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PubMed1998

Does body mass index adequately capture the relation of body composition and body size to health outcomes?

Body mass index (BMI) has become the most commonly used index of body composition in epidemiologic research. It has displaced weight, height, and other measures of body composition. In this paper, the authors show that use of BMI alone does not always capture adequately the joint relation of body composition and body size to health outcomes, and that such use often represents implausible restrictions on the relation. Use of body mass index and height or weight and height will often be needed to describe this relation and to control confounding by these variables.

Adipose Tissue↗
PubMed1990

Three structures associated with the nucleolus in male rat germinal cells: round body, coiled body, and "nubecula" and general presence of round body at male meiosis.

In addition to chromosomes and nucleoli, three structures, i.e., round body, coiled body, and nubecula, are encountered in the nucleus during the meiotic prophase in male rats. These structures have been examined by electron microscopy in random and serial sections. The round body is a finely fibrillar, proteinaceous structure closely associated with the granular component of a nucleolus in rat spermatocytes and young spermatids. A similar structure has been observed in man, the monkey Macaca mulatta, the gastropod Achatina fulica, and the insect Locusta migratoria. Together with evidence from the literature, these results support the view that the round body is of general occurrence in the male meiocytes of eukaryotes and may, therefore, play a role in meiosis. The coiled body is a group of electron-dense elements called "coils", which average 35 nm in width, except after mid-pachytene when their size almost doubles. The coils are composed of 2-nm-wide filaments and 8 to 10-nm-wide granules, both of which are ribonucleoprotein. The coiled bodies are interpreted to be groups of "spliceosomes", that is, structures containing heterogeneous RNA and small nuclear RNA. A remarkable feature of the coiled body is its temporary disappearance at early pachytene and its reappearance at late pachytene, possibly due to drastic changes in the turnover rate of its component RNAs. The nubecula is a newly identified nuclear inclusion, composed of weakly staining threads loosely organized into a 560 nm-wide spheroid. It has been observed only in early pachytene nuclei.

Animals↗
PubMed1988

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease.

Polyclonal antibodies were raised which have a high affinity for conjugated ubiquitin. Immunocytochemistry was performed on paraffin sections of tissues showing well-characterized inclusion bodies. Ubiquitin was found as a component of the intermediate filament inclusion bodies characteristic of several major diseases including Lewy bodies of Parkinson's disease, Pick bodies of Pick's disease, Mallory bodies of alcoholic liver disease, cytoplasmic bodies of a specific myopathy, and Rosenthal fibres within astrocytes. Ubiquitin was also present in the three histological lesions characteristic of Alzheimer's disease. These observations suggest a fundamental role for ubiquitin in the formation of intermediate filament inclusion bodies in man, and have implications regarding the pathogenesis of these important diseases.

Alzheimer Disease↗
PubMed1996

Ketone body ratios of the superior and inferior vena cava and of pulmonary arterial blood compared to that of arterial blood: central venous ketone body ratio as a substitute for the arterial ketone body ratio.

To investigate the ketone body ratio (acetoacetate/3-hydroxybutyrate) of central venous blood compared to that of peripheral arterial blood, the acetoacetate and 3-hydroxybutyrate concentrations in paired peripheral arterial and central venous or pulmonary arterial blood were measured. The ketone body concentrations in superior and inferior vena cava blood were significantly (P < 0.0001) lower than those in peripheral arterial blood, whereas those in pulmonary arterial blood were almost the same as those in peripheral arterial blood. These results indicate that ketone bodies were metabolized in the muscles, which reduced their levels in vena cava blood, but ketone bodies newly produced by the liver were transported to the right side of the heart via the hepatic vein, giving concentrations in pulmonary arterial blood that were almost the same as those in peripheral arterial blood. On the other hand, the correlation coefficients (r2) of the arterial blood ketone body ratio to the ratio of superior and inferior vena cava and pulmonary arterial blood were 0.897, 0.767 and 0.882, respectively. The ratios of central venous ketone body ratio/arterial blood ketone body ratio were 0.89 +/- 0.15 in the superior vena cava, 0.64 +/- 0.18 in the inferior vena cava and 1.01 +/- 0.15 in the pulmonary artery.

3-Hydroxybutyric Acid↗
PubMedDate not supplied

Relationship of body density and lean body mass to body measurements: application to Indian soldiers of relationships developed for people of European descent.

Body density was measured directly in 90 young Indian soldiers from the Gurkha, Rajput and South Indian regiments. Body density was also predicted on the same subjects using skinfold thicknesses as well as other anthropometric measurements. Validity of the regression equations of Pascale, Grossman, Sloan and Frankel (1956), Sloan (1967) and Wilmore and Behnke (1969) was also tested on these Indian soldiers. Lean body mass was estimated directly from another equation of Wilmore and Behnke (1969), where skinfold thicknesses were not involved. The results indicate that all the body density predicting equations underestimate the measured body density, with the equation of Sloan (1967) approximately more closely to the actual value in these ethnic groups. The equation of Wilmore and Behnke (1969) regresses lean body weight from body measurement satisfactorily in all the ethnic groups of this study.

Adolescent↗
PubMed2000

Expression of cucumber lipid-body lipoxygenase in transgenic tobacco: lipid-body lipoxygenase is correctly targeted to seed lipid bodies.

A particular isoform of lipoxygenase (LOX, EC 1.13.11.12) localized on lipid bodies has been shown by earlier investigations to play a role during seed germination in initiating the mobilization of triacylglycerols. On lipid bodies of germinating cucumber (Cucumis sativus L.) seedlings, the modification of linoleoyl moieties by this LOX precedes the hydrolysis of the ester bonds. We analyzed the expression and intracellular location of this particular LOX form in leaves and seeds of tobacco (Nicotiana tabacum L.) transformed with one construct coding for cucumber lipid-body LOX and one construct coding for cucumber LOX fused with a hemagglutinin epitope. In both tissues, the amount of lipid-body LOX was clearly detectable. Biochemical analysis revealed that in mature seeds the foreign LOX was targeted to lipid bodies, and the preferred location of the LOX on lipid bodies was verified by immunofluorescence microscopy. Cells of the endosperm and of the embryo exhibited fluorescence based on the immunodecoration of LOX protein whereas very weak fluorescent label was visible in seeds of untransformed control plants. Further cytochemical analysis of transformed plants showed that the LOX protein accumulated in the cytoplasm when green leaves lacking lipid bodies were analyzed. Increased LOX activity was shown in young leaves of transformed plants by an increase in the amounts of endogenous (2E)-hexenal and jasmonic acid.

Aldehydes↗
PubMed1991

Prediction of total body lipid from total body water in rats. Part 2. In vivo estimation of total body lipid by tritium water dilution.

Body composition data estimated for normal young, normal adult, and adult obese Wistar rats by a tritiated water (THO) dilution procedure (b. wt. range 119-237 g, n = 31; 305-597 g, n = 43; 274-381 g, n = 6) were compared with the results of whole body analysis. As for the predicted total body lipid (TBL), the content was calculated from the virtual THO-dilution space estimated by a simple micro-method and a regression equation between TBL [%] and DM [%] (dry matter) content (Part 1. Relations between directly measured major body components. Nahrung 35 (1991) 581. Due to different degrees of overestimations in the animal groups examined, the THO-space can be corrected via subtraction of 3.8%, 2.2% and 1.1% in the sequence young, obese, and adult groups. The derived TBL [%] data show a non-significant deviation of less than 1 g/100 g b. wt. in comparison to the three group means after direct lipid determinations. In the best case, i. e. after the additional elimination of extremely overestimated values for total body water (outliers) the combined tritium-derived lipid values (y) are correlated with the lipid data obtained analytically (x), both as proportion of the body weight, by the regression equation y = 0.848 + 0.963 x, r = 0.985, Sy.x = 1.77, n = 58. For a group of young rats (n = 14) after a pre-experimental supplementation with a sucrose solution, TBL values, not significantly different from analytically determined ones, could be calculated without any corrections.

Animals↗
PubMed2002

Does ethnicity influence body-size preference? A comparison of body image and body size.

OBJECTIVE: Obesity is most common in the United States among women of ethnic minority groups (black and Hispanic). Researchers have hypothesized that these subcultures are more accepting of overweight figures. The purpose of this study was to examine body image and body size assessments in a large community sample of men and women. RESEARCH METHODS AND PROCEDURES: Participants were 801 women and 428 men: 23% Asian, 45% Hispanic, 17% black, and 15% white. The figure rating scale was used to rate: body dissatisfaction, attractive male and female shapes, acceptable female size, and perceptions of underweight to obese female figures. RESULTS: Controlling for age, education, and body weight, no ethnic differences were found for men. Asian women reported less body dissatisfaction than the other groups. Women were more dissatisfied with their size than men and chose thinner female figures as attractive and acceptable. DISCUSSION: Ethnicity, independent of age, education, and body weight, does not influence preference for female and male shapes or tolerance for obesity.

Adult↗
PubMed1999

Differences in the relationship between body fat and body mass index between two different Indonesian ethnic groups: the effect of body build.

OBJECTIVE: To study the relationship between body fat percent (BF%) and body mass index (BMI) in two different Indonesian ethnic groups (Malays and Chinese) and to relate differences in the relationship to differences in body build and slenderness. DESIGN: Cross-sectional study. SUBJECTS: Except for ethnicity, not specially selected populations living on Java (Depok, south of Jakarta: Malay Indonesians, n = 117) and on Sulawesi (Makale, north of Ujung Pandang: Chinese Indonesians, n = 109). MEASUREMENTS: Weight, height, sitting height, waist and hip circumferences and skeletal widths were measured. BMI was calculated and BF% was predicted from BMI, age and sex using a (Dutch) Caucasian prediction formula. Slenderness was expressed as the ratio of weight: sum of knee and wrist width. BF% assessed by deuterium oxide dilution was used as a reference. RESULTS: BF% in the male and female Malay Indonesians was 24.6+/-7.0 and 35.6+/-5.6% respectively which was not significantly different from the values in the male and female Chinese Indonesians (24.0+/-4.3 and 33.8+/-6.9%). BMI and age were significantly lower in the Malay Indonesians. Malay Indonesians had a more slender body build in terms of skeletal widths compared to the Chinese Indonesians, and they had a higher slenderness index. BF% predicted from BMI using a Caucasian prediction formula was underestimated by 5.8+/-4.8% and 7.7+/-3.8% in the male and female Malay Indonesians but only by 1.3+/-3.0% and 1.7+/-3.7% in the male and female Chinese Indonesians. After correction for differences in age, sex and BF% the Malay Indonesians had a 1.7+/-0.3 kg/m2 (P < 0.0001) lower BMI than the Chinese Indonesians. After correcting for body build and relative sitting height the difference lowered to 0.9+/-0.4 kg/m2 (P < 0.02). CONCLUSIONS: The study confirmed the results of an earlier study that Indonesians have a higher BF% at the same BMI compared to Caucasians, but that there are apparently also differences among Indonesian subgroups. These differences are at least partly related to differences in body build.

Adipose Tissue↗
PubMed2006

Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes.

BACKGROUND: A diet with a high glycemic index (GI) and glycemic load (GL) may promote overconsumption of energy and increase the risk of weight gain. OBJECTIVE: The objective of the study was to investigate the relation between GI and GL of habitual diets and subsequent 6-y changes in body weight, body fat distribution, and body composition in a random group of adult Danes. DESIGN: A prospective cohort study was conducted in a subsample of men and women from the Danish arm of the Monitoring Trends and Determinants in Cardiovascular Disease study. The subsample comprised 185 men and 191 women born in 1922, 1932, 1942, or 1952. A baseline health examination and a dietary history interview were carried out in 1987 and 1988; a follow-up health examination was performed in 1993 and 1994. RESULTS: Positive associations between GI and changes in body weight (DeltaBW), percentage body fat (Delta%BF), and waist circumference (DeltaWC) were observed in women after adjustment for covariates. Significant GI x sex x physical activity interactions for DeltaBW, Delta%BF, and DeltaWC were observed, and the associations in the sedentary women were particularly positive. No significant associations with GI were observed in men, and no significant associations with GL were observed in either sex. CONCLUSIONS: High-GI diets may lead to increases in BW, body fat mass, and WC in women, especially in sedentary women, which suggests that physical activity may protect against diet-induced weight gain. No associations with GI were observed in men, which suggests sex differences in the association between GI and obesity development.

Adult↗
PubMed1991

Body-image marking. Validity of body-width estimates as operational measures of body image.

The relation of image-marking estimates of body width (IM) to actual widths, to other indices of body-size perception, and to measures of body satisfaction were examined using data obtained in a nonclinical sample of 200 women. The results of regression and correlational analyses were as follows: (a) actual widths accounted for only a small proportion of the variance in IM estimates, (b) the variance in IM estimates remaining after actual width was accounted for was not meaningfully related to other body-image indices, and (c) actual widths were more highly correlated with other body-image indices than were differences between estimated and actual widths (IM estimate-actual width). The current results suggest that most of the variance in IM estimates is error variance. Possible methodological confounds, which may bias women's estimates of body widths in the direction of overestimation, are discussed.

Adult↗
PubMed1976

Relationship between red cell mass, body weight, lean body mass, and body cell mass in growing pigs and beagles.

During growth in 55 pigs (from birth through week 12) and 42 beagles studied (from birth through year 1), there was an equally close association between red cell mass (RCM) and body weight, lean body mass (LBM) and body cell mass (BCM); the coefficients of correlation were between 0.94-0.99. The association of RCM with body weight was the result of BCM, extracellular tissue (ECT), and fat, each increasing at a constant rate relative to body weight. The primary relationship appears to be between RCM, the oxygen-delivery system, and BCM, the principla oxygen-using system; and the close association of RCM with body weight and LBM the results of the growth patterns of their components.

Animals↗
PubMed1983

Body composition of adolescent males. Part I. Total body water in normal adolescent males. Part II. Body composition of the male reference adolescent.

This study was undertaken to obtain total body water (TBW) data suitable for derivation of body composition of the typical adolescent male. TBW by the deuterium dilution method, stage of sexual development and anthropometric parameters (weight, height and triceps and subscapular skinfold thickness) were determined in 108 males between 10 and 14 years of age, whose weight and height fell between the 10th and the 90th percentile of the NCHS reference data. TBW/weight did not change significantly between 10 and 14 years, although a slight increase after age 11 years and from genital stage 2 to stage 5 was present. This indicates that body fat content decreases after 11 years and after genital stage 2, especially if the fact is taken into account that water content of fat-free body mass decreases during this age period. The ability of single anthropometric parameters to predict TBW/weight was low (subscapular skinfold thickness, r = -0.62; triceps skinfold thickness, r = -0.54; weight/height cube ratio, r = -0.48). Even with the use of various combinations of anthropometric parameters in multiple stepwise prediction equations it was not possible to explain more than 50% of the variation of TBW/weight and the high standard error of the estimate indicated large errors in prediction. Thus, body composition of normal adolescent males cannot be predicted with an acceptable degree of accuracy by anthropometric parameters. On the other hand, the deuterium dilution method using salivary water represents a noninvasive method for the determination of TBW which is quite simple and suitable for field studies.

Adolescent↗
PubMed1995

Assessing total body protein, mineral, and bone mineral content from total body water and body density.

We hypothesized that investigators could assess bone mineral content (BMC), total body mineral (M), and protein (P) from body water (W) and density (DB) based on the theory of W. E. Siri (Advances in Biological and Medical Physics, 1956, p. 239-280 and Techniques for Measuring Body Composition, 1961, p. 223-224) for body composition analysis. Siri used one or more of the body components and the densities of the body, fat (F), W, M, and P to estimate one of the remaining fractional masses. We compared M, BMC, P. F, and fat-free mass (FFM) in 31 subjects (15 women and 16 men) computed from measurements of W and DB with [4-compartment (4C) model] and without [3-compartment (3C) model] BMC (from dual X-ray absorptiometry). 4C model P was calculated by difference (P = FFM - W - M). Mean difference (P > 0.05) ranged from 0.1 to 0.8%. Correlations [+/- standard error of estimate (%)] between 4C and 3C model values were significant (r = 0.907 +/- 8.8, 0.907 +/- 8.7, 0.969 +/- 6.6, 0.998 +/- 2.0, and 0.999 +/- 0.7% for M, BMC, P, F, and FFM, respectively). We concluded that investigators can assess M, BMC, and P from W and DB.

Adult↗
PubMed1988

Measurement of body potassium with a whole-body counter: relationship between lean body mass and resting energy expenditure.

We conducted studies to determine whether the Mayo whole-body counter could be used to measure body potassium, and thus lean body mass (LBM), and whether moderate obesity alters resting energy expenditure when corrected for LBM. Twenty-four nonobese and 18 moderately obese adults underwent body potassium (40K) counting, as well as tritiated water space measurement and indirect calorimetry. LBM values predicted from 40K counting and tritiated water space measurements were highly correlated (P = 0.001; r = 0.88). Resting energy expenditure was closely related to LBM (P less than 0.0001; r = 0.78): kcal/day = 622 kcal + (LBM.20.0 kcal/kg LBM). In this relationship, the obese subjects did not differ from nonobese subjects. In summary, the Mayo whole-body counter can accurately measure LBM, and moderate obesity has no detectable effect on corrected resting energy expenditure.

Adult↗
PubMed2000

Underestimation of body mass index through perceived body image as compared to self-reported body mass index in the European Union.

An observational, cross-sectional study was conducted in a representative sample of the European Union (7155 men and 8077 women) to calculate the underestimation of body weight as assessed by body image among the overweight and obese population and identify the associated factors to this behavior. Participants were older than 15 years and they were living in the 15 European Union countries. Body mass index (BMI) was grouped into 4 categories using the cutpoints established by the WHO, while perceived body image (PBI) was assessed using a nine-silhouettes drawing. The degree of underestimation between PBI as compared to BMI was identified in overweight and obesity categories of BMI. A multivariable logistic regression model for each gender was used to adjust for potentially confounding variables. Men classified themselves worse than women, being more likely to underestimate their body weight (65.2% of men underestimated their weight vs 32.2% women), regardless of other socioeconomic and attitudinal variables. The greatest degree of underestimation was observed in Mediterranean individuals (68.7% of men and 37.9% of women underestimated their weight). The subjects in the 'maintenance' stage of physical activity tended more often to wrongly select their actual image (71.8% for men and 38.7% for women).

Adolescent↗
PubMed2002

Validity of body mass index compared with other body-composition screening indexes for the assessment of body fatness in children and adolescents.

BACKGROUND: Validation studies of height- and weight-based indexes of body fatness in children and adolescents have examined only small samples of school-age children. OBJECTIVE: The objective was to validate the performance of age- and sex-specific body mass index (BMI) compared with the Rohrer index (RI) and weight-for-height in screening for both underweight and overweight in children aged 2-19 y. DESIGN: Data from the third National Health and Nutrition Examination Survey (n = 11096) and a pooled data set from 3 studies that used dual-energy X-ray absorptiometry (n = 920) were examined. The receiver operating characteristic curve was used to characterize the sensitivity and specificity of these 3 indexes in classifying both underweight and overweight. Percentage body fat and total fat mass were determined by dual-energy X-ray absorptiometry. Subcutaneous fat was assessed on the basis of the average of triceps and subscapular skinfold thicknesses. RESULTS: For children aged 2-19 y, BMI-for-age was significantly better than were weight-for-height and RI-for-age in detecting overweight when average skinfold thicknesses were used as the standard, but no differences were found in detecting underweight. When percentage body fat or total fat mass was used as the standard, BMI-for-age was significantly better than was RI-for-age in detecting overweight in children aged 3-19 y. No differences were found between BMI-for-age and weight-for-height in detecting overweight or underweight. CONCLUSION: For children and adolescents aged 2-19 y, the performance of BMI-for-age is better than that of RI-for-age in predicting underweight and overweight but is similar to that of weight-for-height.

Absorptiometry, Photon↗