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PubMed1993

Overexpression of p53 protein and c-erbB-2 protein in small cell carcinoma of the cervix uteri.

Twenty-eight primary small cell carcinomas of the cervix uteri were examined immunohistochemically for overexpression of p53 protein and c-erbB-2 protein. Twenty-one per cent of the cases showed positive immunostaining for p53 protein, whereas no staining was observed using the antibody against c-erbB-2. Our results indicate that altered expression of p53 protein may be involved in the development of small cell carcinoma of the cervix uteri.

Biomarkers, Tumor↗
PubMed1977

[Classification of precancerous conditions and cancer of the cervix uteri].

The classification consists of three sections: background processes, precancer states, and cancer of cervix uteri. The background processes depending on the etiological factor and the character of lesion of the epithelium are divided into dyshormonal, inflammatory, and posttraumatic. Groups of the so-called morphological precancer and preclinical forms of cervix uteri cancer are identified.

Carcinoma in Situ↗
PubMed1976

The role of scalene lymph node biopsy in advanced carcinoma of the cervix uteri.

Considerable controversy exists in the role of scalene lymph node biopsy in the pretreatment assessment of patients with carcinoma of the cervix uteri. Scalene lymph node biopsy was carried out on ten patients having advanced carcinoma of the cervix uteri with documented para-aortic nodal involvement. Metastatic carcinoma was found in the scalene lymph nodes in five of ten patients. These preliminary findings suggest that excision of scalene lymph nodes should be carried out prior to the institution of therapy in all patients with carcinoma of the cervix uteri which is metastatic to the para-aortic lymph nodes.

Adult↗
PubMed2005

Unaltered innervation of the human cervix uteri in contrast to the corpus during pregnancy and labor as revealed by PGP 9.5 immunohistochemistry.

OBJECTIVE: To examine the occurrence of the general neuronal marker protein gene product 9.5 (PGP 9.5) in the human corpus (isthmus region) and the cervix uteri during pregnancy and parturition STUDY DESIGN: Biopsies were taken from the upper edge of the hysterotomy during caesarean section (CS) at term (n=5), in labor (n=5) and from the corresponding area in the non-pregnant uterus after hysterectomy (n=5). Cervical biopsies were obtained transvaginally from the anterior cervical lip. Serial cryostate sections were prepared for immunohistochemistry using polyclonal antibodies to PGP 9.5. RESULTS: Nerve fibers displaying PGP 9.5 immunoreactivity were observed in all sections from the three groups examined. They were identified in muscle tissue, in the stroma, and around blood vessel walls. A 30-fold decline of immunoreactive nerve fibers was observed in the isthmus part of the corpus uteri at term compared to the non-pregnant. There were no significant differences between the immunoreactivity in the cervix uteri of the three groups CONCLUSIONS: The innervation of the cervix uteri is dense and unaltered throughout pregnancy and labor. In contrast, the corpus is almost denervated. Further studies are needed to clarify the reason and the impact of these findings.

Adult↗
PubMed1993

Radical hysterectomy in the treatment of patients with bulky early stage carcinoma of the cervix uteri.

This study was done to assess the role of radical hysterectomy in patients with bulky (greater than or equal to 4 centimeters) early stage carcinoma of the cervix uteri. Of 48 patients with bulky carcinoma of the cervix uteri undergoing Type III radical hysterectomy between 1970 and 1987, 46 patients were Stage 1B and two were Stage 2A. Pathologic estimate of the dimensions of the lesion ranged from 4 x 3 to 9 x 11 centimeters. Fourteen patients had evidence of pelvic node metastasis and one patient had evidence of microscopic metastasis to the para-aortic nodes. Twelve patients received adjunctive radiation therapy for findings of nodal metastasis or tumor near or at the surgical margin. There were recurrences in 19 patients, 13 of which were isolated to the pelvic area. Of the patients with isolated pelvic recurrences, five were salvaged with secondary treatment. The overall five year survival rate was 73.6 percent and the ten year survival rate was 60.6 percent. Radical hysterectomy and lymphadenectomy seems to have equal efficacy and morbidity rates when compared with radiation therapy or the combination of extrafascial hysterectomy and radiation therapy in the treatment of patients with bulky early stage carcinoma of the cervix uteri.

Adenocarcinoma↗
PubMed1981

Multiple primary cancers of breast and cervix uteri: an epidemiological approach to analysis.

Index sites of breast and cervix uteri were selected from populationbased data held at the West Midlands and Birmingham Regional Cancer Registry, and the expected numbers of second primary cancers in cervix and breast were computed (sequence analyses). In the breast series (17,756 patients) a small deficit of cervical tumours was observed (O = 16, E = 2·119, O/E = 0·76, P > 0·05), while in the cervix series (4817 patients) a small excess of breast tumours was found (O = 29, E = 23·38, O/E = 1·24, P > 0·05) over a period of 15 years.A theoretical statement of the combined risk of the 2 tumours occurring in the same individual of a general population was developed and was compared with the practical approach of summing the sequence analyses (complementary analysis). Complementary analysis indicated that there was no excess of women with the 2 primary tumours (O = 45, E = 44·57, O/E = 1·01) and that cancers of the breast and cervix uteri are not aetiologically related.

Adolescent↗
PubMed2004

Diagnostic, endocrinological, behavioral, and DNA ploidy differences between squamous cell and adenomatous carcinoma of the cervix uteri.

The objective of this study was to compare behavioral and hormonal risk factors, and cancer characteristics in squamous cell and adenocarcinoma of the cervix uteri. The study included 45 women with adenocarcinoma and 190 consecutive women with squamous cell carcinoma of the cervix uteri diagnosed between 1984 and 1990. In addition to routine diagnostic procedures, DNA from biopsies was analyzed with flow cytometry to identify the S-phase fraction as a measure of cancer growth. Serum progesterone and estradiol were measured, and ever hormonal use and smoking were recorded. Ten-year mortality was estimated. There was no significant difference in age at diagnosis. Women with adenocarcinoma, compared with those with squamous epithelial carcinoma, had a significantly shorter duration of ever contraceptive use, were less likely to smoke (nonsignificant), had a lower cancer stage, were less likely to have an S-phase fraction of more than 16%. and had a higher progesterone value (if premenopausal). The results suggest that there are some different risk factors in adenocarcinoma and squamous cell carcinoma of the cervix uteri.

Adenocarcinoma↗
PubMed1996

[Epidermoid carcinoma of the cervix uteri: molecular abnormalities of p53 and rb genes].

The inactivation of p53 and rb genes has been implicated in the pathogenesis of cervix uteri carcinoma. Although this neoplasia presents high incidence and mortality rates in Chile, there are not studies about its molecular abnormalities. We investigated the frequency of loss of heterozygocity (LOH) at p53 and rb genes in 17 invasive squamous cell carcinomas of the cervix uteri, using microdissection technique from microslides and microsatellite sequences amplification by PCR. Moreover, we investigated the immunohistochemical expression of p53 protein in 30 invasive squamous cell carcinomas LOH was detected in 6/12 of informative cases (50%) at p53 gene and in 3/10 (30%) at rb gene. The p53 protein immunohistochemical expression was 47% (14/30 cases). LOH at p53 gene in cases without p53 protein immunohistochemical expression was observed. We concluded that p53 gene molecular abnormalities are important in the pathogenesis of squamous cell carcinoma of the cervix uteri, in contrast than LOH at rb gene.

Autoradiography↗
PubMed1993

[Experience with using laser surgery in the treatment of benign diseases of the cervix uteri when it is deformed].

Contact AYG laser was used in surgery on the deformed cervix uteri for cervicosis. The suggested method of using a contact laser scalpel at the main stages of the operation for partial stratification and miniconization provides a reliable hemostasis, minimal injury to the tissues, sterility of the operation site, and in stratification of the cervix uteri--a sufficiently easy dissection of the desired layer. The authors emphasize the usefulness of a differentiated approach to the choice of the method of surgical intervention (conization, plasty by partial or complete stratification), permitting the surgeon to combine the radical character of a surgical intervention with sparing of the anatomical shape of the cervical canal, and thus providing functionally stable results.

Cervix Uteri↗
PubMed1990

Carcinoma of the cervix uteri and risk factors.

A prospective study included 210 patients and 100 healthy individuals in whom risk factors for the onset of malignant disorders of the cervix uteri were investigated. The following parameters were analyzed: age, profession, religious affiliation, former pregnancies, chronic irritative process on the cervix uteri, socio-economic status, heredity, contraceptive usage, smoking, sexual life and presence of the human papilloma viruses in the injured and healthy cervix. The results of the research emphasized the relevant risk factors for the genesis of the disease. They are presented in an original sheme. The central place in the pathogenesis of the disease is taken by the existing metaplasia on the portio vaginalis uteri and its contact with definite types of human papilloma viruses. The risk factors that contribute to the genesis of metaplasia and cervical infection by human papilloma viruses proved to be of great importance for the appearance of disorder. The adolescent period, the chronic irritative process on the portio vaginalis and the long-term use of hormonal contraceptives influence the genesis of metaplasia. Early sexual life, the changing of sexual partners, the sexual life of male partners, poor sexual hygiene, and the use of nonbarrier contraceptive devices favour the development of human papilloma viral infections of the cervix uteri.

Adult↗
PubMed1982

[Chromosome changes on 20 lesions of cervix uteri ].

Cytogenetic studies on biopsies of cervix uteri (5 dysplasias, 2 carcinomas in situ and 13 invasive carcinomas) are reported in this paper in order to detect the numerical and structural chromosome changes. In dysplasias, the deviation number is mostly restricted around the diploid mode while in carcinomas the range of deviation is wider and more than one modal number could be identified. Structural aberrations of chromosome 1 were found in one case of dysplasia and in 10 cases of invasive carcinomas. A long acrocentric was observed in three carcinomas and one dysplasia, while a medium-sized metacentric in three carcinomas. Further markers : minute chromosomes (in two carcinomas) and double minute bodies (DMs, in one carcinoma). These studies and the early ones suggest that the changes of chromosome 1 may be a relative late appearance of malignant transformation. The possible role of DMs is also discussed.

Adult↗
PubMed1983

Cytophotometric determination of DNA in minimal invasive cancer of the human cervix uteri.

The early invasive cancer of the human cervix uteri is marked by a higher proliferation rate in its DNA histograms, which is a sign of perforation of the basal membrane. When this process finishes and an invasive carcinoma is present, the range of the DNA values decreases. The carcinoma has possibly reached a silent phase that will end with the penetration into the lymphatic system.

Carcinoma↗
PubMed1991

[Cytologic and morphologic characteristics of human papillomavirus infection in cervix uteri pathology].

The role of human papilloma virus (HPV) in genital cancer is not yet clear at present, but the available data testify to serious changes in cervix uteri epithelium in the process of its infection. Close correlation was demonstrated between HPV type specificity and the degree of epithelial morphological changes as well as histologic tumor variant, and its degree of differentiation. Interrelation between HPV type and level of both regression and progression of atypically changed cervix uteri epithelium is established. Cytomorphological method of the evaluation of cell koilocytotic atypia is the marker to diagnose HPV infection when screening a chosen woman population. The development and introducing of sensitive and reliable identification methods of type-specific DNA sequences of HPV infection in diagnostic material to form a low risk (HPV-6 and II types) and a high risk group (HPV-16 and 18 types) by malignancy of cervix uteri epithelium have considerable promise. It is advisable to study HPV role in the development of adenogenic tumors of uterine cervix and body.

Cell Differentiation↗
PubMedDate not supplied

The use of glycogen studies in the evaluation of treatment for carcinoma of the cervix uteri.

Glycogen in the squamous mucosa of the cervix and vagina has been shown to be depleted in carcinoma of the cervix uteri, as reflected in the exfoliated cells. A study was undertaken to ascertain whether a glycogen accumulation is reestablished in cells once the neoplastic lesion is removed by radical therapy: 425 cases of cervical cancer were investigated before and after different types of therapy. A good response to radiotherapy or surgery was associated with a progressive increase in the glycogen observed in the vaginal smears, particular in premenopausal cases; patients with a poor response to radiotherapy or chemotherapy did not exhibit glycogen accumulation in the exfoliated cells. It thus appears that glycogen is a sensitive indicator of the responsiveness of cervical cancer to treatment and hence can be of prognostic value. Such sensitivity is further reflected in the detection of recurrence of the disease after an initially good response to therapy; that indicates that glycogen accumulation can possibly serve as a useful tool in the early diagnosis of recurrence.

Carcinoma, Squamous Cell↗