and 1922 females aged 20-49 years. METHODS: A cross-sectional survey was carried out in 1989 in urban area of the city of Tianjin, China. Commuting and leisure time physical activity, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides were determined. RESULTS: Daily walking or cycling to and from work was inversely associated with serum total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations among men and positively associated with high-density lipoprotein cholesterol concentrations among women as compared to travelling to and from work by bus. CONCLUSIONS: The present study showed a significant association between serum lipids and commuting physical activity, but no relation with leisure time sports.

Adult↗

Mortality risk in a birth cohort of commuter air carrier and air taxi pilots.

Commuter and air taxi pilots have higher work-related death rates than most other occupational groups. In this longitudinal study, the authors examined the mortality in a cohort of 3263 commuter and air taxi pilots. With adjustment for age, proportional hazards modeling revealed that termination or downgrading of medical certificates during the 11-year follow-up was associated with a significantly increased risk of overall mortality (relative risk, 2.32; 95% confidence interval [CI] = 1.43-3.77). Relative to the general population with similar demographic characteristics, commuter air carrier and air taxi pilots had significantly lower overall mortality (standard mortality ratio [SMR], 0.36; 95% CI = 0.32-0.41) and mortality from cardiovascular diseases (SMR, 0.18, 95% CI = 0.15-0.22), but considerably higher mortality from aviation crashes (SMR, 128.88; 95% CI = 6.35-2624.36). The results indicate that the current medical certification system is effective in maintaining a healthy pilot workforce.

Accident Proneness↗

Commutability of reference materials in clinical chemistry.

The term commutability applied to reference materials denotes the ability of the material to show interassay changes comparable to those observed in the measurement of the same analyte in human serum. In this study commutability was studied by first establishing the relationship between the results obtained on patient serum samples with two independent methods for a given analyte. Then, the calibration or control material was assayed with the same pair of methods, and its interassay bias was statistically compared with that shown by patient sera. The results obtained in 27 experiments showed that the frequencies of noncommutability in the measurement of some nonenzymic organic components, enzymes, and inorganic ions were, respectively, 25/83, 44/99, and 32/61. The impact of noncommutability of the materials on the results of external quality assessment schemes (EQAS), matrix interferences, and the behavior of particular components are considered. The conclusion drawn is that each material should be tested for commutability before it is used as a reference material.

Calibration↗

[Tuberculosis microepidemic in a commuter bus].

A tuberculosis microepidemic in a commuter bus was reported. Index patient was a 22-year-old woman who was an employee of an electronic company. An abnormal shadow was found on her chest roentgenogram during an annual medical check-up in June, 1996. As her sputum smear was Gaffky 6, she was admitted to our hospital for medication. Extraordinary examinations including PPD skin test and chest X-ray were carried out on 49 employees of the company in October, 1996. As the result of these examinations, the distribution of maximum diameters of erythema in PPD skin test showed bimodal distribution, and tuberculosis was discovered in two patients by Chest X-ray examination. Moreover, preventive administration of Isonicotinic acid hydrazide (INH) was indicated for 3 employees based on very strong skin reaction to PPD. These five employees were working separately from the index patient and had little contact with the patient in the work places, but using a same commuter bus. Therefore, we strongly suspect that they were infected from the index patient not in the work place but in the commuter bus. The air-conditioning of the bus used a closed recirculation system, hence insufficient ventilation in the bus contributed to the spread of tuberculosis infection.

Adult↗

Commutability assessment of potential reference materials using a multicenter split-patient-sample between-field-methods (twin-study) design: study within the framework of the Dutch project "Calibration 2000".

BACKGROUND: The Dutch project "Calibration 2000" aims at harmonization of laboratory results via calibration by development of commutable, matrix-based, secondary reference materials. An alternative approach to the NCCLS EP14 protocol for studying commutability of reference materials is presented, the "twin-study design", which in essence is a multicenter, split-patient-sample, between-field-methods protocol. METHODS: The study consisted of the simultaneous analysis of fresh patient sera and potential reference materials (PRMs) for HDL-cholesterol (HDL-C) by 86 laboratories forming 43 laboratory couples. Six subgroups of method combinations were formed. The patient sera were selected and interchanged by each laboratory couple. The PRMs consisted of three types: C37, prepared according to the NCCLS C37 protocol; Fro, frozen selectively pooled human serum; and Lyo, which was the same serum pool as Fro but lyophilized in the presence of sucrose. All PRMs were provided in three HDL-C concentrations. The regression line residuals for the PRMs were normalized by expressing them as multiples of the state-of-the-art within laboratory SD (SD(SA)). In addition, the extra contribution of each PRM to the total measurement uncertainty, CV(Netto), was calculated. RESULTS: Averaged over the three PRM concentrations, 1.6% of the C37 residuals were outside the 3 SD(SA) limit. For the Fro and Lyo PRMs, these values were 2.4% and 11.1%. CV(Netto) values for C37, Fro, and Lyo were 2.9%, 4.3%, and 5.3%, respectively. CONCLUSIONS: The present twin-study design, as a practical alternative to the NCCLS EP14 protocol, is a viable way of studying commutability characteristics of PRMs. The study suggests that the C37 PRMs are the best candidates for a future reference material.

Algorithms↗

Problem size and mentally retarded children's judgment of commutativity.

The effects of problem size on judgments of commutativity by 51 moderately and mildly mentally retarded students were investigated. The task required subjects to judge whether commuted addition problems (e.g., 5 + 2 and 2 + 5) and noncommuted problems (e.g., 5 + 3 and 5 + 0) would have the same or different sum. Small problems had addends of five or less; large problems had at least one addend greater than five. The subjects' responses to the commutativity task were highly consistent across the two problem sizes. Results indicated that many retarded students who are given computational practice recognize the general principle that addend order does not affect the sum.

Adolescent↗