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PubMed1983

Irritation and staining by dithranol (anthralin) and related compounds. IV. Visual estimation of erythema compared with contact thermometry and laser Doppler flowmetry.

Irritation and staining caused by equi-irritant doses of dithranol (anthralin) and 10-butyryl dithranol (butantrone) were observed for one week after a single 24-hour exposure under occlusion. The test chambers were applied on the uninvolved dorsal skin of 11 psoriasis patients. The estimates of erythema were made with a refined reading scale, and to test the visual discriminatory power they were compared with objective measurements of contact temperature and blood flow of the skin. A sensitive thermistor and a novel laser Doppler flowmeter were used. On the whole, erythema, contact temperature and superficial blood flow, as interdependent parameters of cutaneous inflammation, all showed a time-dependent statistically significant correlation to the dose of dithranol and 10-butyryl dithranol. The intercorrelations between erythema and blood flow and between erythema and temperature were statistically significant, too. With the doses used, staining of the skin did not hamper the measurement of superficial blood flow, but it did exaggerate visual estimates of erythema at the 4th and 7th day readings.

Anthracenes↗
PubMedDate not supplied

[Thermometry in experimental inflammation. II. Studies of the effect of local cold application on the skin temperature of the rat's paw in experimental inflammation].

In continuation of earlier thermometric investigations on experimental inflammations in rats we studied the effect of a single local cold application on paw skin temperature after injection of caolin , carrageenan and dextran. In all cooling experiments a highly significant drop of skin temperature of the inflamed paw could be demonstrated which came up to an average of 17 degrees C. However, the further course of skin temperature was very different. In caolin edema, the skin of the inflamed paw rewarmed quickly; after injection of carrageenan and dextran the skin temperature was significantly low after 60 min, but it exceeded the values later on. These results demonstrate that local cooling significantly influences experimental inflammations. Depending on different etiology and pathogenesis, however, the reaction of inflammation on cooling is very different.

Animals↗