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Results for “ACARIASIS”

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At least 55 records · Page 3Linked to original sources
PubMed1996

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes.

The authors describe the immunological profile of BALB/c mice with Mite-Associated Ulcerative Dermatitis (MAUD)-like disease, due to Myocoptes musculinus (Koch 1844) infestation. The disease probably involves allergic mechanisms and is characterized by erythematous and pruritic skin lesions, widespread hair loss, lymphadenopathy, lymphocytopenia, granulocytosis and wasting. Affected individuals had much reduced numbers of pre-B and B cells in bone marrow and B cells in blood; decreased T-cell numbers in peripheral lymphoid organs and blood; hypergammaglobulinaemia with selective increases of IgG1, IgE and IgA, and depletion on IgM and IgG3, the same isotype distribution being detected in splenic plasmocytes; qualitative modifications of the serum antibody reactivity pattern; and increased production of IL-4 with decreased IL-2 production after in vitro polyclonal stimulation of T cells. Taken together, these results suggest that infestation by M. musculinus in BALB/c mice leads to a significant immunological disorder resulting in a T-helper-2 (Th-2) type response, with marked systemic consequences. This pathological condition may thus provide a useful model system for the immunobiological perturbation associated with chronic allergic disease.

Animals↗
PubMed1972

Hemagglutination assay of antibodies associated with pulmonary acariasis in rhesus monkeys (Macaca mulatta).

Antibodies associated with infection by lung mites (Pneumonyssus simicola) in rhesus monkeys were measured by passive hemagglutination methods. Tanned human Rh negative O red blood cells or sheep red blood cells coated with soluble acarine antigens were used to detect mite-specific antibodies. Large quantities of host-specific mite antigens (P. simicola) were difficult to obtain, so free-living mite species such as Dermatophagoides farina, Acarina sheldonii, and Tyrophagus putrificiensis were also utilized. Although the best serological specificity and sensitivity were obtained with P. simicola and its derivatives (1:640), several free-living acarine species were useful in detecting antibodies to mites. Skin tests carried out on a limited number of animals were positive for both immediate and delayed hypersensitivity.

Age Factors↗
PubMed2001

Comparison of subcutaneous ivermectin and oral moxidectin for the treatment of notoedric acariasis in hamsters.

Thirty hamsters diagnosed with a Notoedres infestation on the basis of their clinical signs and skin scrapings were allocated to three matched groups. The hamsters in group 1 received ivermectin at 400 microg/kg subcutaneously once a week for eight weeks, those in group 2 were treated with moxidectin at 400 microg/kg orally once a week, and those in group 3 were treated with moxidectin at the same dosage, but twice a week. The hamsters' skin lesions were scored weekly on the basis of the severity of crusting, erythema, scaling and excoriations at various sites. In all three groups the lesion scores were significantly lower after four and eight weeks, and there was no significant difference between the efficacy of the treatments. However, at the end of the treatment, skin scrapings were negative in only 60 to 70 per cent of the animals in each group.

Administration, Oral↗
PubMed1987

Visceral and subcutaneous acariasis caused by hypopi of Hypodectes propus bulbuci in the cattle egret.

Twenty-one of 24 adult male and female cattle egrets (Bubulcus ibis ibis) collected in Geneva County, Alabama had numerous white cyst-like structures (1,466 microns X 354 microns) found within the loose connective tissues of the skeletal muscles of the inguinal region, beneath the serosa of the proventriculus and in the heart beneath the epicardium (one adult male bird). These were identified as hypopi of Hypodectes (Hypodectoides) propus bulbuci. Histologic sections were prepared from the subcutis, proventriculus and heart. The histopathologic changes consisted of cross sections of mites surrounded by macrophages often containing basophilic or clear intracytoplasmic vacuoles and by plasma cells. A minimal fibrous encapsulation was rarely seen surrounding the mites.

Alabama↗