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Results for “5-Methoxytryptamine”

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At least 55 records · Page 3Linked to original sources
PubMed1977

Changes in radiosensitivity induced by cyclic nucleotides and chemical radioprotection.

Cyclic AMP has a radioprotective effect and its aministration results in a significant increase in LD50/30 values in Chinese hamsters. The efficiency of these radioprotective effects is comparable to that of such radioprotective compounds as AET and cystamine + mexamine. Cyclic GMP is responsible for significant radiosensitizing effects. Changes in radiosensitivity after administration of cyclic nucleotides are both immediate and delayed and correlate closely with dose and time of administration.

5-Methoxytryptamine↗
PubMedDate not supplied

[Comparative evaluation of the effect of serotonin, melatonin and methoxytryptamine on the content of biogenic amines in the hypothalamus and gonadotropic hormones in the pituitary gland depending on the periodicity of phases of the estrous cycle in rats].

This work is experimental and devoted to the study of functional activity of the pineal gland. The influence of the main biologically active substances (serotonin, melatonin, mexamin) produced by the epiphysis, on the hypothalamo-hypophysial structures was studied; results pointed to the significant role played by the epiphysis in the neuroendocrine regulation system.

5-Methoxytryptamine↗
PubMed1975

Differential effects of inhibitors of monoamine oxidase Types A and B on the adrenergic system of the rabbit iris.

Topical instillation of inhibitors of monoamine oxidase Types A and B into the rabbit eye, followed by the administration of a releaser of monoamines (Ro 4-1284), induces strong and sustained dilation of the iris. The mydriatic pattern differs markedly with A- and B-inhibitors and with the duration of the inhibitor treatment. The Type B inhibitor, deprenyl, prevents the degradation of exogenous 2-phenylethylamine and possibly of the endogenous amine X capable of releasing monoamines from a compartment less accessible to Ro-1284.

5-Methoxytryptamine↗
PubMed1977

[Effect of serotonin on smooth muscle].

Serotonin caused contracion of the smooth muscles of the deferent duct and of the strip of rat stomach, acting upon the D-serotonin receptors. Only a small portion of its contractile effect (about 10--14%) was caused by the release of endogenous catecholamines. The action of serotonin on the strip of the rat stomach was accompanied by an increase of its entrance into the cells of Ca45 and Na22 isotopes. The concentration turn of the concentration-effect curve of serotonin on the stomach strip was connected with the accumulation of sodium ions in the cells.

5-Methoxytryptamine↗
PubMedDate not supplied

[Effect of radioprotectars from various chemical compound classes on dynamic work capacity and carbohydrate metabolism].

The influence of radioprotectors cystamine, mexamine and gammaphos on the physical performance capacity and carbohydrate metabolism was subjected to a comparative study. Cystamine and mexamine were found to lower the capacity of the animals to endure physical loads, this being attended by falling stocks of glycogen in the liver and muscles and a rising level of the blood lactate and pyruvate in comparison with controls. Gammaphos has no effect on the performance capacity of the animals and carbohydrate metabolism.

5-Methoxytryptamine↗
PubMed1978

[Protective effect of sodium hydroxybutyrate and mexamine on the body and cerebral cortex neurons during hypoxia].

Experiments on white non-pure male mice have established that NA oxybutirate in doses 100 mg/kg and mexamine in doses 2.5 mg/kg possess antihypoxic properties in conditions of severe hypoxia corresponding to a height of 10 000 m. In a combined introduction of Na oxybutirate and mexamine in the above-mentioned doses there is an increase of their antihypoxic action. It was demonstrated that Na oxybutirate, mexamine and their combination exposes a distinct protective effect on the cortical neurons on rats in conditions of hypoxia. It is assumed that the protective action of the studied antihypoxants on the cortical neurons is realized with the aid of the same mechanisms as in a physiological adaptation to hypoxia.

5-Methoxytryptamine↗
PubMedDate not supplied

[Effect of mexamine on arterial tonus in dogs].

The effect of mexamin (5 and 10 mg/kg) on the vascular tone of thoracic and abdominal cavity vessels and pelvic limbs was investigated by angiography in experiments on 19 mongrel dogs under nembutal anesthesia (30 mg/kg). 5-7 minutes after intramuscular administration of the drug there was a constriction of the aorta, of the hepatic, splenic, cranial mesenteric, internal and external iliac, branched femoral and tibial arteries by about 15-40% as compared to the initial diameter. Mexamin exerted no substantial vasoconstrictive action on the segmental (intercostal, lumbar, phrenoabdominal) and renal arteries.

5-Methoxytryptamine↗
PubMedDate not supplied

[Effectiveness of hypoxic hypoxia as a means of protecting the body from ionizing radiation exposure with the use of sodium oxybutyrate and mexamine].

While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxic hypoxia the drugs did not exhibit any antihy-oxic action.

5-Methoxytryptamine↗