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PubMed1994

Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin.

OBJECTIVE: To determine the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene in several ethnic groups: Caucasian Europeans, Black Nigerians, Samoan Polynesians and Yanomami Indians. RESULTS: The ratio of the frequencies of the II, ID and DD genotypes were 1:2:1 in the Europeans, but there was a tendency towards a higher frequency of the D allele in the Nigerians. In contrast, the Samoans and the Yanomami Indians displayed a much higher frequency of the I allele than of the D allele. CONCLUSION: The relationship between ACE genotype and disease in these latter groups is still not known, but the present results clearly suggest that ethnic origin should be carefully considered in the increasing number of studies on the association between I/D ACE genotype and disease aetiology.

Alleles↗
PubMed1978

Margaret Mead.

Explore the source record for details and available documents.

Anthropology↗
PubMed1996

Overview of the Native American Cancer Conference III. Risk factors, outreach and intervention strategies.

BACKGROUND: Based on the lack of published information regarding Native Americans and cancer and the success of previous meetings, the Network for Cancer Control Research among American Indian and Alaska Native Populations (NCCR-AIANP) and the Native Hawaiian and American Samoan Cancer Research Network determined there was sufficient need to have annual national Native American cancer conferences. METHODS: The NCCR-AIANP, the Native Hawaiian and American Samoan Cancer Research Network, and the AMC Native American Cancer Research Program collaborated to organize the third national Native American cancer conference, "Native American Cancer Conference III: Risk Factors, Outreach and Intervention Strategies." RESULTS: The conference was held in Seattle, Washington, June 16-19, 1995. It provided a forum for scientific discussion and dissemination of information related to cancer prevention and control. CONCLUSIONS: Conference participants benefited from the topics presented and the diversity of the audience members. There continues to be a need to share what is happening in cancer research with this unique population and to address new issues of concern. A cancer conference seems to be a useful mechanism to provide such an opportunity.

American Samoa↗
PubMed1996

Native American Cancer Conference III. Cognitive correlates and impressions of attendees.

BACKGROUND: The results of preconference and postconference surveys, as well as conference evaluation forms, distributed to attendees at the "Native American Cancer Conference III: Risk Factors, Outreach and Intervention Strategies," Seattle, Washington, June 16-19, 1995, are presented. METHODS: Conference attendees were requested to complete a multi-item survey designed to assess knowledge and perceptions relating to cancer among native peoples at the beginning and end of the conference. The evaluation instrument solicited qualitative impressions of the conference. RESULTS: Survey respondents were predominantly female (70%), and approximately half were native persons representing 48 different American Indian and Alaska Native communities. Knowledge levels were generally high at baseline for most items relating to cancer, with evidence of significant improvement for several items on the postconference survey. The majority of respondents believed that cancer was of equal importance compared with other health problems and that cancer services for American Indians and Alaska Natives are generally less extensive compared with the majority population; there was no evidence of opinion change noted in the postconference survey. Results from the qualitative evaluation expressed the unique and affirmative experiences among participants in terms of the social, cultural, and informational sharing that occurred. CONCLUSIONS: It is hoped that the positive experiences of conference attendees will serve to stimulate the organization of similar programs and the design of research projects that both assess and expand cancer control services among Native peoples.

Adult↗
PubMed1996

Native Americans' cancer rates in comparison with other peoples of color.

BACKGROUND: The National Cancer Institute developed population-specific programs to better understand cancer as it occurs within underserved populations such as American Indians, Alaska Natives, Native Hawaiians, and American Samoans. METHODS: The data for American Samoans are derived from regional studies and from data collected from the Hawaii Surveillance, Epidemiology, and End Results (SEER) Registry. Native Hawaiian data are from the Hawaii SEER program and are limited to Native Hawaiians who live in that state. Alaska Native data are from the Lanier and Knutson 15-year summary of Alaska Native cancer data. American Indian data are from the New Mexico SEER program, which is generalizable to natives living in Arizona and New Mexico only and is relatively free of racial misclassification errors. RESULTS: An overview of age-adjusted cancer incidence and mortality rates among American Indians, Alaska Natives, Native Hawaiians, African Americans, and whites for 1977-1983 is provided. Five-year relative survival rates from cancer are from 1975-1984. Relative survival rates are provided for American Indians, Native Hawaiians, African Americans, and whites. CONCLUSIONS: Based on the limited data available, divergent cancer patterns appear to be present in these Native American populations. Alaska Natives and Native Hawaiians consistently display elevated rates that are frequently camouflaged when data are collapsed into "other" racial categories.

Black or African American↗
PubMed1996

Overview of National Cancer Institute networks for cancer control research in Native American populations.

BACKGROUND: The National Cancer Institute established two Native American cancer control research networks. These networks were created to develop and promote a cadre of cancer prevention and control scientists to conduct culturally sensitive research among Native American populations (i.e., American Indian, Alaska Native, Native Hawaiian, and American Samoan). The primary objective of these research efforts is to reduce morbidity and mortality from cancer. Toward reaching this objective, the networks have (1) conducted research, (2) affiliated with or stimulated other groups to conduct research, or (3) facilitated research by encouraging the training of new researchers of Native American origin to promote prevention and early detection as well as state-of-the-art treatment among their people. METHODS: The networks are organized and financially supported by the NCI. Members of the network have established working committees that follow up on tasks identified during the meetings. RESULTS: Accomplishments of these networks have been recorded between 1990 and 1996. Two strategic plans for cancer control research among American Indians and Alaska Natives have been drafted and disseminated. One of the plans was designed for federal agencies and the other for state health departments. The networks have conducted three national surveys regarding native peoples' access to cancer prevention and control services and conducted two national Native American cancer conferences. The Native Hawaiian/American Samoan Task Force was established in 1992 due to the high incidence and mortality statistics for cancer in these populations. CONCLUSIONS: Through support mechanisms such as those implemented by the NCI, independent networks can be created to advocate actively for cancer prevention and control efforts within Native American communities, among nonnatives, and within professional organizations and governmental agencies.

American Samoa↗