Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “sequelae”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 523 records · Page 29Linked to original sources
PubMed2005

[Treatment of an infant with severe neonatal hypoxic-ischemic encephalopathy sequelae with transplantation of human neural stem cells into cerebral ventricle].

OBJECTIVE: Severe newborn hypoxic-ischemic encephalopathy (HIE) has a very high rate of disability and no effective treatment is available. The present study aimed to preliminarily evaluate the effects of human neural stem cell transplantation in treatment of severe neonatal HIE. METHODS: The patient was a 75-day old male infant with sequelae of severe HIE who had highly delayed development of intelligence and movement and myotonia. MRI showed multiple cerebromalacia and encephalatrophy. Cells obtained from the forebrain of an 11-week old fetus were cultured and amplified for 15 days. And then the human fetal neural stem cells were injected into cerebral ventricle of this infant. RESULTS: Twenty eight days after transplantation, remarkable improvement occurred not only in his myotonia but also in his intelligence and movement, which became similar to those of the normal infants of the same age. Positron emission tomography (PET) showed significantly increased radioactivity at temporal and occipital lobes which suggested that the cellular metabolism had increased greatly. CONCLUSION: The short-term effect of NSCs transplantation on the infant with severe HIE sequelae was significant. PET suggested that the implanted NSCs survived. Many more studies are needed to evaluate long-term effects of NSC transplantation in treatment of HIE.

Asphyxia Neonatorum↗
PubMed2005

[The study on donor site sequelae after autologous breast reconstruction with an extended latissimus dorsi flap].

OBJECTIVE: To study the prevention and treatment on the donor site sequelae after autologous breast reconstruction with extended latissimus dorsi flap. METHODS: 88 patients received breast reconstruction with extended latissimus dorsi flap between May 1999 and Nov 2004 were concerned. We analyzed the donor site sequelae by objective and subjective evaluation and we assessed the functional condition. Results Dorsal hematoma developed in 1 patient. There are 7 patients with dorsal seromas and 2 of them developed capsules; 5 patients with mild skin exfoliate and 1 patient with dry skin necrosis, 2 winged shoulders. No infection and no hypertrophic scars appeared in donor site. There is no significant functional limitation and no influence in daily life. CONCLUSIONS: The main complication after autologous breast reconstruction with extended latissimus dorsi flap was seromas and it can be controlled to decrease. There is no severe complication. It's a worthy method in autologous breast reconstruction in oriental people.

Adult↗
PubMed1991

[Late sequelae of mild closed cranio-cerebral injuries (incidence, clinical course and criteria of the conditions of compensation and decompensation)].

The authors present the results of clinical catamnestic, clinical neurologic analysis, and of specific neurophysiologic examinations of 292 patients with a history of slight craniocerebral injuries. Late sequelae of these injuries were detected in 70% of the examinees. The criteria and factors of decompensation risk were defined on the basis of the total and clinical structure of the disease, history of the injury, variation pulsometry, bioelectric reactivity, and visual analyzer adaptation function. The data may be used in prophylactic work to predict the course of these sequelae and for secondary prevention.

Action Potentials↗
PubMed2006

Natural history of the long-term cognitive, affective, and physical sequelae of mild traumatic brain injury.

Mild traumatic brain injury (MTBI) is associated with cognitive,affective, and physical sequelae. When symptoms persist for more than 3 months, a diagnosis of Post-Concussion Syndrome (PCS) is often given. The current study tracked symptom development to explore the natural sequelae of MTBI. Twenty-six MTBI patients received a comprehensive neuropsychological assessment at three intervals: within 1 week, at 4 months and at 7 months post-concussion. Based on DSMIV criteria and clinical judgment, two external raters diagnosed five MTBI participants with PCS. Results suggested that aspects of cognitive functioning of the symptomatic MTBI (i.e., PCS) participants were different from matched normal control (NC) subjects, and from the 21 MTBI patients who were asymptomatic, at 4 months. Asymptomatic MTBI participants improved in overall level of functioning from 4 to 7 months, but remained significantly different from NC participants in their reduced verbal fluency and working memory functioning.

Affective Symptoms↗
PubMedDate not supplied

[A descriptive study of perinatal asphyxia and its sequelae].

INTRODUCTION: Perinatal asphyxia is a potential cause of brain injury that can produce some alterations on the neurologic development of the newborn. On the last years most part of the investigation have been focused on the physiopathology of the perinatal asphyxia, but correlation between asphyxia and brain damage is not well defined. PATIENTS AND METHODS: A retrospective study was made of the patients with the diagnosis of perinatal asphyxia born at the General Hospital of Segovia during a period of ten years (1992-2001). We took data about gestation, birth, neonatal period and follow-up period from their clinical histories. RESULTS: Over this period of ten years 703 cases of perinatal asphyxia have been diagnosed, supposing this an incidence of 7,2 cases of each 100 newborns. 116 of these newborns present risk factors of brain damage and were followed at least two years. 53 of the 116 newborns (45%) present evidence of hypoxic-ischemic encephalopathy on neonatal period. During the period of two years, 42 of the asphyxiated infants follow up (36%) present neurologic sequelae, being psychomotor retardation the most common. CONCLUSION: For a correct interpretation of the relationship between perinatal asphyxia and neurologic sequelae we have to analyze all of the perinatal data and discard any other possible aetiology or pathogenic mechanism.

Apgar Score↗
PubMedDate not supplied

The etiology, prevalence, and sequelae of infraclusion of primary molars.

Dental infraclusion, teeth below the occlusal plane, is a common condition, especially in mandibular primary molars, with more than seventy references in the literature. Most claim infracluded molars do not exfoliate within normal time limits and must be extracted to prevent detrimental sequelae. The few documented studies on this topic suggest, however, that most infracluded teeth exfoliate normally; however, there is a tendency toward a delay of six months. The degree of infraclusion does not appear to correspond with exfoliation time. The frequent sequelae of severely infracluded teeth, space loss and molar tipping, may be prevented by either restoring the height of the affected tooth or by using space maintainers without extraction. The successors of infracluded molars reportedly develop normally and have few occlusal abnormalities.

Ankylosis↗
PubMed1991

Sequelae of perinatal central nervous system damage after long-term survival.

We presented the case of a 78-year-old man with mental retardation and spastic paraparesis diagnosed early in life as cerebral palsy. Six years prior to demise he had post-traumatic subdural hematoma, which was removed surgically. The neuropathological examination revealed the sequelae of the recent trauma, superimposed on the extensive old lesions. Cavitary changes in the periventricular white matter and cortical ulegyria in the border zones of the major cerebral arteries vascularization were characteristic of perinatal hypoxic-ischemic lesions. Peculiar in the ulegyria were extensive areas with numerous corpora amylacea adjacent to the areas of fibrillar and cellular gliosis. Another sequelae of involution processes was the atrophy of brain hemispheres (secondary microcephaly). The case appears to be an example of the late degenerative involution changes developing on the background of lesions originated from the perinatal period.

Adult↗
PubMed1991

[Evaluation of coronary hemodynamics and coronary reserve in children with coronary sequelae of Kawasaki disease].

We measured coronary blood flow by the continuous thermodilution method during coronary sinus catheterization via the femoral vein, and evaluated coronary reserve based on the findings of coronary hemodynamics and myocardial metabolism during atrial pacing. The study subjects consisted of 31 pediatric cases with a history of Kawasaki disease. Among them, 19 had normal coronary angiograms (Group A), 8 had dilated coronary lesions (Group B), and 4 had stenotic coronary lesions (Group C) on selective left coronary angiograms. 1. Coronary blood flow at rest: There were no significant differences between Groups A and B. In Group C, slightly low values were obtained in 2 patients with obstruction or recanalization in the left anterior descending artery. 2. Rate of an increase in coronary blood flow during atrial pacing: It was significantly lower in 5 of 19 patients in Group A, in 2 of 8 in Group B, and in one of 4 in Group C. However, in 2 patients with lower coronary blood flow at rest, the rate of an increase in coronary blood flow during atrial pacing was higher. 3. Following atrial pacing, enhanced anaerobic metabolism was observed in 6 of 17 patients (Group A, 2 of 5; Group B, 2 of 8; Group C, 2 of 4) who showed a poor increase in coronary blood flow during atrial pacing. These results indicate that coronary reserve may decrease even in patients without any coronary sequelae of Kawasaki disease on selective coronary angiograms possibly because of inadequate imaging of the microcirculation, i.e., the problem of the pathologic process at the level of small intramyocardial arterioles. To investigate the coronary sequelae of Kawasaki disease, the evaluation of coronary hemodynamics and myocardial metabolism by coronary sinus catheterization before and after atrial pacing is highly recommended.

Adolescent↗
PubMed1991

[Sequelae of severe craniocerebral injuries. An epidemiological study in the Canton of St. Gallen].

Severe head injuries often lead to serious medical and socioeconomic sequelae. The incidence rate indicated in other studies shows a wide variation due to differences in selection criteria. Based upon an unselected population, the incidence of severe head injury was calculated and the surviving patients were interviewed and clinically examined 3 years after the accident in order to describe the course, rehabilitation and psychosocial sequelae after severe head injury. Retrospectively we collected 80 patients living in the canton of St. Gallen who had a severe head injury requiring hospitalization in 1987, indicating an incidence of 20 per 100,000 inhabitants. 22 (28%) of these patients died as a consequence of the head trauma. The best predictor was the Glasgow coma score at admission, which showed a highly significant direct correlation with survival rate. Regarding the degree of impairment of survivors the duration of posttraumatic amnesia was the best predictive parameter. Of the 45 patients controlled 3 years after the head trauma only 11% were severely impaired in daily activities. 79% of the patients who were gainfully employed before the accident were working full- or at least part-time. However, only 3 patients (7%) were absolutely free of symptoms. Most patients suffered from cognitive and emotional deficits. Based on an estimated incidence for minor head trauma of 174 per 100,000 inhabitants, a total annual incidence for all head traumas of 194 per 100,000 inhabitants is calculated, with severe head injury representing about 1/9 of all head injuries.

Adolescent↗
PubMed1990

[Sequelae and evaluation after distal radius fractures].

The sequela of fractures of the distal radius show the same variety as the fracture models themselves, depending on conservative or operative repositioning. The most frequent disadvantages are deviation of the bone axis, depression of the basis of the radius, steps in the cartilage plain and rough deformity. Most important are the arthrotic changes in the joint, such as entrapment and compression neuropathies. The sequela of fractures in children, adults and the aged differ. The purpose of the expert appraisal is not only to assess the damages after fracture but also to give new proposals for further therapy.

Diagnostic Imaging↗
PubMed1991

Are complex partial seizures a sequela of temporal lobe dysgenesis?

1. Complex partial seizures are closely associated with a group of discrete neuropathological entities which include focal lesions (such as hamartomas and heterotopias) and small vascular lesions, all of which are generally considered to have been present at birth. 2. The pathological change most frequently found in patients with temporal lobe epilepsy is mesiotemporal sclerosis. Although this pathological alteration in subicular and hippocampal structures has been attributed to any one of a number of perinatal or postnatal insults, we suggest that it also may represent a sequela of disturbed neuroembryogenesis. 3. We suggest that many, perhaps most, cases of temporal lobe epilepsy may resemble other major disorders of cognition and behavior (such as schizophrenia) in representing the sequelae of temporal lobe dysgenesis.

Animals↗
PubMed1990

[Clinico-genealogical and phenotypic characteristics of patients with late sequelae of closed cranio-cerebral injuries].

As many as 100 patients with late sequelae of closed craniocerebral injuries (CCCI) and 50 healthy persons underwent a clinico-genealogical and phenotypic analysis. Multifactorial diseases (in particular essential hypertension and other cardiovascular diseases) which correlate with the clinical features of late sequelae of CCCI were noted to occur in the patients' pedigree significantly more often as compared to normal persons. The patients manifest a high frequency of the stigmas of dysembryogenesis. After CCCI part of them manifested certain hereditary diseases. Genetic risk factors should be taken into account in forecasting CCCI outcomes and planning follow up measures.

Adolescent↗
PubMed1990

[Hearing and language sequelae in survivors of a neonatal intensive care unit].

INTRODUCTION: The purpose of this study is to record the hearing and language sequelae in a sample of children from the Intensive Care Unit between the ages of two and three. MATERIALS AND METHODS: Forty-one children were studied after being submitted to neuropsychological, hearing and language tests. Both normal and abnormal parameters for each test allowed the categorization of the children. RESULTS: In the general sample there were 24 full-term children versus 17 preterm children. The neurological testing showed a tendency towards normality. The same was seen in language testing since the proportion of normality corresponded to those children born after a full term. There were practically no differences in those suspected from both groups and a greater percentage of abnormal children were found among the pre-term infants. From an audiological standpoint there was a predominance of normal children; there was only one patient with severe bilateral hypoacusis who needed an electric auxiliary hearing device and two other patients with peripheral ear dysfunction classified as serous middle ear otitis. CONCLUSIONS: The incidence of hypoacusis in this sampling type is similar to that reported in the literature. Those patients with a history of assisted mechanical ventilation have been later found to have, as a sequelae, serous middle ear otitis, which corresponds to that reported by Paradise. The development of language stages were altered more so in preterm children. In some patients, the lack of stimulation associated with a low socioeconomic back group favors the delay in the development of language skills.

Child, Preschool↗
PubMed1990

Pulmonary sequelae in survivors of the adult respiratory distress syndrome.

A spectrum of pulmonary impairment may follow an episode of the adult respiratory distress syndrome (ARDS). At one end of the spectrum is normal pulmonary function; at the opposite is severe impairment. The late pulmonary effects of ARDS usually lie between these two extremes. This article describes the pulmonary sequelae of ARDS, reviews information concerning factors that may influence these sequelae, and provides suggestions for clinical evaluation of ARDS survivors.

Dyspnea↗
PubMedDate not supplied

[Long-term sequelae of deep venous thrombosis of the legs. Experience with mesoglycan].

Ninety consecutive patients, affected by venographically proven deep-vein thrombosis (DVT) of the lower limbs, were given full-dose heparin followed by oral anticoagulants for 12 weeks, and then selected randomly to receive, for one year, either mesoglycan (72 mg/day orally) or placebo with a double-blind protocol. All patients wore elastic graduated compression stockings, and were prospectively followed for a period ranging from 5 to 48 months. In each scheduled examination programmed every three months for one year and then twice per year, an accurate clinical evaluation was performed and a predetermined objective score was applied. Furthermore, impedance plethysmography and Doppler ultrasound tests were executed serially to assess the persistence of venous obstruction and/or the development of valve incompetence. After a mean follow-up of 3 years, 80% of the patients were totally asymptomatic, and severe post-thrombotic sequelae (ulcer and/or edema associated with skin induration) were recorded in only 6 patients (6.6%). We failed to identify any correlation between post-thrombotic sequelae and persistence of venous obstruction (as shown by impedance plethysmography) or development of valve incompetence (as shown by Doppler ultrasound test). The behaviour of patients treated with mesoglycan did not differ from that of patients treated with placebo. However, objectively documented recurrences of DVT and/or pulmonary embolism were less frequent in patients treated with mesoglycan (6.6 vs 11.1%, non-significant difference), and the only two deaths attributable to pulmonary embolism occurred among the patients treated with placebo.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Are the sequelae predictable for sectional and multiple partial nephrolithotomies of completely intrarenal coral stones? (experimental and clinical research)].

In the assessment of surgical intervention for fully intrarenal stone casts, different kinds of nephrotomies (sectional or multiple partial ones, those supplementing pyelolithotomy or performed in the kidneys with marked parenchyma) should be compared in terms of functional outcomes, severity and incidence of complications (intraoperative or postoperative bleeding from the violated kidney), postoperative urinary fistulas, aggravated renal failure and postoperative mortality. It is these milestones that have determined the scope of the present study. An experimental assessment of the degree of trauma, associated with sectional nephrolithotomy as well as its functional sequelae was made in dogs after a stone-like structure was simulated and the kidney reached the necessary degree of secretory deficiency. The comparison of pre- and postoperative renographic parameters over different spans of follow-up of animals after sectional nephrolithotomy was made to assess the latter's organ-damaging effect and, in part, functional results of surgery in a kidney with a profound functional deficiency by the time of the operation. A similar methodology was used in clinical patients, subjected to nephrolithotomy (either sectional or multiple partial procedure) for fully intrarenal coral stones. Functional results of nephrolithotomies in animals and in patients are presented in Figs 1-3. For cases where postoperative results were good or satisfactory at 1-2 months, follow-up results are presented in Tables 4-5. Postoperative complications of sectional and partial nephrolithotomies are reflected in Figs. 4-5. The incidence of paranephritis and postoperative mortality are reported in Tables 6-7. Therefore, functional results of sectional nephrolithotomy are indicative of its considerable organ-sparing effect in experimental animals. Functional outcomes of the clinical sectional and multiple partial nephrolithotomies are similar, yet partial nephrolithotomies are more detrimental to the kidney and the upper urinary tract in terms of the pattern and rate of postoperative complications, as compared to sectional nephrolithotomy. As the sequelae of sectional and partial nephrolithotomies are largely unpredictable, indications for surgical removal of intrarenal stereometrically-composite coral stones should be as limited as possible.

Animals↗
PubMed1989

[The surgical cure of the sequelae of noma (cancrum oris). A report of 2 cases].

The surgical treatment of the sequelae in the patients affected by noma is possible even in emerging countries if the surgeon carefully evaluates each patient individually choosing simple, safe, sound and satisfactory techniques which are conditioned by sex and age of the patients. Two cases of sequelae treated with different techniques are described.

Adolescent↗