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PubMed1965

A COMPUTER SYSTEM FOR A UNION CATALOG: THEME AND VARIATIONS.

This article describes a computer system for the generation and maintenance of a union catalog of periodicals and for printouts of both the entire file and selected portions. Although the system was designed to meet the specifications of the Union Catalog of Medical Periodicals of New York, its use is not limited. Only the basic file maintenance program is indispensable; the subsidiary programs may be used as needed. The scope and content of the catalog are determined by the input. The preparation of the input is described in detail, with comment on the keypunching of library records. Applications to other kinds of catalogs are suggested.

Catalogs, Union as Topic↗
PubMed1973

Computer information project for monographs at the Medical Research Library of Brooklyn.

The article describes a resource library's computer-based project that provides cataloging and other bibliographic services and promotes greater use of the book collection. A few studies are cited to show the significance of monographic literature in medical libraries. The educational role of the Medical Research Library of Brooklyn is discussed, both with regard to the parent institution and to smaller medical libraries in the same geographic area. Types of aid given to smaller libraries are enumerated. Information is given on methods for providing machine-produced catalog cards, current awareness notes, and bibliographic lists. Actualities and potentialities of the computer project are discussed.

Bibliographies as Topic↗
PubMed1972

Union list development: control of the serial literature.

The discussion covers the development of a national union list or finding tool for biomedical serial holdings and its integration into the National Serials Data Program, which is being developed under the auspices of the three National Libraries. Specific topics which are covered include: (1) Selection of the Union Catalog of Medical Periodicals (UCMP) as the basis for a biomedical list and the status of that activity; (2) discussion of the various methods of recording holdings; (3) status of the National Serials Data Program and a discussion of its relationship to the UCMP file; and (4) status of the Standard Serial Number and its relationship to other existing coding schemes for serial titles.

Catalogs, Union as Topic↗
PubMed1992

Completeness of catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes.

The completeness of McKusick's catalogs of Mendelian Inheritance in Man (MIM) as to the number of phenotypes included was studied by estimating the degree of concordance with the Dutch Gene Catalog of the Department of Medical Genetics of the University of Groningen, The Netherlands. On a total of 355 Mendelian phenotypes described in persons living in The Netherlands or originating from this country, there were nine disease entities which were not present in MIM. As judged from this comparison MIM attains 97.5% completeness (95% CI: 95.3-98.7%). Similar comparisons with data from other countries are needed before a final conclusion can be reached. Corresponding contributors in different countries or linguistic areas might further improve MIM's completeness.

Catalogs as Topic↗
PubMed1989

An online tests catalog for clinical laboratories.

An attempt to integrate an online catalog for clinical laboratory tests in a university hospital medical computing environment is presented here. The need for such a catalog is evident, due to the dynamic changes in the area, new tests, and new test methods. Physicians are able to access the catalog through department terminals. The catalog has been designed and implemented as a relational database, including seven tables. Context-sensitive help screens are available at any step, as well as specific instructions for each laboratory.

Catalogs as Topic↗
PubMed2004

Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

We previously published a series of detailed maps of single nucleotide polymorphisms (SNPs) in the genomic regions of 209 gene loci encoding drug metabolizing enzymes, transporters, receptors, and other potential drug targets. In addition to the maps reported earlier, we provide here high-resolution SNP maps of 23 genes encoding G-protein coupled receptors in the Japanese population. A total of 300 SNPs were identified through screening of these loci; 83 in four adenosine receptor family genes, 45 in three adrenergic receptor family genes, 22 in three EDG receptor family genes, 29 in three melanocortin receptor family genes, 22 in two somatostatin receptor family genes, 21 in five anonymous G protein-coupled receptor family genes, and 78 in the others (AVPR1B, OXTR, and TNFRSF1A). We also discovered a total of 33 genetic variations of other types. Of the 300 SNPs, 132 (44%) appeared to be novel on the basis of comparisons with the dbSNP database of the National Center for Biotechnology Information (US) or with previous publications. The maps constructed in this study will serve as an additional resource for studies of complex genetic diseases and drug-response phenotypes to be mapped by linkage-disequilibrium association analyses.

Catalogs as Topic↗
PubMed2002

Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.

Single-nucleotide polymorphisms (SNPs) at some gene loci are useful as markers of individual risk for adverse drug reactions or susceptibility to complex diseases. We have been focusing on identifying SNPs in and around genes encoding drug-metabolizing enzymes and transporters, and have constructed several high-density SNP maps of such regions. Here we report SNPs at additional loci, specifically 13 genes belonging to the superfamily of ATP-binding cassette transporters ( ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8). Sequencing a total of 416 kb of genomic DNA from 48 Japanese volunteers identified 605 SNPs among these 13 loci: 14 in 5' flanking regions, 5 in 5' untranslated regions, 37 within coding elements, 529 in introns, 8 in 3' untranslated regions, and 12 in 3' flanking regions. By comparing our data with SNPs deposited in the dbSNP database of the National Center for Biotechnology Information (US) and with published reports, we determined that 491 (81%) of the SNPs reported here were novel. We also detected 107 genetic variations of other types among the loci examined (insertion-deletions or mono- di-, or trinucleotide polymorphisms). The high-density SNP maps we constructed on the basis of these data should provide useful information for investigating associations between genetic variations and common diseases or responsiveness to drug therapy.

ATP-Binding Cassette Transporters↗
PubMed1983

A teaching catalogue of physical findings developed on the geriatric ward of an acute-care teaching hospital.

A catalogue of physical findings from patients on a geriatric ward run by a Family Practice Centre was developed for the use of both medical educators and students. The collection and organization of the data is described, as well as the ethical problems involved. Advantages to both teachers and students are discussed with respect to the teaching of physical diagnosis. An added benefit of producing and using a catalogue of this nature could be the changing of negative attitudes towards the geriatric patient.

Aged↗
PubMed2002

Information retrieval on the Internet: a guide for dental practitioners.

The Internet is not designed for efficient information retrieval. Searchers experience difficulties when trying to find information quickly. Once they find the information, they often cannot assess the validity of the information or its origin. Various Internet search engines and information retrieval systems try to facilitate this process to make the searching more efficient. Searchers use these services, which are usually free, to satisfy their information needs. Knowing when to use which search engine and how to use it is crucial to finding the right information in a timely fashion.

Algorithms↗
PubMed2002

Mineralogy and mineral collections in 18th-century France.

During the 18th century, mineralogy constituted an integral part of natural history, sharing the concerns of botany and zoology over collection and classification. In Paris, many people owned private mineral collections, but these have been largely neglected by historians. Here, I examine the place of private collections in the history of mineralogy, arguing that they contributed socially, economically and intellectually to the field in a period before the dominance of the large national collection. I also show how the interests of private collectors diverged from those of the curators of public collections, particularly following the French Revolution.

Catalogs as Topic↗
PubMed2001

Availability and characterization of transgenic and knockout mice with behavioral manifestations: where to look and what to search for.

Mice altered by transgenesis or gene targeting ("knockouts") have increasingly been employed as alternative effective tools in elucidating the genetic basis of neurophysiology and behavior. Standardization of specific behavioral paradigms and phenotyping strategies will ensure that these behavioral mouse mutants offer robust models for evaluating the efficacy of novel therapeutics in the treatment of hereditary neurological disorders. The Induced Mutant Resource (IMR) at The Jackson Laboratory (Bar Harbor, Maine, USA) imports, cryopreserves, develops, maintains, and distributes to the research community biomedically valuable stocks of transgenic and targeted mutant mice. Information on behavioral and neurological strains-including a phenotypic synopsis, husbandry requirements, strain availability, and genetic typing protocols-is available through the IMR database (http://www.jax.org/resources/documents/imr/). A current catalog of available strains is readily accessible via the JAX Mice Web site at http://jaxmice.jax.org/index.shtml. In addition, The Jackson Laboratory is now home to TBASE (http://tbase.jax.org/), a comprehensive, community database whose primary focus is on mouse knockouts. TBASE accommodates an exhaustive bibliographical resource for transgenic and knockout mice and provides a detailed phenotypic characterization of numerous behavioral knockouts that is primarily extracted from the literature. Concerted efforts to merge the two resources into a new, schematically reformed database are underway.

Animals↗
PubMed1996

Benchmarking patient satisfaction at academic health centers.

BACKGROUND: In 1991 the University HealthSystem Consortium (UHC), an alliance of 70 academic health centers, began its patient satisfaction benchmarking project. The survey, adapted from the Picker Institute survey, was pilot tested in 1992 and has been in use since 1993. Each year the project's steering committee refines the survey on the basis of member needs and survey item performance. KEY FINDINGS: Findings have shown that the survey can document the effects of specific quality improvement efforts, that patients from different medical services report different levels of satisfaction with their care, and that physician and nursing care have had the greatest impact on overall satisfaction. USING THE RESULTS: Each participating organization receives concise narrative reports of the survey results, with priorities for improvement efforts clearly highlighted. A five-to six-page Executive Summary provides the organization's executive team with a quick overview of the results, as well as a summary of the areas where quality improvements are most needed. A longer Managers' Report provides a more detailed analysis of the findings for quality managers and department heads. Sections for each major area of care can be copied and distributed as "stand alone" reports to the appropriate decision makers. For example, the section on nursing care can be distributed to the chief nursing officer and nurse managers. For each key aspect of the patient's experience, best practices for maintaining patient satisfaction are identified from across the hospitals and compiled into a catalogue. LESSONS LEARNED: The UHC patient satisfaction benchmarking program has created ongoing communication among the participating hospitals, whose staff members have been willing to share problems encountered and possible solutions.

Academic Medical Centers↗