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Angiomyoma of the upper lip: report of a case with electron microscopic and immunohistochemical observation.

Immunohistochemical and electron microscopic observations of a vascular leiomyoma of the upper lip are presented. Tumour cells were positive for desmin, vimentin and neuron specific enolase but not for S-100 protein. Factor VIII was detected in the endothelium of blood vessels. Ultramicroscopically, the spindle-shaped tumour cells had elongated nuclei and cytoplasm containing abundant myofilaments and pinocytotic vesicles. Emphasis is placed on the fact that an immunohistochemical approach using appropriate antibodies can be used in identifying this tumour.

Adult↗

Dermal angiomyoma of the upper extremity.

Twenty-four of a series of 85 dermal angiomyomata were located in the upper extremity distal to the elbow. Eleven occurred in the right arm and 13 appeared in the left. Women exceeded men by 13 to 1 in number. The greatest number occurred in the 40 to 70 year age group. One case recurred as a leiomyosarcoma. This report is intended to bring this lesion to the attention of the surgeon in the differential diagnosis of painless masses of the hand, wrist, or forearm.

Adolescent↗

Lymphangiomyomatosis of the uterus associated with tuberous sclerosis and malignant neoplasia of the female genital tract: a report of two cases.

Lymphangiomyomatosis (LAM) is a rare disease that does not generally affect the female genital tract. We report two cases of uterine involvement by LAM in young women with tuberous sclerosis and renal angiomyolipomas. In both, the uterine lesions were grossly inapparent and were discovered during microscopic examination of hysterectomy specimens removed during surgical treatment for a primary ovarian adenocarcinoma with peritoneal and lymph node metastases in one case and a retroperitoneal lymphangiomyoma in the other. In one case, an area of uterine LAM with atypical features was interpreted as focal sarcomatous transformation. This patient also had pelvic and paraaortic lymph node involvement by typical lymphangiomyomas, a small uterine angiomyoma, and an occult primary endometrial adenocarcinoma. Immunostains for HMB-45 were strongly positive in the uterine LAM in both cases, the retroperitoneal and lymph node lymphangiomyomatous lesions, the uterine angiomyoma, and a resected renal angiomyolipoma. Although LAM is a rare uterine lesion, it must be distinguished from a variety of uterine smooth-muscle tumors.

Adenocarcinoma↗

Vascular leiomyoma of the mesentery in a dog.

A 4-year-old male, miniature Schnauzer dog showed two large masses in the mesentery at necropsy. Histological examination of both masses revealed plain smooth muscle tumour cells intermingled with thick-walled blood vessels. The bundles of tumour cells often extended from the periphery of the vessels. Mitotic figures were rare. From these findings, the tumour was diagnosed as a vascular leiomyoma (angiomyoma), previously unreported in animals. The term, vascular leiomyoma, was proposed to describe this tumour in order to avoid confusion with hamartomatous angiomyoma.

Actins↗

A transmission electron microscopic study of two cases of oral smooth muscle neoplasm.

Two cases of smooth muscle tumors that had appeared in the oral regions were examined by means of histopathology and electron microscopy. One was a case of angiomyoma that appeared in the lip of a 33-year-old man, and the other was a case of leiomyosarcoma in the maxilla of a 63-year-old woman. The results of the examination of both cases were as follows: the benign tumor (angiomyoma) was composed of mainly mature smooth muscle cells having dark cytoplasm, and the malignant tumor (leiomyosarcoma) consisted mainly of two types of cells, undifferentiated mesenchymal cells or fibroblast-like cells (type I) and myofibroblast-like cells (type II). Based upon these results, the relationship between the myogenous differentiation and the component cell types, and biological behavior of these smooth muscle tumors was discussed.

Adult↗