Effect of azodicarbonamide (1,1'-azobisformamide) on thyroid function.
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The effect of N-nitrozo-N-methylbiuret (NMB) on various features of Didymocladium ternatum, an organism producing termatin was studied. It was found that the lethal effect of NMB depended on the exposure time, prolongation of which resulted in increased numbers of the plus variants, morphological mutations and reverses into the populations. Variants possessing 8 times higher activity as compared to the initial culture were obtained as a result of selection of active variants.
N-Nitrozo-N-methylbiuret (NMB) in a concentration of 0.2% and exposition for 2,3,4 and 6 hours with the survival rate of the conidia of 4-25% induced slight morphological variation of the griseofulvin-producing organism and increased the variation rate with respect to the antibiotic production by 40-140%. Preliminary treatment of the conidia with NMB decreased the lethal effect of UV-rays approximately by 15-25 times. The protective range with respect to morphological variation was 10 times lower. With an increase in the toxicity of NMB its protective effect in irradiation with UV-light decreased.
The effect of a tranquillizer mebicar on the cardiovascular system was studied experimentally. The drug was shown to increase the myocardial contractility, to exert a slight effect on the cardiac rhythm, to dilate the peripheral arteries. The analysis revealed that the vasodilating properties of mebicar are related to its central neurotropic action. The cardiac stimulating effects depend on the involvement of mebicar in the myocardial metabolism.
Di-ureido iso-butane (DUIB) was overdosed on three occasions to two year-old bullocks, under experimental conditions. Six g/kg live weight of DUIB was mixed manually into the rumen contents formed by a predominantly hay diet (10 kg) with added concentrates (2 kg). Marked clinical signs were observed for 72 h before recovery. Food and water intake were interrupted and a smell of ammonia saturated the accommodation. Blood concentrations of urea-nitrogen increased, while glucose fell; a metabolic alkalosis was present. Rumen VFA concentrations fell, but without altering the proportions of the individual acids present, pH increased, urea-nitrogen and ammonia-nitrogen concentrations fluctuated markedly. The pH of duodenal contents increased. Clinical recovery appeared complete after six days with biochemical homeostasis nearly restored.
The results of the experimental and clinical studies showed that administration of mebikar in combination with neuroleptics reduced the degree of side effects of the neuroleptics without decreasing their antipsychotic effect.
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