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PubMed1976

Neurotrophic activity of brain extracts in forelimb regeneration of the urodele, Triturus.

The loss in protein synthesis which the regenerating forelimb of the newt suffers after denervation can be recovered by infusing into it an extract of newt soluble brain protein. Moreover, the synthesis of basic protein shows a greater response to the active brain principle than does that of acidic protein. The active agent of the nervous tissue is destroyed by heat and trypsin digestion. Extracts of liver and spleen, similarly prepared, do not evoke recovery of lost protein synthesis. Synaptosomal extracts of the frog brain also cause recovery of protein synthesis in the denervated regenerate, demonstrating the likelihood that the active agent is not species-specific within these amphibians, that it is a constituent of the neuronal fraction of nervous tissue, and that it is present in axonal terminals. Additional experiments showed that the nervous agent is likely a basic protein, and that the amount of protein infused is of the order of only 1.0% of the total regenerate protein. The significance of the findings is discussed in relation to the nature of the effect on protein synthesis and the nature of the active principle.

Animals↗
PubMed1977

Neurotrophic stimulation of DNA synthesis in the regenerating forelimb of the newt, Triturus.

The effect of infusions of soluble newt brain extracts on deoxyribonucleic acid (DNA) synthesis in the denervated, regenerating newt blastema has been studied. When moderate early to early regenerates are denervated for 48 hours, DNA synthesis normally drops to about 40% of that found in contralateral, innervated blastemas. Infusion of brain extract halfway through the denervation period (at 24 hours) approximately doubles the rate of DNA synthesis in denervated regenerates.

Animals↗