Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ABO FACTORS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 55 records · Page 3Linked to original sources
PubMed1985

Factor VIII and factor IX in a twin population. Evidence for a major effect of ABO locus on factor VIII level.

In order to establish the relative importance of genetic factors on the variation in plasma concentration of coagulation factors VIII and IX, these parameters were determined in 74 monozygotic and 84 like-sexed dizygotic twin pairs. The twins belonged to two age groups: 33-39 years and 57-62 years. Factor VIII was determined as factor VIII coagulant antigen (VIIICAg) and as factor VIII-related antigen (VIIIRAg). Factor IX was determined as factor IX antigen (IXAg). A higher value for each coagulation factor was found in the older-age group compared to the younger group, whereas no difference was found between the sexes. A significant correlation was found between values for VIIIRAg and VIIICAg (r = .56). For VIIICAg, it could be demonstrated that the age effect was secondary to the age effect on VIIIRAg. The concentration of VIIICAg and VIIIRAg varied among ABO blood types, being lowest in type O individuals, higher in A2 individuals, and highest in A1 and B individuals. The effect of the ABO locus on VIIICAg was secondary to an effect on VIIIRAg. Analysis of variance revealed a significant genetic influence on the variance of VIIICAg and VIIIRAg with a heritability estimate of .57 for VIIICAg and .66 for VIIIRAg. This is in agreement with a previous hypothesis of an effect of several autosomal genes on factor VIII concentration. Thirty percent of the genetic variance of VIIIRAg was due to the effect of ABO blood type. The ABO locus is therefore a major locus for the determination of factor VIII concentration. No significant genetic effect on the variation in plasma concentration of IXAg could be detected.

ABO Blood-Group System↗
PubMed1979

Genetic and nongenetic influences on the ABH and Lea antigen levels of saliva and milk.

The saliva and milk of 250 parturient women were studied in relation to ABH antigen levels; part of the sample was also investigated for the Lewis (Lea) substance. The levels of A and B are higher in saliva, and those of H and Lea higher in milk. The H average salivary titers presented the relationship O greater than A2 greater than A1 greater than B greater than AB, but these differences were not present in milk. In addition, the salivary levels of A and B are similar in individuals of these groups but B greater than A in AB persons, and A1 greater than A2; while in milk A greater than B in A, B and AB subjects, and A1 approximately equal to A2. The amount of Lea substance depends of the ABH secretor status in both secretions; but independently of this difference, the average titers were always higher in milk. Correlation coefficients between the levels observed in the two secretions are statistically significant for the A substance in A persons (0.46), H in B (0.58) and Lea in all subjects tested (0.47). A stepwise multiple regression analysis performed to verify the influence of four genetic and six nongenetic variables in the ABH levels of both fluids indicated only one consistent modifying factor: ABO type.

ABO Blood-Group System↗
PubMed1978

[Genetic limitations of erythrocyte lysis by bacteria of the genus Salmonella].

Lytic effect of Salmonella bacteria on the erythrocates of 1301 humans (including 150 twins), 1059 hens, 600 mice, 33 guinea pigs, 47 rabbits, 22 horses, 16 sheeps, 7 dogs, 2 cats and 2 monkeys was investigated. Erythrocytes of all horses, guinea pigs and rabbits tested appeared to be sensible. The same cells of humans, sheeps, hens, dogs, monkeys and cats turned to be either sensible, or stable. Human erythrocytes were the most stable. Erythrocytes of humans having had typhus or other Salmonella infections appeared to be more sensible. Homozygous twins developed complete two by two concordance of the sign of sensibility in all details investigated. Relation of erythrocytes to Salmonella hemolysins was not influences with time and specific immunization, did not correlate with blood groups and factors ABO, MN, P and rhesis systems, with age, sex and nationality of people tested. It also did not correlate with the presence of anti-salmonella agglutinins, with different osmotic and acid stability of erythrocytes. The display of hemolytic activity of Salmonella is limited by genetically predestinated species and individual properties of erythrocytes.

Animals↗
PubMed1983

Epidemiology of group B streptococcal colonization in pregnancy.

These data support the conclusions that: 1) An intrapartum screening program for GBS colonization favorably affects the outcome of GBSD, with mortality decreased to 10%. 2) Four risk factors--ABO blood group B, unregistered status, PROM and premature labor at less than 32 weeks--identify 83% of mothers whose infants develop GBSD. 3) There is no association between internal monitoring and mode of delivery and the vertical transmission of GBS. 4) Duration of membrane rupture does not affect vertical transmission or development of early-onset disease. This differs from previous findings. 5) Lastly, our findings regarding the natural history of asymptomatic infant carriers suggest that these infants play a previously unsuspected role in the epidemiology of GBS in the entire population.

Carrier State↗
PubMed1991

Factor VIII:C, ABO blood groups, and black admixture in a Brazilian sample.

The effects of ABO blood groups and black admixture on the level of factor VIII:C are studied in healthy adults from Salvador, Bahia, Brazil. A racially mixed sample of 125 males was selected as follows: 25 whites, 25 light mulattoes, 25 medium mulattoes, 25 dark mulattoes, and 25 blacks. Levels of both factor VIII:C and K-PTT followed normal distributions. O blood group subjects showed lower factor VIII:C levels (110.20 +/- 30.76%) than non-O blood group members (135.24 +/- 31.42%) (t123 = 4.47; p less than 0.0001) and higher K-PTT levels (37.69 +/- 4.57 s) than non-O blood group subjects (35.25 +/- 3.82 s) (t123 = 3.24; p less than 0.01). By holding ABO blood type constant, there is a significant racial effect (white) on lowering the factor VIII:C level within both blood group O (t43 = 2.23; p less than 0.05) and non-O (t36 = 3.44; p less than 0.002). There is no interaction effect of race and blood group (F = 0.19; p greater than 0.6) on the factor VIII:C levels.

ABO Blood-Group System↗
PubMed2005

Is the ABO incompatibility a risk factor in bone marrow transplantation?

ABO histo-bloodgroups are strong transplantation antigens. In bone marrow transplantation, foreign ABO red cell antigens are not ignored by the immune system of the host, neither by the immunocompetent cells of the graft. Although ABO incompatibility is not considered a contraindication in bone marrow transplantation (BMT), its clinical consequences are still a matter of investigation. An overview of reports published by different groups is given and discussed. They present conflicting data regarding the role of the ABO match between patient and donor in the haematopoietic stem cell (HSC) transplantation. We report on the clinical outcome of bone marrow transplantation in 223 patients who received grafts from MHC identical siblings. Included are 139 ABO identical, 32 ABO minor mismatched, 34 major mismatched and 13 bi-directionally mismatched pairs. The statistical evaluation of standard parameters used to monitor the post-transplant period gave a proof that in neither group of patients with an ABO incompatible donor the recovery and success rate of transplantation, including the relapse incidence, risk of graft vs. host disease (GVHD) or overall survival, were significantly inferior. However, in all three cohorts of ABO mismatched patients, a delayed recovery of neutrophils was recorded as compared to the group receiving an ABO compatible graft. These finding leads us to the conclusion that the ABO compatibility is not a disadvantage in BMT, whereas the delayed recovery of neutrophils in patients having received an ABO mismatched graft is probably reflecting a transient humoral process leading to immune tolerance and graft accommodation.

ABO Blood-Group System↗
PubMed2002

Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels.

To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the ABH antigenic determinants carried on N-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in A(1)A(1) individuals and higher in A(1)O(1) than in A(2)O(1) or O(1)O(1) individuals. Plasma A transferase activity and the amount of A antigen expressed per unit vWF (AvWF) were significantly higher in A(1)A(1) than in A(1)O(1) individuals and higher in A(1)O(1) than in A(2)O(1) individuals. AvWF was correlated strongly with plasma levels of A transferase activity. Thus, we have clearly demonstrated a direct relationship between ABO genotype, A transferase expression, and the amount of A antigen expressed on circulating vWF. H antigen expression per unit vWF (HvWF) was highest in group O individuals. Among group A individuals, the pattern of HvWF expression was A(2)O(1)>A(1)O(1)>A(1)A(1). In group O and group A(2)O(1) individuals, HvWF was inversely correlated with plasma vWF levels. In contrast, among group A(1)A(1) and A(1)O(1) individuals, there was no relationship between AvWF and plasma vWF levels. These findings suggest that it is H antigen expression that mediates the ABO effect on plasma vWF concentration.

ABO Blood-Group System↗
PubMed1976

[The distribution of blood groups (ABO, Rh-factor, MNS) in psychic disorders (author's transl)].

1. 942 resp. 821 patients with psychic disorders (843 resp. 339 patients with neurotic disorders, 443 resp. 191 patients with manic-depressive psychoses, 436 resp. 193 patients with schizophrenic psychoses, 220 resp. 98 patients with organic syndromes) are compared with regard to the distribution of the ABO blood groups and the Rh-Factor with 5.000 normal controls and of the MNS blood group with the expected distribution respectively. Significant differences are demonstrated: AB (-2.63%, P less than 0.10) in organic syndromes; Rh+ (+3.65%, P less than 0.02) in neurotic disorders; Rh+ (+3.10%, P less than 0.005) in all diagnoses; 0, Rh+ (+4.31%, P less than 0,05) in neurotic disorders; AB, Rh+ (+2.29%, P less than 0.05) in manic-depressive psychoses; A, Rh- (-1.59%, P less than 0.05) in all diagnoses; AB, Rh- (-0.58%, P less than 0.05) in all diagnoses; MNS (Ms +2.26%, MS +2.10%, MNs -3.65%, MNS -0.35%, Ns +0.52%, NS -0.88%, P less than 0.05) in all diagnoses. The results are compared with the literature, and methodical problems are discussed.

ABO Blood-Group System↗
PubMed2003

The role of the platelet function analyser (PFA-100) in the characterization of patients with von Willebrand's disease and its relationships with von Willebrand factor and the ABO blood group.

Determination of the closure time (CT) with the platelet function analyser (PFA-100) is a useful screening test for von Willebrand's disease (VWD) but its role in the characterization of VWD is not well established. We studied the relationship between the prolongation of the CT with adenosine diphosphate (ADP) (CT-ADP) and epinephrine (CT-EPI) cartridges and the von Willebrand factor (VWF) in 53 patients with VWD. We found that a relatively small percentage of the prolongation of the CT-ADR and CT-ADP (16 and 29%, respectively) was determined by a reduction in VWF levels. The CT-ADP was significantly more prolonged in the presence of qualitative defects in VWF but could not discriminate between the VWD subtypes. The ABO blood group had no effect on the prolongation of the CT or the bleeding time. In conclusion, the PFA-100 appears of little use in the characterization of severity and subtype of VWD.

ABO Blood-Group System↗