[Therapy of bladder diseases at the Swabian mineral springs].
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Whether or not to treat bacteriuria (greater than or equal to 100,000 col/cc) in the asymptomatic patient has long been controversial. Fifty-two patients with uncomplicated neurogenic bladder disease secondary to spinal cord injury and bacteriuria were followed throughout their hospitalization. Antibiotics were reserved only for symptomatic patients. Our results indicate the value of no treatment for chronic bacteriuria as an alternative to chronic suppressive therapy.
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The practice of routinely obtaining after fatty meal films during oral cholecystography has been questioned. A retrospective analysis of 45 cases of adenomyomatosis or polyps revealed that, in 28% of patients with adenomyomatosis, the gall-bladder appeared entirely normal before fat. It is concluded that, for the detection of acalculous gall-bladder disease, the fatty meal should be a routine part of oral cholecystography.
Neurogenic bladders are susceptible to bladder cancer development, especially in the case of chronic indwelling catheters. The classic carcinogenesis theory involves the formation of carcinogenic nitrosamines by bacteria due to chronic infection. We designed a pilot study to evaluate the expression of the of Nitric Oxide Synthase (NOS) isoforms in bladder tissue to study the role of the endogenous formation of NO (Nitric Oxide) in neurogenic bladders. Immunohistochemistry was performed on bladder biopsies from neurogenic, normal, and obstructed bladders. The neurogenic bladder had a higher expression of endothelial NOS (eNOS), but especially of neuronal NOS (nNOS). Besides, this extra-neuronal expression of nNOS by urothelium and interstitial cells was observed. This study proves the important role of endogenous formation of NO by suburothelial nerves but also by urothelium and interstitial cells. This overexpression could possibly be a factor in the higher incidence of bladder cancer in neurogenic bladders. On the other hand, it shows the plasticity of the NO pathways in these cases and raises important research questions concerning the physiological role of these changes.
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A case-control study comprising 216 cases of pancreatic cancer and 279 controls was conducted to investigate the relationship of pancreatic cancer with certain chronic medical conditions and with the consumption of tea, coffee and alcoholic beverages. Significant positive associations with pre-existing diabetes mellitus and gall-bladder disease were observed and there was weak evidence of association with liver disease. The relative risks for diabetes mellitus and gallstones diagnosed at least one year previously were 4.1 (p = 0.005) and 2.8 (p = 0.01) respectively. Cases drank significantly more beer than controls (p = 0.005) and there was evidence of a positive trend in risk with total alcohol consumption. Smoking was a clear risk factor, but cases and controls were very similar with respect to tea and coffee drinking habits.
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The reliability of overnight 8-hour infusion cholangiography in confirming the diagnosis of acute cholecystitis or biliary colic was assessed by a prospective study in 100 patients. 55 positive infusion cholangiograms were subsequently confirmed at operation in 45 patients and by cholecystogram in 10 patients who did not have surgical treatment. The absence of false positive examinations is of fundamental importance if early cholecystectomy is to be performed without the risk of an unnecessary laparotomy. Infusion cholangiography proved to be a safe, simple and reliable investigation in the confirmation of acute gall-bladder disease.
New and exciting diagnostic modalities which substantially change the evaluation of the urinary bladder have become available in the last decade. This is a review of the principles involved in and the advantages of diagnostic imaging using the modalities available to study the urinary bladder in a modern radiologic facility. It emphasizes the values of the different modalities in specific disease states. Excretory urography, cystography, and voiding cystourethrography were the mainstay of the evaluation of bladder pathology. These modalities are still good screening methods under certain circumstances but are relatively limited in comprehensive assessment of the bladder. Bladder studies using radionuclides, such as nuclear cystography, still have a space in the long-term follow-up of pediatric patients due to their relative low radiation dose. Since the addition of ultrasonography, computed tomography, and more recently, magnetic resonance imaging to the radiologist's armamentarium of imaging modalities, there has been a tremendous improvement not only in the demonstration of bladder abnormalities, but also in the staging of bladder neoplasms. The relative merits of these past and present imaging modalities are illustrated. Their appropriate contributions to improved quality of care of patients with bladder disease are also discussed.
The multiplanar and soft-tissue characterization capabilities of MR imaging make it a valuable diagnostic tool for imaging the urinary bladder. This article reviews the techniques used for MR imaging of the bladder, bladder anatomy, and the various MR features of many bladder pathologies.
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