ON THE USE OF FLUORIDATED TOOTHPASTES.
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Sixty-five subjects were assigned to use Crest or Rembrandt dentifrice with either a placebo or Peridex rinse for eight weeks. One group, using Peridex, started with Crest and switched to Rembrandt at week four of the study. There were no significant differences among the groups on gingivitis, plaque, or calculus by the conclusion of the study. On the stain intensity index there was a significant statistical difference on buccal surfaces between Crest and Rembrandt with placebo compared to Crest with Peridex. On lingual surfaces, Rembrandt with placebo rinse was significantly lower than all Peridex rinse groups by the end of the study. From baseline to the conclusion of the study, Crest with placebo had no change in stain intensity, while Rembrandt with placebo had a significant drop on both buccal and lingual surfaces. The Peridex groups had increases on buccal stain intensity. On stain area scores, by the conclusion of the study both Crest and Rembrandt with placebo were significantly different from Crest with Peridex on buccal and lingual surfaces. Over time there was no significant change in stain area for the Crest with placebo groups. Rembrandt and placebo was significantly lower on stain area from baseline to week eight on buccal surfaces. The Peridex groups had increases in stain area over the study period.
Eighteen subjects participated in a stain removal study following two months of Peridex use. The subjects were randomly assigned to use either Rembrandt dentifrice or Crest dentifrice for two months. Indices for stain area and intensity were taken at baseline, two, four, and eight weeks. After eight weeks' use, the Rembrandt group had a 37.1% lower stain area score on facial and 30% lower stain score on lingual surfaces compared to the Crest dentifrice group. On total surface stain area, the Rembrandt group was significantly lower than the Crest dentifrice group at p less than .05. Over eight weeks, the Rembrandt group had a significant drop in stain area while the Crest group had no significant change. On the stain intensity index, there was a 45.7% reduction on facial surfaces and 38.2% on lingual surfaces compared to the Crest dentifrice group which was significant at p less than .01.
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The purpose of this article is to compare the gingivitis reduction efficacy relative to baseline of an integrated power toothbrush/toothpaste dispensing system prototype, the IntelliClean System from Sonicare and Crest. This was a randomized, controlled, parallel-group, examiner-blind study that examined the gingivitis reduction efficacy of a novel integrated system compared to a positive control consisting of manual toothbrushing coupled with daily flossing over a 4-week period. Mean change from baseline for gingival index (GI) and bleeding scores were tested using paired t tests for each treatment group, separately. Between-group comparisons were made with respect to change from baseline using analysis of covariance. Baseline values were used as the covariate. All tests were 2-sided with a 0.05 level of significance. A total of 66 subjects (61 women and 5 men) completed the study. The subjects ranged in age from 20 to 64 years with an overall mean age of 39.4 years. Baseline GI and bleeding scores were not statistically significantly different (P > .2) between the experimental integrated system group and the positive-control group. Both treatment regimen groups demonstrated highly statistically significant reductions in GI and bleeding scores vs baseline (P < .0001) at weeks 2 and 4. After 4 weeks, there was a 28% mean reduction in GI for the experimental group and a 23% mean reduction for the positive-control group. Similarly, there was a 28% mean reduction in bleeding for the experimental integrated system group and a 23% reduction for the positive-control group. However, no statistically significant treatment difference was found between the 2 groups (P > .5) for either measure at week 2 or week 4. This study demonstrated the efficacy of the IntelliClean System from Sonicare and Crest in significantly reducing gingivitis and bleeding relative to baseline after 4 weeks of use according to the manufacturer's instructions.
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"C31G" means and amine mixture, which shall be, a new "sure" substance of small toxicity and is used as an effective plaque and caries reducing chemotherapeutical substance in a tooth paste. In this study we report on: the caries reducing effect in the teeth cleaning experiment in Osborn-Mendel-rats (96 animals, 6 Groups) with C-31G-containing tooth pastes in different concentrations and also in combinations with and without fluoride. the effect of an 1% C31G-containing tooth paste on plaque formation (SLI + QHI) and gingivitis (SBI) in a clinical double blind cross over-study (section % patients, 2 groups, 2 pre-experimental OH-Plases, teeth cleaning once per day). The study results don't show the expected plaque and caries reducind effect. The results of the in vivo and in vitro experiments call for a critical examination of the substances with attention of further parameters.
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A caries preventive effect depending on the free fluoride concentration was registrated on rats using dentifrices with NaF or MFP (alone or in combination) despite the presence of CaCO3 as abrasive material because the composition of these dentifrices was changed. The free fluoride concentration of dentifrices had induced the accumulation of fluoride into enamel. The ionized fluoride content of NaF-dentifrices was unchanged for 3 years. MFP was hydrolized and had continuously released fluoride ions. The caries preventive effect which was increased by HCO3- was reproducible in correspondence with the fluoride concentration after the storage for two years.